公开(公告)号：US08415250B2

公开(公告)日：2013-04-09

申请号：US13097459

申请日：2011-04-29

申请人： Emre Alptekin ,  Dong-Ick Lee ,  Viraj Yashawant Sardesai ,  Cung Do Tran ,  Jian Yu ,  Reinaldo Ariel Vega ,  Rajasekhar Venigalla

发明人： Emre Alptekin ,  Dong-Ick Lee ,  Viraj Yashawant Sardesai ,  Cung Do Tran ,  Jian Yu ,  Reinaldo Ariel Vega ,  Rajasekhar Venigalla

IPC分类号： H01L29/417

CPC分类号： H01L29/7833 ,  H01L21/28518 ,  H01L21/76805 ,  H01L21/76843 ,  H01L21/76855 ,  H01L23/485 ,  H01L29/0847 ,  H01L29/66636 ,  H01L29/7834 ,  H01L2924/0002 ,  H01L2924/00

摘要： A structure and method for fabricating silicide contacts for semiconductor devices is provided. Specifically, the structure and method involves utilizing chemical vapor deposition (CVD) and annealing to form silicide contacts of different shapes, selectively on regions of a semiconductor field effect transistor (FET), such as on source and drain regions. The shape of silicide contacts is a critical factor that can be manipulated to reduce contact resistance. Thus, the structure and method provide silicide contacts of different shapes with low contact resistance, wherein the silicide contacts also mitigate leakage current to enhance the utility and performance of FETs in low power applications.

摘要翻译： 提供了一种用于制造用于半导体器件的硅化物触点的结构和方法。 具体地，该结构和方法涉及利用化学气相沉积（CVD）和退火以在半导体场效应晶体管（FET）（例如源极和漏极区域）的区域上选择性地形成不同形状的硅化物接触。 硅化物触点的形状是可以被操纵以降低接触电阻的关键因素。 因此，该结构和方法提供具有低接触电阻的不同形状的硅化物触点，其中硅化物触点还减轻漏电流以增强低功率应用中的FET的效用和性能。

公开(公告)号：US20120273798A1

公开(公告)日：2012-11-01

申请号：US13097459

申请日：2011-04-29

申请人： Emre Alptekin ,  Dong-Ick Lee ,  Viraj Yashawant Sardesai ,  Cung Do Tran ,  Jian Yu ,  Reinaldo Ariel Vega ,  Rajasekhar Venigalla

发明人： Emre Alptekin ,  Dong-Ick Lee ,  Viraj Yashawant Sardesai ,  Cung Do Tran ,  Jian Yu ,  Reinaldo Ariel Vega ,  Rajasekhar Venigalla

IPC分类号： H01L29/772

CPC分类号： H01L29/7833 ,  H01L21/28518 ,  H01L21/76805 ,  H01L21/76843 ,  H01L21/76855 ,  H01L23/485 ,  H01L29/0847 ,  H01L29/66636 ,  H01L29/7834 ,  H01L2924/0002 ,  H01L2924/00

摘要： A structure and method for fabricating silicide contacts for semiconductor devices is provided. Specifically, the structure and method involves utilizing chemical vapor deposition (CVD) and annealing to form silicide contacts of different shapes, selectively on regions of a semiconductor field effect transistor (FET), such as on source and drain regions. The shape of silicide contacts is a critical factor that can be manipulated to reduce contact resistance. Thus, the structure and method provide silicide contacts of different shapes with low contact resistance, wherein the silicide contacts also mitigate leakage current to enhance the utility and performance of FETs in low power applications.

摘要翻译： 提供了一种用于制造用于半导体器件的硅化物触点的结构和方法。 具体地，该结构和方法涉及利用化学气相沉积（CVD）和退火以在半导体场效应晶体管（FET）（例如源极和漏极区域）的区域上选择性地形成不同形状的硅化物接触。 硅化物触点的形状是可以被操纵以降低接触电阻的关键因素。 因此，该结构和方法提供具有低接触电阻的不同形状的硅化物触点，其中硅化物触点还减轻漏电流以增强低功率应用中的FET的效用和性能。

公开(公告)号：US09796988B2

公开(公告)日：2017-10-24

申请号：US14358911

申请日：2011-11-17

申请人： Jian Yu

发明人： Jian Yu

IPC分类号： C12P7/62

CPC分类号： C12P7/625

摘要： A process for producing hydroxyalkanoate copolymers, which comprises: (i) pre-treating a sucrose-containing feedstock in an acidic solution; (ii) feeding the pre-treated feedstock into a bioreactor containing polyhydroxyalkanoate producing microbial cells; (iii) cultivating the polyhydroxyalkanoate producing microbial cells to form a cell mass containing the hydroxyalkanoate copolymers; (iv) recovering the hydroxyalkanoate copolymers from the cell mass. The pre-treating step has the main function of hydrolyzing sucrose into glucose and fructose, which in turn are converted into 4-ketovaleric acid to give a mixture of mono-saccharides and organic precursors for microbial synthesis of hydroxyalkanoate copolymers, and particularly of PHBVV ter-polymers. Complex and expensive purification processes of the substrates obtained from the pre-treating step are not needed. The solutions can be directly used as the feeding solutions for microbial PHA biosynthesis.

公开(公告)号：US09451337B2

公开(公告)日：2016-09-20

申请号：US14448121

申请日：2014-07-31

申请人： David W. Chen ,  Vipul B. Patel ,  Kenneth L. Gould ,  Jian Yu

发明人： David W. Chen ,  Vipul B. Patel ,  Kenneth L. Gould ,  Jian Yu

IPC分类号： H04N7/18 ,  H04N21/858 ,  H04N21/41 ,  H04N21/43 ,  H04N21/436 ,  H04N21/4363 ,  H04N21/81 ,  H04N21/472

CPC分类号： H04N21/8586 ,  H04N21/4126 ,  H04N21/4307 ,  H04N21/43615 ,  H04N21/43637 ,  H04N21/472 ,  H04N21/8133 ,  H04N21/8173

摘要： Techniques disclosed herein include systems and methods for transmitting TV program related content to IP connected devices on a home network, or other local area network. Users can watch television while simultaneously receiving content related to TV programs currently being displayed on a television. TV centric and TV program related content can be transmitted to IP connected devices. Moreover, this TV program related content can be displayed at the same time as a television program is being displayed on a television. As such, the system can provide media synchronization within home network using the set-top box as a gateway for delivering the content. Users can watch TV at home, and at the same time receive TV program related content on a laptop, tablet computer, mobile phone, etc.

摘要翻译： 本文公开的技术包括用于向家庭网络或其他局域网上的IP连接设备发送TV节目相关内容的系统和方法。 用户可以同时收看与电视上正在显示的电视节目有关的内容。 电视中心和电视节目相关内容可以传输到IP连接的设备。 此外，与电视节目正在显示在电视机上的同时，可以显示该TV节目相关的内容。 因此，系统可以使用机顶盒作为用于递送内容的网关来在家庭网络内提供媒体同步。 用户可以在家中看电视，同时在笔记本电脑，平板电脑，手机等上接收电视节目相关的内容。

公开(公告)号：US08832750B2

公开(公告)日：2014-09-09

申请号：US13468451

申请日：2012-05-10

申请人： David W. Chen ,  Vipul B. Patel ,  Kenneth L. Gould ,  Jian Yu

发明人： David W. Chen ,  Vipul B. Patel ,  Kenneth L. Gould ,  Jian Yu

IPC分类号： H04N7/18 ,  H04N7/173 ,  H04N7/16

CPC分类号： H04N21/8586 ,  H04N21/4126 ,  H04N21/4307 ,  H04N21/43615 ,  H04N21/43637 ,  H04N21/472 ,  H04N21/8133 ,  H04N21/8173

摘要： Techniques disclosed herein include systems and methods for transmitting TV program related content to IP connected devices on a home network, or other local area network. Users can watch television while simultaneously receiving content related to TV programs currently being displayed on a television. TV centric and TV program related content can be transmitted to IP connected devices. Moreover, this TV program related content can be displayed at the same time as a television program is being displayed on a television. As such, the system can provide media synchronization within home network using the set-top box as a gateway for delivering the content. Users can watch TV at home, and at the same time receive TV program related content on a laptop, tablet computer, mobile phone, etc.

摘要翻译： 本文公开的技术包括用于向家庭网络或其他局域网上的IP连接设备发送TV节目相关内容的系统和方法。 用户可以同时收看与电视上正在显示的电视节目有关的内容。 电视中心和电视节目相关内容可以传输到IP连接的设备。 此外，与电视节目正在显示在电视机上的同时，可以显示该TV节目相关的内容。 因此，系统可以使用机顶盒作为用于递送内容的网关来在家庭网络内提供媒体同步。 用户可以在家中看电视，同时在笔记本电脑，平板电脑，手机等上接收电视节目相关的内容。

公开(公告)号：US08486645B2

公开(公告)日：2013-07-16

申请号：US13438218

申请日：2012-04-03

申请人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

发明人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

IPC分类号： G01N33/53 ,  G01N33/563 ,  C12Q1/48 ,  C12N9/12 ,  G01N35/08

CPC分类号： G01N33/574 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/1205 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/57484 ,  G01N2333/9121 ,  Y10T436/117497

摘要： Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant polypeptides, probes for detecting it, isolated mutant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The invention also provides methods for determining the presence of these mutant polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides.

摘要翻译： 涉及染色体2的新型基因缺失和易位导致融合蛋白的结合，其部分的间变型淋巴瘤激酶（ALK）激酶与部分二级蛋白结合，已经在人类实体瘤中被鉴定。 非小细胞肺癌（NSCLC）。 次级蛋白包括棘皮动物微管相关蛋白样4（EML-4）和TRK-融合基因（TFG）。 确认了保留ALK酪氨酸激酶活性的EML4-ALK融合蛋白，以驱动以这种突变为特征的NSCLC的增殖和存活。 因此，本发明部分地提供分离的多核苷酸和编码所公开的突变多肽的载体，用于检测其的探针，分离的突变多肽和用于检测融合和截短的多肽的试剂。 本发明还提供了用于确定生物样品中这些突变体多肽的存在的方法，用于筛选抑制蛋白质的化合物的方法，以及用于突变多核苷酸或多肽特征的癌症进展抑制方法。

公开(公告)号：US08396055B2

公开(公告)日：2013-03-12

申请号：US12582653

申请日：2009-10-20

申请人： Vipul Patel ,  Scott Miller ,  Mehul Shah ,  Jian Yu

发明人： Vipul Patel ,  Scott Miller ,  Mehul Shah ,  Jian Yu

IPC分类号： H04L12/66

CPC分类号： H04L12/66 ,  H04L65/4015 ,  H04L65/4069 ,  H04N21/4782 ,  H04N21/4788

摘要： Methods and apparatus for providing unified access to interactive media applications and services in a network. In one embodiment, the network comprises a content-based network such as a cable television or satellite network, and the applications are disposed at the network headend. A servlet is provided to facilitate communication between the applications and client devices. The servlet acts as a proxy for applications utilizing a different content format than the client devices. The applications obtain data from e.g., an internet host server via a gateway device. The client application(s) may comprise Enhanced TV Binary Interchange Format (EBIF) pages, and are configured so as to permit use via a common interface (e.g., the user's set top box and television display). These client applications enable a user to, for example, search the internet for data relating to displayed content, post and navigate micro-blogs, instant messaging or SMS, making telephone calls (e.g., VoIP), address/contact management, or provide the user with additional information about a product or service. An application providing internet content to the client device is also provided.

摘要翻译： 在网络中提供对交互式媒体应用和服务的统一访问的方法和装置。 在一个实施例中，网络包括诸如有线电视或卫星网络的基于内容的网络，并且应用被布置在网络头端。 提供servlet以便于应用程序和客户端设备之间的通信。 servlet充当使用与客户端设备不同的内容格式的应用程序的代理。 应用程序通过网关设备从例如互联网主机服务器获得数据。 客户端应用可以包括增强型电视二进制交换格式（EBIF）页面，并且被配置为允许经由公共接口（例如，用户的机顶盒和电视显示器）使用。 这些客户端应用使得用户能够例如在互联网上搜索与显示的内容有关的数据，发布和浏览微博，即时消息或SMS，进行电话呼叫（例如，VoIP），地址/联系人管理，或提供 用户提供有关产品或服务的附加信息。 还提供了向客户端设备提供因特网内容的应用。

公开(公告)号：US20120288872A1

公开(公告)日：2012-11-15

申请号：US13438218

申请日：2012-04-03

申请人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

发明人： Klarisa Rikova ,  Herbert Haack ,  Laura Sullivan ,  Ailan Guo ,  Anthony Possemato ,  Joan MacNeill ,  Ting-Lei Gu ,  Jian Yu

IPC分类号： G01N33/574

CPC分类号： G01N33/574 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/1205 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/57484 ,  G01N2333/9121 ,  Y10T436/117497

摘要： Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC characterized by this mutation. The invention therefore provides, in part, isolated polynucleotides and vectors encoding the disclosed mutant polypeptides, probes for detecting it, isolated mutant polypeptides, and reagents for detecting the fusion and truncated polypeptides. The invention also provides methods for determining the presence of these mutant polypeptides in a biological sample, methods for screening for compounds that inhibit the proteins, and methods for inhibiting the progression of a cancer characterized by the mutant polynucleotides or polypeptides.

摘要翻译： 涉及染色体2的新型基因缺失和易位导致融合蛋白的结合，其部分的间变型淋巴瘤激酶（ALK）激酶与部分二级蛋白结合，已经在人类实体瘤中被鉴定。 非小细胞肺癌（NSCLC）。 次级蛋白包括棘皮动物微管相关蛋白样4（EML-4）和TRK-融合基因（TFG）。 确认了保留ALK酪氨酸激酶活性的EML4-ALK融合蛋白，以驱动以这种突变为特征的NSCLC的增殖和存活。 因此，本发明部分地提供分离的多核苷酸和编码所公开的突变多肽的载体，用于检测其的探针，分离的突变多肽和用于检测融合和截短的多肽的试剂。 本发明还提供了用于确定生物样品中这些突变体多肽的存在的方法，用于筛选抑制蛋白质的化合物的方法，以及用于突变多核苷酸或多肽特征的癌症进展抑制方法。

公开(公告)号：US20120261804A1

公开(公告)日：2012-10-18

申请号：US13087915

申请日：2011-04-15

申请人： Junjun Li ,  Zhengwen Li ,  Chengwen Pei ,  Jian Yu

发明人： Junjun Li ,  Zhengwen Li ,  Chengwen Pei ,  Jian Yu

IPC分类号： H01L29/06 ,  H01L21/22 ,  B82Y99/00

CPC分类号： H01L29/861 ,  H01L21/76256 ,  H01L27/0255

摘要： A diode structure, formed under a buried dielectric layer of a silicon on insulator (SOI), method of manufacturing the same and design structure thereof are provided. In an embodiment the p-n junction of the diode structure can be advantageously arranged in a vertical orientation. The cathode comprises an N+ epitaxial layer formed upon a P-type substrate. The anode comprises an active region of the P-substrate. Contacts to the cathode and anode are formed through the buried dielectric layer. Contact to the anode is accomplished via a deep trench filled with a conductive plug. The deep trench also provides electrical isolation for the cathode (as well as p-n junction). Advantageously, embodiments of the present invention may be formed during formation of other structures which also include trenches (for example, deep trench capacitors) in order to reduce process steps required to form the diode structure under the buried dielectric layer of the SOI substrate.

摘要翻译： 提供了一种二极管结构，其形成在绝缘体上的绝缘体（SOI）的埋置介质层下，其制造方法及其设计结构。 在一个实施例中，二极管结构的p-n结可以有利地以垂直取向布置。 阴极包括在P型衬底上形成的N +外延层。 阳极包括P基底的有源区。 通过埋入介电层形成与阴极和阳极的接触。 通过填充有导电插塞的深沟槽实现与阳极的接触。 深沟槽还为阴极（以及p-n结）提供电隔离。 有利地，本发明的实施例可以在形成其它结构的过程中形成，这些结构还包括沟槽（例如，深沟槽电容器），以便减少在SOI衬底的埋置介质层下形成二极管结构所需的工艺步骤。

公开(公告)号：US20120252081A1

公开(公告)日：2012-10-04

申请号：US13502323

申请日：2009-10-16

申请人： Jian Yu

发明人： Jian Yu

IPC分类号： C12P7/62

CPC分类号： C12P7/625

摘要： The present invention relates to a process for producing biodegradable polymeric materials including polyhydroxyalkanoates (PHAs) by using the cell debris left from PHA recovery and purification. The process comprises: (a) cultivating PHA-producing microbial cells in a medium solution containing an organic carbon source to form PHAs that are accumulated in the cells as inclusion bodies; (b) harvesting the cells from the spent medium and solubilizing the non-PHA cell mass to obtain a PHA solid and a cell debris solution; (c) separating the PHA solid from the cell debris solution; (d) feeding the cell debris solution to the cultivation step (a). By reusing the cell debris generated from PHA recovery, the invention avoids disposal of a large amount of aqueous waste. In addition, a remarkable increase of cell growth and PHA synthesis is achieved, because the cell debris can be readily assimilated by the microbial cells as the nutrients.

摘要翻译： 本发明涉及通过使用从PHA回收和纯化留下的细胞碎片来生产包括聚羟基链烷酸酯（PHA）的生物可降解聚合物材料的方法。 该方法包括：（a）在含有机碳源的培养基溶液中培养产生PHA的微生物细胞，形成作为包涵体积聚在细胞中的PHA; （b）从废培养基中收获细胞并溶解非PHA细胞块以获得PHA固体和细胞碎片溶液; （c）将PHA固体与细胞碎片溶液分离; （d）将细胞碎片溶液送入培养步骤（a）。 通过重新利用由PHA回收产生的细胞碎片，本发明避免了大量的含水废物的处置。 此外，实现了细胞生长和PHA合成的显着增加，因为细胞碎片可以容易地被微生物细胞作为营养物质吸收。