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    DELTA3, FTHMA-070, TANGO85, TANGO77, SPOIL, NEOKINE, TANGO129, and INTEGRIN ALPHA SUBUNIT Protein and nucleic acid molecules and uses thereof
    1.
    发明申请
    DELTA3, FTHMA-070, TANGO85, TANGO77, SPOIL, NEOKINE, TANGO129, and INTEGRIN ALPHA SUBUNIT Protein and nucleic acid molecules and uses thereof 有权
    DELTA3，FTHMA-070，TANGO85，TANGO77，SPOIL，NEOKINE，TANGO129和INTEGRIN ALPHA SUBUNIT蛋白质和核酸分子及其用途

    公开(公告)号：US20090286956A1

    公开(公告)日：2009-11-19

    申请号：US11974478

    申请日：2007-10-12

    申请人： Sean A. McCarthy ,  David P. Gearing ,  Douglas A. Holtzman ,  Yang Pan ,  Samantha J. Busfield ,  Thomas M. Barnes ,  Charles R. Mackay ,  Jose M. Lora

    发明人： Sean A. McCarthy ,  David P. Gearing ,  Douglas A. Holtzman ,  Yang Pan ,  Samantha J. Busfield ,  Thomas M. Barnes ,  Charles R. Mackay ,  Jose M. Lora

    IPC分类号： C07K14/705

    CPC分类号： C12Q1/48 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6876

    摘要： The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供新颖的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259多肽，蛋白质和核酸分子。 除了分离的全长Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259蛋白外，本发明还提供了分离的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259融合 蛋白质，抗原肽和抗Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259抗体。 本发明还提供了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259核酸分子，含有本发明的核酸分子的重组表达载体，已经引入表达载体的宿主细胞， 已经引入或破坏了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129或A259基因的人类转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。

    DELTA3, FTHMA-070, TANGO85, TANGO77, SPOIL, NEOKINE, TANGO129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
    2.
    发明申请
    DELTA3, FTHMA-070, TANGO85, TANGO77, SPOIL, NEOKINE, TANGO129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof 审中-公开
    DELTA3，FTHMA-070，TANGO85，TANGO77，SPOIL，NEOKINE，TANGO129和整合素α亚基蛋白和核酸分子及其用途

    公开(公告)号：US20080220495A1

    公开(公告)日：2008-09-11

    申请号：US11974465

    申请日：2007-10-12

    申请人： Sean A. McCarthy ,  David P. Gearing ,  Douglas A. Holtzman ,  Yang Pan ,  Samantha J. Busfield ,  Thomas M. Barnes ,  Charles R. Mackay ,  Jose M. Lora

    发明人： Sean A. McCarthy ,  David P. Gearing ,  Douglas A. Holtzman ,  Yang Pan ,  Samantha J. Busfield ,  Thomas M. Barnes ,  Charles R. Mackay ,  Jose M. Lora

    IPC分类号： C12N11/00 ,  C07K16/00 ,  C07K17/00

    CPC分类号： C12Q1/48 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6876

    摘要： The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供新颖的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259多肽，蛋白质和核酸分子。 除了分离的全长Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259蛋白外，本发明还提供了分离的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259融合 蛋白质，抗原肽和抗Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259抗体。 本发明还提供了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞， 已经引入或破坏了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129或A259基因的人类转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。

    EGF-like nucleic acids and polypeptides and uses thereof
    5.
    发明授权
    EGF-like nucleic acids and polypeptides and uses thereof 失效
    EGF样核酸和多肽及其用途

    公开(公告)号：US07803564B2

    公开(公告)日：2010-09-28

    申请号：US11904098

    申请日：2007-09-26

    申请人： Samantha J. Busfield ,  David P. Gearing

    发明人： Samantha J. Busfield ,  David P. Gearing

    IPC分类号： G01N33/567 ,  C12N15/24 ,  C12N15/64 ,  C12P21/02 ,  C07K14/47

    CPC分类号： C07K14/485

    摘要： The invention provides isolated nucleic acid molecules, designated ELVIS-1, ELVIS-2, and ELVIS-3 (for Epidermal Growth Factor-Like Variant In Skin-1,2, and 3). ELVIS nucleic acid molecules encode wholly secreted and transmembrane proteins with homology to EGF and TGF-α. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

    摘要翻译： 本发明提供分离的核酸分子，命名为ELVIS-1，ELVIS-2和ELVIS-3（用于皮肤中的表皮生长因子样变体-1,2和3）。 ELVIS核酸分子编码与EGF和TGF-α具有同源性的完全分泌和跨膜蛋白。 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

    EGF-like nucleic acids and polypeptides and uses thereof
    6.
    发明申请
    EGF-like nucleic acids and polypeptides and uses thereof 失效
    EGF样核酸和多肽及其用途

    公开(公告)号：US20090117583A1

    公开(公告)日：2009-05-07

    申请号：US11904098

    申请日：2007-09-26

    申请人： Samantha J. Busfield ,  David P. Gearing

    发明人： Samantha J. Busfield ,  David P. Gearing

    IPC分类号： G01N33/53 ,  C07K14/00

    CPC分类号： C07K14/485

    摘要： The invention provides isolated nucleic acid molecules, designated ELVIS-1, ELVIS-2, and ELVIS-3 (for Epidermal Growth Factor-Like Variant In Skin-1,2, and 3). ELVIS nucleic acid molecules encode wholly secreted and transmembrane proteins with homology to EGF and TGF-α. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

    摘要翻译： 本发明提供分离的核酸分子，命名为ELVIS-1，ELVIS-2和ELVIS-3（用于皮肤中的表皮生长因子样变体-1,2和3）。 ELVIS核酸分子编码与EGF和TGF-α具有同源性的完全分泌和跨膜蛋白。 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

    EGF-like nucleic acids
    9.
    发明授权
    EGF-like nucleic acids 失效
    EGF样核酸

    公开(公告)号：US07294482B2

    公开(公告)日：2007-11-13

    申请号：US10345764

    申请日：2003-01-16

    申请人： Samantha J. Busfield ,  David P. Gearing

    发明人： Samantha J. Busfield ,  David P. Gearing

    IPC分类号： C12N15/12 ,  C12N5/10 ,  C12P21/02 ,  C07K14/47

    CPC分类号： C07K14/485

    摘要： The invention provides isolated nucleic acid molecules, designated ELVIS-1, ELVIS-2, and ELVIS-3 (for Epidermal Growth Factor-Like Variant In Skin-1, 2, and 3). ELVIS nucleic acid molecules encode wholly secreted and transmembrane proteins with homology to EGF and TGF-α. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The ELVIS nucleic acids of the present invention are useful as modulating agents in regulating a variety of cellular processes, and are particularly useful for diagnostic, screening and therapeutic methods for the treatment of skin conditions, such as for wound healing. Accordingly, in one aspect, this invention provides isolated nucleic acid molecules encoding a polypeptide of the invention or biologically active portion thereof. The present invention also provides nucleic acid molecules which are suitable as primers or hybridization probes for the detection of nucleic acids encoding a polypeptide of the invention.

    摘要翻译： 本发明提供分离的核酸分子，命名为ELVIS-1，ELVIS-2和ELVIS-3（用于皮肤中的表皮生长因子样变体-1,2和3）。 ELVIS核酸分子编码与EGF和TGF-α具有同源性的完全分泌和跨膜蛋白。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞，以及其中引入或破坏了本发明的核酸分子的非人类转基因动物。 本发明的ELVIS核酸可用作调节多种细胞过程中的调节剂，并且特别可用于治疗皮肤病症如伤口愈合的诊断，筛选和治疗方法。 因此，一方面，本发明提供了编码本发明的多肽或其生物活性部分的分离的核酸分子。 本发明还提供了适用于检测编码本发明多肽的核酸的引物或杂交探针的核酸分子。

    Novel secreted immunomodulatory proteins and uses thereof
    10.
    发明申请
    Novel secreted immunomodulatory proteins and uses thereof 审中-公开
    新型分泌的免疫调节蛋白及其用途

    公开(公告)号：US20100279313A1

    公开(公告)日：2010-11-04

    申请号：US12215729

    申请日：2008-06-30

    申请人： Samantha J. Busfield

    发明人： Samantha J. Busfield

    IPC分类号： G01N33/567 ,  C07H21/00 ,  C12N15/12 ,  C12N5/07 ,  C07K14/435 ,  C07K16/18 ,  C12P21/00 ,  G01N33/53 ,  G01N33/48 ,  C12N5/00 ,  G01N33/68

    CPC分类号： C07K14/47 ,  C07K14/715 ,  Y10T436/143333

    摘要： The invention concerns cDNA molecules encoding TANGO 191 and TANGO 195, both of which are transmembrane proteins.The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes. Accordingly, in one aspect, this invention provides isolated nucleic acid molecules encoding a polypeptide of the invention or biologically active portion thereof. The present invention also provides nucleic acid molecules which are suitable as primers or hybridization probes for the detection of nucleic acids encoding a polypeptide of the invention.

    摘要翻译： 本发明涉及编码TANGO 191和TANGO 195的cDNA分子，它们都是跨膜蛋白。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。 因此，一方面，本发明提供了编码本发明的多肽或其生物活性部分的分离的核酸分子。 本发明还提供了适用于检测编码本发明多肽的核酸的引物或杂交探针的核酸分子。