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    Sample manipulator
    1.
    发明申请
    Sample manipulator 有权
    样品机械手

    公开(公告)号：US20060038120A1

    公开(公告)日：2006-02-23

    申请号：US10921556

    申请日：2004-08-19

    申请人： Meng Lean ,  Francisco Torres ,  Huangpin Hsieh ,  Armin Volkel ,  Bryan Preas ,  Scott Elrod ,  John Fitch ,  Richard Bruce

    发明人： Meng Lean ,  Francisco Torres ,  Huangpin Hsieh ,  Armin Volkel ,  Bryan Preas ,  Scott Elrod ,  John Fitch ,  Richard Bruce

    IPC分类号： H01J49/00

    CPC分类号： B03C1/253

    摘要： A sample manipulator that utilizes electrostatic traveling waves to selectively displace one or more samples deposited on its face is disclosed. The sample manipulator enables an operator to perform a wide variety of processes upon the deposited samples. Also disclosed are strategies for separating two or more samples, focusing a sample, and passing a reagent through a sample, all conducted on the face of the sample manipulator.

    摘要翻译： 公开了一种使用静电行波选择性地移动沉积在其表面上的一个或多个样品的样品操纵器。 样品操纵器使得操作者能够在沉积的样品上执行各种各样的处理。 还公开了用于分离两个或更多个样品，聚焦样品并使试剂通过样品的策略，全部在样品操纵器的表面上进行。

    Portable bioagent concentrator
    5.
    发明申请
    Portable bioagent concentrator 失效
    便携式生物聚焦器

    公开(公告)号：US20050247565A1

    公开(公告)日：2005-11-10

    申请号：US10838937

    申请日：2004-05-04

    申请人： H. Hsieh ,  Meng Lean ,  Bryan Preas ,  Armin Volkel

    发明人： H. Hsieh ,  Meng Lean ,  Bryan Preas ,  Armin Volkel

    IPC分类号： G01N27/27 ,  G01N27/453

    CPC分类号： G01N27/453

    摘要： A portable apparatus for extracting and concentrating bioagents within a fluid medium includes a container with sample solution inlet port and traveling wave grids patterned on surfaces of the container. The traveling wave grids cause bioagents to migrate to a specified surface within the container and then to an extraction port. The traveling wave grids include a substrate, across which extend a collection of closely spaced and parallel electrically conductive electrodes, and a collection of buses providing electrical communication with the collection of conductive electrodes. A voltage controller provides a multiphase electrical signal to the collection of buses and electrodes of the traveling wave grids.

    摘要翻译： 用于在流体介质中提取和浓缩生物体的便携式设备包括具有样品溶液入口的容器和在容器表面上图案化的行波网格。 行波网格使生物体迁移到容器内的指定表面，然后迁移到提取口。 行波网格包括基板，跨越其延伸紧密间隔且平行的导电电极的集合，以及提供与导电电极集合电连通的总线的集合。 电压控制器提供多相电信号，用于收集行波网格的总线和电极。

    Concentration and focusing of bio-agents and micron-sized particles using traveling wave grids
    6.
    发明申请
    Concentration and focusing of bio-agents and micron-sized particles using traveling wave grids 有权
    使用行波网格集中和聚焦生物剂和微米级颗粒

    公开(公告)号：US20050123992A1

    公开(公告)日：2005-06-09

    申请号：US10727289

    申请日：2003-12-03

    申请人： Armin Volkel ,  Meng Lean ,  Huangpin Hsieh ,  Jurgen Daniel

    发明人： Armin Volkel ,  Meng Lean ,  Huangpin Hsieh ,  Jurgen Daniel

    IPC分类号： C12M1/34 ,  G01N33/53 ,  G01N33/543

    CPC分类号： G01N33/5438

    摘要： Several traveling wave grid systems are disclosed that may be used to concentrate and form highly localized regions of bio-agents or other charged species. In addition, specific detection systems are described that enable currently available detectors and sensors, including those to be developed in the future, to be used for measuring the presence and concentration of certain bio-agents or charged particles, which otherwise are present at concentrations too low to readily detect or measure.

    摘要翻译： 公开了几种可以用于浓缩和形成高度局部化的生物剂或其他带电物质区域的行波系统。 此外，描述了使得目前可用的检测器和传感器（包括将来要开发的检测器和传感器）能够用于测量某些生物试剂或带电粒子的存在和浓度的具体检测系统，否则其浓度也是以浓度存在 低易于检测或测量。

    Sensing photons from objects in channels
    8.
    发明申请
    Sensing photons from objects in channels 有权
    从通道中的物体感测光子

    公开(公告)号：US20070145249A1

    公开(公告)日：2007-06-28

    申请号：US11315992

    申请日：2005-12-22

    申请人： Peter Kiesel ,  Meng Lean ,  Oliver Schmidt ,  Armin Volkel ,  Noble Johnson

    发明人： Peter Kiesel ,  Meng Lean ,  Oliver Schmidt ,  Armin Volkel ,  Noble Johnson

    IPC分类号： H01J40/14

    CPC分类号： G01N21/05 ,  G01N21/645 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/0346 ,  G01N2021/1734 ,  G01N2021/6421 ,  G01N2021/6482

    摘要： A fluidic structure includes a channel and along the channel is a series of sensing components to obtain information about objects traveling within the channel, such as droplets or other objects carried by fluid. At least one sensing component includes a set of cells of a photosensor array. The set of cells photosense a range of photon energies that emanate from objects, and include a subset of cells that photosense within subranges. A processor can receive information about objects from the sensing components and use it to obtain spectral information. The processor can perform an initial analysis using information from one set of sensing components and, based on the results, control a fluidic device in the channel, such as a gate, to retain objects, such as for concentration and more detailed analysis by other sensing components, or to purge objects from the channel.

    摘要翻译： 流体结构包括通道，并且沿着通道是一系列感测部件，以获得关于在通道内行进的物体的信息，例如由流体携带的液滴或其它物体。 至少一个感测组件包括一组光电传感器阵列的单元。 该组细胞照射从物体发出的一系列光子能量，并且包括在子范围内的光密度的子集。 处理器可以从感测组件接收关于对象的信息，并使用它来获得光谱信息。 处理器可以使用来自一组感测组件的信息来执行初始分析，并且基于该结果，控制通道（例如门）中的流体装置以保持对象，例如通过其他感测的浓度和更详细的分析 组件，或从通道清除对象。

    Continuous flow particle concentrator
    9.
    发明申请
    Continuous flow particle concentrator 有权
    连续流粒子集中器

    公开(公告)号：US20050247564A1

    公开(公告)日：2005-11-10

    申请号：US10838570

    申请日：2004-05-04

    申请人： Armin Volkel ,  Meng Lean ,  H. Hsieh ,  Jurgen Daniel

    发明人： Armin Volkel ,  Meng Lean ,  H. Hsieh ,  Jurgen Daniel

    IPC分类号： B03C5/02 ,  G01N27/27 ,  G01N27/453 ,  G01N30/00 ,  G01N33/487

    CPC分类号： B03C5/028 ,  G01N2030/0035

    摘要： An apparatus for extracting and concentrating bioagents within a continuously flowing fluid medium includes a flow channel fluid inlet, in which bioagents are concentrated from three dimensions to a two-dimensional transport layer in a preconcentration area. Traveling wave grids cause the preconcentrated bioagents to migrate to one side of the flow channel and then to an extraction port. Each of the traveling wave grids includes a substrate, a collection of closely spaced and parallel electrically conductive electrodes extending across said substrate, and a collection of buses providing electrical communication with the collection of conductive electrodes. A voltage controller provides a multiphase electrical signal to the collection of buses and electrodes of the traveling wave grids. Fluid exits through an outlet port.

    摘要翻译： 用于在连续流动的流体介质中提取和浓缩生物体的装置包括流动通道流体入口，其中生物体从三维集中到预浓缩区域中的二维输送层。 旅行波谷使预浓缩的生物标签迁移到流动通道的一侧，然后迁移到提取口。 每个行波波谷包括基板，跨越所述基板的紧密间隔且平行的导电电极的集合，以及提供与导电电极集合电连通的总线的集合。 电压控制器提供多相电信号，用于收集行波网格的总线和电极。 流体通过出口排出。

    Electrostatic gating
    10.
    发明申请
    Electrostatic gating 有权
    静电门控

    公开(公告)号：US20060077231A1

    公开(公告)日：2006-04-13

    申请号：US10960599

    申请日：2004-10-07

    申请人： Meng Lean ,  John Ricciardelli ,  Osman Polatkan ,  Michael Savino ,  Armin Volkel

    发明人： Meng Lean ,  John Ricciardelli ,  Osman Polatkan ,  Michael Savino ,  Armin Volkel

    IPC分类号： B41J2/06

    CPC分类号： B41J2/06

    摘要： Various systems and techniques are disclosed for stopping, selectively controlling, and optimizing a flow of particles in a flowing stream. The systems and techniques utilize a multi-electrode assembly and various voltage waveforms applied to those electrodes. The particles flow past or near the electrode assembly and their flow is controlled by the configuration and arrangement of the electrodes and the voltage waveforms applied thereto. An additional strategy for countering particle leakage flow is also described.

    摘要翻译： 公开了用于停止，选择性地控制和优化流动流中的颗粒流的各种系统和技术。 该系统和技术利用多电极组件和施加到那些电极的各种电压波形。 颗粒流过或靠近电极组件，并且其流动由电极的构造和布置以及施加到其上的电压波形控制。 还描述了用于抵抗颗粒泄漏流的附加策略。