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    Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
    1.
    发明申请
    Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses 失效
    编码具有预后，诊断，预防，治疗和其他用途的蛋白质的新基因

    公开(公告)号：US20070048771A1

    公开(公告)日：2007-03-01

    申请号：US11491318

    申请日：2006-07-21

    申请人： Sean McCarthy ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes ,  Susan Kirst ,  Paul Myers ,  Nicholas Wrighton ,  Andrew Goodearl ,  Douglas Holtzman ,  Mehran Khodadoust

    发明人： Sean McCarthy ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes ,  Susan Kirst ,  Paul Myers ,  Nicholas Wrighton ,  Andrew Goodearl ,  Douglas Holtzman ,  Mehran Khodadoust

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

    CPC分类号： C07K14/47

    摘要： The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

    摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了使用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

    Antibodies having diagnostic, preventive, therapeutic, and other uses
    2.
    发明申请
    Antibodies having diagnostic, preventive, therapeutic, and other uses 失效
    具有诊断，预防，治疗和其他用途的抗体

    公开(公告)号：US20070053904A1

    公开(公告)日：2007-03-08

    申请号：US11499835

    申请日：2006-08-04

    申请人： Susan Kirst ,  Douglas Holtzman ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes

    发明人： Susan Kirst ,  Douglas Holtzman ,  Christopher Fraser ,  John Sharp ,  Thomas Barnes

    IPC分类号： G01N33/567 ,  A61K39/395 ,  C07K16/28

    CPC分类号： C07K16/18 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/47 ,  C07K16/28 ,  G01N33/5058

    摘要： The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

    摘要翻译： 本发明提供编码具有诊断，预防，治疗和其它用途的各种蛋白质和核酸的分离的核酸。 这些核酸和蛋白质可用于诊断，预防和治疗许多人类和其他动物疾病。 本发明还提供反义核酸分子，含有本发明的核酸分子的表达载体，已经引入了表达载体的宿主细胞和其中引入了本发明的核酸分子的非人转基因动物，或 中断了 本发明还进一步提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节各种细胞过程的调节剂。

    Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof
    5.
    发明申请
    Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof 审中-公开
    Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和整合素α亚基蛋白和核酸分子及其用途

    公开(公告)号：US20060122373A1

    公开(公告)日：2006-06-08

    申请号：US11175714

    申请日：2005-07-05

    申请人： Sean McCarthy ,  David Gearing ,  Douglas Holtzman ,  Yang Pan ,  Samantha Busfield ,  Thomas Barnes ,  Charles Mackay ,  Jose Lora

    发明人： Sean McCarthy ,  David Gearing ,  Douglas Holtzman ,  Yang Pan ,  Samantha Busfield ,  Thomas Barnes ,  Charles Mackay ,  Jose Lora

    IPC分类号： C07K14/705 ,  C07K14/715 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C12Q1/48 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/00 ,  C12Q1/6876

    摘要： The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins, antigenic peptides and anti-Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 antibodies. The invention also provides Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 or A259 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供新颖的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259多肽，蛋白质和核酸分子。 除了分离的全长Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259蛋白外，本发明还提供了分离的Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259融合 蛋白质，抗原肽和抗Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259抗体。 本发明还提供了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129和A259核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞， 已经引入或破坏了Delta3，FTHMA-070，Tango85，Tango77，SPOIL，NEOKINE，Tango129或A259基因的人类转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。

    Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic and other uses
    7.
    发明申请
    Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic and other uses 审中-公开

    公开(公告)号：US20060211848A1

    公开(公告)日：2006-09-21

    申请号：US11441587

    申请日：2006-05-26

    申请人： Douglas Holtzman ,  Andrew Goodearl ,  Sean McCarthy

    发明人： Douglas Holtzman ,  Andrew Goodearl ,  Sean McCarthy

    IPC分类号： C07K14/705 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C12N9/6489 ,  A01K2217/05 ,  A01K2227/105 ,  A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/70578 ,  C07K2319/00

    摘要： The invention relates to Tango-73, Tango-74, Tango-76, Tango-78, and Tango-83 polypeptides, nucleic acid molecules encoding Tango-73, Tango-74, Tango-76, Tango-78, and Tango-83, and uses thereof. The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

    Tumor necrosis factor receptor related proteins Tango-63d and Tango-63e
    9.
    发明申请
    Tumor necrosis factor receptor related proteins Tango-63d and Tango-63e 审中-公开
    肿瘤坏死因子受体相关蛋白Tango-63d和Tango-63e

    公开(公告)号：US20060069246A1

    公开(公告)日：2006-03-30

    申请号：US11280654

    申请日：2005-11-16

    申请人： Douglas Holtzman

    发明人： Douglas Holtzman

    IPC分类号： C07K14/715 ,  C07H21/04 ,  C12P21/06

    CPC分类号： C07K14/70578 ,  A61K38/00 ,  A61K48/00 ,  Y02A50/411

    摘要： The invention relates to the discovery and characterization of Tango-63d, Tango-63e genes and the polypeptides they encode. Tango-63d and Tango-63e are two novel polypeptides within the tumor necrosis factor (TNF) receptor superfamily. The invention encompasses nucleic acid molecules encoding nucleic acids and polypeptides of the invention, or mutant forms thereof that encode dysfunctional receptor polypeptides, vectors containing these nucleic acid molecules, cells harboring recombinant DNA molecules encoding nucleic acids or polypeptides of the invention, or mutant forms thereof, host fusion proteins that include functional or dysfunctional polypeptides of the invention, transgenic animals that express nucleic acids or polypeptides of the invention, screening methods and therapeutic methods employing the nucleic acid molecules and polypeptides described above, substantially purified nucleic acids and polypeptides of the invention, and therapeutic compositions containing these nucleic acid molecules and polypeptides.

    摘要翻译： 本发明涉及Tango-63d，Tango-63e基因及其编码的多肽的发现和表征。 Tango-63d和Tango-63e是肿瘤坏死因子（TNF）受体超家族中的两种新型多肽。 本发明包括编码本发明的核酸和多肽的核酸分子，或其编码功能障碍受体多肽的突变形式，含有这些核酸分子的载体，携带编码本发明的核酸或多肽的重组DNA分子的细胞，或其突变形式 ，包括本发明的功能性或功能失调多肽的宿主融合蛋白，表达本发明的核酸或多肽的转基因动物，使用上述核酸分子和多肽的筛选方法和治疗方法，本发明的基本纯化的核酸和多肽 以及含有这些核酸分子和多肽的治疗组合物。

    Novel FDRG protein and nucleic acid molecules and uses therefor
    10.
    发明申请
    Novel FDRG protein and nucleic acid molecules and uses therefor 审中-公开
    新型FDRG蛋白和核酸分子及其用途

    公开(公告)号：US20050100940A1

    公开(公告)日：2005-05-12

    申请号：US10955218

    申请日：2004-09-30

    申请人： Douglas Holtzman ,  Bruce Spiegelman ,  Clifford Yoon

    发明人： Douglas Holtzman ,  Bruce Spiegelman ,  Clifford Yoon

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/515 ,  C07K16/22 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/475

    CPC分类号： C07K16/22 ,  A61K38/00 ,  A61K48/00 ,  C07K14/515

    摘要： Novel FDRG polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length FDRG proteins, the invention further provides isolated FDRG fusion proteins, antigenic peptides and anti-FDRG antibodies. The invention also provides FDRG nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a FDRG gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

    摘要翻译： 公开了新型FDRG多肽，蛋白质和核酸分子。 除了分离的全长FDRG蛋白，本发明还提供了分离的FDRG融合蛋白，抗原肽和抗FDRG抗体。 本发明还提供了FDRG核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞和其中引入或破坏FDRG基因的非人转基因动物。 还提供利用本发明组合物的诊断，筛选和治疗方法。