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公开(公告)号：US20050154186A1
公开(公告)日：2005-07-14
申请号：US11006475
申请日：2004-12-07
申请人： Fabrice Gallou , Said Saim , Nathan Yee
发明人： Fabrice Gallou , Said Saim , Nathan Yee
CPC分类号： B01J31/4038 , B01J31/2208 , B01J31/2273 , B01J31/2404 , B01J31/4069 , B01J2038/005 , B01J2231/543 , B01J2531/821 , C07K5/06139 , Y02P20/544 , Y02P20/584
摘要： A process for removing ruthenium or ruthenium-containing compounds from a reaction mixture comprising a compound of the following formula I in an organic solvent using supercritical fluid processing techniques: wherein RA, R3, R4, D and A are as defined herein. This invention has particular application for removing ruthenium-containing catalyst and ruthenium-containing catalyst by products from reaction mixtures that result from ring-closing olefin metathesis (RCM) reactions.
摘要翻译： 一种使用超临界流体处理技术在有机溶剂中从包含下式I化合物的反应混合物中除去含钌或含钌化合物的方法：其中R A，R 3， D S，R 4，D和A如本文所定义。 本发明特别适用于通过由闭环烯烃复分解（RCM）反应产生的反应混合物的产物除去含钌催化剂和含钌催化剂。
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公开(公告)号：US07268211B2
公开(公告)日：2007-09-11
申请号：US11006475
申请日：2004-12-07
申请人： Fabrice Gallou , Said Saim , Nathan K. Yee
发明人： Fabrice Gallou , Said Saim , Nathan K. Yee
IPC分类号： C07K5/12 , C07D245/00 , C07F15/00
CPC分类号： B01J31/4038 , B01J31/2208 , B01J31/2273 , B01J31/2404 , B01J31/4069 , B01J2038/005 , B01J2231/543 , B01J2531/821 , C07K5/06139 , Y02P20/544 , Y02P20/584
摘要： A process for removing ruthenium or ruthenium-containing compounds from a reaction mixture comprising a compound of the following formula I in an organic solvent using supercritical fluid processing techniques: wherein RA, R3, R4, D and A are as defined herein. This invention has particular application for removing ruthenium-containing catalyst and ruthenium-containing catalyst by products from reaction mixtures that result from ring-closing olefin metathesis (RCM) reactions.
摘要翻译： 一种使用超临界流体处理技术在有机溶剂中从包含下式I化合物的反应混合物中除去含钌或含钌化合物的方法：其中R A，R 3， D S，R 4，D和A如本文所定义。 本发明特别适用于通过由闭环烯烃复分解（RCM）反应产生的反应混合物的产物除去含钌催化剂和含钌催化剂。
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公开(公告)号：US06884911B2
公开(公告)日：2005-04-26
申请号：US09774232
申请日：2001-01-30
CPC分类号： B01D11/0203 , B01D9/005 , B01D9/0054 , B01D11/0257
摘要： A method for repeatedly converting a solvent from a state of solvent to a state of antisolvent with relatively little loss of solvent. The method is used to allow for processing of large amounts of solute material with minimum amounts of solvent.
摘要翻译： 一种溶剂从溶剂状态重复转化为反溶剂状态的方法，溶剂损失相对较少。 该方法用于允许用最少量的溶剂处理大量溶质材料。
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公开(公告)号：US06858166B2
公开(公告)日：2005-02-22
申请号：US10268879
申请日：2002-10-10
IPC分类号： A61J3/02 , A61J3/06 , A61K9/14 , A61K9/16 , A61K9/28 , A61K9/48 , A61K9/50 , A61K9/51 , A61K31/46 , A61K47/26 , B29B9/00 , B01J2/00 , B01J3/00
CPC分类号： A61K9/1694 , A61K9/1623
摘要： Disclosed is a method of small particle precipitation, retention and dispersion of a solid or semi-solid material onto or into a carrier material. In this method, solute particles are precipitated from a pressurized gaseous fluid solution or a liquid solution and effectively retained and dispersed within a carrier material. This technique can be advantageously used in pharmaceutical processing to produce a blend of solid or semi-solid material particles and carrier material, a granulation of the solid or semi-solid material particles with carrier material, carrier material partially or fully coated with the solid or semi-solid material particles, or mixtures thereof.
摘要翻译： 公开了一种将固体或半固体材料小颗粒沉淀，保留和分散在载体材料上或其中的方法。 在该方法中，溶质颗粒从加压的气态流体溶液或液体溶液中沉淀出来并有效地保留并分散在载体材料中。 该技术可有利地用于药物加工以产生固体或半固体材料颗粒和载体材料的混合物，固体或半固体材料颗粒与载体材料的颗粒，部分或完全涂覆有固体的载体材料或 半固体材料颗粒或其混合物。
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5.发明授权Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent 失效通过从喷射到压缩抗溶剂中的有机溶液重结晶进行颗粒微粉化和纳米化的方法
公开(公告)号：US5874029A
公开(公告)日：1999-02-23
申请号：US723463
申请日：1996-10-09
CPC分类号： B05D1/025 , A61K9/1676 , A61K9/1688 , B01J2/04 , A61K9/1694 , A61K9/5089 , B05D2401/90 , Y10S977/773
摘要： A method and an apparatus useful for the production of microparticles and nanoparticles are disclosed in which a compressed fluid and a solution including a solvent and a solute are introduced into a nozzle to produce a mixture. The mixture is then passed out of the nozzle to produce a spray of atomized droplets. The atomized droplets are contacted with a supercritical antisolvent to cause depletion of the solvent in the droplets so that particles are produced from the solute. Preferably, these particles have an average diameter of 0.6 .mu.m or less. The invention can be used in the pharmaceutical, food, chemical, electronics, catalyst, polymer, pesticide, explosives, and coating industries, all of which have a need for small-diameter particles.
摘要翻译： 公开了一种用于生产微粒和纳米颗粒的方法和装置，其中将压缩流体和包含溶剂和溶质的溶液引入喷嘴中以产生混合物。 然后将混合物从喷嘴中排出以产生雾化液滴的喷雾。 雾化的液滴与超临界反溶剂接触以引起液滴中溶剂的消耗，使得从溶质中产生颗粒。 优选地，这些颗粒的平均直径为0.6μm以下。 本发明可用于制药，食品，化工，电子，催化剂，聚合物，农药，爆炸物和涂料工业，所有这些都需要小直径颗粒。
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6.发明授权Chemically bound fullerenes to resin and silica supports and their use as stationary phases for chromatography 失效化学结合的富勒烯与树脂和二氧化硅载体和它们作为色谱固定相的用途
公开(公告)号：US5308481A
公开(公告)日：1994-05-03
申请号：US892307
申请日：1992-06-02
申请人： David L. Stalling , Congyuan Guo , Kenneth C. Kuo , Kevin P. Kelly , Said Saim
发明人： David L. Stalling , Congyuan Guo , Kenneth C. Kuo , Kevin P. Kelly , Said Saim
CPC分类号： B01D15/08 , B01J20/3204 , B01J20/3212 , B01J20/3219 , B01J20/324 , G01N2030/484 , G01N2030/528 , Y10S977/735 , Y10S977/753 , Y10S977/835
摘要： The present invention relates to buckminsterfullerenes or related condensed carbon molecules covalently bonded to a polymer particle or a siliceous support particle and their use for packing media for column chromatography.
摘要翻译： 本发明涉及共价键合到聚合物颗粒或硅质载体颗粒上的巴克明斯特富勒烯或相关的冷凝碳分子及其用于柱层析的培养基的用途。
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7.发明授权公开(公告)号：US08840928B2
公开(公告)日：2014-09-23
申请号：US12965572
申请日：2010-12-10
CPC分类号： A61K31/485 , A61K9/14 , A61K9/1617 , A61K9/1635 , A61K9/1641 , A61K9/1664 , A61K9/1694 , A61K9/4808 , A61K9/5042 , A61K47/12 , A61K47/44 , B29C70/60
摘要： Tamper-resistant pharmaceutical compositions have been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opioids. The tamper-resistant compositions retard the release of drug, even if the physical integrity of the formulation is compromised (for example, by chopping with a blade or crushing) and the resulting material is placed in water, snorted, or swallowed. However, when administered as directed, the drug is slowly released from the composition as the composition is passes through the GI tract.
摘要翻译： 已经开发了防篡改的药物组合物，以减少不适当地施用药物，特别是诸如阿片样物质的药物的可能性。 即使制剂的物理完整性受损（例如通过用刀片切碎或破碎），防篡改组合物也能延缓药物的释放，并将所得材料置于水中，嗅到或吞咽。 然而，当按照指导给药时，当组合物通过胃肠道时，药物从组合物缓慢释放。
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公开(公告)号：USD480811S1
公开(公告)日：2003-10-14
申请号：US29150538
申请日：2001-11-06
申请人： Stephen Horhota , Said Saim , Leigh Ann Rondano , Michael Hardy
设计人： Stephen Horhota , Said Saim , Leigh Ann Rondano , Michael Hardy
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公开(公告)号：USD492786S1
公开(公告)日：2004-07-06
申请号：US29188006
申请日：2003-08-11
申请人： Said Saim , Stephen Horhota , Leigh Ann Rondano , Michael Hardy
设计人： Said Saim , Stephen Horhota , Leigh Ann Rondano , Michael Hardy
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公开(公告)号：US06294194B1
公开(公告)日：2001-09-25
申请号：US09517883
申请日：2000-03-03
申请人： Stephen T. Horhota , Said Saim
发明人： Stephen T. Horhota , Said Saim
IPC分类号： A61K964
CPC分类号： A61M15/00 , A61J3/07 , A61K9/0073 , A61K9/0075 , A61K9/4883 , A61M2209/02 , B01D11/0203 , Y02C10/08
摘要： Methods for removing soluble material from confined spaces within substrates such as containers, capsules and porous powders comprising extraction with supercritical fluids, the pressure of which is preferably modulated between an upper level and a lower level within a relatively narrow range of fluid pressure and density. The method permits enhanced extraction efficiency, catalytic reaction rates and ability to maintain catalyst activity.
摘要翻译： 从诸如容器，胶囊和多孔粉末的基底内的密闭空间中除去可溶性材料的方法，其包括用超临界流体萃取，其压力优选在相对窄的流体压力和密度范围内在上层和下层之间调节。 该方法允许提高萃取效率，催化反应速率和维持催化剂活性的能力。
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