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13 条记录 (耗时 0.024 秒)

    6-hydroxy-2(2-hydroxy-4-methoxyphenyl)benzofuran derivatives to inhibit leukotriene biosynthesis
    1.
    发明授权
    6-hydroxy-2(2-hydroxy-4-methoxyphenyl)benzofuran derivatives to inhibit leukotriene biosynthesis 失效
    6-羟基-2-（2-羟基-4-甲氧基苯基）苯并呋喃衍生物以抑制白细胞三烯生物合成

    公开(公告)号：US4714711A

    公开(公告)日：1987-12-22

    申请号：US927200

    申请日：1986-11-05

    申请人： Douglas K. Miller ,  Henry Joshua

    发明人： Douglas K. Miller ,  Henry Joshua

    IPC分类号： A61K31/34 ,  A61K31/36

    CPC分类号： A61K31/34

    摘要： 6-Hydroxy-2-(2-hydroxy-4-methoxyphenyl)benzofuran derivatives and related pharmaceutical compositions and methods of treatment are disclosed. The compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, they are useful therapuetic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation.

    摘要翻译： 公开了6-羟基-2-（2-羟基-4-甲氧基苯基）苯并呋喃衍生物及相关药物组合物和治疗方法。 该化合物可用作哺乳动物白三烯生物合成的抑制剂。 因此，它们是治疗过敏性疾病，哮喘，心血管疾病和炎症的有用的治疗剂。

    Medicarpin derivatives and analogs
    2.
    发明授权
    Medicarpin derivatives and analogs 失效
    Medicarpin衍生物和类似物

    公开(公告)号：US4704400A

    公开(公告)日：1987-11-03

    申请号：US877936

    申请日：1986-06-24

    申请人： Douglas K. Miller ,  Henry Joshua ,  Sharon J. Sadowski

    发明人： Douglas K. Miller ,  Henry Joshua ,  Sharon J. Sadowski

    IPC分类号： A61K31/35 ,  A61K31/205

    CPC分类号： A61K31/35

    摘要： Medicarpin derivatives and related pharmaceutical compositions and methods of treatment are disclosed. The compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, they are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation.

    摘要翻译： Medicarpin衍生物和相关的药物组合物和治疗方法被公开。 该化合物可用作哺乳动物白三烯生物合成的抑制剂。 因此，它们是用于治疗过敏性疾病，哮喘，心血管疾病和炎症的有用的治疗剂。

    Cholesterol lowering compounds
    4.
    发明授权
    Cholesterol lowering compounds 失效
    胆固醇降低化合物

    公开(公告)号：US5262435A

    公开(公告)日：1993-11-16

    申请号：US833282

    申请日：1992-02-10

    申请人： Henry Joshua ,  Guy H. Harris

    发明人： Henry Joshua ,  Guy H. Harris

    IPC分类号： C07D493/08 ,  A61K31/335 ,  C07D319/08

    CPC分类号： C07D493/08

    摘要： A new Zaragozic acid analog has been isolated from a culture of MF5453. The compound and its derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.

    摘要翻译： 已经从MF5453的培养物中分离出新的萨拉哥孜酸类似物。 该化合物及其衍生物作为角鲨烯合成酶抑制剂是有活性的，可用于治疗高胆固醇血症。

    High pressure liquid chromatography column jacket
    5.
    发明授权
    High pressure liquid chromatography column jacket 失效
    高压液相色谱柱套

    公开(公告)号：US4966695A

    公开(公告)日：1990-10-30

    申请号：US346782

    申请日：1989-05-03

    申请人： Henry Joshua

    发明人： Henry Joshua

    IPC分类号： B01D15/08 ,  G01N30/30 ,  G01N30/36 ,  G01N30/60

    CPC分类号： B01D15/22 ,  G01N30/30 ,  G01N30/36 ,  G01N30/6047 ,  G01N30/6026 ,  G01N30/6082

    摘要： A high pressure liquid chromatography jacket includes a rectangular, fluid-tight enclosure which has a removable cover on which a pair of tubing seal fittings are mounted. The fittings form a fluid-tight seal around the inlet and discharge tubes of a chromatographic column which is mounted in the enclosure. The enclosure is connected to a source of temperature controlled fluid which circulates through the enclosure and controls the temperature of the chromatographic column.In an alternative embodiment of the invention, a valve is provided which allows sample materials being loaded to enter a sample storage loop, which is exposed to the temperature controlled fluid. The sample, whose temperature has been controlled by the temperature controlled fluid, is then injected into a chromatographic column under high pressure.

    摘要翻译： 高压液相色谱夹套包括矩形的流体密封外壳，其具有可移除的盖，一对管密封配件安装在其上。 配件在安装在外壳中的色谱柱的入口和放电管周围形成流体密封。 外壳连接到温度控制流体源，循环通过外壳并控制色谱柱的温度。 在本发明的替代实施例中，提供了一种阀，其允许加载样品材料进入暴露于受温度控制的流体的样品储存环路。 然后将其温度由温度控制的流体控制的样品在高压下注入色谱柱。

    Filter-degasser
    6.
    发明授权
    Filter-degasser 失效
    过滤脱气机

    公开(公告)号：US4523934A

    公开(公告)日：1985-06-18

    申请号：US586664

    申请日：1984-03-06

    申请人： Henry Joshua

    发明人： Henry Joshua

    IPC分类号： B01D36/00 ,  B01D29/00

    CPC分类号： B01D36/00

    摘要： An all-TEFLON filter-degasser for removing solids and gases from a solvent. The filter-degasser has a filtering portion, a vacuum application portion downstream of the filtering portion, and a solvent bottle connecting portion. The vacuum application portion includes an externally tapered male member, and the solvent bottle connecting portion includes an internally identically tapered female member. The male member can be inserted into and withdrawn from the female member without requiring any relative rotation therebetween, so that the filter-degasser can be connected hermetically airtight to the solvent bottle likewise without any rotation being required therebetween. This abstract is not to be taken either as a complete exposition or as a limitation of the present invention, however, the full nature and extent of the invention being discernible only by reference to and from the entire disclosure.

    摘要翻译： 全TEFLON过滤器 - 脱气机，用于从溶剂中除去固体和气体。 过滤器脱气机具有过滤部分，过滤部分下游的真空施加部分和溶剂瓶连接部分。 真空施加部分包括外锥形凸构件，并且溶剂瓶连接部分包括内部相同锥形的阴构件。 阳构件可以插入阴构件中并从阴构件中取出，而不需要它们之间的任何相对旋转，使得过滤器脱气器可以气密地连接到溶剂瓶，同时不需要任何旋转。 该摘要不应被视为完全阐述或作为本发明的限制，然而，本发明的完整性质和范围仅在参考和从整个公开内容中可以看出。