公开(公告)号：US20050019338A1

公开(公告)日：2005-01-27

申请号：US10918845

申请日：2004-08-13

申请人： James Holland ,  Edward Chow

发明人： James Holland ,  Edward Chow

IPC分类号： G01N33/15 ,  A61K49/00 ,  A61K39/00 ,  A61K39/08 ,  A61K39/38

CPC分类号： G01N33/5014 ,  A61K49/0004 ,  G01N33/5088 ,  G01N2333/33

摘要： Methods for determining the effect of a Clostridial neurotoxin on muscle are disclosed. In particular, methods for determining a potency and/or diffusion of a neurotoxin based on a nuclear index and/or an amount of muscle atrophy are disclosed. The methods may be used to distinguish two different Clostridial neurotoxins. In certain embodiments, the neurotoxins are obtained from Clostridium botulinum.

摘要翻译： 公开了确定梭菌神经毒素对肌肉的作用的方法。 特别地，公开了基于核指数和/或肌肉萎缩量确定神经毒素的效力和/或扩散的方法。 这些方法可用于区分两种不同的梭菌神经毒素。 在某些实施方案中，神经毒素从肉毒杆菌获得。

公开(公告)号：US4461262A

公开(公告)日：1984-07-24

申请号：US225786

申请日：1981-01-16

申请人： Edward Chow

发明人： Edward Chow

IPC分类号： F02B3/06 ,  F02M27/04 ,  F23C99/00 ,  F23K5/08 ,  F23D21/00 ,  F02B75/10

CPC分类号： F23K5/08 ,  F02M27/045 ,  F02B3/06

摘要： A fuel treating device comprises two pairs of magnets, one pair positioned on each inlet for fuel and oxygen so that the incoming fuel is exposed to a magnetic field. Each pair of magnets is positioned diametrically opposed about the inlet line with the south magnetic pole of each magnet placed upstream furthest away from the mixing zone. The magnets are insulated from each other and from the inlet line by nonmagnetic materials, such as Neoprene, which do not disrupt the magnetic field.

摘要翻译： 燃料处理装置包括两对磁体，一对位于每个入口上用于燃料和氧气，使得进入的燃料暴露于磁场。 每一对磁体定位在入口线的两端，每个磁体的南磁极位于最远离混合区的上游。 这些磁体通过非磁性材料（例如氯丁橡胶）彼此绝缘并且与入口线绝缘，这不会破坏磁场。

公开(公告)号：US4868818A

公开(公告)日：1989-09-19

申请号：US113956

申请日：1987-10-29

申请人： Herb. S. Madan ,  Edward Chow

发明人： Herb. S. Madan ,  Edward Chow

IPC分类号： G06F11/00 ,  G06F11/273 ,  G11C29/00

CPC分类号： G06F11/2038 ,  G06F11/0724 ,  G06F11/0757 ,  G06F11/2736 ,  G11C29/006

摘要： A fault-tolerant multi-processor computer system of the hypercube type comprising a hierarchy of computers of like kind which can be functionally substituted for one another as necessary. Communication between the working nodes is via one communications network while communications between the working nodes and watch dog nodes and load balancing nodes higher in the structure is via another communications network separate from the first. A typical branch of the hierarchy reporting to a master node or host computer (50) comprises, a plurality of first computing nodes (22); a first network of message conducting paths (30) for interconnecting the first computing nodes (22) as a hypercube (28'), the first network (30) providing a path for message transfer between the first computing nodes (22); a first watch dog node (40); and, a second network of message conducting paths (34) for connecting the first computing nodes (22) to the first watch dog node (40) independent from the first network (30), the second network (34) providing an independent path for test message and reconfiguration affecting transfers between the first computing nodes (22) and the first switch watch dog node (40). There is additionally, a plurality of second computing nodes (22); a third network of message conducting paths (30) for interconnecting the second computing nodes (22) as a hypercube (28'), the third network (30) providing a path for message transfer between the second computing nodes (22); a fourth network of message conducting paths (34) for connecting the second computing nodes (22) to the first watch dog node (40) independent from the third network (30) the fourth network (34) providing an independent path for test message and reconfiguration affecting transfers between the second computing nodes (22) and the first watch dog node (40); and, a first multiplexer disposed between the first watch dog node (40) and the second and fourth networks (34) for allowing the first watch dog node (40) to selectively communicate with individual ones of the computing nodes (22) through the second and fourth networks (34); as well as, a second watch dog node (40) operably connected to the first multiplexer whereby the second watch dog node (40) can selectively communicate with individual ones of the computing nodes (22) through the second and fourth networks (34). The branch is completed by a first load balancing node (ORIGIN OF THE INVENTIONThe invention described herein was made in the performance of work under a NASA contract and is subject to the provisions of Public Law 96-517 (35 USC 202) in which the Contractor has elected not to retain title.

公开(公告)号：US10598956B2

公开(公告)日：2020-03-24

申请号：US15988079

申请日：2018-05-24

申请人： Edward Chow

发明人： Edward Chow

IPC分类号： A61B3/00 ,  G02C7/00 ,  G02C7/04 ,  G02C7/02 ,  A61B3/10 ,  A61B3/103 ,  A61B3/107

摘要： Generating an aspheric contact lens design for facilitating myopia control of a cornea of a patient includes operations of: obtain measurement for degree refractive error of the eye in diopters; obtain measurement of one or more biomechanical properties of the cornea; define a diameter of a central zone of the contact lens based on pupil size; select a base curve profile and width for the central zone based on the refractive error and the one or more biomechanical properties; define a width of a reverse zone adjacent to and encircling the central zone, the width being greater than 0.5 mm; select a reverse curve profile for the reverse zone compatible with the base curve profile; modify the base curve profile adjacent to the reverse zone by applying a selected base eccentricity curve profile for enhancing the tension force strength of the reverse zone; define a width of a relief zone of the contact lens adjacent to and encircling the reverse zone; select a relief curve profile for the relief zone; define a width of an alignment zone of the contact lens adjacent to and encircling the relief zone; select an alignment curve profile for the alignment zone; and define a width of a peripheral zone of the contact lens adjacent to and encircling the alignment zone; select a peripheral curve profile for the peripheral zone; wherein the compression force strength and the tension force strength of the contact lens cooperate to reshape corneal curvature in a mid-peripheral region to address the myopia control when the contact lens is applied to the eye.

公开(公告)号：US07229605B2

公开(公告)日：2007-06-12

申请号：US10918845

申请日：2004-08-13

申请人： James M. Holland ,  Edward Chow

发明人： James M. Holland ,  Edward Chow

IPC分类号： A61K49/00

CPC分类号： G01N33/5014 ,  A61K49/0004 ,  G01N33/5088 ,  G01N2333/33

摘要： Methods for determining the effect of a Clostridial neurotoxin on muscle are disclosed. In particular, methods for determining a potency and/or diffusion of a neurotoxin based on a nuclear index and/or an amount of muscle atrophy are disclosed. The methods may be used to distinguish two different Clostridial neurotoxins. In certain embodiments, the neurotoxins are obtained from Clostridium botulinum.

摘要翻译： 公开了确定梭菌神经毒素对肌肉的作用的方法。 特别地，公开了基于核指数和/或肌肉萎缩量确定神经毒素的效力和/或扩散的方法。 这些方法可用于区分两种不同的梭菌神经毒素。 在某些实施方案中，神经毒素从肉毒杆菌获得。

公开(公告)号：US06984375B2

公开(公告)日：2006-01-10

申请号：US10208165

申请日：2002-07-29

申请人： James M. Holland ,  Edward Chow

发明人： James M. Holland ,  Edward Chow

IPC分类号： A61K49/00

CPC分类号： G01N33/5014 ,  A61K49/0004 ,  G01N33/5088 ,  G01N2333/33

摘要： Methods for determining the effect of a Clostridal toxin on muscle are disclosed. In particular, methods for determining a potency and/or diffusion of a toxin based on a nuclear index and/or the extent of muscle atrophy are disclosed.

摘要翻译： 公开了确定梭菌毒素对肌肉的作用的方法。 特别地，公开了基于核指数和/或肌肉萎缩程度确定毒素的效力和/或扩散的方法。

公开(公告)号：US11460718B2

公开(公告)日：2022-10-04

申请号：US16827522

申请日：2020-03-23

申请人： Edward Chow

发明人： Edward Chow

IPC分类号： G02C7/04 ,  G02C7/02 ,  A61B3/00 ,  A61B3/10 ,  A61B3/103 ,  A61B3/107

摘要： Generating an aspheric contact lens design for facilitating myopia control of a cornea of a patient includes operations of: obtain measurement for degree refractive error of the eye in diopters; obtain measurement of one or more biomechanical properties of the cornea; define a diameter of a central zone of the contact lens based on pupil size; select a base curve profile and width for the central zone based on the refractive error and the one or more biomechanical properties; define a width of a reverse zone adjacent to and encircling the central zone, the width being greater than 0.5 mm; select a reverse curve profile for the reverse zone compatible with the base curve profile; modify the base curve profile adjacent to the reverse zone by applying a selected base eccentricity curve profile for enhancing the tension force strength of the reverse zone; define a width of a relief zone of the contact lens adjacent to and encircling the reverse zone; select a relief curve profile for the relief zone; define a width of an alignment zone of the contact lens adjacent to and encircling the relief zone; select an alignment curve profile for the alignment zone; and define a width of a peripheral zone of the contact lens adjacent to and encircling the alignment zone; select a peripheral curve profile for the peripheral zone; wherein the compression force strength and the tension force strength of the contact lens cooperate to reshape corneal curvature in a mid-peripheral region to address the myopia control when the contact lens is applied to the eye.

公开(公告)号：US20180093753A1

公开(公告)日：2018-04-05

申请号：US15723134

申请日：2017-10-02

申请人： Edward Chow

发明人： Edward Chow

IPC分类号： B64C1/30 ,  B64C39/02 ,  B64C27/08 ,  B64F1/06

CPC分类号： B64C1/30 ,  B64C11/28 ,  B64C27/08 ,  B64C39/024 ,  B64C2201/024 ,  B64C2201/027 ,  B64C2201/042 ,  B64C2201/084 ,  B64C2201/108 ,  B64C2201/123 ,  B64C2201/146 ,  B64C2201/201 ,  B64F1/06 ,  F41F1/00 ,  F41F3/042 ,  F42B10/16 ,  F42B15/01

摘要： A collapsible, rapidly-deployable unmanned aerial vehicle includes a cylindrical structural body, a plurality of deployable mechanisms, a control unit, and a portable power source. The cylindrical structural body is dimensioned to be stored in a small space and deployed rapidly. The plurality of deployable mechanisms includes a lift-generating device for generating an upward thrust that allows the unmanned aerial vehicle to fly. Further, the plurality of deployable mechanisms can collapse to reduce the overall footprint of the cylindrical structural body, thereby allowing the unmanned aerial vehicle to be stored in a confined area. The control unit is integrated into the cylindrical structural body, whereby the control unit controls the flight of the present invention. The portable power source provides electrical energy to the electrically operated components of the unmanned aerial vehicle such as the plurality of deployable mechanisms and the control unit.

公开(公告)号：US08709467B2

公开(公告)日：2014-04-29

申请号：US13380520

申请日：2009-06-26

申请人： Erik Pierstorff ,  Edward Chow ,  Dean Ho ,  Christian Behrenbruch

发明人： Erik Pierstorff ,  Edward Chow ,  Dean Ho ,  Christian Behrenbruch

IPC分类号： A61F2/00

CPC分类号： A61K47/32 ,  A61K9/0024 ,  A61K9/2086 ,  A61K9/7007 ,  A61L15/24 ,  A61L15/26 ,  A61L15/425 ,  A61L15/44 ,  A61L2300/416 ,  A61L2300/426 ,  A61L2300/43 ,  A61L2300/602 ,  A61L2300/608 ,  C08L53/02 ,  C08L65/04

摘要： This invention is in the field of controlled elution devices for therapeutic delivery. There exists a need for a stand-alone capable device for the localized and extended delivery of a therapeutic. This need is overcome by the present invention having an exemplary embodiment comprised of a microfilm base (12), a reservoir of a therapeutic (14) disposed about the microfilm base (12) and a top layer (24) that is (i) a plurality of laminated layers (24) of para-xylyelne polymer and/or (ii) para-xylyelne polymer endowed with oxidatively functionalized para-xyele units. The thicknesses of the device is optimally in the range of about 10 to about 200 microns. The device is usable for the localized release of broad spectrum therapeutics for interventional and preventative medicine.

摘要翻译： 本发明在用于治疗性递送的受控洗脱装置领域。 存在对用于治疗剂的局部和延长递送的独立能力的装置的需要。 本发明克服了这个需求，本发明具有由微缩胶片基底（12），围绕微缩胶片基底（12）设置的治疗剂（14）的储存器和顶层（24）组成的示例性实施方案，所述顶层是（i） 多聚苯乙烯聚合物的层压层（24）和/或（ii）赋予氧化官能化的对位单元的对 - 木聚烯聚合物。 该装置的厚度最好在约10至约200微米的范围内。 该装置可用于介入和预防性药物的广谱治疗剂的局部释放。

公开(公告)号：US20070218005A1

公开(公告)日：2007-09-20

申请号：US11749427

申请日：2007-05-16

申请人： James Holland ,  Edward Chow

发明人： James Holland ,  Edward Chow

IPC分类号： A61K49/00

CPC分类号： G01N33/5014 ,  A61K49/0004 ,  G01N33/5088 ,  G01N2333/33

摘要： Methods for determining the effect of a Clostridial neurotoxin on muscle are disclosed. In particular, methods for determining a potency and/or diffusion of a neurotoxin based on a nuclear index and/or an amount of muscle atrophy are disclosed. The methods may be used to distinguish two different Clostridial neurotoxins. In certain embodiments, the neurotoxins are obtained from Clostridium botulinum.

摘要翻译： 公开了确定梭菌神经毒素对肌肉的作用的方法。 特别地，公开了基于核指数和/或肌肉萎缩量确定神经毒素的效力和/或扩散的方法。 这些方法可用于区分两种不同的梭菌神经毒素。 在某些实施方案中，神经毒素从肉毒杆菌获得。