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9 条记录 (耗时 0.027 秒)

    Integrin antagonists
    2.
    发明申请
    Integrin antagonists 审中-公开
    整合素拮抗剂

    公开(公告)号：US20060177443A1

    公开(公告)日：2006-08-10

    申请号：US11392436

    申请日：2006-03-28

    申请人： William Fanslow ,  Douglas Cerretti ,  Kurt Poindexter ,  Roy Black

    发明人： William Fanslow ,  Douglas Cerretti ,  Kurt Poindexter ,  Roy Black

    IPC分类号： A61K39/395 ,  A61K38/17

    CPC分类号： C12N9/6489 ,  A61K38/00 ,  C07K14/705

    摘要： The present invention provides methods and compositions for inhibiting the biological activity of integrins, for inhibiting endothelial cell migration, and for inhibiting angiogenesis. In particular, the invention provides compositions comprising ADAM disintegrin domains and methods for using said compositions. In preferred embodiments the methods and compositions of the invention are used to inhibit angiogenesis and to treat diseases or conditions mediated by angiogenesis.

    摘要翻译： 本发明提供抑制整联蛋白的生物学活性，抑制内皮细胞迁移和抑制血管发生的方法和组合物。 特别地，本发明提供包含ADAM去整合素结构域的组合物和使用所述组合物的方法。 在优选的实施方案中，本发明的方法和组合物用于抑制血管发生和治疗由血管发生介导的疾病或病症。

    ULBP antibodies
    5.
    发明申请
    ULBP antibodies 失效

    公开(公告)号：US20080008715A1

    公开(公告)日：2008-01-10

    申请号：US11638966

    申请日：2006-12-13

    申请人： David Cosman ,  Jurgen Mullberg ,  William Fanslow ,  Marek Kubin ,  Richard Armitage

    发明人： David Cosman ,  Jurgen Mullberg ,  William Fanslow ,  Marek Kubin ,  Richard Armitage

    IPC分类号： A61K39/395 ,  C07K16/30

    CPC分类号： C07K16/28 ,  A61K38/00 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/30

    摘要： The invention is directed to purified and isolated novel ULBP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above. ULBP polypeptide can be found on the surface of human B cell lymphomas. Mammalian forms of ULBP polypeptide in isolated or purified forms are provided. In addition, isolated nucleic acids encoding ULBP polypeptides and expression vectors comprising a cDNA encoding ULBP polypeptides are provided. The ULBP polypeptides can be isolated or synthesized and used to prepare antibodies, and in particular monoclonal antibodies, against the polypeptides. The antibodies, in turn, are useful for detecting the presence of ULBP polypeptides in human cell samples, which can be correlated with the existence of a malignant condition in a patient. ULBP polypeptides stimulate IFN-γ production, NK cell proliferation, and CTL activity.

    Antibodies to angiogenesis inhibiting domains of CD148
    6.
    发明申请
    Antibodies to angiogenesis inhibiting domains of CD148 审中-公开
    CD148的血管生成抑制结构域的抗体

    公开(公告)号：US20050287140A1

    公开(公告)日：2005-12-29

    申请号：US11112240

    申请日：2005-04-21

    申请人： James Smothers ,  William Fanslow ,  Revital Kariv

    发明人： James Smothers ,  William Fanslow ,  Revital Kariv

    IPC分类号： A61K39/395 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30

    CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/76

    摘要： The present invention provides compositions and methods relating to anti-CD148 receptor antibodies. Methods provided include inhibiting angiogenesis and, thereby, vascularization of solid tumors in human patients. The present invention also provides compositions and methods for in vivo imaging of tumors expressing CD 148. Compositions of the invention include: anti-CD148 antibodies, antigen binding regions of anti-CD148 antibodies, polynucleotides encoding anti-CD148 antibodies or binding regions thereof, vectors comprising these polynucleotides, host cells, and pharmaceutical compositions. Methods of making and using each of these compositions is also provided.

    摘要翻译： 本发明提供了与抗CD148受体抗体相关的组合物和方法。 提供的方法包括抑制血管发生，从而抑制人类患者中实体瘤的血管形成。 本发明还提供了表达CD148的肿瘤的体内成像的组合物和方法。本发明的组合物包括：抗CD148抗体，抗CD148抗体的抗原结合区，编码抗CD148抗体的多核苷酸或其结合区，载体 包括这些多核苷酸，宿主细胞和药物组合物。 还提供了制备和使用这些组合物的方法。