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    Compositions and methods for the treatment and diagnosis of immune disorders
    1.
    发明申请
    Compositions and methods for the treatment and diagnosis of immune disorders 审中-公开
    用于治疗和诊断免疫疾病的组合物和方法

    公开(公告)号：US20090041752A1

    公开(公告)日：2009-02-12

    申请号：US11888354

    申请日：2007-07-31

    申请人： Douglas Adam Levinson ,  Clare M. Lloyd ,  Sean A. McCarthy

    发明人： Douglas Adam Levinson ,  Clare M. Lloyd ,  Sean A. McCarthy

    IPC分类号： A61K39/395 ,  A61K38/00 ,  A61P9/00

    CPC分类号： C07K14/47

    摘要： The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders, and also for the treatment of mast cell-related processes and disorders, ischemic disorders and injuries, including ischemic renal disorders and injuries. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials. Methods are also provided for the treatment of symptoms associated with mast cell-related processes or disorders and ischemic disorders and injuries using the genes, gene products and antibodies of the invention.

    摘要翻译： 本发明涉及用于治疗和诊断免疫疾病，特别是T辅助淋巴细胞相关病症的方法和组合物，还涉及治疗肥大细胞相关过程和病症，缺血性疾病和损伤，包括缺血性肾病和损伤 。 例如，识别在T辅助细胞（TH）细胞和TH细胞亚群内部和之间差异表达的基因，其包括但不限于TH0，TH1和TH2细胞亚群。 基因也通过其基因产物与涉及TH细胞和TH细胞亚群的分化，维持和效应子功能的基因产物相互作用的能力进行鉴定。 所鉴定的基因可以诊断使用或作为治疗干预的靶标。 在这方面，本发明提供了用于鉴定和治疗性使用化合物作为免疫疾病，特别是TH细胞亚群相关病症治疗的方法。 另外，提供了用于TH细胞亚群相关病症的诊断评估和预后的方法，用于鉴定表现出对这些病症倾向的受试者，用于监测接受临床评估治疗这种病症的患者，以及用于监测 化合物用于临床试验。 还提供了使用本发明的基因，基因产物和抗体治疗与肥大细胞相关过程或病症相关的症状以及缺血性疾病和损伤的方法。

    COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF IMMUNE DISORDERS
    2.
    发明申请
    COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF IMMUNE DISORDERS 审中-公开
    用于治疗和诊断免疫缺陷病的组合物和方法

    公开(公告)号：US20120171204A1

    公开(公告)日：2012-07-05

    申请号：US13166982

    申请日：2011-06-23

    申请人： Douglas Adam Levinson ,  Clare M. Lloyd ,  Sean A. McCarthy

    发明人： Douglas Adam Levinson ,  Clare M. Lloyd ,  Sean A. McCarthy

    IPC分类号： A61K39/395 ,  A61P11/06 ,  A61P37/08 ,  A61P27/02 ,  G01N33/53 ,  A61P31/08 ,  C07K19/00 ,  C12Q1/68 ,  G01N21/64 ,  A61P37/00 ,  A61P33/02

    CPC分类号： C07K14/47

    摘要： The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders, and also for the treatment of mast cell-related processes and disorders, ischemic disorders and injuries, including ischemic renal disorders and injuries. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials. Methods are also provided for the treatment of symptoms associated with mast cell-related processes or disorders and ischemic disorders and injuries using the genes, gene products and antibodies of the invention.

    摘要翻译： 本发明涉及用于治疗和诊断免疫疾病，特别是T辅助淋巴细胞相关病症的方法和组合物，还涉及治疗肥大细胞相关过程和病症，缺血性疾病和损伤，包括缺血性肾病和损伤 。 例如，识别在T辅助细胞（TH）细胞和TH细胞亚群内部和之间差异表达的基因，其包括但不限于TH0，TH1和TH2细胞亚群。 基因也通过其基因产物与涉及TH细胞和TH细胞亚群的分化，维持和效应子功能的基因产物相互作用的能力进行鉴定。 所鉴定的基因可以诊断使用或作为治疗干预的靶标。 在这方面，本发明提供了用于鉴定和治疗性使用化合物作为免疫疾病，特别是TH细胞亚群相关病症治疗的方法。 另外，提供了用于TH细胞亚群相关病症的诊断评估和预后的方法，用于鉴定表现出对这些病症倾向的受试者，用于监测接受临床评估治疗这种病症的患者，以及用于监测 化合物用于临床试验。 还提供了使用本发明的基因，基因产物和抗体治疗与肥大细胞相关过程或病症相关的症状以及缺血性疾病和损伤的方法。

    COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF IMMUNE DISORDERS
    3.
    发明申请
    COMPOSITIONS AND METHODS FOR THE TREATMENT AND DIAGNOSIS OF IMMUNE DISORDERS 审中-公开
    用于治疗和诊断免疫缺陷病的组合物和方法

    公开(公告)号：US20110123548A1

    公开(公告)日：2011-05-26

    申请号：US12729438

    申请日：2010-03-23

    申请人： Douglas Adam Levinson ,  Clare M. Lloyd ,  Sean A. McCarthy

    发明人： Douglas Adam Levinson ,  Clare M. Lloyd ,  Sean A. McCarthy

    IPC分类号： A61K39/395 ,  A61K38/17 ,  A61K48/00 ,  A61P9/10 ,  A61P13/12

    CPC分类号： C07K14/47

    摘要： The present invention relates to methods and compositions for the treatment and diagnosis of immune disorders, especially T helper lymphocyte-related disorders, and also for the treatment of mast cell-related processes and disorders, ischemic disorders and injuries, including ischemic renal disorders and injuries. For example, genes which are differentially expressed within and among T helper (TH) cells and TH cell subpopulations, which include, but are not limited to TH0, TH1 and TH2 cell subpopulations are identified. Genes are also identified via the ability of their gene products to interact with gene products involved in the differentiation, maintenance and effector function of such TH cells and TH cell subpopulations. The genes identified can be used diagnostically or as targets for therapeutic intervention. In this regard, the present invention provides methods for the identification and therapeutic use of compounds as treatments of immune disorders, especially TH cell subpopulation-related disorders. Additionally, methods are provided for the diagnostic evaluation and prognosis of TH cell subpopulation-related disorders, for the identification of subjects exhibiting a predisposition to such conditions, for monitoring patients undergoing clinical evaluation for the treatment of such disorders, and for monitoring the efficacy of compounds used in clinical trials. Methods are also provided for the treatment of symptoms associated with mast cell-related processes or disorders and ischemic disorders and injuries using the genes, gene products and antibodies of the invention.

    摘要翻译： 本发明涉及用于治疗和诊断免疫疾病，特别是T辅助淋巴细胞相关病症的方法和组合物，还涉及治疗肥大细胞相关过程和病症，缺血性疾病和损伤，包括缺血性肾病和损伤 。 例如，识别在T辅助细胞（TH）细胞和TH细胞亚群内部和之间差异表达的基因，其包括但不限于TH0，TH1和TH2细胞亚群。 基因也通过其基因产物与涉及TH细胞和TH细胞亚群的分化，维持和效应子功能的基因产物相互作用的能力进行鉴定。 所鉴定的基因可以诊断使用或作为治疗干预的靶标。 在这方面，本发明提供了用于鉴定和治疗性使用化合物作为免疫疾病，特别是TH细胞亚群相关病症治疗的方法。 另外，提供了用于TH细胞亚群相关病症的诊断评估和预后的方法，用于鉴定表现出对这些病症倾向的受试者，用于监测接受临床评估治疗这种病症的患者，以及用于监测 化合物用于临床试验。 还提供了使用本发明的基因，基因产物和抗体治疗与肥大细胞相关过程或病症相关的症状以及缺血性疾病和损伤的方法。

    DELTA3, FTHMA-070, TANGO85, TANGO77, SPOIL, NEOKINE, TANGO129, and INTEGRIN ALPHA SUBUNIT Protein and nucleic acid molecules and uses thereof
    5.
    发明申请
    DELTA3, FTHMA-070, TANGO85, TANGO77, SPOIL, NEOKINE, TANGO129, and INTEGRIN ALPHA SUBUNIT Protein and nucleic acid molecules and uses thereof 有权
    DELTA3，FTHMA-070，TANGO85，TANGO77，SPOIL，NEOKINE，TANGO129和INTEGRIN ALPHA SUBUNIT蛋白质和核酸分子及其用途

    公开(公告)号：US20090286956A1

    公开(公告)日：2009-11-19

    申请号：US11974478

    申请日：2007-10-12

    申请人： Sean A. McCarthy ,  David P. Gearing ,  Douglas A. Holtzman ,  Yang Pan ,  Samantha J. Busfield ,  Thomas M. Barnes ,  Charles R. Mackay ,  Jose M. Lora

    发明人： Sean A. McCarthy ,  David P. Gearing ,  Douglas A. Holtzman ,  Yang Pan ,  Samantha J. Busfield ,  Thomas M. Barnes ,  Charles R. Mackay ,  Jose M. Lora

    IPC分类号： C07K14/705

    CPC分类号： C12Q1/48 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6876

    摘要： The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供新颖的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259多肽，蛋白质和核酸分子。 除了分离的全长Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259蛋白外，本发明还提供了分离的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259融合 蛋白质，抗原肽和抗Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259抗体。 本发明还提供了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259核酸分子，含有本发明的核酸分子的重组表达载体，已经引入表达载体的宿主细胞， 已经引入或破坏了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129或A259基因的人类转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。

    Delta3 (tango24) protein and nucleic acid molecules and uses thereof
    6.
    发明授权
    Delta3 (tango24) protein and nucleic acid molecules and uses thereof 有权
    Delta3（tango24）蛋白质和核酸分子及其用途

    公开(公告)号：US07897725B2

    公开(公告)日：2011-03-01

    申请号：US11974478

    申请日：2007-10-12

    申请人： Sean A. McCarthy ,  David P. Gearing

    发明人： Sean A. McCarthy ,  David P. Gearing

    IPC分类号： C07K1/00 ,  C07H21/04 ,  C12N15/85 ,  C12N15/63

    CPC分类号： C12Q1/48 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6876

    摘要： The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供新颖的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259多肽，蛋白质和核酸分子。 除了分离的全长Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259蛋白外，本发明还提供了分离的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259融合 蛋白质，抗原肽和抗Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259抗体。 本发明还提供了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞， 已经引入或破坏了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129或A259基因的人类转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。

    Novel Human Dickkopf-Related Protein and Nucleic Acid Molecules and uses Therefor
    8.
    发明申请
    Novel Human Dickkopf-Related Protein and Nucleic Acid Molecules and uses Therefor 有权
    新型人类Dickkopf相关蛋白和核酸分子及其用途

    公开(公告)号：US20100216140A1

    公开(公告)日：2010-08-26

    申请号：US12616901

    申请日：2009-11-12

    申请人： Sean A. McCarthy

    发明人： Sean A. McCarthy

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C07K14/435 ,  C07K16/00 ,  C12P21/06 ,  G01N33/53

    CPC分类号： C07K14/4718 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  Y10S530/866 ,  Y10S530/867

    摘要： Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides Dkk and Dkk-related nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Dkk and Dkk-related gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了新的Dkk和Dkk相关多肽，蛋白质和核酸分子。 除了分离的全长Dkk和Dkk相关蛋白之外，本发明还提供分离的融合蛋白，抗原肽和抗体。 本发明还提供了Dkk和Dkk相关核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中Dkk和Dkk相关基因的非人转基因动物 已被引入或中断。 还提供利用本发明组合物的诊断，筛选和治疗方法。

    Novel human dickkopf-related protein and nucleic molecules and uses therefor
    9.
    发明申请
    Novel human dickkopf-related protein and nucleic molecules and uses therefor 审中-公开
    新型人类dickkopf相关蛋白和核酸分子及其用途

    公开(公告)号：US20090092992A1

    公开(公告)日：2009-04-09

    申请号：US12284121

    申请日：2008-09-17

    申请人： Sean A. McCarthy

    发明人： Sean A. McCarthy

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N15/63 ,  C12N5/00 ,  C12N5/02 ,  C07K14/435 ,  C12P21/06 ,  G01N33/53

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/4718 ,  C07K2319/00 ,  Y10S530/866

    摘要： Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides Dkk and Dkk-related nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Dkk and Dkk-related gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了新的Dkk和Dkk相关多肽，蛋白质和核酸分子。 除了分离的全长Dkk和Dkk相关蛋白之外，本发明还提供分离的融合蛋白，抗原肽和抗体。 本发明还提供了Dkk和Dkk相关核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中Dkk和Dkk相关基因的非人转基因动物 已被引入或中断。 还提供利用本发明组合物的诊断，筛选和治疗方法。