公开(公告)号：US20100062487A1

公开(公告)日：2010-03-11

申请号：US12387959

申请日：2009-05-08

申请人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

发明人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

IPC分类号： C12P21/02 ,  C07H21/04 ,  C12N5/00 ,  C12N1/00 ,  C07K14/00 ,  C07K16/00 ,  G01N33/53

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  Y02A50/411 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US20120045777A1

公开(公告)日：2012-02-23

申请号：US13169686

申请日：2011-06-27

申请人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

发明人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

IPC分类号： G01N33/53 ,  C12Q1/37 ,  C12P21/02 ,  C12N9/99 ,  C12N9/64 ,  C12N15/57 ,  C12N5/00 ,  C12N15/63 ,  G01N33/50 ,  C07K14/00 ,  C07K16/18 ,  C07H21/04 ,  G01N33/573 ,  C12N5/10

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  Y02A50/411 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US20090136959A1

公开(公告)日：2009-05-28

申请号：US12288775

申请日：2008-10-23

申请人： Sean A. McCarthy ,  Christopher C. Fraser ,  John D. Sharp ,  Thomas M. Barnes ,  Susan J. Kirst ,  Paul S. Myers ,  Nicholas Wrighton ,  Andrew D.J. Goodearl ,  Douglas A. Holtzman ,  Mehran Khodadoust

发明人： Sean A. McCarthy ,  Christopher C. Fraser ,  John D. Sharp ,  Thomas M. Barnes ,  Susan J. Kirst ,  Paul S. Myers ,  Nicholas Wrighton ,  Andrew D.J. Goodearl ,  Douglas A. Holtzman ,  Mehran Khodadoust

IPC分类号： C12Q1/68 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C07K14/00 ,  G01N33/00 ,  C07K1/00 ,  C07K16/18 ,  C12P21/04 ,  G01N33/53

CPC分类号： C07K14/47

摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US20110065124A1

公开(公告)日：2011-03-17

申请号：US12800681

申请日：2010-05-20

申请人： Douglas A. Holtzman ,  John D. Sharp ,  Kevin R. Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas M. Barnes ,  Christopher C. Fraser ,  Nicholas Wrighton ,  Paul S. Myers ,  Gillian Kingsbury

发明人： Douglas A. Holtzman ,  John D. Sharp ,  Kevin R. Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas M. Barnes ,  Christopher C. Fraser ,  Nicholas Wrighton ,  Paul S. Myers ,  Gillian Kingsbury

IPC分类号： G01N33/53 ,  C12N15/12 ,  C12N5/07 ,  C07K14/435 ,  C07K16/18 ,  C12P21/00 ,  G01N33/68 ,  G01N33/00

CPC分类号： C07K14/7151 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/78 ,  C07K2319/00 ,  Y10T436/143333

摘要： The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供了分离的TANGO 239，TANGO 219，TANGO 232，TANGO 281，A236（INTERCEPT 236），TANGO 300，TANGO 353，TANGO 393，TANGO 402，TANGO 351和TANGO 509核酸分子和多肽分子。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20080213778A1

公开(公告)日：2008-09-04

申请号：US11983233

申请日：2007-11-08

申请人： Douglas A. Holtzman ,  John D. Sharp ,  Kevin R. Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas M. Barnes ,  Christopher C. Fraser ,  Nicholas Wrighton ,  Paul S. Myers ,  Gillian Kingsbury

发明人： Douglas A. Holtzman ,  John D. Sharp ,  Kevin R. Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas M. Barnes ,  Christopher C. Fraser ,  Nicholas Wrighton ,  Paul S. Myers ,  Gillian Kingsbury

IPC分类号： C12N15/11 ,  C12N5/00 ,  C12N1/00 ,  C07K14/00 ,  C07K16/00 ,  C12P21/02 ,  G01N33/53 ,  C12Q1/68

CPC分类号： C07K14/7151 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/78 ,  C07K2319/00 ,  Y10T436/143333

摘要： The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供了分离的TANGO 239，TANGO 219，TANGO 232，TANGO 281，A236（INTERCEPT 236），TANGO 300，TANGO 353，TANGO 393，TANGO 402，TANGO 351和TANGO 509核酸分子和多肽分子。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20120270219A1

公开(公告)日：2012-10-25

申请号：US13540352

申请日：2012-07-02

申请人： Douglas A. Holtzman ,  John D. Sharp ,  Kevin R. Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas M. Barnes ,  Christopher C. Fraser ,  Nicholas Wrighton ,  Paul S. Myers ,  Gillian Kingsbury

发明人： Douglas A. Holtzman ,  John D. Sharp ,  Kevin R. Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas M. Barnes ,  Christopher C. Fraser ,  Nicholas Wrighton ,  Paul S. Myers ,  Gillian Kingsbury

IPC分类号： C07K14/47 ,  C12N5/10 ,  C12P21/02 ,  C07K16/18 ,  C12Q1/68 ,  C12N5/071 ,  C12N15/12 ,  C12N15/85 ,  G01N33/566

CPC分类号： C07K14/705 ,  C07K14/70503 ,  G01N33/54313

摘要： The invention provides isolated TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供了分离的TANGO 509核酸分子和多肽分子。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20100291579A1

公开(公告)日：2010-11-18

申请号：US12803671

申请日：2010-07-01

申请人： Christopher C. Fraser ,  Sean Anthony McCarthy ,  John D. Sharp ,  Thomas M. Barnes ,  Nicholas C. Wrighton ,  Charles R. Mackay ,  Kevin R. Leiby ,  Douglas A. Holtzman

发明人： Christopher C. Fraser ,  Sean Anthony McCarthy ,  John D. Sharp ,  Thomas M. Barnes ,  Nicholas C. Wrighton ,  Charles R. Mackay ,  Kevin R. Leiby ,  Douglas A. Holtzman

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12P21/06 ,  C12N5/10 ,  C12N5/02 ,  C12N15/63 ,  C07K14/435 ,  C07K16/18 ,  C07K1/00 ,  C07H21/04

CPC分类号： C07K16/18

摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子和多肽分子。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20090220977A1

公开(公告)日：2009-09-03

申请号：US12319689

申请日：2009-01-09

申请人： Christopher C. Fraser ,  Sean Anthony McCarthy ,  John D. Sharp ,  Thomas M. Barnes ,  Nicholas C. Wrighton ,  Charles R. Mackay ,  Kevin R. Leiby ,  Douglas A. Holtzman

发明人： Christopher C. Fraser ,  Sean Anthony McCarthy ,  John D. Sharp ,  Thomas M. Barnes ,  Nicholas C. Wrighton ,  Charles R. Mackay ,  Kevin R. Leiby ,  Douglas A. Holtzman

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12N5/10 ,  C12N15/63 ,  C07K14/435 ,  C07K16/00 ,  C07H21/04

CPC分类号： C07K16/18

摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子和多肽分子。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20090286956A1

公开(公告)日：2009-11-19

申请号：US11974478

申请日：2007-10-12

申请人： Sean A. McCarthy ,  David P. Gearing ,  Douglas A. Holtzman ,  Yang Pan ,  Samantha J. Busfield ,  Thomas M. Barnes ,  Charles R. Mackay ,  Jose M. Lora

发明人： Sean A. McCarthy ,  David P. Gearing ,  Douglas A. Holtzman ,  Yang Pan ,  Samantha J. Busfield ,  Thomas M. Barnes ,  Charles R. Mackay ,  Jose M. Lora

IPC分类号： C07K14/705

CPC分类号： C12Q1/48 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6876

摘要： The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供新颖的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259多肽，蛋白质和核酸分子。 除了分离的全长Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259蛋白外，本发明还提供了分离的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259融合 蛋白质，抗原肽和抗Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259抗体。 本发明还提供了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259核酸分子，含有本发明的核酸分子的重组表达载体，已经引入表达载体的宿主细胞， 已经引入或破坏了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129或A259基因的人类转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20080220495A1

公开(公告)日：2008-09-11

申请号：US11974465

申请日：2007-10-12

申请人： Sean A. McCarthy ,  David P. Gearing ,  Douglas A. Holtzman ,  Yang Pan ,  Samantha J. Busfield ,  Thomas M. Barnes ,  Charles R. Mackay ,  Jose M. Lora

发明人： Sean A. McCarthy ,  David P. Gearing ,  Douglas A. Holtzman ,  Yang Pan ,  Samantha J. Busfield ,  Thomas M. Barnes ,  Charles R. Mackay ,  Jose M. Lora

IPC分类号： C12N11/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： C12Q1/48 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6876

摘要： The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供新颖的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259多肽，蛋白质和核酸分子。 除了分离的全长Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259蛋白外，本发明还提供了分离的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259融合 蛋白质，抗原肽和抗Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259抗体。 本发明还提供了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞， 已经引入或破坏了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129或A259基因的人类转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。