公开(公告)号：US20080248477A1

公开(公告)日：2008-10-09

申请号：US12001395

申请日：2007-12-11

申请人： Douglas A. Holtzman ,  Sean A. McCarthy ,  Kyle J. MacBeth ,  Samantha J. Busfield ,  Yang Pan ,  David White ,  Mehran M. Khodadoust ,  Wei Gu

发明人： Douglas A. Holtzman ,  Sean A. McCarthy ,  Kyle J. MacBeth ,  Samantha J. Busfield ,  Yang Pan ,  David White ,  Mehran M. Khodadoust ,  Wei Gu

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N15/00 ,  C12N5/00 ,  C07K14/00 ,  C07K16/00 ,  C12P19/34 ,  G01N33/53

CPC分类号： C12N9/0022 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/525 ,  C07K14/705 ,  C07K14/70575 ,  C07K14/70578 ,  C07K14/723 ,  C07K2319/00 ,  Y02A50/411

摘要： Novel ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST proteins, the invention further provides isolated ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST fusion proteins, antigenic peptides and anti-ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST antibodies. The invention also provides ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 公开了新型意大利，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST多肽，蛋白质和核酸分子。 除了分离的全长ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST蛋白之外，本发明还提供了分离的ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST融合蛋白， 抗原肽和抗ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST抗体。 本发明还提供意大利，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST核酸分子，含有本发明的核酸分子的重组表达载体，已经引入表达载体的非宿主细胞 其中引入或破坏意大利，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST基因的转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20110020798A1

公开(公告)日：2011-01-27

申请号：US12653955

申请日：2009-12-18

申请人： Douglas A. Holtzman ,  Sean A. McCarthy ,  Kyle J. MacBeth ,  Samantha J. Busfield ,  Yang Pan ,  David White ,  Mehran M. Khodadoust ,  Wei Gu

发明人： Douglas A. Holtzman ,  Sean A. McCarthy ,  Kyle J. MacBeth ,  Samantha J. Busfield ,  Yang Pan ,  David White ,  Mehran M. Khodadoust ,  Wei Gu

IPC分类号： C12Q1/68 ,  G01N33/566 ,  C12N5/10 ,  C12P21/02 ,  C07K16/18 ,  C07H21/00 ,  C07K14/47 ,  C12N15/63

CPC分类号： C12N9/0022 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/525 ,  C07K14/705 ,  C07K14/70575 ,  C07K14/70578 ,  C07K14/723 ,  C07K2319/00 ,  Y02A50/411

摘要： Novel ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST proteins, the invention further provides isolated ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST fusion proteins, antigenic peptides and anti-ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST antibodies. The invention also provides ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which an ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 公开了新型意大利，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST多肽，蛋白质和核酸分子。 除了分离的全长ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST蛋白之外，本发明还提供了分离的ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST融合蛋白， 抗原肽和抗ITALY，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST抗体。 本发明还提供意大利，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST核酸分子，含有本发明的核酸分子的重组表达载体，已经引入表达载体的非宿主细胞 其中引入或破坏意大利，LOR-2，STRIFE，TRASH，BDSF，LRSG和STMST基因的转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US06300092B1

公开(公告)日：2001-10-09

申请号：US09448076

申请日：1999-11-23

申请人： Mehran M. Khodadoust ,  Kyle J. MacBeth

发明人： Mehran M. Khodadoust ,  Kyle J. MacBeth

IPC分类号： C12Q152

CPC分类号： C12N9/0022 ,  A01K2217/05 ,  A61K38/00

摘要： Novel Lor-2 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Lor-2 proteins, the invention further provides isolated Lor-2 fusion proteins, antigenic peptides and anti-Lor-2 antibodies. The invention also provides Lor-2 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Lor-2 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 公开了新的Lor-2多肽，蛋白质和核酸分子。 除了分离的全长Lor-2蛋白，本发明还提供了分离的Lor-2融合蛋白，抗原肽和抗Lor-2抗体。 本发明还提供了Lor-2核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中导入了Lor-2基因的非人转基因动物，或 中断了 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US06383780B1

公开(公告)日：2002-05-07

申请号：US09443795

申请日：1999-11-19

申请人： Rosana Kapeller-Libermann ,  David White ,  Kyle J. MacBeth

发明人： Rosana Kapeller-Libermann ,  David White ,  Kyle J. MacBeth

IPC分类号： C12P2106

CPC分类号： C12N9/48

摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.

摘要翻译： 本发明涉及新鉴定的人类氨基肽酶。 本发明还涉及编码氨基肽酶的多核苷酸。 本发明还涉及使用氨基肽酶多肽和多核苷酸作为在氨基肽酶相关疾病中进行诊断和治疗的靶标的方法。 本发明还涉及使用氨基肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于氨基肽酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及生产氨基肽酶多肽和多核苷酸的方法。

公开(公告)号：US07235634B2

公开(公告)日：2007-06-26

申请号：US10767308

申请日：2004-01-29

申请人： Rosana Kapeller-Libermann ,  David White ,  Kyle J. MacBeth

发明人： Rosana Kapeller-Libermann ,  David White ,  Kyle J. MacBeth

IPC分类号： C07K14/00

CPC分类号： C12N9/48

摘要： The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.

摘要翻译： 本发明涉及新鉴定的人类氨基肽酶。 本发明还涉及编码氨基肽酶的多核苷酸。 本发明还涉及使用氨基肽酶多肽和多核苷酸作为在氨基肽酶相关疾病中进行诊断和治疗的靶标的方法。 本发明还涉及使用氨基肽酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于氨基肽酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及生产氨基肽酶多肽和多核苷酸的方法。

公开(公告)号：US20100136010A1

公开(公告)日：2010-06-03

申请号：US12288465

申请日：2008-10-21

申请人： Rosana Kappeller-Libermann ,  David White ,  Keith E. Robison ,  Kyle J. MacBeth ,  Joseph M. Carroll ,  William James Cook ,  Rachel E. Meyers ,  Miyoung Chun ,  Mark J. Williamson

发明人： Rosana Kappeller-Libermann ,  David White ,  Keith E. Robison ,  Kyle J. MacBeth ,  Joseph M. Carroll ,  William James Cook ,  Rachel E. Meyers ,  Miyoung Chun ,  Mark J. Williamson

IPC分类号： A61K39/395 ,  A61K38/45 ,  A61K38/46 ,  A61K38/48 ,  C12Q1/68 ,  G01N33/53 ,  C12Q1/34 ,  C12P21/00 ,  C12N5/10 ,  C12N5/00 ,  A61K38/00 ,  A61K38/17 ,  A61K31/713 ,  A61K31/7088 ,  C07K14/435 ,  C07K16/40 ,  C07H21/04 ,  A61P31/12 ,  A61P9/00 ,  A61P35/00 ,  A61P19/08 ,  A61P7/00

CPC分类号： G01N33/5008 ,  A61K38/00 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/6489 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/04017 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/56983 ,  G01N33/56994 ,  G01N33/57426 ,  G01N33/5761 ,  G01N33/5767 ,  G01N33/68 ,  G01N2333/916 ,  G01N2333/96486 ,  G01N2500/04

摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。 本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。 本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US06322982B1

公开(公告)日：2001-11-27

申请号：US09365405

申请日：1999-08-02

申请人： Andrew W. Shyjan ,  Kyle J. MacBeth

发明人： Andrew W. Shyjan ,  Kyle J. MacBeth

IPC分类号： C12Q168

CPC分类号： G01N33/5011 ,  A61K38/00 ,  A61K48/00 ,  C12N9/16 ,  C12Y301/02015 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5091

摘要： The expression of ubiquitin carboxy-terminal hydrolase is aberrent in cells that are resistant to treatment with chemical agents. Accordingly, the invention features methods for diagnosing and treating drug resistant cells (e.g., tumor cells) by examining and modulating the expression or activity of UCH

摘要翻译： 泛素羧基端水解酶的表达在耐化学药剂治疗的细胞中是异常的。 因此，本发明的特征在于通过检查和调节UCH的表达或活性来诊断和治疗耐药细胞（例如肿瘤细胞）的方法

公开(公告)号：US5932422A

公开(公告)日：1999-08-03

申请号：US970733

申请日：1997-11-14

申请人： Andrew W. Shyjan ,  Kyle J. MacBeth

发明人： Andrew W. Shyjan ,  Kyle J. MacBeth

IPC分类号： A61K38/00 ,  A61K48/00 ,  A61P37/00 ,  C12N1/19 ,  C12N9/16 ,  G01N33/50 ,  C12Q1/68 ,  C07H21/04 ,  C12N15/63

CPC分类号： G01N33/5011 ,  C12N9/16 ,  C12Y301/02015 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5091 ,  A61K38/00 ,  A61K48/00

摘要： The expression of ubiquitin carboxy-terminal hydrolase is aberrent in cells that are resistant to treatment with chemical agents. Accordingly, the invention features methods for diagnosing and treating drug resistant cells (e.g., tumor cells) by examining and modulating the expression or activity of UCH.

摘要翻译： 泛素羧基端水解酶的表达在耐化学药剂治疗的细胞中是异常的。 因此，本发明的特征在于通过检查和调节UCH的表达或活性来诊断和治疗耐药性细胞（例如肿瘤细胞）的方法。

公开(公告)号：US20130274219A1

公开(公告)日：2013-10-17

申请号：US13913248

申请日：2013-06-07

申请人： Aaron N. NGUYEN ,  Kyle J. MacBeth

发明人： Aaron N. NGUYEN ,  Kyle J. MacBeth

IPC分类号： A61K31/706 ,  A61K45/06

CPC分类号： A61K31/706 ,  A61K31/7068 ,  A61K45/06

摘要： The present disclosure provides methods for treating subjects having non-small cell lung cancer, wherein the methods comprise administering to the subject a cytidine analog, such as 5-azacytidine. Also provided are methods relating to identification and treatment of particular non-small cell lung cancer types sensitive to particular cytidine analogs.

摘要翻译： 本公开提供了用于治疗患有非小细胞肺癌的受试者的方法，其中所述方法包括向受试者施用胞苷类似物，例如5-氮杂胞苷。 还提供了与对特定胞苷类似物敏感的特定非小细胞肺癌类型的鉴定和治疗有关的方法。

公开(公告)号：US20090068187A1

公开(公告)日：2009-03-12

申请号：US11903752

申请日：2007-09-24

申请人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Fong-Ying Tsai ,  Martin R. Hodge ,  Rachel E. Meyers ,  Kyle J. MacBeth ,  Rajasekhar Bandaru

发明人： Maria A. Glucksmann ,  Rory A.J. Curtis ,  Fong-Ying Tsai ,  Martin R. Hodge ,  Rachel E. Meyers ,  Kyle J. MacBeth ,  Rajasekhar Bandaru

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12N5/10 ,  C07K14/705 ,  C07K16/28 ,  C12P21/02 ,  C12Q1/68 ,  A61K31/7088 ,  A61K38/17 ,  G01N33/567 ,  G01N33/68 ,  C12N5/06 ,  C07K1/113 ,  A61K38/02

CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K2319/00 ,  C07K2319/02 ,  C12N9/0071 ,  C12N9/1051 ,  C12N9/1205

摘要： The invention provides isolated nucleic acids molecules, designated 14275, 54420, 8797, 27439, 68730, 69112 or 52908 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14275, 54420, 8797, 27439, 68730, 69112 or 52908 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14275, 54420, 8797, 27439, 68730, 69112 or 52908 gene has been introduced or disrupted. The invention still further provides isolated 14275, 54420, 8797, 27439, 68730, 69112 or 52908 proteins, fusion proteins, antigenic peptides and anti-14275, 54420, 8797, 27439, 68730, 69112 or 52908 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，命名为14275,54420,8797,27439,67830,69112或52908核酸分子。 本发明还提供反义核酸分子，含有14275,54420,8797,27439,67830,69112或52908核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中14275， 54420,8797,27439,67830,69112或52908基因被引入或破坏。 本发明还进一步提供分离的14275,54420,8797,27439,68730,69112或52908蛋白，融合蛋白，抗原肽和抗-14275,54420,8797,27439,68730,69112或52908抗体。 还提供了利用本发明组合物的诊断和治疗方法。