公开(公告)号：US06701767B2

公开(公告)日：2004-03-09

申请号：US10071793

申请日：2002-02-08

Applicant: Duane Hartwell ,  Jonathan Wright

Inventor： Duane Hartwell ,  Jonathan Wright

IPC: B21D504

CPC classification number: B21D5/00 ,  B60P3/14

Abstract: A trailered brake workstation mounts on the horizontal frame of a two-wheeled trailer, a pair of longitudinally-spaced transverse horizontal guide bars at an elevated position above the frame. The guide bars mount slides which are secured to the bottom of a longitudinally-disposed brake. Thus the brake, via the slides, can be shifted laterally on the horizontal guide bars between an internal or centered position it which it may be locked for hauling and storing, and a side position in which it may be locked and available for operative use. A box and a cover protect the brake in the internal or centered position from the elements. A work table may also be transported, being stored in the throat of the brake during transportation, and disposed for use on the other side of the trailer when the brake is operative.

Abstract translation: 引导式制动工作站安装在两轮拖车的水平框架上，一对纵向间隔的横向水平导杆位于框架上方的升高位置。 导杆安装滑块，固定在纵向设置的制动器的底部。 因此，通过滑块的制动器可以在水平导杆之间在内部或中心位置之间横向移动，其内部或中心位置可以被锁定以用于牵引和存储，以及可以锁定并可用于操作使用的侧部位置。 盒子和盖子保护内部或中心位置上的制动器与元件。 工作台也可以运输，在运输过程中被储存在制动器的喉部中，并且当制动器可操作时被设置用于拖车的另一侧。

公开(公告)号：US20100233114A1

公开(公告)日：2010-09-16

申请号：US12699941

申请日：2010-02-04

Applicant: Michael S. DeGeorge ,  Jonathan Wright ,  Jeremy Puco

Inventor： Michael S. DeGeorge ,  Jonathan Wright ,  Jeremy Puco

IPC: A61K8/84 ,  A61K8/898 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12

CPC classification number: A61Q5/12 ,  A61K8/585 ,  A61K8/898 ,  A61K2800/594 ,  A61Q5/00 ,  A61Q5/02

Abstract: The invention relates to compositions containing at least one silicone film forming resin and at least one polysilicone polymer, as well as to methods of applying such compositions to keratin materials.

Abstract translation: 本发明涉及含有至少一种硅氧烷成膜树脂和至少一种聚硅氧烷聚合物的组合物，以及将这些组合物应用于角蛋白材料的方法。

公开(公告)号：US06448270B1

公开(公告)日：2002-09-10

申请号：US09592883

申请日：2000-06-13

Applicant: Christopher F. Bigge ,  Jonathan Wright ,  Sui Xiong Cai ,  Eckard Weber ,  Richard Woodward ,  Nancy C. Lan ,  Zhang-Lin Zhou ,  John F.W. Keana

Inventor： Christopher F. Bigge ,  Jonathan Wright ,  Sui Xiong Cai ,  Eckard Weber ,  Richard Woodward ,  Nancy C. Lan ,  Zhang-Lin Zhou ,  John F.W. Keana

IPC: A61K31445

CPC classification number: C07D401/06 ,  C07D211/14 ,  C07D211/18 ,  C07D211/42 ,  C07D211/44 ,  C07D211/46 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D405/06

Abstract: Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using the 4-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as cerebral ischemia, central nervous system trauma, hypoglycemia, neurodegenerative disorders, anxiety, migraine headaches, convulsions, aminoglycoside antibiotics-induced hearing loss, chronic pain, psychosis, glaucoma, CMV retinitis, opioid tolerance or withdrawal, urinary incontinence and neurodegenerative disorders such as lathyrism, Alzheimers' Disease, Parkinsonism, and Huntington's Disease are described. Also described are novel methods for preparing 4-substituted piperidine analogs and novel intermediates of the 4-substituted piperidine analogs.

Abstract translation: 新的4-取代的哌啶类似物，含有它们的药物组合物和使用4-取代的哌啶类似物作为N-甲基-D-天冬氨酸（NMDA）受体亚型的选择性活性拮抗剂的方法，用于治疗诸如脑缺血，中枢神经 系统性创伤，低血糖症，神经退行性疾病，焦虑症，偏头痛，惊厥，氨基糖苷类抗生素诱发的听力损失，慢性疼痛，精神病，青光眼，CMV视网膜炎，阿片样物质耐受或戒断，尿失禁和神经退行性疾病，如莱姆里斯，阿尔茨海默病， 描述了帕金森综合征和亨廷顿氏病。 还描述了制备4-取代的哌啶类似物和4-取代的哌啶类似物的新中间体的新方法。

公开(公告)号：US6130234A

公开(公告)日：2000-10-10

申请号：US91594

申请日：1996-12-20

Applicant: Christopher F. Bigge ,  Jonathan Wright ,  Sui Xiong Cai ,  Eckard Weber ,  Richard Woodward ,  Nancy C. Lan ,  Zhang-Lin Zhou ,  John F. W. Keana

Inventor： Christopher F. Bigge ,  Jonathan Wright ,  Sui Xiong Cai ,  Eckard Weber ,  Richard Woodward ,  Nancy C. Lan ,  Zhang-Lin Zhou ,  John F. W. Keana

IPC: A61K31/00 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/451 ,  A61K31/4523 ,  A61K31/4525 ,  A61K31/4535 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/498 ,  A61K31/505 ,  A61K31/517 ,  A61K31/529 ,  A61K31/55 ,  A61K31/551 ,  A61K31/5513 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P43/00 ,  C07D211/14 ,  C07D211/18 ,  C07D211/42 ,  C07D211/44 ,  C07D211/46 ,  C07D211/48 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D211/70 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D235/08

CPC classification number: C07D401/06 ,  C07D211/14 ,  C07D211/18 ,  C07D211/42 ,  C07D211/44 ,  C07D211/46 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D405/06

Abstract: Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, anxiety, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headaches, glaucoma, CMV retinitis, chronic pain, opioid tolerance or withdrawals, or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described. Also described are novel methods for preparing 4-substituted piperidine analogs and novel intermediates of the 4-substituted piperidine analogs.

Abstract translation: PCT No.PCT / US96 / 20766 Sec。 371日期：1998年9月16日 102（e）1998年9月16日PCT PCT 1996年12月20日PCT公布。 公开号WO97 / 23214 PCT 日期1997年7月3日新颖的4-取代的哌啶类似物，含有它们的药物组合物和使用4-取代的哌啶类似物作为N-甲基-D-天冬氨酸（NMDA）受体亚型的选择性活性拮抗剂的方法，用于治疗诸如中风 ，脑缺血，中枢神经系统创伤，低血糖症，焦虑症，抽搐，氨基糖苷类抗生素诱发的听力损失，偏头痛，青光眼，CMV视网膜炎，慢性疼痛，阿片样物质耐受或戒断，或神经退行性疾病，如幻影，阿尔茨海默病，帕金森综合征 并描述亨廷顿氏病。 还描述了制备4-取代的哌啶类似物和4-取代的哌啶类似物的新中间体的新方法。

公开(公告)号：US20090074701A1

公开(公告)日：2009-03-19

申请号：US11855450

申请日：2007-09-14

Applicant: Delphine Allard ,  David W. Cannell ,  Michael S. DeGeorge ,  Jeremy Puco ,  Jonathan Wright

Inventor： Delphine Allard ,  David W. Cannell ,  Michael S. DeGeorge ,  Jeremy Puco ,  Jonathan Wright

IPC: A61K8/58 ,  A61Q5/10

CPC classification number: A61Q5/065 ,  A61K8/891 ,  A61K8/898 ,  A61K2800/594

Abstract: The invention relates to methods of artificially coloring hair including applying to hair a composition containing at least one silicone film forming resin, at least one polysilicone polymer, and at least one hair colorant.

Abstract translation: 本发明涉及人发毛发的方法，包括向毛发施用含有至少一种硅氧烷成膜树脂，至少一种聚硅氧烷聚合物和至少一种毛发着色剂的组合物。

公开(公告)号：US20070060598A1

公开(公告)日：2007-03-15

申请号：US11411413

申请日：2006-04-26

Applicant: Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

Inventor： Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC: A61K31/52 ,  C07D473/14

CPC classification number: A61K31/52 ,  C07D473/32

Abstract: Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

Abstract translation: 本文提供具有以下结构的氨基嘌呤化合物：其中R 1，R 2和R 3如本文所定义，包含有效量的组合物 的氨基嘌呤化合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关的方法 条件，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的氨基嘌呤化合物。

公开(公告)号：US5314896A

公开(公告)日：1994-05-24

申请号：US957277

申请日：1992-10-15

Applicant: Bradley W. Caprathe ,  Dennis M. Downing ,  Juan C. Jaen ,  Stephen J. Johnson ,  William J. Smith, III ,  Lawrence D. Wise ,  Jonathan Wright ,  David J. Wustrow

Inventor： Bradley W. Caprathe ,  Dennis M. Downing ,  Juan C. Jaen ,  Stephen J. Johnson ,  William J. Smith, III ,  Lawrence D. Wise ,  Jonathan Wright ,  David J. Wustrow

IPC: A61K31/36 ,  A61K31/357 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/495 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P43/00 ,  C07D20060101 ,  C07D211/70 ,  C07D211/82 ,  C07D213/38 ,  C07D213/74 ,  C07D239/26 ,  C07D239/42 ,  C07D295/02 ,  C07D295/03 ,  C07D295/04 ,  C07D317/58 ,  C07D401/08 ,  C07D405/08 ,  C07D409/04 ,  C07D409/08 ,  C07D417/08

CPC classification number: C07D213/74 ,  C07D211/70 ,  C07D295/03 ,  C07D401/08 ,  C07D405/08 ,  C07D409/04 ,  C07D409/08

Abstract: 1,3-Substituted cycloalkenes and cycloalkanes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.

Abstract translation: 描述了1,3-取代的环烯烃和环烷烃，以及其制备方法及其药物组合物，其可用作中枢神经系统试剂，并且特别可用作多巴胺能抗精神病药和抗高血压药以及用于治疗高泌乳素血症 相关病症和中枢神经系统疾病。

公开(公告)号：US07601179B2

公开(公告)日：2009-10-13

申请号：US11855598

申请日：2007-09-14

Applicant: Delphine Allard ,  David W. Cannell ,  Michael S. DeGeorge ,  Jeremy Puco ,  Jonathan Wright

Inventor： Delphine Allard ,  David W. Cannell ,  Michael S. DeGeorge ,  Jeremy Puco ,  Jonathan Wright

IPC: A61Q5/10

CPC classification number: A61Q5/065 ,  A61K8/891 ,  A61K8/898 ,  A61K2800/594

Abstract: The invention relates to methods of preserving artificial color on keratin materials including applying to artificially colored keratin materials a composition containing at least one silicone film forming resin and at least one polysilicone polymer.

Abstract translation: 本发明涉及在角蛋白材料上保存人造色的方法，包括向人造着色的角蛋白材料施用含有至少一种硅氧烷成膜树脂和至少一种聚硅氧烷聚合物的组合物。

公开(公告)号：US07521446B2

公开(公告)日：2009-04-21

申请号：US11411413

申请日：2006-04-26

Applicant: Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

Inventor： Ronald J. Albers ,  Leticia Ayala ,  Steven S. Clareen ,  Maria Mercedes Delgado Mederos ,  Robert Hilgraf ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy S. S. Palanki ,  Kiran Sahasrabudhe ,  Yoshitaka Satoh ,  Marianne K. Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC: C07D473/32 ,  A61K31/52 ,  A61P3/10 ,  A61P11/00 ,  C07D239/50 ,  C07D239/48

CPC classification number: A61K31/52 ,  C07D473/32

Abstract: Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

Abstract translation: 本文提供具有以下结构的氨基嘌呤化合物：其中R1，R2和R3如本文所定义，包含有效量的氨基嘌呤化合物的组合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症， 炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关病症，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症包括给予有效量的氨基嘌呤 与需要的患者复合。

公开(公告)号：US20090074702A1

公开(公告)日：2009-03-19

申请号：US11855598

申请日：2007-09-14

Applicant: Delphine Allard ,  David W. Cannell ,  Michael S. DeGeorge ,  Jeremy Puco ,  Jonathan Wright

Inventor： Delphine Allard ,  David W. Cannell ,  Michael S. DeGeorge ,  Jeremy Puco ,  Jonathan Wright

IPC: A61K8/58 ,  A61Q99/00

CPC classification number: A61Q5/065 ,  A61K8/891 ,  A61K8/898 ,  A61K2800/594

Abstract: The invention relates to methods of preserving artificial color on keratin materials including applying to artificially colored keratin materials a composition containing at least one silicone film forming resin and at least one polysilicone polymer.

Abstract translation: 本发明涉及在角蛋白材料上保存人造色的方法，包括向人造着色的角蛋白材料施用含有至少一种硅氧烷成膜树脂和至少一种聚硅氧烷聚合物的组合物。