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公开(公告)号：US11511116B2
公开(公告)日：2022-11-29
申请号：US16769208
申请日：2018-11-29
Inventor： Fabien Wagner , Karen Minassian , Marco Capogrosso , Gregoire Courtine , Robin Brouns , Jurriaan Bakker , Andre Kleibeuker , Bert Bakker , Vincent Delattre
IPC: A61N1/36 , G16H20/30 , G16H40/67 , G16H10/60 , G16H40/40 , A61N1/02 , A61B5/397 , A61B5/372 , A61B5/11 , A61N1/05
Abstract: The present invention relates to systems and methods for planning and/or providing neuromodulation. An example system includes a first data input module for stimulation related basic data, a second data input module for stimulation related response data, a transfer module configured and arranged such that the stimulation related basic data received by the data input module are linked and/or translated into and/or with the response data and/or artificial response data created by the transfer module, wherein the data generated by the transfer module are transfer data, the transfer data comprising link data and/or translation data and/or artificial response data, and a mapping module configured and arranged such that based on the stimulation related basic data and stimulation related response data and the transfer data a digital characteristic map is generated, which describes an interrelation between the stimulation related basic data and the stimulation related response data and the transfer data.
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公开(公告)号：US20190269917A1
公开(公告)日：2019-09-05
申请号：US16292227
申请日：2019-03-04
Inventor： Gregoire Courtine , Nikolaus Wenger , Eduardo Martin Moraud , Silvestro Micera , Marco Bonizzato
IPC: A61N1/36 , A61B5/11 , A61N1/05 , A61B5/04 , A61B5/0476 , A61B5/0488 , A61B5/00
Abstract: The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), or a multiple input-single output (MISO) model.
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公开(公告)号：USD1061914S1
公开(公告)日：2025-02-11
申请号：US29796527
申请日：2021-06-24
Designer： Damien Ganty , Edoardo Paoles , Jocelyne Bloch , Gregoire Courtine , Leonie Asboth , Robin Demesmaeker , Henri Lorach , Jordan Squair
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公开(公告)号：US10265525B2
公开(公告)日：2019-04-23
申请号：US15033063
申请日：2014-10-29
Inventor： Gregoire Courtine , Nikolaus Wenger , Eduardo Martin Moraud , Silvestro Micera , Marco Bonizzato
IPC: A61B5/04 , A61B5/11 , A61N1/05 , A61B5/0476 , A61B5/0488 , A61N1/36 , A61B5/00
Abstract: The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), or a multiple input-single output (MISO) model.
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5.发明申请公开(公告)号：US20150190200A1
公开(公告)日：2015-07-09
申请号：US14404853
申请日：2013-05-29
Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Inventor： Gregoire Courtine , Silvestro Micera , Joachim Von Zitzewitz
IPC: A61B19/00 , A61N1/36 , A61K31/55 , A61K31/135 , A61K31/496
CPC classification number: A61H1/0262 , A61B5/0004 , A61B5/0048 , A61B5/0053 , A61B5/0057 , A61B5/04001 , A61B5/0482 , A61B5/0484 , A61B5/1036 , A61B5/112 , A61B5/1123 , A61B5/1124 , A61B5/4005 , A61B5/4023 , A61B5/4076 , A61B5/4519 , A61B5/4538 , A61B5/4566 , A61B5/4824 , A61B5/4848 , A61B5/70 , A61B5/721 , A61B34/30 , A61B2034/302 , A61B2560/02 , A61H1/001 , A61H1/0229 , A61H2201/0196 , A61H2201/165 , A61H2201/1666 , A61H2201/5007 , A61H2201/5061 , A61H2201/5069 , A61H2230/08 , A61H2230/085 , A61K31/135 , A61K31/496 , A61K31/55 , A61N1/36003 , A61N1/36057 , A63B21/00181 , A63B22/0235 , A63B22/203 , A63B24/0087 , A63B69/0057 , A63B69/0064 , A63B2022/0094 , A63B2022/206 , A63B2213/004 , A63B2220/10 , A63B2220/51 , B25J9/0006
Abstract: It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is capable of evaluating, enabling and training motor pattern generation and balance across a variety of natural walking behaviors in subjects with neuromotor impairments. Optionally, pharmacological cocktails can be administered to enhance rehabilitation results. It is also disclosed a method for the evaluation, enablement and training of a subject suffering from neuromotor impairments by combining robotically assisted evaluation tools with sophisticated neurobiomechanical and statistical analyses. A method for the rehabilitation (by this term also comprising restoring voluntary control of locomotion) of a subject suffering from a neuromotor impairment in particular partial or total paralysis of limbs, is also disclosed.
Abstract translation: 公开了一种用于恢复患有神经运动障碍的受试者的自愿控制的装置，包括多方向躯体支撑系统和用于硬膜外电刺激的装置。 机器人界面能够评估，启用和训练运动模式的产生和平衡，在具有神经运动障碍的受试者中的各种自然行走行为。 任选地，可以施用药理学鸡尾酒以增强康复结果。 还公开了一种通过将机器人辅助评估工具与复杂的神经生物力学和统计分析结合来评估，启用和训练患有神经运动障碍的受试者的方法。 还公开了一种患有神经运动障碍，特别是肢体部分或全部麻痹的受试者的康复方法（通过该术语还包括恢复自愿控制运动）。
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Patent Agency Ranking
公开(公告)号：US11420056B2
公开(公告)日：2022-08-23
申请号：US16769525
申请日：2018-11-29
Inventor： Marco Capogrosso , Karen Minassian , Fabien Wagner , Gregoire Courtine , Miroslav Caban , Robin Brouns , Jurriaan Bakker , Andre Kleibeuker , Bert Bakker , Vincent Delattre
Abstract: The present invention relates to methods and systems for planning and/or providing neuromodulation. An example system comprises
a neurostimulator comprising a least one electrode,
functional mapping module configured and arranged such that based on stimulation related basic data and stimulation related response data and transfer data a digital characteristic functional map is generated and/or provided, which describes the interrelation between the stimulation related basic data and the stimulation related response data and the transfer data, and analysis module configured and arranged such that the digital characteristic functional map may be analyzed in connection with neurostimulation provided by the neurostimulator such that the provided neurostimulation and its response may be analyzed on the basis of the functional map and that on the basis of this analysis a placement analysis of a placement of the electrode is provided.-
公开(公告)号：US11413459B2
公开(公告)日：2022-08-16
申请号：US16769519
申请日：2018-11-29
Inventor： Flavio Raschella , Silvestro Misera , Gregoire Courtine , Tomislav Milekovic , Fabien Wagner , Marco Capogrosso , Jurriaan Bakker , Robin Brouns , Vincent Delattre
Abstract: The present invention relates to systems and methods for planning and/or providing neurostimulation for a patient. An example system includes a pathological spinal cord map storage module for storing at least one pathological spinal cord map describing activation of a spinal cord of a patient, a healthy spinal cord map storage module for storing at least one reference map describing physiological activation of the spinal cord of at least one healthy subject, an analysis module for generating a deviation map, the deviation map describing an activation difference between the pathological spinal cord map and the reference map, and a compensation module for calculating, based on the deviation map, a neurostimulation protocol for compensating the activation difference.
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公开(公告)号：US10668280B2
公开(公告)日：2020-06-02
申请号：US15340728
申请日：2016-11-01
Inventor： Tomislav Milekovic , Marco Capogrosso , Gregoire Courtine , Eduardo Martin Moraud , Fabien Wagner , Jerome Gandar
IPC: A61N1/36 , A61B5/0482 , A61B5/00 , A61B5/04 , A61B5/0476 , A61N1/04 , A61B5/0484 , A61N1/05 , A61F2/54 , A61B5/0488 , A61B5/055 , A61F2/60
Abstract: Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a first mode where one or more nerve fibers are not stimulated, and during a second mode where the one or more nerve fibers are stimulated. Delivery timing of electrical stimulation may be closed-loop controlled based on current motor cortex activity and the motor cortex activity recorded previously during both the first and second modes.
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9.发明授权公开(公告)号：US09968406B2
公开(公告)日：2018-05-15
申请号：US14404853
申请日：2013-05-29
Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Inventor： Gregoire Courtine , Silvestro Micera , Joachim Von Zitzewitz
IPC: A61B19/00 , A61N1/36 , B25J9/00 , A63B69/00 , A61H1/02 , A63B24/00 , A63B21/00 , A61B5/11 , A61K31/135 , A61K31/496 , A61K31/55 , A61B5/103 , A63B22/02 , A63B22/20 , A63B22/00 , A61B34/30
CPC classification number: A61H1/0262 , A61B5/0004 , A61B5/0048 , A61B5/0053 , A61B5/0057 , A61B5/04001 , A61B5/0482 , A61B5/0484 , A61B5/1036 , A61B5/112 , A61B5/1123 , A61B5/1124 , A61B5/4005 , A61B5/4023 , A61B5/4076 , A61B5/4519 , A61B5/4538 , A61B5/4566 , A61B5/4824 , A61B5/4848 , A61B5/70 , A61B5/721 , A61B34/30 , A61B2034/302 , A61B2560/02 , A61H1/001 , A61H1/0229 , A61H2201/0196 , A61H2201/165 , A61H2201/1666 , A61H2201/5007 , A61H2201/5061 , A61H2201/5069 , A61H2230/08 , A61H2230/085 , A61K31/135 , A61K31/496 , A61K31/55 , A61N1/36003 , A61N1/36057 , A63B21/00181 , A63B22/0235 , A63B22/203 , A63B24/0087 , A63B69/0057 , A63B69/0064 , A63B2022/0094 , A63B2022/206 , A63B2213/004 , A63B2220/10 , A63B2220/51 , B25J9/0006
Abstract: It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is capable of evaluating, enabling and training motor pattern generation and balance across a variety of natural walking behaviors in subjects with neuromotor impairments. Optionally, pharmacological cocktails can be administered to enhance rehabilitation results. It is also disclosed a method for the evaluation, enablement and training of a subject suffering from neuromotor impairments by combining robotically assisted evaluation tools with sophisticated neurobiomechanical and statistical analyzes. A method for the rehabilitation (by this term also comprising restoring voluntary control of locomotion) of a subject suffering from a neuromotor impairment in particular partial or total paralysis of limbs, is also disclosed.
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10.发明申请SYSTEM TO DELIVER ADAPTIVE EPIDURAL AND/OR SUBDURAL ELECTRICAL SPINAL CORD STIMULATION TO FACILITATE AND RESTORE LOCOMOTION AFTER A NEUROMOTOR IMPAIRMENT 审中-公开系统提供自适应膈肌和/或子系统电动脊髓刺激，以便在神经元损伤后进行修复和恢复机械公开(公告)号：US20160279418A1
公开(公告)日：2016-09-29
申请号：US15033063
申请日：2014-10-29
Inventor： Gregoire Courtine , Nikolaus Wenger , Eduardo Martin Moraud , Silvestro Micera , Marco Bonizzato
IPC: A61N1/36 , A61B5/11 , A61N1/05 , A61B5/04 , A61B5/0476 , A61B5/00 , A61B5/0488
CPC classification number: A61N1/36067 , A61B5/04001 , A61B5/0476 , A61B5/0488 , A61B5/112 , A61B5/1121 , A61B5/1127 , A61B5/4836 , A61B5/7282 , A61B2562/0219 , A61B2562/0247 , A61N1/0551 , A61N1/36003 , A61N1/36103 , A61N1/36135 , A61N1/36139
Abstract: The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment. A Real Time Automatic Control Algorithm is used, comprising a feedforward component employing a single input-single output model (SISO), or a multiple input-single output (MISO) model.
Abstract translation: 本发明提供了一种用于硬膜外和/或硬膜下电刺激的实时控制的闭环系统，包括：用可调刺激参数对受试者进行神经调节的装置，所述装置与包括传感器的实时监测部件 所述信号是提供所述对象运动特征的神经信号和/或信号，所述系统与接收所述反馈信号的信号处理设备和操作实时自动控制算法可操作地连接，所述信号 处理装置与所述装置可操作地连接，并以最小的延迟向所述装置提供新的刺激参数。 本发明的系统提高了在具有神经运动障碍的受试者中行走的一致性。 使用实时自动控制算法，其包括采用单输入单输出模型（SISO）或多输入单输出（MISO）模型的前馈分量。
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