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    OPTICAL SYSTEM FOR FLUORESCENCE IMAGING
    1.
    发明申请
    OPTICAL SYSTEM FOR FLUORESCENCE IMAGING 有权

    公开(公告)号：US20210223531A1

    公开(公告)日：2021-07-22

    申请号：US17151020

    申请日：2021-01-15

    Applicant: Element Biosciences, Inc.

    Inventor： Minghao Guo ,  Michael Previte ,  Steven Xiangling Chen ,  Chunhong Zhou

    IPC: G02B21/16 ,  B01L3/00 ,  G01N21/64 ,  G02B21/06 ,  G02B21/02

    Abstract: Optical systems for DNA sequencing and other assays are described. Microscope designs may include a light source configured to emit an excitation beam and an objective lens disposed to receive the excitation beam, direct the excitation beam to a specimen, and receive emission light emitted by the specimen in response to the excitation beam. A plurality of detection channels includes optics configured to receive at least a portion of the emission light. A first dichroic filter can be disposed to reflect the excitation beam into the objective lens and to transmit the emission light, and a second dichroic filter can be disposed to receive the transmitted emission light, transmit a first portion of the transmitted emission light to a first channel of the plurality of channels, and reflect a second portion of the transmitted emission light to a second channel of the plurality of channels. Imaging or detection performance may further be improved by a reduced angle of incidence between the emission light and some or all of the dichroic filters, and/or by linearly polarizing the excitation beam such that the excitation beam is s-polarized with respect to the first dichroic filter.

    OPTICAL SYSTEM FOR FLUORESCENCE IMAGING
    2.
    发明申请
    OPTICAL SYSTEM FOR FLUORESCENCE IMAGING 有权

    公开(公告)号：US20210223530A1

    公开(公告)日：2021-07-22

    申请号：US16902188

    申请日：2020-06-15

    Applicant: Element Biosciences, Inc.

    Inventor： Minghao Guo ,  Michael Previte ,  Steven Xiangling Chen ,  Chunhong Zhou

    IPC: G02B21/16 ,  G02B21/02 ,  G02B21/36 ,  G02B21/06 ,  G01N21/64

    Abstract: Multi-channel fluorescence microscopes and optical systems may include a light source configured to emit an excitation beam and an objective lens disposed to receive the excitation beam, direct the excitation beam to a specimen, and receive emission light emitted by the specimen in response to the excitation beam. A plurality of detection channels include optics configured to receive at least a portion of the emission light. A first dichroic filter can be disposed to reflect the excitation beam into the objective lens and to transmit the emission light, and a second dichroic filter can be disposed to receive the transmitted emission light, transmit a first portion of the transmitted emission light to a first channel of the plurality of channels, and reflect a second portion of the transmitted emission light to a second channel of the plurality of channels.

    Nucleic acid sequencing systems
    3.
    发明授权
    Nucleic acid sequencing systems 有权

    公开(公告)号：US11060138B1

    公开(公告)日：2021-07-13

    申请号：US17016353

    申请日：2020-09-09

    Applicant: Element Biosciences, Inc.

    Inventor： Steve Xiangling Chen ,  Minghao Guo ,  Michael Previte ,  Chunhong Zhou ,  Derek Fuller

    IPC: C12Q1/6869 ,  G01N15/14

    Abstract: Methods and systems for sequencing a nucleic acid molecule are described that comprise imaging a first surface and an axially-displaced second surface using a compensation-free optical system, the system comprising an objective lens and at least one image sensor, wherein said optical system has a numerical aperture (NA) of less than 0.6 and a field-of-view (FOV) of greater than 1.0 mm2; and) processing the images of the first surface and the axially-displaced second surface to correct for optical aberration such that the images of the first surface and the axially-displaced second surface have substantially the same optical resolution.

    Single-pass primary analysis
    5.
    发明授权
    Single-pass primary analysis 有权

    公开(公告)号：US11200446B1

    公开(公告)日：2021-12-14

    申请号：US17219556

    申请日：2021-03-31

    Applicant: Element Biosciences, Inc.

    Inventor： Chunhong Zhou ,  Semyon Kruglyak ,  Francisco Garcia ,  Minghao Guo ,  Haosen Wang ,  Ryan Kelly

    IPC: G06K9/62 ,  G06K9/00 ,  G06T7/30

    Abstract: Methods and systems for image analysis are provided, and in particular for identifying a set of base-calling locations in a flow cell for DNA sequencing. These include capturing flow cell images after each sequencing step performed on the flow cell, and identifying candidate cluster centers in at least one of the flow cell images. Intensities are determined for each candidate cluster center in a set of flow cell images. Purities are determined for each candidate cluster center based on the intensities. Each candidate cluster center with a purity greater than the purity of the surrounding candidate cluster centers within a distance threshold is added to a template set of base-calling locations.

    OPTICAL SYSTEM FOR FLUORESCENCE IMAGING
    9.
    发明申请
    OPTICAL SYSTEM FOR FLUORESCENCE IMAGING 有权

    公开(公告)号：US20210223178A1

    公开(公告)日：2021-07-22

    申请号：US17151029

    申请日：2021-01-15

    Applicant: Element Biosciences, Inc.

    Inventor： Minghao Guo ,  Michael Previte ,  Steven Xiangling Chen ,  Chunhong Zhou

    IPC: G01N21/64 ,  C12Q1/6869

    Abstract: Optical systems for DNA sequencing and other assays are described. Microscope designs may include a light source configured to emit an excitation beam and an objective lens disposed to receive the excitation beam, direct the excitation beam to a specimen, and receive emission light emitted by the specimen in response to the excitation beam. A plurality of detection channels includes optics configured to receive at least a portion of the emission light. A first dichroic filter can be disposed to reflect the excitation beam into the objective lens and to transmit the emission light, and a second dichroic filter can be disposed to receive the transmitted emission light, transmit a first portion of the transmitted emission light to a first channel of the plurality of channels, and reflect a second portion of the transmitted emission light to a second channel of the plurality of channels. Imaging or detection performance may further be improved by a reduced angle of incidence between the emission light and some or all of the dichroic filters, and/or by linearly polarizing the excitation beam such that the excitation beam is s-polarized with respect to the first dichroic filter.

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