Multiplexed Olfactory Receptor-Based Microsurface Plasmon Polariton Detector
    3.
    发明申请
    Multiplexed Olfactory Receptor-Based Microsurface Plasmon Polariton Detector 有权
    多重嗅觉受体基微表面等离子体极谱探测器

    公开(公告)号:US20120021932A1

    公开(公告)日:2012-01-26

    申请号:US13015851

    申请日:2011-01-28

    摘要: The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

    摘要翻译: 本发明提供了一种生物感测纳米装置,其包括:载体上的稳定的G-蛋白偶联受体,实时受体 - 配体结合检测方法,测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。 纳米器件提供更大的表面积,以提高气味检测的精度和灵敏度。 本发明进一步提供了一种微流控芯片,其含有固定在载体上的稳定化的G蛋白偶联受体,并且被布置在至少二维微阵列系统中。 本发明还提供了一种递送加臭剂的方法,其包括在复杂微流体网络中操作气泡的步骤,其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。 本发明还提供了制备hOR17-4嗅觉受体的方法。

    Multiplexed olfactory receptor-based microsurface plasmon polariton detector
    4.
    发明授权
    Multiplexed olfactory receptor-based microsurface plasmon polariton detector 有权
    基于多重嗅觉受体的微表面等离子体激元检测器

    公开(公告)号:US08748111B2

    公开(公告)日:2014-06-10

    申请号:US13015851

    申请日:2011-01-28

    摘要: The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

    摘要翻译: 本发明提供了一种生物感测纳米装置,其包括:载体上的稳定的G-蛋白偶联受体,实时受体 - 配体结合检测方法,测试组合物递送系统和测试组合物识别程序。 G蛋白偶联受体可以使用表面活性肽稳定。 纳米器件提供更大的表面积,以提高气味检测的精度和灵敏度。 本发明进一步提供了一种微流控芯片,其含有固定在载体上的稳定化的G蛋白偶联受体,并且被布置在至少二维微阵列系统中。 本发明还提供了一种递送加臭剂的方法,其包括在复杂微流体网络中操作气泡的步骤,其中气泡在携带各种气体样品的微流体通道中移动到芯片上的精确位置。 本发明还提供了制备hOR17-4嗅觉受体的方法。

    Sensing Chip
    5.
    发明申请
    Sensing Chip 有权
    感应芯片

    公开(公告)号:US20090209028A1

    公开(公告)日:2009-08-20

    申请号:US12346950

    申请日:2008-12-31

    IPC分类号: C12M1/34 G01N21/41

    摘要: There is provided a sensing chip capable of measuring a refractive index by utilizing a long-range surface plasmon polariton, accurately measuring an accumulative refractive index in a wide range, and more easily enabling sealing for measurement. The present invention relates to the sensing chip which has a thin metal film or a strip-like metal grown on an underlayer, and has a dielectric that limits a refractive index and a dielectric buffer layer on an upper surface and a lower surface of the thin metal film or the strip-like metal. The dielectric buffer layer is attached onto the thin metal film or the strip-like metal. The thin metal film or the strip-like metal and the buffer layer are sandwiched between two dielectric layers. A hole is made in a surface of the upper dielectric layer to serve as a measurement groove.

    摘要翻译: 提供了一种能够通过利用远程表面等离子体激元测量折射率的感测芯片,精确地测量宽范围内的累积折射率,并且更容易实现测量密封。 本发明涉及一种感测芯片,其具有在底层上生长的薄金属膜或带状金属,并且具有限制薄膜的上表面和下表面上的折射率和介电缓冲层的电介质 金属膜或带状金属。 介电缓冲层附着在薄金属膜或带状金属上。 金属薄膜或带状金属和缓冲层夹在两个电介质层之间。 在上部电介质层的表面形成孔作为测量槽。

    SURFACE PLASMON RESONANCE SENSOR CHIP
    6.
    发明申请
    SURFACE PLASMON RESONANCE SENSOR CHIP 有权
    表面等离子体共振传感器芯片

    公开(公告)号:US20090195783A1

    公开(公告)日:2009-08-06

    申请号:US12365307

    申请日:2009-02-04

    IPC分类号: G01N21/55

    摘要: A surface plasmon resonance sensor chip includes: a first dielectric layer; a metal layer disposed on the first dielectric layer; and a second dielectric layer covering the metal layer, the chip being provided with an opening that makes a part of a surface on the side of the second dielectric layer of the metal layer be exposed, and allows a measurement sample and the surface on the side of the second dielectric layer to contact each other, wherein an organic molecule film is provided at least one of between the first dielectric layer and the metal layer, and between the metal layer and the second dielectric layer.

    摘要翻译: 表面等离子体共振传感器芯片包括:第一介电层; 设置在所述第一电介质层上的金属层; 以及覆盖所述金属层的第二电介质层,所述芯片设置有使金属层的第二电介质层侧的表面的一部分露出的开口,并且允许测量样品和侧面上的表面 的第二电介质层彼此接触,其中在所述第一介电层和所述金属层之间以及所述金属层和所述第二介电层之间的至少一个上设置有机分子膜。

    Sensing chip
    7.
    发明授权
    Sensing chip 有权
    感应芯片

    公开(公告)号:US08048385B2

    公开(公告)日:2011-11-01

    申请号:US12346950

    申请日:2008-12-31

    IPC分类号: G01N21/75

    摘要: There is provided a sensing chip capable of measuring a refractive index by utilizing a long-range surface plasmon polariton, accurately measuring an accumulative refractive index in a wide range, and more easily enabling sealing for measurement. The present invention relates to the sensing chip which has a thin metal film or a strip-like metal grown on an underlayer, and has a dielectric that limits a refractive index and a dielectric buffer layer on an upper surface and a lower surface of the thin metal film or the strip-like metal. The dielectric buffer layer is attached onto the thin metal film or the strip-like metal. The thin metal film or the strip-like metal and the buffer layer are sandwiched between two dielectric layers. A hole is made in a surface of the upper dielectric layer to serve as a measurement groove.

    摘要翻译: 提供了一种能够通过利用远程表面等离子体激元测量折射率的感测芯片,精确地测量宽范围内的累积折射率,并且更容易实现测量密封。 本发明涉及一种感测芯片,其具有在底层上生长的薄金属膜或带状金属,并且具有限制薄膜的上表面和下表面上的折射率和介电缓冲层的电介质 金属膜或带状金属。 介电缓冲层附着在薄金属膜或带状金属上。 金属薄膜或带状金属和缓冲层夹在两个电介质层之间。 在上部电介质层的表面形成孔作为测量槽。

    Surface plasmon resonance sensor chip
    8.
    发明授权
    Surface plasmon resonance sensor chip 有权
    表面等离子体共振传感器芯片

    公开(公告)号:US08035810B2

    公开(公告)日:2011-10-11

    申请号:US12365307

    申请日:2009-02-04

    IPC分类号: G01N21/01

    摘要: A surface plasmon resonance sensor chip includes: a first dielectric layer; a metal layer disposed on the first dielectric layer; and a second dielectric layer covering the metal layer, the chip being provided with an opening that makes a part of a surface on the side of the second dielectric layer of the metal layer be exposed, and allows a measurement sample and the surface on the side of the second dielectric layer to contact each other, wherein an organic molecule film is provided at least one of between the first dielectric layer and the metal layer, and between the metal layer and the second dielectric layer.

    摘要翻译: 表面等离子体共振传感器芯片包括:第一介电层; 设置在所述第一电介质层上的金属层; 以及覆盖所述金属层的第二电介质层,所述芯片设置有使金属层的第二电介质层侧的表面的一部分露出的开口,并且允许测量样品和侧面上的表面 的第二电介质层彼此接触,其中在所述第一介电层和所述金属层之间以及所述金属层和所述第二介电层之间的至少一个上设置有机分子膜。