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公开(公告)号:US20070254957A1
公开(公告)日:2007-11-01
申请号:US11737475
申请日:2007-04-19
申请人: Francis WILSON , Alison Reid , Valerie Reader , Richard Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Yan Zhang , Chih Ho
发明人: Francis WILSON , Alison Reid , Valerie Reader , Richard Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Yan Zhang , Chih Ho
IPC分类号: A61K31/192 , C07C59/40 , C07C62/30
CPC分类号: C07D257/04 , C07C51/09 , C07C57/38 , C07C57/58 , C07C59/56 , C07C59/64 , C07C63/331 , C07C69/65
摘要: The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, R10 given below, and solvates, hydrates, esters, and pharmaceutically acceptable salts thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
摘要翻译: 本发明涉及具有通式(I)的化合物,其具有X,Y,R 1,R 2,R 3,R 3, R 4,R 9,R 10,及其溶剂合物,水合物,酯和药学上可接受的盐。 此外,本发明涉及所述化合物用于治疗阿尔茨海默氏病及其用于调节γ-分泌酶活性的用途。
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公开(公告)号:US20070293567A1
公开(公告)日:2007-12-20
申请号:US11737938
申请日:2007-04-20
申请人: Francis WILSON , Alison Reid , Valerie Reader , Richard Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Chih Ho , Yan Zhang
发明人: Francis WILSON , Alison Reid , Valerie Reader , Richard Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Chih Ho , Yan Zhang
IPC分类号: A61K31/196 , A61K31/24 , A61P25/28 , C07C229/28
CPC分类号: C07C229/42 , C07C59/68
摘要: The present invention relates to compounds having the general Formula (I) with the definitions of X, Y, R1, R2, R3, R4 R9, and R10 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
摘要翻译: 本发明涉及具有通式(I)的化合物,其具有X,Y,R 1,R 2,R 3, ,R 4 R 9和R 10,和/或其盐或酯。 此外,本发明涉及所述化合物用于治疗阿尔茨海默氏病及其用于调节γ-分泌酶活性的用途。
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公开(公告)号:US08106236B2
公开(公告)日:2012-01-31
申请号:US11737475
申请日:2007-04-19
申请人: Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Yan Zhang , Chih Yung Ho
发明人: Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernandez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Yan Zhang , Chih Yung Ho
IPC分类号: C07C63/00
CPC分类号: C07D257/04 , C07C51/09 , C07C57/38 , C07C57/58 , C07C59/56 , C07C59/64 , C07C63/331 , C07C69/65
摘要: The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, R10 given below, and solvates, hydrates, esters, and pharmaceutically acceptable salts thereof.Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
摘要翻译: 本发明涉及具有以下给出的X,Y,R 1,R 2,R 3,R 4,R 9,R 10的定义的通式(I)的化合物及其溶剂化物,水合物,酯和药学上可接受的盐。 此外,本发明涉及所述化合物用于治疗阿尔茨海默氏病及其用于调节γ-分泌酶活性的用途。
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公开(公告)号:US07557244B2
公开(公告)日:2009-07-07
申请号:US11737938
申请日:2007-04-20
申请人: Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernadez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Chih Yung Ho , Yan Zhang
发明人: Francis Wilson , Alison Reid , Valerie Reader , Richard John Harrison , Mihiro Sunose , Remedios Hernadez-Perni , Jeremy Major , Cyrille Boussard , Kathryn Smelt , Jess Taylor , Adeline LeFormal , Andrew Cansfield , Svenja Burckhardt , Chih Yung Ho , Yan Zhang
IPC分类号: C07C321/00 , C07C229/00 , C07C59/00 , C07D249/08 , A01N43/64 , A01N37/10
CPC分类号: C07C229/42 , C07C59/68
摘要: The present invention relates to compounds having the general Formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, and R10 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
摘要翻译: 本发明涉及具有以下给出的X,Y,R 1,R 2,R 3,R 4,R 9和R 10的定义的通式(I)的化合物和/或其盐或酯。 此外,本发明涉及所述化合物用于治疗阿尔茨海默氏病及其用于调节γ-分泌酶活性的用途。
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公开(公告)号:US08247610B2
公开(公告)日:2012-08-21
申请号:US12253444
申请日:2008-10-17
申请人: Chih Yung Ho , Yan Zhang , Umar S. M. Maharoof , John Harrison , Jeremy Major , Svenja Burckhardt , Alison Jones
发明人: Chih Yung Ho , Yan Zhang , Umar S. M. Maharoof , John Harrison , Jeremy Major , Svenja Burckhardt , Alison Jones
IPC分类号: C07C211/00 , C07D213/72 , C07D213/00 , A61K31/135 , A61K31/44
CPC分类号: C07C229/42 , C07C229/34 , C07C255/58 , C07C2602/10 , C07D209/08 , C07D213/74 , C07D215/06 , C07D215/12 , C07D215/38 , C07D217/04
摘要: The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, X, Y, R1 R2, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.
摘要翻译: 本发明涉及如下所示的式I化合物,其中A,X,Y,R 1,R 2,R 3,R 4,R 5,R 6,R 7,R 8和R 9的定义在说明书中提供。 式I化合物可用于治疗与γ-分泌酶活性相关的疾病,包括阿尔茨海默氏病。
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公开(公告)号:US08692017B2
公开(公告)日:2014-04-08
申请号:US12253264
申请日:2008-10-17
申请人: Chih Yung Ho , Yan Zhang , Svenja Burckhardt , Alison Jones
发明人: Chih Yung Ho , Yan Zhang , Svenja Burckhardt , Alison Jones
IPC分类号: C07C63/33 , A01N43/40 , A61K31/435
CPC分类号: C07C59/88 , C07C57/42 , C07C57/58 , C07C57/60 , C07C59/56 , C07C255/57 , C07D213/61
摘要: The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, X, R1, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.
摘要翻译: 本发明涉及如下所示的式I化合物,其中A,X,R 1,R 3,R 4,R 5,R 6,R 7,R 8和R 9的定义在说明书中提供。 式I化合物可用于治疗与γ-分泌酶活性相关的疾病,包括阿尔茨海默氏病。
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公开(公告)号:US08252935B2
公开(公告)日:2012-08-28
申请号:US12251521
申请日:2008-10-15
申请人: Chih Yung Ho , Yan Zhang , Umar S. M. Maharoof , Jeremy Major , John Harrison
发明人: Chih Yung Ho , Yan Zhang , Umar S. M. Maharoof , Jeremy Major , John Harrison
IPC分类号: C07D211/08 , C07D237/00 , A61K31/497 , A61K31/445
CPC分类号: C07D295/155 , C07D211/18 , C07D211/38 , C07D241/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D417/06
摘要: The present invention relates to compounds of Formula I as shown below, wherein the definitions of Het, R0, R1 R2, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.
摘要翻译: 本发明涉及如下所示的式I化合物,其中Het,R0,R1R2,R3,R4,R5,R6,R7,R8和R9的定义在说明书中提供。 式I化合物可用于治疗与γ-分泌酶活性相关的疾病,包括阿尔茨海默氏病。
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公开(公告)号:US20180246004A1
公开(公告)日:2018-08-30
申请号:US15443658
申请日:2017-02-27
申请人: Yan Zhang
发明人: Yan Zhang
CPC分类号: G01M3/243 , G01M3/2815
摘要: Four (4) methods and systems that utilize these methods are claimed in the present invention for intelligently detecting pipeline small leaks, thefts, and their details.In the Energy Flow Line Method, the measured flow data at both ends of the pipeline will be monitored and analyzed. If flow changes that meet the criteria are identified, a leak or a theft is detected. The energy wave front speed is introduced and the unsteady flow mathematical model of the subject pipeline is utilized to calculate leak details.In the Filtered Pressure Waves Method, the measured pressure data at both ends of the pipeline will be monitored and analyzed. After filtering, only those pressure waves that are not originated at the ends of the pipeline will be selected as candidates. For each computation step, consecutively apply the 2 travelling time windows template 1 and template 2 to those candidates, and process those candidates within each window. Leaks, thefts and their details (except for leaked amount) can be obtained if the detected leak locations meet the criteria, even when the fluid is stagnant for some time.The Enhanced Filtered Pressure Waves Method, as the name suggests, is the enhanced version of the Filtered Pressure Waves Method if the fluid is not stagnant for some time. The essential part of the Energy Flow Line Method is used to extend the function not only to provide the leaked amount, but also to verify the leak and the leak location in order to avoid sending false alarms. The measured flow data at the outlet end of the pipeline is also monitored and the unsteady flow mathematical model of the subject pipeline is utilized. If the fluid is stagnant for some time, the leaked amount will be calculated without measured data to be compared. The estimated leak location will be provided with a search range.In the Mutual Confirmation Method, essential parts of the above 3 methods are utilized to extend the capability and to confirm each finding. If any result that contradicts the solution is identified, find a new one that fits. By providing the solution that is mutually confirmed with 2 sets of leak details, sending false alarms can be avoided. This method is particularly developed to solve some issues in the real time monitoring applications, especially in SCADA environments, to have shorter calculation time. The unsteady flow mathematical model of the subject pipeline is indispensable for this method. If the fluid is stagnant for some time, the leaked amount will be calculated without measured data to be compared. Also the estimated leak location will be provided with a search range.The present invention is suitable for most pipeline applications, including very long pipelines (for instance, over 200 km), existing pipelines (with min or no modification on existing sensor groups), and pipelines that are shut for some time (excluding using the Energy Flow Line Method), and easily used as a cross checking tool to other pipelines and other online leak detection systems. The fluids in pipelines can be gases, liquids, and multi-phase fluids.
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公开(公告)号:US09780291B2
公开(公告)日:2017-10-03
申请号:US14344179
申请日:2012-09-13
申请人: Zhong L. Wang , Xinyu Xue , Yan Zhang , Sihong Wang
发明人: Zhong L. Wang , Xinyu Xue , Yan Zhang , Sihong Wang
IPC分类号: H01M14/00 , H01L41/113 , H01M4/505 , H01M4/525 , H01G11/06 , H01G11/58 , H01M10/0525 , H01M10/42 , H01M10/46 , H01M10/0568 , H01M10/0569
CPC分类号: H01L41/113 , H01G11/06 , H01G11/58 , H01M4/505 , H01M4/525 , H01M10/0525 , H01M10/0568 , H01M10/0569 , H01M10/425 , H01M10/46 , H01M14/00
摘要: A self-charging power pack (300) includes a cathode (312) and an anode (310) that is spaced apart from the cathode (312). An electrolyte (318) is disposed between the anode (310) and the cathode (312). A piezoelectric ion transport layer (322) is disposed between the anode (310) and the cathode (312). The piezoelectric ion transport layer (322) has a piezoelectric property that generates a piezoelectric field when a mechanical force is applied thereto. The piezoelectric field causes transportation of ions in the electrolyte (318) through the piezoelectric ion transport layer (322) towards the anode (310).
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