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    Negatively charged minor groove binders
    1.
    发明申请
    Negatively charged minor groove binders 有权
    带负电荷的小槽粘合剂

    公开(公告)号：US20050187383A1

    公开(公告)日：2005-08-25

    申请号：US10507267

    申请日：2003-03-11

    申请人： Eugeny Lukhtanov ,  Sergey Lokhov ,  Nicolaas Vermeulen

    发明人： Eugeny Lukhtanov ,  Sergey Lokhov ,  Nicolaas Vermeulen

    IPC分类号： C07H21/00 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： C07H21/04 ,  C07H21/00

    摘要： The present invention provides a negatively charged minor groove binding compound, oligonucleotide conjugates comprising the same, and methods for using the same. The negatively charged minor groove binding compounds of the present invention comprises an acidic moiety that is capable of being ionized under physiological conditions. In particular, the negatively charged minor groove binding compound of the present invention comprises a binding moiety that binds preferentially into a minor groove of a double, triple or higher stranded DNA, RNA, PNA or hybrids thereof. The binding moiety comprises at least one aryl moiety and an acidic moiety which is covalently attached to a phenyl portion of the aryl moiety or to a heteroatom of a heteroaryl portion of the aryl moiety.

    摘要翻译： 本发明提供带负电荷的小沟结合化合物，包含其的寡核苷酸缀合物及其使用方法。 本发明的带负电荷的小沟结合化合物包含能够在生理条件下电离的酸性部分。 特别地，本发明的带负电荷的小沟结合化合物包含优先结合双重，三重或更高链DNA，RNA，PNA或其杂交体的小沟的结合部分。 结合部分包含至少一个芳基部分和酸性部分，其共价连接到芳基部分的苯基部分或芳基部分的杂芳基部分的杂原子。