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公开(公告)号：US20140357513A1
公开(公告)日：2014-12-04
申请号：US14331112
申请日：2014-07-14
Applicant: Fluidigm Corporation
Inventor： Michael Lucero , Marc Unger
CPC classification number: C12Q1/686 , C12Q1/6804 , C12Q1/6813 , C12Q1/6876 , C12Q2600/118 , G01N33/53 , G01N33/6845 , G01N2333/435 , G01N2458/10
Abstract: The invention provides an assay method for detection and/or quantification of a plurality of nucleic acid or protein targets in a sample. In the method probes are used to associate a detectable tag sequence with each of the selected targets present in the sample. Probes or primers sufficient to identify at least 25, and preferably at least 500, different targets are used. The method involves segregating aliquots of the sample from each other and detecting the tag sequences in each aliquot.
Abstract translation: 本发明提供了用于检测和/或定量样品中多个核酸或蛋白质靶标的测定方法。 在该方法中，探针用于将可检测标签序列与存在于样品中的每个选定靶标相关联。 使用足以鉴定至少25个，优选至少500个不同靶标的探针或引物。 该方法包括将样品的等分试样彼此分离并检测每个等分试样中的标签序列。
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公开(公告)号：US09644235B2
公开(公告)日：2017-05-09
申请号：US14810388
申请日：2015-07-27
Applicant: Fluidigm Corporation
Inventor： Michael Lucero , Marc Unger
CPC classification number: C12Q1/686 , C12Q1/6804 , C12Q1/6813 , C12Q1/6876 , C12Q2600/118 , G01N33/53 , G01N33/6845 , G01N2333/435 , G01N2458/10
Abstract: The invention provides an assay method for detection and/or quantification of a plurality of nucleic acid or protein targets in a sample. In the method probes are used to associate a detectable tag sequence with each of the selected targets present in the sample. Probes or primers sufficient to identify at least 25, and preferably at least 500, different targets are used. The method involves segregating aliquots of the sample from each other and detecting the tag sequences in each aliquot.
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3.发明申请METHODS FOR DETECTION AND QUANTIFICATION OF NUCLEIC ACID OR PROTEIN TARGETS IN A SAMPLE 有权在样品中检测和定量核酸或蛋白质目标的方法公开(公告)号：US20160108460A1
公开(公告)日：2016-04-21
申请号：US14810388
申请日：2015-07-27
Applicant: Fluidigm Corporation
Inventor： Michael Lucero , Marc Unger
CPC classification number: C12Q1/686 , C12Q1/6804 , C12Q1/6813 , C12Q1/6876 , C12Q2600/118 , G01N33/53 , G01N33/6845 , G01N2333/435 , G01N2458/10
Abstract: The invention provides an assay method for detection and/or quantification of a plurality of nucleic acid or protein targets in a sample. In the method probes are used to associate a detectable tag sequence with each of the selected targets present in the sample. Probes or primers sufficient to identify at least 25, and preferably at least 500, different targets are used. The method involves segregating aliquots of the sample from each other and detecting the tag sequences in each aliquot.
Abstract translation: 本发明提供了用于检测和/或定量样品中多个核酸或蛋白质靶标的测定方法。 在该方法中，探针用于将可检测标签序列与存在于样品中的每个选定靶标相关联。 使用足以鉴定至少25个，优选至少500个不同靶标的探针或引物。 该方法包括将样品的等分试样彼此分离并检测每个等分试样中的标签序列。
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Patent Agency Ranking
公开(公告)号：US10131934B2
公开(公告)日：2018-11-20
申请号：US15805720
申请日：2017-11-07
Applicant: Fluidigm Corporation
Inventor： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Wienecke , Geoffrey Facer
Abstract: A method for carrying out nucleic acid amplification reactions using a microfluidic device is described. Amplification primers and other amplification reagents are deposited at a plurality of reaction sites in the device, a sample solution containing amplifiable polynucleotides is introduced into the reaction sites, and amplification is carried out.
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公开(公告)号：US20180073051A1
公开(公告)日：2018-03-15
申请号：US15805720
申请日：2017-11-07
Applicant: Fluidigm Corporation
Inventor： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Wienecke , Geoffrey Facer
CPC classification number: C12Q1/68 , B01L3/0248 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/10 , B01L2200/142 , B01L2200/147 , B01L2300/06 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , B01L2400/0638 , B01L2400/0655 , C12Q1/686 , G01N27/453
Abstract: A method for carrying out nucleic acid amplification reactions using a microfluidic device is described. Amplification primers and other amplification reagents are deposited at a plurality of reaction sites in the device, a sample solution containing amplifiable polynucleotides is introduced into the reaction sites, and amplification is carried out.
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公开(公告)号：US20190169676A1
公开(公告)日：2019-06-06
申请号：US16150096
申请日：2018-10-02
Applicant: Fluidigm Corporation
Inventor： Marc Unger , Ian D. Manger , Michael Lucero , Yong Yi , Emily Miyashita-Lin , Anja Wienecke , Geoffrey Facer
IPC: C12Q1/68 , B01L3/00 , C12Q1/686 , G01N27/453
Abstract: A method for carrying out nucleic acid amplification reactions using a microfluidic device is described. Amplification primers and other amplification reagents are deposited at a plurality of reaction sites in the device, a sample solution containing amplifiable polynucleotides is introduced into the reaction sites, and amplification is carried out.
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公开(公告)号：US20160129441A1
公开(公告)日：2016-05-12
申请号：US14873958
申请日：2015-10-02
Applicant: Fluidigm Corporation
Inventor： Lincoln McBride , Geoffrey Facer , Marc Unger , Michael Lucero , Hany Ramez Nassef
IPC: B01L3/00
CPC classification number: C12Q1/68 , B01L3/0248 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/10 , B01L2200/142 , B01L2200/147 , B01L2300/06 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , B01L2400/0638 , B01L2400/0655 , C12Q1/686 , G01N27/453
Abstract: An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.
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8.发明授权Methods for detection and quantification of nucleic acid or protein targets in a sample 有权检测和定量样品中核酸或蛋白质靶标的方法公开(公告)号：US09090934B2
公开(公告)日：2015-07-28
申请号：US14331112
申请日：2014-07-14
Applicant: Fluidigm Corporation
Inventor： Michael Lucero , Marc Unger
CPC classification number: C12Q1/686 , C12Q1/6804 , C12Q1/6813 , C12Q1/6876 , C12Q2600/118 , G01N33/53 , G01N33/6845 , G01N2333/435 , G01N2458/10
Abstract: The invention provides an assay method for detection and/or quantification of a plurality of nucleic acid or protein targets in a sample. In the method probes are used to associate a detectable tag sequence with each of the selected targets present in the sample. Probes or primers sufficient to identify at least 25, and preferably at least 500, different targets are used. The method involves segregating aliquots of the sample from each other and detecting the tag sequences in each aliquot.
Abstract translation: 本发明提供了用于检测和/或定量样品中多个核酸或蛋白质靶标的测定方法。 在该方法中，探针用于将可检测标签序列与存在于样品中的每个选定靶标相关联。 使用足以鉴定至少25个，优选至少500个不同靶标的探针或引物。 该方法包括将样品的等分试样彼此分离并检测每个等分试样中的标签序列。
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