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    APPARATUS AND METHOD FOR EVALUATING DIABETIC PERIPHERAL NEUROPATHY
    8.
    发明申请
    APPARATUS AND METHOD FOR EVALUATING DIABETIC PERIPHERAL NEUROPATHY 审中-公开
    用于评估糖尿病性外周神经病变的装置和方法

    公开(公告)号：US20150182158A1

    公开(公告)日：2015-07-02

    申请号：US14411470

    申请日：2012-09-18

    申请人： Noriyo TAKAHASHI ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY ,  SHOWA UNIVERSITY ,  ASUKA ELECTRIC CO., LTD.

    发明人： Shuichi Ino ,  Mitsuru Sato ,  Noriyo Takahashi ,  Shinichi Yoshimura

    IPC分类号： A61B5/00

    CPC分类号： A61B5/4076 ,  A61B5/0051 ,  A61B5/4005 ,  A61B5/4029 ,  A61B5/4827 ,  A61B5/6829 ,  A61B5/742 ,  F04C2270/041

    摘要： [Problem]To provide an apparatus for measuring a sensory threshold at the time of application of a moving stimulus to a sole simply with high reproducibility and evaluating peripheral neuropathy originating in diabetes.[Solution]Provided are a foot pedestal 2, a probe 4 for applying a moving stimulus to a sole, and a probe driving structure 3, disposed on a base 1, for operating the probe 4 to separately move in directions intersecting at right angles along the sole. Also provided are an input switch 5 to be operated by a subject recognizing a moving stimulus, a drive controller 51 for controlling drive condition of the probe driving structure 3, and a main controller B for evaluating a measured sensory threshold. The main controller B preliminarily stores reference data of known sensory thresholds obtained by applying a moving stimulus to a sole of patients, and age correction factors calculated from standard values of sensory thresholds based on different ages of patients. The drive controller 51 controls drive condition of the probe driving structure 3 by using the reference data and the age correction factors to conduct a primary stimulus applying condition. Further, a secondary stimulus applying condition, and a tertiary stimulus applying condition are sequentially conducted to measure a sensory threshold.

    摘要翻译： 本发明提供一种用于在将运动刺激应用于鞋底的情况下测量感觉阈值的装置，简单地具有高再现性并评估源于糖尿病的周围神经病变。 [解决方案]设置有脚踏座2，用于向鞋底施加移动刺激的探针4和设置在基座1上的探针驱动结构3，用于操作探针4以沿直角相交的方向分开移动 唯一的。 还提供了由被识别移动刺激的被摄体操作的输入开关5，用于控制探针驱动结构3的驱动条件的驱动控制器51和用于评估测量的感觉阈值的主控制器B. 主控制器B预先存储通过将运动刺激应用于患者唯一而获得的已知感觉阈值的参考数据，以及基于患者不同年龄的感觉阈值的标准值计算的年龄校正因子。 驱动控制器51通过使用参考数据和年龄校正因子来控制探针驱动结构3的驱动条件以进行主刺激施加条件。 此外，依次进行二次刺激施加条件和三次刺激施加条件以测量感觉阈值。

    METHOD FOR ANALYZING NERVE FIBER DISTRIBUTION AND MEASURING NORMALIZED EVOKED COMPOUND ACTION ELECTRIC POTENTIAL
    9.
    发明申请
    METHOD FOR ANALYZING NERVE FIBER DISTRIBUTION AND MEASURING NORMALIZED EVOKED COMPOUND ACTION ELECTRIC POTENTIAL 有权
    用于分析神经纤维分布和测量正常化的复合动作电位的方法

    公开(公告)号：US20140066803A1

    公开(公告)日：2014-03-06

    申请号：US14014788

    申请日：2013-08-30

    申请人： National Chiao Tung University

    发明人： Charles Tak Ming Choi

    IPC分类号： A61B5/00

    CPC分类号： A61B5/4005 ,  A61B5/04001 ,  A61N1/0541 ,  A61N1/36036

    摘要： A method for analyzing nerve fibers distribution is provided, including inputting a stimulation signal into a nerve tissue through at least two sensing and conducting electrodes, applying a stimulation signal ratio to control the stimulation signal using an electric current steering technique to electrically stimulate a plurality of nerve fibers within a plurality of stimulations areas of the nerve tissue; receiving a plurality of evoked compound action potentials (ECAP) using at least two sensing and conducting electrodes due to the nerve fibers electrically stimulated and computing a distance between the nerve fiber and the conducting electrodes including eliminating non-ideal effect caused by an electric potential attenuation factor, wherein the electric potential attenuation factor is a function of the distance between each of the conducting electrodes and the nerve tissue; and integrating and comparing the received ECAPs and analyzing the nerve fibers distribution of the nerve tissue.

    摘要翻译： 提供了一种用于分析神经纤维分布的方法，包括通过至少两个感测和传导电极将刺激信号输入神经组织，施加刺激信号比率以使用电流转向技术来电刺激多个 在神经组织的多个刺激区域内的神经纤维; 由于神经纤维被电刺激并且计算神经纤维和导电电极之间的距离，使用至少两个感测和导电电极接收多个诱发复合动作电位（ECAP），包括消除由电位衰减引起的非理想效应 因子，其中所述电位衰减因子是每个所述导电电极和所述神经组织之间的距离的函数; 并整合和比较接收的ECAP并分析神经纤维的神经纤维分布。