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公开(公告)号：US20100028879A1
公开(公告)日：2010-02-04
申请号：US12320169
申请日：2009-01-21
申请人： Fernand Labrie , Michel Rivier , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Sophie Deret , Johannes Voegel
发明人： Fernand Labrie , Michel Rivier , Van Luu-The , Ezequiel L. Calvo , Jerome Aubert , Sophie Deret , Johannes Voegel
IPC分类号： C12Q1/68 , G01N33/573
CPC分类号： C12Q1/32 , G01N2333/904 , G01N2500/04 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of hydroxysteroid (17-beta) dehydrogenase type 7, and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or in vitro prognosis of these pathologies are also described.
摘要翻译： 用于筛选候选化合物以预防或治疗痤疮的体外方法包括测定化合物调节7型羟基类固醇（17-β）脱氢酶的表达或活性的能力，以及使用调节剂 该酶用于治疗与高脂血症相关的痤疮或皮肤病症的表达或活性; 还描述了这些病理学的体外诊断或体外预后的方法。
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公开(公告)号：US20090298074A1
公开(公告)日：2009-12-03
申请号：US12320167
申请日：2009-01-21
申请人： Fernand Labrie , Mohamed El-Alfy , Van Luu-The , Ezequiel L. Calvo , Pascal Collette , Sophie Deret , Michel Rivier
发明人： Fernand Labrie , Mohamed El-Alfy , Van Luu-The , Ezequiel L. Calvo , Pascal Collette , Sophie Deret , Michel Rivier
CPC分类号： G01N33/5023 , C12N9/1029 , G01N2333/91051 , G01N2500/00
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of ELOVL5 and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described.
摘要翻译： 用于筛选用于预防或治疗痤疮的候选化合物的体外方法包括测定化合物调节ELOVL5的表达或活性的能力，以及使用该酶的表达或活性的调节剂用于 治疗与高脂血症相关的痤疮或皮肤疾病; 还描述了这些病理学的体外诊断或预后的方法。
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3.发明申请Modulators of the transporter ABCD3 for treating acne or hyperseborrhea 审中-公开转运蛋白ABCD3的调节剂用于治疗痤疮或高脂血症公开(公告)号：US20090258356A1
公开(公告)日：2009-10-15
申请号：US12320174
申请日：2009-01-21
申请人： Fernand Labrie , Mohamed El-Alfy , Ezequiel L. Calvo , Isabelle Carlavan , Pascal Collette , Sophie Deret , Michel Rivier
发明人： Fernand Labrie , Mohamed El-Alfy , Ezequiel L. Calvo , Isabelle Carlavan , Pascal Collette , Sophie Deret , Michel Rivier
CPC分类号： G01N33/5008 , G01N33/6872 , G01N2333/914 , G01N2500/00 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of the peroxisome membrane transporter 1 comprising a type 3 ATP-binding site of the sub-family D (ABCD3), and the use of modulators of the expression or activity of this transporter for the treatment of acne or skin disorders associated with a hyperseborrhea; methods for the in vitro diagnosis or prognosis of these pathologies are also described.
摘要翻译： 用于筛选用于预防或治疗痤疮的候选化合物的体外方法包括测定化合物调节包含亚型的3型ATP结合位点的过氧化物酶体转运蛋白1的表达或活性的能力 - 家族D（ABCD3），以及使用该转运蛋白的表达或活性的调节剂来治疗与上呼吸道相关的痤疮或皮肤疾病; 还描述了这些病理学的体外诊断或预后的方法。
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4.发明申请Modulators of UDP-glucose ceramide glucosyltransferase for treating acne or hyperkeratinization 审中-公开用于治疗痤疮或过度角化的UDP-葡萄糖神经酰胺葡糖基转移酶的调节剂公开(公告)号：US20100028878A1
公开(公告)日：2010-02-04
申请号：US12320168
申请日：2009-01-21
申请人： Fernand Labrie , Michel Rivier , Van Luu-The , Ezquiel L. Calvo , Irina Safonova , Isabelle Carlavan
发明人： Fernand Labrie , Michel Rivier , Van Luu-The , Ezquiel L. Calvo , Irina Safonova , Isabelle Carlavan
CPC分类号： G01N33/5008 , C12Q1/48 , G01N33/6893 , G01N2333/91102 , G01N2500/00 , G01N2800/20
摘要： An in vitro method for screening candidate compounds for the preventive or curative treatment of acne, includes the determination of the capacity of a compound to modulate the expression or the activity of UDP-glucose ceramide glucosyltransferase (UGCG), and the use of modulators of the expression or activity of this enzyme for the treatment of acne or skin disorders associated with a hyperkeratinization; methods for the in vitro diagnosis or prognosis of these pathologies are also described.
摘要翻译： 用于筛选候选化合物以预防或治疗痤疮的体外方法包括测定化合物调节UDP-葡萄糖神经酰胺葡糖基转移酶（UGCG）的表达或活性的能力，以及使用调节剂 该酶用于治疗与过度角化相关的痤疮或皮肤病症的表达或活性; 还描述了这些病理学的体外诊断或预后的方法。
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公开(公告)号：US20100099689A1
公开(公告)日：2010-04-22
申请号：US12562665
申请日：2009-09-18
申请人： Laurence CLARY , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
发明人： Laurence CLARY , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
IPC分类号： A61K31/505 , A61K31/425 , A61K31/506 , A61K31/44 , A61P17/00
CPC分类号： C07D213/75 , C07D213/55 , C07D239/26 , C07D239/42 , C07D249/14 , C07D277/30 , C07D277/48 , C07D307/54 , C07D333/24 , C07D401/12 , C07D409/04 , C07D413/06 , C07D417/06 , C07D417/10 , C07D417/12
摘要： Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.
摘要翻译： 具有以下通式（I）的新型化合物可用于人或兽医学（在皮肤病学以及心血管疾病，免疫疾病和/或与脂质代谢相关的疾病领域）的广泛应用中，或 ，或者配制成化妆品组合物。
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6.发明授权Compounds that modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof 失效调节PPARγ型受体的化合物和包含它们的化妆品/药物组合物公开(公告)号：US07625914B2
公开(公告)日：2009-12-01
申请号：US11311449
申请日：2005-12-20
申请人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
发明人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
IPC分类号： A61K31/505 , A61K31/445 , A61K31/44 , A61K31/41 , A61K31/425 , A61K31/415 , A61K31/38 , A61K31/34 , C07D239/02 , C07D211/06 , C07D213/00 , C07D285/10 , C07D277/20 , C07D249/14 , C07D233/28 , C07D333/36 , C07D307/02
CPC分类号： C07D213/75 , C07D213/55 , C07D239/26 , C07D239/42 , C07D249/14 , C07D277/30 , C07D277/48 , C07D307/54 , C07D333/24 , C07D401/12 , C07D409/04 , C07D413/06 , C07D417/06 , C07D417/10 , C07D417/12
摘要： Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.
摘要翻译： 具有以下通式（I）的新型化合物可用于人或兽医学（在皮肤病学以及心血管疾病，免疫疾病和/或与脂质代谢相关的疾病领域）的广泛应用中，或 ，或者配制成化妆品组合物。
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7.发明申请Compounds that modulate PPAR gamma-type receptors and cosmetic/pharmaceutical compositions comprising said compounds 失效调节PPARγ型受体的化合物和包含所述化合物的化妆品/药物组合物公开(公告)号：US20100247468A1
公开(公告)日：2010-09-30
申请号：US12585634
申请日：2009-09-21
申请人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
发明人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
IPC分类号： A61K8/49 , C07D417/10 , A61K31/427 , A61P17/14 , A61P35/00 , A61Q19/00 , A61Q5/00 , A61P17/10 , A61P3/04 , A61P3/06 , A61P3/10 , A61P19/02 , A61P9/10 , A61P9/12 , A61P11/06 , C07D333/24 , A61K31/381 , C07D213/75 , A61K31/4418 , C07D249/14 , A61K31/4196 , C07D213/56
CPC分类号： C07D213/75 , C07D213/55 , C07D239/26 , C07D239/42 , C07D249/14 , C07D277/30 , C07D277/48 , C07D307/54 , C07D333/24 , C07D401/12 , C07D409/04 , C07D413/06 , C07D417/06 , C07D417/10 , C07D417/12
摘要： Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.
摘要翻译： 具有以下通式（I）的新型化合物可用于人或兽医学（在皮肤病学以及心血管疾病，免疫疾病和/或与脂质代谢相关的疾病领域）的广泛应用中，或 ，或者配制成化妆品组合物。
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8.发明申请Novel compounds that modulate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof 失效调节PPARγ型受体的新型化合物及其组合的美容/药物组合物公开(公告)号：US20060148862A1
公开(公告)日：2006-07-06
申请号：US11311449
申请日：2005-12-20
申请人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
发明人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
IPC分类号： A61K31/433 , A61K31/427 , A61K31/4245 , C07D417/02 , C07D413/02
CPC分类号： C07D213/75 , C07D213/55 , C07D239/26 , C07D239/42 , C07D249/14 , C07D277/30 , C07D277/48 , C07D307/54 , C07D333/24 , C07D401/12 , C07D409/04 , C07D413/06 , C07D417/06 , C07D417/10 , C07D417/12
摘要： Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.
摘要翻译： 具有以下通式（I）的新型化合物可用于人或兽医学（在皮肤病学以及心血管疾病，免疫疾病和/或与脂质代谢相关的疾病领域）的广泛应用中，或 ，或者配制成化妆品组合物。
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9.发明申请PACAP SIGNALING PATHWAY MODULATORS FOR TREATING INFLAMMATORY SKIN DISEASES HAVING A NEUROGENIC COMPONENT, NOTABLY ROSACEA, AND COMPOSITIONS COMPRISED THEREOF 审中-公开用于治疗具有神经细胞成分，非特异性ROSACEA及其组合物的炎症性皮肤疾病的PACAP信号途径调节剂公开(公告)号：US20110229423A1
公开(公告)日：2011-09-22
申请号：US13054769
申请日：2009-07-17
IPC分类号： A61K31/713 , G01N33/566 , C12Q1/68 , C07H21/02 , A61P29/00 , A61P17/10 , A61P17/02 , A61P17/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/00 , A61P31/10 , A61P23/00 , A61P37/08 , A61P39/06 , A61P37/06 , A61P17/08 , A61P17/12 , A61Q17/04 , A61P3/02
CPC分类号： G01N33/6881 , A61K9/0014 , A61K38/00 , G01N2500/04 , G01N2800/20 , G01N2800/202
摘要： Modulators of specific PACAP receptors are useful for treating inflammatory skin diseases having a neurogenic component, and more particularly rosacea and/or facial erythema, compositions containing these and screening methods are described for identifying PACAP signaling pathway modulators.
摘要翻译： 特异性PACAP受体的调节剂可用于治疗具有神经源成分的炎性皮肤疾病，更具体地，涉及红斑痤疮和/或面部红斑，含有这些和组合物的组合物和筛选方法用于鉴定PACAP信号通路调节剂。
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公开(公告)号：US08022079B2
公开(公告)日：2011-09-20
申请号：US12562665
申请日：2009-09-18
申请人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
发明人： Laurence Clary , Etienne Thoreau , Michel Rivier , Jerome Aubert , Laurent Chantalat , Johannes Voegel
IPC分类号： A61K31/505 , A61K31/445 , A61K31/44 , A61K31/41 , A61K31/425 , A61K31/415 , A61K31/38 , A61K31/34 , C07D239/02 , C07D211/06 , C07D213/00 , C07D285/10 , C07D277/20 , C07D249/14 , C07D233/28 , C07D333/36 , C07D307/02
CPC分类号： C07D213/75 , C07D213/55 , C07D239/26 , C07D239/42 , C07D249/14 , C07D277/30 , C07D277/48 , C07D307/54 , C07D333/24 , C07D401/12 , C07D409/04 , C07D413/06 , C07D417/06 , C07D417/10 , C07D417/12
摘要： Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.
摘要翻译： 具有以下通式（I）的新型化合物可用于人或兽医学（在皮肤病学以及心血管疾病，免疫疾病和/或与脂质代谢相关的疾病领域）的广泛应用中，或 ，或者配制成化妆品组合物。
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