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公开(公告)号：US20080305101A1
公开(公告)日：2008-12-11
申请号：US11967509
申请日：2007-12-31
Applicant: Erkki Ruoslahti , Dmitri Simberg
Inventor： Erkki Ruoslahti , Dmitri Simberg
IPC: A61K39/395 , C07K5/09 , C07K17/00 , C07K16/46 , C07K19/00 , C07K14/76 , A61K38/02 , C01G49/02 , B32B9/00 , C07D305/08 , C07F13/00 , C07H21/00 , A61K38/06
CPC classification number: A61K47/48861 , A61K47/48238 , A61K47/48815 , A61K47/48884 , A61K47/62 , A61K47/6911 , A61K47/6923 , A61K47/6929 , A61K49/1863 , A61K49/1866 , B82Y5/00 , Y10T428/2984
Abstract: Disclosed are compositions and methods related to clot binding compounds. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.
Abstract translation: 公开了与凝块结合化合物相关的组合物和方法。 所公开的靶向对于治疗癌症和其它疾病和病症是有用的。
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公开(公告)号：US09101671B2
公开(公告)日：2015-08-11
申请号：US11967509
申请日：2007-12-31
Applicant: Erkki Ruoslahti , Dmitri Simberg
Inventor： Erkki Ruoslahti , Dmitri Simberg
CPC classification number: A61K47/48861 , A61K47/48238 , A61K47/48815 , A61K47/48884 , A61K47/62 , A61K47/6911 , A61K47/6923 , A61K47/6929 , A61K49/1863 , A61K49/1866 , B82Y5/00 , Y10T428/2984
Abstract: Disclosed are compositions and methods related to clot binding compounds. For example, disclosed are conjugates comprising a surface molecule and a plurality of clot binding compounds. The clot binding compounds can selectively bind to clotted plasma protein. The conjugate can, for example, cause clotting and amplify the accumulation of the conjugate in tumors. In one example, the conjugate can comprise a sufficient number and composition of clot binding compounds such that the conjugate causes clotting and amplifies the accumulation of the conjugate in tumors. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.
Abstract translation: 公开了与凝块结合化合物相关的组合物和方法。 例如，公开了包含表面分子和多个凝块结合化合物的缀合物。 凝块结合化合物可以选择性地结合凝血的血浆蛋白。 结合物可以例如引起凝血并且扩增缀合物在肿瘤中的积累。 在一个实例中，缀合物可以包含足够数量和组合物的凝块结合化合物，使得缀合物引起凝血并扩增缀合物在肿瘤中的积累。 所公开的靶向对于治疗癌症和其它疾病和病症是有用的。
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公开(公告)号：US11642391B2
公开(公告)日：2023-05-09
申请号：US15502170
申请日：2015-08-04
Applicant: Vascular BioSciences , Sanford Burnham Prebys Medical Discovery Institute , David Mann , Erkki Ruoslahti , Masanobu Komatsu
Inventor： David Mann , Erkki Ruoslahti , Masanobu Komatsu
IPC: A61K38/12 , G16B35/00 , G16C20/60 , A61K31/337 , A61K31/506 , A61K38/55 , A61K45/06 , A61K31/222 , A61K31/573 , A61K47/68 , A61K47/64 , G01N33/15 , G16B35/20 , G16B35/10 , A61P31/00 , A61P1/16 , A61P9/12 , A61P13/12 , A61P11/00 , A61P35/00 , A61K31/18 , A61K31/436 , A61K31/438 , A61K38/08 , G01N33/50
CPC classification number: A61K38/12 , A61K31/18 , A61K31/222 , A61K31/337 , A61K31/436 , A61K31/438 , A61K31/506 , A61K31/573 , A61K38/08 , A61K38/55 , A61K45/06 , A61K47/64 , A61K47/643 , A61K47/6811 , A61K47/6851 , A61P1/16 , A61P9/12 , A61P11/00 , A61P13/12 , A61P31/00 , A61P35/00 , G01N33/15 , G01N33/5008 , G16B35/00 , G16B35/10 , G16B35/20 , G16C20/60 , A61K31/506 , A61K2300/00 , A61K31/222 , A61K2300/00 , A61K31/337 , A61K2300/00 , A61K31/573 , A61K2300/00
Abstract: Compositions and methods useful for delivery of targeted therapies for pulmonary arterial hypertension, sepsis, cancer and cachexia. The compositions and methods are based on peptide pharmacophores that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. Peptide pharmacophores may selectively target tumor vasculature, regenerating tissue, wounded tissue, inflamed tissue, fibrotic tissue, remodeled tissue, tissue characterized by elevated heparanase levels, and have the ability to internalize into such diseased cells.
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公开(公告)号：US10370245B2
公开(公告)日：2019-08-06
申请号：US12821050
申请日：2010-06-22
Applicant: Erkki Ruoslahti , Tambet Teesalu , Kazuki Sugahara
Inventor： Erkki Ruoslahti , Tambet Teesalu , Kazuki Sugahara
Abstract: Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
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5.发明授权CAR peptide for homing, diagnosis and targeted therapy for pulmonary and fibrotic disorders 有权CAR肽用于肺和纤维化疾病的归巢，诊断和靶向治疗公开(公告)号：US09180161B2
公开(公告)日：2015-11-10
申请号：US13581457
申请日：2011-02-28
Applicant: Masanobu Komatsu , David Marshall Mann , Erkki Ruoslahti
Inventor： Masanobu Komatsu , David Marshall Mann , Erkki Ruoslahti
CPC classification number: A61K47/64 , A61K31/506 , A61K31/551 , A61K38/00 , A61K38/08 , A61K45/06 , C07K7/06 , C12Q1/6883 , C12Q2600/158
Abstract: Disclosed are compositions and methods useful for delivering targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to effect a beneficial therapeutic result. The disclosed targeting is useful for delivering therapeutic and detectable agents to diseased tissue in an animal.
Abstract translation: 公开了用于递送针对肺部疾病，纤维化疾病和癌症的靶向治疗的组合物和方法。 组合物和方法基于选择性结合病变组织并置于患病组织的肽序列，并使靶向疗法能够产生有益的治疗结果。 所公开的靶向对于将治疗性和可检测的药物递送到动物中的病变组织是有用的。
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Patent Agency Ranking
6.发明申请Truncated LYP-1 Peptides and Methods and Compositions Using Truncated LYP-1 Peptides 审中-公开截短的LYP-1肽和使用截短的LYP-1肽的方法和组合物公开(公告)号：US20150259380A1
公开(公告)日：2015-09-17
申请号：US13594194
申请日：2012-08-24
Applicant: Erkki Ruoslahti , Tambet Teesalu , Kazuki Sugahara , Lise Roth
Inventor： Erkki Ruoslahti , Tambet Teesalu , Kazuki Sugahara , Lise Roth
IPC: C07K7/06 , A61K38/10 , A61K31/337 , A61K47/48
CPC classification number: C07K7/06 , A61K31/337 , A61K38/08 , A61K45/06 , A61K47/62 , A61K47/6929 , A61K47/6953 , C07K7/08 , C07K14/4748
Abstract: Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences, such as truncated LyP-1 peptides, that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
Abstract translation: 公开了用于将分子靶向和内化到目标细胞和用于目标组织分子穿透的组合物和方法。 组合物和方法基于肽序列，例如截短的LyP-1肽，其被细胞选择性内化，穿透组织或两者。 所公开的内化和组织穿透对于将治疗和可检测的药物递送到感兴趣的细胞和组织是有用的。
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公开(公告)号：US09061079B2
公开(公告)日：2015-06-23
申请号：US13531245
申请日：2012-06-22
Applicant: Erkki Ruoslahti , Juliana Hamzah
Inventor： Erkki Ruoslahti , Juliana Hamzah
Abstract: Methods of targeting atherosclerotic plaques using LyP-1 related peptides are provided. In some embodiments, the methods include administering a peptide comprising a LyP peptide to an animal, wherein the peptide homes to an atherosclerotic plaque, thereby targeting the atherosclerotic plaque. Also provided are methods for ameliorating a sign or symptom associated with an inflammatory condition using LyP-1 related peptides.
Abstract translation: 提供了使用LyP-1相关肽靶向动脉粥样硬化斑块的方法。 在一些实施方案中，所述方法包括向动物施用包含LyP肽的肽，其中肽适应于动脉粥样硬化斑块，从而靶向动脉粥样硬化斑块。 还提供了使用LyP-1相关肽改善与炎性病症相关的症状或症状的方法。
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公开(公告)号：US20120219502A1
公开(公告)日：2012-08-30
申请号：US13448820
申请日：2012-04-17
Applicant: Erkki Ruoslahti , Valentina Fogal
Inventor： Erkki Ruoslahti , Valentina Fogal
IPC: G01N33/574 , C12Q1/70 , A61K38/02 , A61K39/395 , A61P35/00 , A61K31/713 , C12Q1/68 , A61K49/00
CPC classification number: C07K16/30 , A61K38/08 , C07K2317/76 , G01N33/574 , G01N2333/4716
Abstract: Disclosed are compositions and methods useful for targeting gC1q/p32 receptors. The disclosed targeting is useful for delivering therapeutic and detectable agents to cancerous cells, and to areas of inflammation.
Abstract translation: 公开了用于靶向gC1q / p32受体的组合物和方法。 所公开的靶向对于将治疗和可检测的药物递送到癌细胞和炎症区域是有用的。
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公开(公告)号：US08188221B2
公开(公告)日：2012-05-29
申请号：US12991755
申请日：2009-05-08
Applicant: Pirjo Laakkonen , Erkki Ruoslahti , Gabriele Bergers
Inventor： Pirjo Laakkonen , Erkki Ruoslahti , Gabriele Bergers
IPC: C07K16/00
CPC classification number: A61K38/10 , C07K7/06 , G01N33/57407
Abstract: The present invention relates to a peptide, which specifically homes to the intracranial, early stage astrocytoma model that grows as islets and harbors co-opted tumor vessels in the brain. The peptide finds its use in targeted delivery of therapeutic substances to invasive brain cancer or metastatic brain lesions as such and in combination with conventional therapies, such as surgery and radiation, and anti-angiogenic therapies, and as a tool in diagnosis of, e.g., invasive brain cancer or metastatic brain lesions.
Abstract translation: 本发明涉及一种肽，其特别适用于颅内早期星形细胞瘤模型，其随着胰岛和海湾在脑中的选择性肿瘤血管生长。 该肽可用于将治疗物质靶向递送至侵袭性脑癌或转移性脑损伤，并与常规治疗如手术和放射疗法以及抗血管生成治疗结合使用，并且作为诊断例如， 侵袭性脑癌或转移性脑损伤。
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公开(公告)号：US20110262347A1
公开(公告)日：2011-10-27
申请号：US13083176
申请日：2011-04-08
Applicant: Erkki Ruoslahti , Lilach Agemy , Dinorah Friedmann-Morviniski , Venkata Ramana Kotamraju , Kazuki Sugahara , Inder Verma
Inventor： Erkki Ruoslahti , Lilach Agemy , Dinorah Friedmann-Morviniski , Venkata Ramana Kotamraju , Kazuki Sugahara , Inder Verma
IPC: A61K51/00 , C07K7/08 , C07K14/76 , A61K47/42 , A61K9/127 , C07F13/00 , C07H21/00 , A61K38/16 , A61K31/7088 , A61K31/28 , C07D305/14 , A61K31/337 , A61K49/00 , A61P35/00 , A61P43/00 , C07K7/06 , B82Y5/00
CPC classification number: A61K38/04 , A61K47/55 , A61K47/66 , A61K47/6923 , B82Y5/00
Abstract: Disclosed are compositions and methods related to multivalent compositions targeted to cells and tissues. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.
Abstract translation: 公开了与针对细胞和组织的多价组合物相关的组合物和方法。 所公开的靶向对于治疗癌症和其它疾病和病症是有用的。
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