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12 条记录 (耗时 0.019 秒)

    Screening for ligand binding at specific target sites
    1.
    发明申请
    Screening for ligand binding at specific target sites 有权
    筛选特定靶位点上的配体结合

    公开(公告)号：US20050112710A1

    公开(公告)日：2005-05-26

    申请号：US10719457

    申请日：2003-11-21

    申请人： Francisco Torres ,  Richard Bruce ,  Rodney Turner

    发明人： Francisco Torres ,  Richard Bruce ,  Rodney Turner

    IPC分类号： B01J19/00 ,  C12Q1/00 ,  C40B50/08 ,  G01N25/48 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/537 ,  G01N33/543

    CPC分类号： G01N25/4846 ,  B01J2219/00599 ,  B01J2219/00702 ,  C40B50/08 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2575

    摘要： A method for screening of compounds for binding differentiation at various drug target binding sites is used with a device measuring the enthalpy of reaction for the binding. The method includes merging test ligand with target compound and merging test ligand with target compound in the presence of at least one blocking agent. A first heat of reaction is detected for the merged test ligand and target compound solution and a second heat of reaction is detected for the merged test ligand and target compound solution in the presence of a blocking agent. The two heats of reaction are compared to determine whether a reaction has occurred.

    摘要翻译： 使用用于筛选用于结合各种药物靶标结合位点的分化的化合物的方法，其中测量用于结合的反应焓的装置。 该方法包括在至少一种封闭剂的存在下将试验配体与目标化合物合并，并将试验配体与目标化合物合并。 检测合并的试验配体和目标化合物溶液的第一反应热，并在封闭剂存在下检测合并的试验配体和目标化合物溶液的第二反应热。 比较两个反应热，以确定是否发生反应。

    Sample manipulator
    2.
    发明申请
    Sample manipulator 有权
    样品机械手

    公开(公告)号：US20060038120A1

    公开(公告)日：2006-02-23

    申请号：US10921556

    申请日：2004-08-19

    申请人： Meng Lean ,  Francisco Torres ,  Huangpin Hsieh ,  Armin Volkel ,  Bryan Preas ,  Scott Elrod ,  John Fitch ,  Richard Bruce

    发明人： Meng Lean ,  Francisco Torres ,  Huangpin Hsieh ,  Armin Volkel ,  Bryan Preas ,  Scott Elrod ,  John Fitch ,  Richard Bruce

    IPC分类号： H01J49/00

    CPC分类号： B03C1/253

    摘要： A sample manipulator that utilizes electrostatic traveling waves to selectively displace one or more samples deposited on its face is disclosed. The sample manipulator enables an operator to perform a wide variety of processes upon the deposited samples. Also disclosed are strategies for separating two or more samples, focusing a sample, and passing a reagent through a sample, all conducted on the face of the sample manipulator.

    摘要翻译： 公开了一种使用静电行波选择性地移动沉积在其表面上的一个或多个样品的样品操纵器。 样品操纵器使得操作者能够在沉积的样品上执行各种各样的处理。 还公开了用于分离两个或更多个样品，聚焦样品并使试剂通过样品的策略，全部在样品操纵器的表面上进行。

    Thermal sensing
    3.
    发明申请
    Thermal sensing 有权
    热传感

    公开(公告)号：US20050254552A1

    公开(公告)日：2005-11-17

    申请号：US11167746

    申请日：2005-06-27

    申请人： Richard Bruce ,  Dirk De Bruyker ,  Francisco Torres ,  Michal Wolkin

    发明人： Richard Bruce ,  Dirk De Bruyker ,  Francisco Torres ,  Michal Wolkin

    IPC分类号： G01F1/68 ,  G01K1/00 ,  G01K7/30 ,  G01K17/00 ,  G01N25/20 ,  G01N25/48 ,  G01N27/00

    CPC分类号： G01K7/30 ,  G01K17/00 ,  G01K17/006 ,  G01N25/482

    摘要： In thermal sensing devices, such as for calorimetry, a support layer or central layer can have a thermometer element or other thermal sensor on one side and a thermally conductive structure or component on the other. The thermally conductive structure can conduct temperature or other thermal input signals laterally across the support layer or central layer. The temperature or signals can then be provided to the thermometer element, such as by thermal contact through the support layer. An electrically conducting, thermally isolating anti-coupling layer, such as of gold or chromium, can reduce capacitive coupling between the thermally conductive structure and the thermometer element or other thermal sensor.

    摘要翻译： 在诸如用于量热法的热感测装置中，支撑层或中心层可以在一侧具有温度计元件或其它热传感器，而在另一侧可以具有导热结构或部件。 导热结构可以横跨支撑层或中心层横向传导温度或其他热输入信号。 然后可以将温度或信号提供给温度计元件，例如通过通过支撑层的热接触。 导电的，热隔离的抗耦合层（例如金或铬）可以减少导热结构和温度计元件或其它热传感器之间的电容耦合。

    Use of physical barriers to minimize evaporative heat losses
    5.
    发明申请
    Use of physical barriers to minimize evaporative heat losses 有权
    使用物理障碍来减少蒸发热损失

    公开(公告)号：US20060159585A1

    公开(公告)日：2006-07-20

    申请号：US11037666

    申请日：2005-01-18

    申请人： Francisco Torres ,  Michael Chabinyc ,  Scott Elrod ,  Eric Peeters ,  Gregory Anderson ,  Alan Bell ,  Richard Bruce

    发明人： Francisco Torres ,  Michael Chabinyc ,  Scott Elrod ,  Eric Peeters ,  Gregory Anderson ,  Alan Bell ,  Richard Bruce

    IPC分类号： G01N25/20

    CPC分类号： G01N25/482 ,  G01K17/006

    摘要： A detection system includes a detection device and an anti-evaporation device. The detection device comprises a region configured to merge at least two small drops and to detect a potential transient signal generated by the merger of the drops. The an anti-evaporation is configured to enclose the region and limit evaporation from the region. A method for detecting a signal includes the following steps: depositing drops of potentially reactive chemical solutions on a detection device within a drop-merging region; placing an anti-evaporation device over the drop-merging region to form a seal around the drop-merging region; merging the drops of potentially reactive chemical solutions; and measuring a signal occurring within the merged solution drops.

    摘要翻译： 检测系统包括检测装置和防蒸发装置。 检测装置包括被配置为合并至少两个小液滴并且检测由液滴的合并产生的潜在瞬态信号的区域。 防蒸发被配置为包围该区域并限制该区域的蒸发。 一种用于检测信号的方法包括以下步骤：在滴合并区域内的检测装置上沉积潜在的反应性化学溶液滴; 将防蒸发装置放置在熔融合并区域上以形成围绕滴合并区域的密封; 合并潜在的活性化学溶液滴; 并且测量在合并的溶液中发生的信号下降。

    Apparatus and method for a nanocalorimeter for detecting chemical reactions
    6.
    发明申请
    Apparatus and method for a nanocalorimeter for detecting chemical reactions 失效
    用于检测化学反应的纳米光度计的装置和方法

    公开(公告)号：US20060078999A1

    公开(公告)日：2006-04-13

    申请号：US11149632

    申请日：2005-06-10

    申请人： Alan Bell ,  Richard Bruce ,  Scott Elrod ,  Eric Peeters ,  Francisco Torres

    发明人： Alan Bell ,  Richard Bruce ,  Scott Elrod ,  Eric Peeters ,  Francisco Torres

    IPC分类号： G01K17/02

    CPC分类号： B82Y15/00 ,  G01N25/4846 ,  G01N25/4866 ,  Y10S977/957 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

    摘要： A method for detecting chemical reactions uses a nanocalorimeter having a substrate including thermal isolation capability residing on the substrate, thermal equilibration regions residing within the thermal isolation capability, and thermal measurement capability residing within each of the thermal equilibration regions. The thermal measurement device is connected to detection electronics. The method includes depositing drops of potentially reactive chemical solutions within the thermal equilibration region. These potentially reactive solution drops are merged through the use of drop merging electrodes residing within the thermal isolation region. The thermal change occurring within the merged solution drops is then measured with the detection electronics.

    摘要翻译： 用于检测化学反应的方法使用具有包含驻留在基底上的热隔离能力的基底，驻留在热隔离能力内的热平衡区域和驻留在每个热平衡区域内的热测量能力的纳米尺度计。 热测量设备连接到检测电子设备。 该方法包括在热平衡区域内沉积潜在的反应性化学溶液的液滴。 这些潜在的反应性溶液滴通过使用位于热隔离区域内的滴合并电极而合并。 然后用检测电子元件测量在合并溶液中发生的热变化。

    Method for high-throughput screening assay sample preparation and analysis
    8.
    发明申请
    Method for high-throughput screening assay sample preparation and analysis 有权
    高通量筛选测定方法样品制备和分析方法

    公开(公告)号：US20050112766A1

    公开(公告)日：2005-05-26

    申请号：US10719961

    申请日：2003-11-21

    申请人： Richard Bruce ,  Francisco Torres ,  Alan Bell ,  Eric Peeters

    发明人： Richard Bruce ,  Francisco Torres ,  Alan Bell ,  Eric Peeters

    IPC分类号： B01J19/00 ,  C40B50/08 ,  G01N25/48 ,  G01N37/00 ,  G01N31/10

    CPC分类号： G01N25/4866 ,  B01J2219/00599 ,  B01J2219/00702 ,  C40B50/08 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/2575

    摘要： A method is disclosed for high-throughput screening assay sample preparation and testing for the identification of binding between drug targets and library compounds, for use with a calorimetric device measuring the enthalpy of reaction for the binding. The method includes mixing a library compound with a specified solvent and mixing a target compound solution with a second specified solvent on a calorimetric device. The library compound/solvent is merged with the target compound/solvent solution and the library compound/solvent solution is also merged with a third solvent solution on the calorimetric device. The heats of reaction are detected for both merged solutions and are compared.

    摘要翻译： 公开了用于高通量筛选测定样品制备和用于鉴定药物靶标和文库化合物之间的结合的测试的方法，用于测量结合反应焓的量热器件。 该方法包括将文库化合物与指定溶剂混合，并将目标化合物溶液与第二指定溶剂混合在量热装置上。 文库化合物/溶剂与目标化合物/溶剂溶液合并，文库化合物/溶剂溶液也与量热装置上的第三溶剂溶液合并。 对于两个合并的溶液检测反应热，并进行比较。

    Osmotic reaction detector for detecting biological and non-biological reactions
    10.
    发明申请
    Osmotic reaction detector for detecting biological and non-biological reactions 有权
    用于检测生物和非生物反应的渗透反应检测器

    公开(公告)号：US20060134601A1

    公开(公告)日：2006-06-22

    申请号：US11017394

    申请日：2004-12-20

    申请人： Francisco Torres ,  Jonathan Daniels ,  Meng Lean

    发明人： Francisco Torres ,  Jonathan Daniels ,  Meng Lean

    IPC分类号： C12Q1/00

    CPC分类号： B01L3/505 ,  G01N13/04 ,  Y10S436/807

    摘要： A method and apparatus for measuring the presence or absence of interaction between at least a first and second material of interest by measuring osmotic pressure changes in an osmotic cell. Changes in osmotic pressure are determined by measuring the amount of compression exhibited by a compressible, semi-permeable material positioned in the cell.

    摘要翻译： 一种用于通过测量渗透细胞中的渗透压变化来测量至少第一和第二物质之间存在或不存在相互作用的方法和装置。 渗透压的变化通过测量位于细胞中的可压缩的半渗透材料显示的压缩量来确定。