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公开(公告)号：US20180087044A1
公开(公告)日：2018-03-29
申请号：US15647223
申请日：2017-07-11
IPC分类号： C12N13/00 , H01L41/09 , B01D21/28 , C12M1/00 , H01L41/187 , H01L41/053 , B06B1/06 , B01D17/04
CPC分类号： C12N13/00 , B01D17/044 , B01D21/28 , B01D21/283 , B06B1/0644 , C12M47/02 , H01L41/053 , H01L41/0913 , H01L41/1876
摘要： A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.
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公开(公告)号：US20180010085A1
公开(公告)日：2018-01-11
申请号：US15696176
申请日：2017-09-05
发明人： Bart Lipkens , Erik Miller , Benjamin Ross-Johnsrud , Walter M. Presz , Kedar Chitale , Thomas J. Kennedy, III , Lauren Winiarski
IPC分类号： C12M1/00 , C12M1/42 , C12M1/26 , B06B1/06 , B01D21/28 , B01D17/06 , C12N13/00 , B01D17/04 , H01L41/09
摘要： Acoustic perfusion devices for separating biological cells from other material in a fluid mixture are disclosed. The devices include an inlet port, an outlet port, and a collection port that are connected to an acoustic chamber. An ultrasonic transducer creates an acoustic standing wave in the acoustic chamber that permits a continuous flow of fluid to be recovered through the collection port while keeping the biological cells within the acoustic chamber to be returned to the bioreactor from which the fluid mixture is being drawn.
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公开(公告)号：US09670477B2
公开(公告)日：2017-06-06
申请号：US15143481
申请日：2016-04-29
IPC分类号： C12N13/00 , B01D21/00 , G01N29/00 , B01D21/28 , A61M1/36 , C12M1/00 , G01N15/00 , G01N15/10 , G01N15/14
CPC分类号： C12N13/00 , A61M1/3678 , B01D21/283 , B01L3/502761 , B01L2300/0864 , B01L2300/0867 , B01L2400/0436 , B01L2400/0439 , C12M47/04 , G01N15/1484 , G01N2015/0053 , G01N2015/1006 , G01N2015/149
摘要： Devices for separating materials from a host fluid are disclosed. The devices include a flow chamber, an ultrasonic transducer, and a reflector. The ultrasonic transducer and reflector create an angled acoustic standing wave oriented at an angle relative to the direction of mean flow through the flow chamber. The angled acoustic standing wave results in an acoustic radiation force having an axial force component that deflects the materials, so that the materials and the host fluid can thus be separated. The angled acoustic standing wave can be oriented at an angle of about 20° to about 70° relative to the direction of mean flow through the flow chamber to deflect, collect, differentiate, or fractionate the materials from the fluid flowing through the device at flow rates of about 400 mL/min up to about 700 mL/min.
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公开(公告)号：US20170029802A1
公开(公告)日：2017-02-02
申请号：US15222800
申请日：2016-07-28
CPC分类号： C12N13/00 , A61K2039/545 , C07K16/2851 , C12M35/04 , C12M47/02 , G01N30/462 , G01N30/72 , G01N30/96 , G01N33/54313 , G01N2030/027
摘要： Methods and systems for separating a first biomaterial from a second biomaterial can use functionalized material retained in a liquid-filled chamber at locales within an acoustic standing wave field. A culture suspension containing the first biomaterial and the second biomaterial flows into the liquid-filled chamber and at least portions of the first biomaterial with features complementary to the functionalized material becomes bound to the functionalized material while other portions of the culture suspension containing the second material pass through the chamber. The portion of the first biomaterial bound to the functionalized material is subsequently released from the liquid filled chamber.
摘要翻译： 用于从第二生物材料分离第一生物材料的方法和系统可以使用保持在充满液体的腔室中的功能化材料在声驻波场内的区域。 包含第一生物材料和第二生物材料的培养悬浮液流入液体填充的室，并且具有与官能化材料互补的特征的第一生物材料的至少部分变得与官能化材料结合，而含有第二材料的培养悬浮液的其它部分 通过房间。 与功能化材料结合的第一生物材料的部分随后从充满液体的室中释放。
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