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公开(公告)号：US09005943B2
公开(公告)日：2015-04-14
申请号：US11906580
申请日：2007-10-02
申请人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
IPC分类号： C12N11/00 , A61F13/00 , A61K9/52 , A61L27/36 , A61K9/00 , A61K47/48 , A61L27/38 , C12N5/077 , A61K35/12
CPC分类号： A61F2/00 , A61K9/0024 , A61K47/6901 , A61K2035/126 , A61L27/3608 , A61L27/3808 , B33Y80/00 , C12N5/0654 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
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公开(公告)号：US08962316B2
公开(公告)日：2015-02-24
申请号：US11451994
申请日：2006-06-12
申请人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
IPC分类号： C12N5/071 , C12N5/00 , C12N5/02 , A61K47/48 , A61K9/00 , A61L27/36 , A61L27/38 , C12N5/079 , C12N5/077 , A61K35/12
CPC分类号： C12N5/0691 , A61K9/0024 , A61K35/44 , A61K47/6901 , A61K2035/126 , A61L27/18 , A61L27/3608 , A61L27/3612 , A61L27/3808 , A61L27/3813 , A61L27/54 , A61L2300/64 , B33Y80/00 , C12N5/0618 , C12N5/0654 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
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公开(公告)号：US08906687B2
公开(公告)日：2014-12-09
申请号：US11452019
申请日：2006-06-12
申请人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
IPC分类号： C12N11/00 , C12N11/16 , C12N5/00 , C12N5/02 , A61F2/00 , A61L27/38 , A61K47/48 , A61L27/36 , C12N5/079 , C12N5/077 , A61K9/00 , A61K35/12
CPC分类号： C12N5/0691 , A61K9/0024 , A61K35/44 , A61K47/6901 , A61K2035/126 , A61L27/18 , A61L27/3608 , A61L27/3612 , A61L27/3808 , A61L27/3813 , A61L27/54 , A61L2300/64 , B33Y80/00 , C12N5/0618 , C12N5/0654 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
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公开(公告)号：US08114647B2
公开(公告)日：2012-02-14
申请号：US11975605
申请日：2007-10-18
申请人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
CPC分类号： C12N5/0691 , A61K9/0024 , A61K35/44 , A61K47/6901 , A61K2035/126 , A61L27/18 , A61L27/3608 , A61L27/3612 , A61L27/3808 , A61L27/3813 , A61L27/54 , A61L2300/64 , B33Y80/00 , C12N5/0618 , C12N5/0654 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
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公开(公告)号：US08053220B2
公开(公告)日：2011-11-08
申请号：US11451986
申请日：2006-06-12
申请人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
CPC分类号： C12N5/0691 , A61K9/0024 , A61K35/44 , A61K47/6901 , A61K2035/126 , A61L27/18 , A61L27/3608 , A61L27/3612 , A61L27/3808 , A61L27/3813 , A61L27/54 , A61L2300/64 , B33Y80/00 , C12N5/0618 , C12N5/0654 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
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公开(公告)号：US08900865B2
公开(公告)日：2014-12-02
申请号：US11389268
申请日：2006-03-24
申请人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
IPC分类号： C12N5/00 , C12N5/02 , C12N11/00 , C12N11/16 , A61F2/00 , A61L27/36 , C12N5/077 , A61K47/48 , C12N5/079 , A61L27/38 , A61K9/00 , A61K35/12
CPC分类号： C12N5/0691 , A61K9/0024 , A61K35/44 , A61K47/6901 , A61K2035/126 , A61L27/18 , A61L27/3608 , A61L27/3612 , A61L27/3808 , A61L27/3813 , A61L27/54 , A61L2300/64 , B33Y80/00 , C12N5/0618 , C12N5/0654 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
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公开(公告)号：US09617157B2
公开(公告)日：2017-04-11
申请号：US12322367
申请日：2009-01-30
申请人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
CPC分类号： C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要： Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.
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公开(公告)号：US09187330B2
公开(公告)日：2015-11-17
申请号：US12283908
申请日：2008-09-15
申请人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Mahalaxmi Gita Bangera , Ed Harlow , Roderick A. Hyde , Muriel Y. Ishikawa , Edward K. Y. Jung , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
CPC分类号： C07K16/32 , A61K38/1703 , A61K38/1732 , A61K47/60 , A61K47/6871 , A61K47/6901 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B21/0648 , C01B32/168 , C01B32/174 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01P2004/13 , Y02A50/473 , Y10S977/743 , Y10S977/75 , Y10S977/762 , Y10S977/788 , Y10S977/795 , Y10S977/848 , Y10S977/896 , Y10S977/915
摘要： Devices, compositions, and methods are described which provide a tubular nanostructure targeted to a lipid bilayer membrane. The targeted tubular nanostructure can have a surface region configured to pass through a lipid bilayer membrane of a cell, a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane of a cellular organelle, and at least one ligand configured to bind one or more cognates on the lipid bilayer membrane of the cellular organelle. The target cell can be, for example, a tumor cell, an infected cell, or a diseased cell in a subject. The tubular nanostructure can form a pore in the lipid bilayer membrane of the cellular organelle, e.g., mitochondria, which can permit transit or translocation of at least one compound across the membrane and cause cell death of the target cell.
摘要翻译： 描述了提供靶向脂质双层膜的管状纳米结构的装置，组合物和方法。 目标管状纳米结构可以具有被配置为穿过细胞的脂质双层膜的表面区域，侧壁有两个亲水性表面区域的疏水性表面区域，所述疏水性表面区域配置成在细胞器官细胞器的脂质双层膜中形成孔，以及至少一个 配体被配置为结合细胞器的脂质双层膜上的一个或多个同源物。 靶细胞可以是例如受试者中的肿瘤细胞，感染细胞或患病细胞。 管状纳米结构可以在细胞器（例如线粒体）的脂质双层膜中形成孔，其可以允许至少一种化合物跨过膜的转运或易位并导致靶细胞的细胞死亡。
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公开(公告)号：US09061075B2
公开(公告)日：2015-06-23
申请号：US11900776
申请日：2007-09-12
CPC分类号： A61K47/48776 , A61K9/0024 , A61K47/6901 , A61K2035/126 , B33Y80/00 , C12N5/0654 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
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公开(公告)号：US07855062B2
公开(公告)日：2010-12-21
申请号：US11304492
申请日：2005-12-14
CPC分类号： A61F2/00 , A61K9/0024 , A61K47/6901 , A61K2035/126 , A61L27/3608 , A61L27/3808 , B33Y80/00 , C12N5/0654 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
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