公开(公告)号：US20100062487A1

公开(公告)日：2010-03-11

申请号：US12387959

申请日：2009-05-08

申请人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

发明人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

IPC分类号： C12P21/02 ,  C07H21/04 ,  C12N5/00 ,  C12N1/00 ,  C07K14/00 ,  C07K16/00 ,  G01N33/53

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  Y02A50/411 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US20120045777A1

公开(公告)日：2012-02-23

申请号：US13169686

申请日：2011-06-27

申请人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

发明人： Christopher C. Fraser ,  Thomas M. Barnes ,  John D. Sharp ,  Susan J. Kirst ,  Paul S. Myers ,  Kevin R. Leiby ,  Douglas A. Holtzman ,  Sean A. McCarthy ,  Nicholas Wrighton ,  Charles R. Mackay ,  Andrew D.J. Goodearl

IPC分类号： G01N33/53 ,  C12Q1/37 ,  C12P21/02 ,  C12N9/99 ,  C12N9/64 ,  C12N15/57 ,  C12N5/00 ,  C12N15/63 ,  G01N33/50 ,  C07K14/00 ,  C07K16/18 ,  C07H21/04 ,  G01N33/573 ,  C12N5/10

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  Y02A50/411 ,  Y10T436/143333

摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US20090136959A1

公开(公告)日：2009-05-28

申请号：US12288775

申请日：2008-10-23

申请人： Sean A. McCarthy ,  Christopher C. Fraser ,  John D. Sharp ,  Thomas M. Barnes ,  Susan J. Kirst ,  Paul S. Myers ,  Nicholas Wrighton ,  Andrew D.J. Goodearl ,  Douglas A. Holtzman ,  Mehran Khodadoust

发明人： Sean A. McCarthy ,  Christopher C. Fraser ,  John D. Sharp ,  Thomas M. Barnes ,  Susan J. Kirst ,  Paul S. Myers ,  Nicholas Wrighton ,  Andrew D.J. Goodearl ,  Douglas A. Holtzman ,  Mehran Khodadoust

IPC分类号： C12Q1/68 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C07K14/00 ,  G01N33/00 ,  C07K1/00 ,  C07K16/18 ,  C12P21/04 ,  G01N33/53

CPC分类号： C07K14/47

摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

公开(公告)号：US20110065124A1

公开(公告)日：2011-03-17

申请号：US12800681

申请日：2010-05-20

申请人： Douglas A. Holtzman ,  John D. Sharp ,  Kevin R. Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas M. Barnes ,  Christopher C. Fraser ,  Nicholas Wrighton ,  Paul S. Myers ,  Gillian Kingsbury

发明人： Douglas A. Holtzman ,  John D. Sharp ,  Kevin R. Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas M. Barnes ,  Christopher C. Fraser ,  Nicholas Wrighton ,  Paul S. Myers ,  Gillian Kingsbury

IPC分类号： G01N33/53 ,  C12N15/12 ,  C12N5/07 ,  C07K14/435 ,  C07K16/18 ,  C12P21/00 ,  G01N33/68 ,  G01N33/00

CPC分类号： C07K14/7151 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/78 ,  C07K2319/00 ,  Y10T436/143333

摘要： The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供了分离的TANGO 239，TANGO 219，TANGO 232，TANGO 281，A236（INTERCEPT 236），TANGO 300，TANGO 353，TANGO 393，TANGO 402，TANGO 351和TANGO 509核酸分子和多肽分子。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20080213778A1

公开(公告)日：2008-09-04

申请号：US11983233

申请日：2007-11-08

申请人： Douglas A. Holtzman ,  John D. Sharp ,  Kevin R. Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas M. Barnes ,  Christopher C. Fraser ,  Nicholas Wrighton ,  Paul S. Myers ,  Gillian Kingsbury

发明人： Douglas A. Holtzman ,  John D. Sharp ,  Kevin R. Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas M. Barnes ,  Christopher C. Fraser ,  Nicholas Wrighton ,  Paul S. Myers ,  Gillian Kingsbury

IPC分类号： C12N15/11 ,  C12N5/00 ,  C12N1/00 ,  C07K14/00 ,  C07K16/00 ,  C12P21/02 ,  G01N33/53 ,  C12Q1/68

CPC分类号： C07K14/7151 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/78 ,  C07K2319/00 ,  Y10T436/143333

摘要： The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供了分离的TANGO 239，TANGO 219，TANGO 232，TANGO 281，A236（INTERCEPT 236），TANGO 300，TANGO 353，TANGO 393，TANGO 402，TANGO 351和TANGO 509核酸分子和多肽分子。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20120270219A1

公开(公告)日：2012-10-25

申请号：US13540352

申请日：2012-07-02

申请人： Douglas A. Holtzman ,  John D. Sharp ,  Kevin R. Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas M. Barnes ,  Christopher C. Fraser ,  Nicholas Wrighton ,  Paul S. Myers ,  Gillian Kingsbury

发明人： Douglas A. Holtzman ,  John D. Sharp ,  Kevin R. Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas M. Barnes ,  Christopher C. Fraser ,  Nicholas Wrighton ,  Paul S. Myers ,  Gillian Kingsbury

IPC分类号： C07K14/47 ,  C12N5/10 ,  C12P21/02 ,  C07K16/18 ,  C12Q1/68 ,  C12N5/071 ,  C12N15/12 ,  C12N15/85 ,  G01N33/566

CPC分类号： C07K14/705 ,  C07K14/70503 ,  G01N33/54313

摘要： The invention provides isolated TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

摘要翻译： 本发明提供了分离的TANGO 509核酸分子和多肽分子。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供利用本发明组合物的诊断，筛选和治疗方法。

公开(公告)号：US20060216727A1

公开(公告)日：2006-09-28

申请号：US11287573

申请日：2005-11-23

申请人： Douglas Holtzman ,  John Sharp ,  Kevin Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas Barnes ,  Christopher Fraser ,  Nicholas Wrighton ,  Paul Myers ,  Gillian Kingsbury

发明人： Douglas Holtzman ,  John Sharp ,  Kevin Leiby ,  Steven Bossone ,  Yang Pan ,  Thomas Barnes ,  Christopher Fraser ,  Nicholas Wrighton ,  Paul Myers ,  Gillian Kingsbury

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/715 ,  C07K16/28

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/705 ,  C07K14/7151 ,  C07K14/78 ,  C07K2319/00

摘要： The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

公开(公告)号：US20060205034A1

公开(公告)日：2006-09-14

申请号：US11265762

申请日：2005-11-02

申请人： Christopher Fraser ,  Sean McCarthy ,  John Sharp ,  Thomas Barnes ,  Nicholas Wrighton ,  Charles Mackay ,  Kevin Leiby ,  Douglas Holtzman

发明人： Christopher Fraser ,  Sean McCarthy ,  John Sharp ,  Thomas Barnes ,  Nicholas Wrighton ,  Charles Mackay ,  Kevin Leiby ,  Douglas Holtzman

IPC分类号： C07K14/715 ,  C07H21/04 ,  C12P21/06 ,  C07K16/28

CPC分类号： C07K16/18

摘要： The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

公开(公告)号：US20070148091A1

公开(公告)日：2007-06-28

申请号：US11610226

申请日：2006-12-13

申请人： William Dower ,  Ronald Barrett ,  Steven Cwirla ,  David Duffin ,  Christian Gates ,  Sherril Haselden ,  Larry Mattheakis ,  Peter Schatz ,  Christopher Wagstrom ,  Nicholas Wrighton

发明人： William Dower ,  Ronald Barrett ,  Steven Cwirla ,  David Duffin ,  Christian Gates ,  Sherril Haselden ,  Larry Mattheakis ,  Peter Schatz ,  Christopher Wagstrom ,  Nicholas Wrighton

IPC分类号： A61K51/00 ,  C07K7/64

CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K7/64 ,  C07K14/521 ,  C07K14/524

摘要： Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.

摘要翻译： 描述了结合并激活血小板生成素受体的肽和肽模拟物。 这样的肽和肽模拟物可用于治疗血液学疾病，特别是由化疗，放射治疗或骨髓输注引起的血小板减少症以及使用标记肽和肽模拟物的诊断方法。

公开(公告)号：US20070048771A1

公开(公告)日：2007-03-01

申请号：US11491318

申请日：2006-07-21

申请人： Sean McCarthy ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes ,  Susan Kirst ,  Paul Myers ,  Nicholas Wrighton ,  Andrew Goodearl ,  Douglas Holtzman ,  Mehran Khodadoust

发明人： Sean McCarthy ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes ,  Susan Kirst ,  Paul Myers ,  Nicholas Wrighton ,  Andrew Goodearl ,  Douglas Holtzman ,  Mehran Khodadoust

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C07K14/47

摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。