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1.发明授权
公开(公告)号：US6066340A
公开(公告)日：2000-05-23
申请号：US169558
申请日：1993-12-20
IPC分类号： A61K9/50 , A61K9/00 , A61K9/16 , A61K9/52 , A61K31/715 , A61K38/18 , A61K38/22 , A61K38/23 , A61K38/28 , A61K39/395 , A61K47/36
CPC分类号： A61K38/28 , A61K38/185 , A61K38/23 , A61K9/0034 , A61K9/1652 , Y10S514/866 , Y10S514/951 , Y10S514/963
摘要： The present invention is directed to a microsphere for the controlled release of a biologically active molecule which comprises a biologically active molecule and an ester of hyaluronic acid or mixtures of said esters of hyaluronic acids, and wherein said biologically active molecule is surrounded by or adhered to said ester of hyaluronic acid, and wherein said microsphere has a diameter of between 1 .mu.m to 100 .mu.m.
摘要翻译： 本发明涉及用于受控释放生物活性分子的微球，其包含生物活性分子和透明质酸的酯或所述透明质酸酯的混合物，并且其中所述生物活性分子包围或粘附于 所述透明质酸酯，其中所述微球的直径在1μm至100μm之间。
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公开(公告)号：US6039970A
公开(公告)日：2000-03-21
申请号：US231353
申请日：1999-01-13
IPC分类号： A61K9/50 , A61K9/00 , A61K9/16 , A61K9/52 , A61K31/715 , A61K38/18 , A61K38/22 , A61K38/23 , A61K38/28 , A61K39/395 , A61K47/36
CPC分类号： A61K38/28 , A61K38/185 , A61K38/23 , A61K9/0034 , A61K9/1652 , Y10S514/866 , Y10S514/951 , Y10S514/963
摘要： The present invention is directed to a microsphere for the controlled release of a biologically active molecule which comprises a biologically active molecule and an ester of hyaluronic acid or mixtures of said esters of hyaluronic acids, and wherein said biologically active molecule is surrounded by or adhered to said ester of hyaluronic acid, and wherein said microsphere has a diameter of between 1 .mu.m to 100 .mu.m.
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公开(公告)号：US5300493A
公开(公告)日：1994-04-05
申请号：US945495
申请日：1992-09-16
申请人： Aurelio Romeo , Gino Toffano , Lanfranco Callegaro
发明人： Aurelio Romeo , Gino Toffano , Lanfranco Callegaro
IPC分类号： A61K20060101 , A61K31/045 , A61K31/715 , A61K31/73
CPC分类号： A61K31/045 , A61K31/715 , Y10S514/925 , Y10S514/926
摘要： Acidic polysaccharide esters containing carboxylic groups are useful for protecting against and curing ulcers of the gastro-enteric system. These esters include choline esters with acidic polysaccharide selected from the group consisting of hyaluronic acid, alginic acid, gellan, oxidized cellulose, oxidized chitin, carboxy-hydrocarbyl-cellulose, carboxy-hydrocarbyl-starch and carboxy-hydrocarbyl-chitin, wherein the term hydrocarbyl means the residue of a hydrocarbon selected from the group consisting of by alkyl, aralkyl and cycloalkyl.
摘要翻译： 含有羧基的酸性多糖酯可用于防止和治疗胃肠系统的溃疡。 这些酯包括选自透明质酸，海藻酸，结冷胶，氧化纤维素，氧化几丁质，羧基 - 烃基 - 纤维素，羧基 - 烃基 - 淀粉和羧基 - 烃基几丁质的酸性多糖的胆碱酯，其中术语烃基 是指选自烷基，芳烷基和环烷基的烃的残基。
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4.发明授权Non-woven fabric material comprising auto-crosslinked hyaluronic acid derivatives 失效包含自动交联透明质酸衍生物的无纺布材料
公开(公告)号：US5824335A
公开(公告)日：1998-10-20
申请号：US487407
申请日：1995-06-07
IPC分类号： D04H1/42 , D04H1/46 , D04H1/64 , D04H3/10 , D04H3/12 , A61K31/00 , A61L15/28 , B32B27/02 , B32B27/04
CPC分类号： D04H1/46 , D04H1/4266 , D04H1/64 , D04H3/105 , D04H3/12 , Y10T428/249922 , Y10T428/249934 , Y10T428/24994 , Y10T428/249942 , Y10T428/249947 , Y10T428/249953 , Y10T428/249955 , Y10T428/249962 , Y10T428/249964
摘要： Biomaterials are disclosed comprised of biodegradable, biocompatible, and bioabsorbable non-woven fabric materials for use in surgery for the guided regeneration of tissues. The non-woven fabric materials constitute threads embedded in a matrix, wherein both the matrix and the threads constitute auto-crosslinked hyaluronic acid.
摘要翻译： 公开的生物材料包括用于组织引导再生的手术中的可生物降解的，生物相容的和生物可吸收的无纺织物材料。 无纺布材料构成嵌入基质中的线，其中基质和线都构成自动交联的透明质酸。
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公开(公告)号：US5538730A
公开(公告)日：1996-07-23
申请号：US216858
申请日：1994-03-24
申请人： Aurelio Romeo , Gino Toffano , Lanfranco Callegaro
发明人： Aurelio Romeo , Gino Toffano , Lanfranco Callegaro
IPC分类号： A61K8/72 , A61K8/00 , A61K8/73 , A61L15/28 , A61L27/00 , A61L27/20 , A61Q19/00 , C08B37/08 , A61K47/38 , A61K9/00
CPC分类号： A61K8/736 , A61L15/28 , A61L27/20 , A61Q19/00 , C08B37/003
摘要： Copolymers of the formula: ##STR1## wherein the bonds between the glucoside units are .beta. (1.fwdarw.4), the degree of polymerization referred to a single glucoside unit varies from about 50 to 50,000, R is a free or esterified carboxy group and S is an amino or acylamino group. The part designated by x may vary between about 5% and 100% and that designated by y may vary between about 95% and 0%. At least a part of the R groups are esterified carboxy groups, and at least a part of the S groups are acylamino groups. Salts of these copolymers are also disclosed. The products of the invention are particularly useful in the cosmetic field.
摘要翻译： 下式的共聚物：其中葡萄糖苷单元之间的键是β（1-> 4），所指的单糖苷单元的聚合度在约50至50,000之间变化，R是游离或酯化的羧基， S是氨基或酰氨基。 由x指定的部分可以在约5％和100％之间变化，并且由y指定的部分可以在约95％和0％之间变化。 R基团的至少一部分是酯化的羧基，并且至少一部分S基团是酰基氨基。 还公开了这些共聚物的盐。 本发明的产品在化妆品领域特别有用。
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公开(公告)号：US06533820B2
公开(公告)日：2003-03-18
申请号：US09335900
申请日：1999-06-18
IPC分类号： A61F228
CPC分类号： A61L27/446 , A61L24/08 , A61L27/46 , A61L2430/02 , A61L24/0015 , A61F2/28 , A61F2/00 , C08L5/08 , A61L27/54
摘要： The present invention involves compositions for use as granular bone replacements. The compositions of the present invention are comprised of hyaluronic acid esters or salts of hyaluronic acid in association with a pharmacologically active compound wherein the molecular weight of the hyaluronic acid is below 250,000 and either artificial or natural bone granules. The present invention further involves a method of promoting the growth or repair of damaged or defective bones in either humans or animals using the compositions of hyaluronic acid derivatives and bone granules.
摘要翻译： 本发明涉及用作粒状骨替代物的组合物。 本发明的组合物由透明质酸酯或透明质酸的盐与透明质酸的分子量低于25万的药物活性化合物和人造或天然骨颗粒组成。 本发明还涉及使用透明质酸衍生物和骨颗粒的组合物促进人或动物中损伤或有缺陷的骨骼的生长或修复的方法。
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7.发明授权Biodegradable guide channels comprised of esters of hyaluronic acid for use in tissue repair as surgical aids 失效包含透明质酸的酯的可生物降解的导流通道用于组织修复，作为手术辅助剂
公开(公告)号：US5879359A
公开(公告)日：1999-03-09
申请号：US855285
申请日：1997-05-13
CPC分类号： A61L31/16 , A61F2/02 , A61L31/047 , A61L31/129 , A61L2300/412 , A61L2300/414 , A61L2430/32
摘要： The present invention is drawn to medical devices comprising biodegradable guide channels for use in the repair and regeneration of nerve tissue. The guide channels of the present invention comprise interlaced threads imbedded in a matrix, wherein both the matrix and the threads comprise biocompatible and bioabsorbable esters of hyaluronic acid. The matrix of the present invention further optionally comprises biologically or pharmacologically active factors in association with the guide channels.
摘要翻译： 本发明涉及包括用于神经组织的修复和再生的可生物降解的引导通道的医疗装置。 本发明的引导通道包括嵌入基质中的交织线，其中基质和线均包含透明质酸的生物相容性和生物可吸收的酯。 本发明的基质还任选地包括与引导通道相关联的生物学或药理学活性因子。
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8.发明授权Method of using low molecular weight hyaluronic acid for stimulating bone formation 失效使用低分子量透明质酸刺激骨形成的方法
公开(公告)号：US5646129A
公开(公告)日：1997-07-08
申请号：US318804
申请日：1995-01-17
申请人： Lanfranco Callegaro , Aurelio Romeo
发明人： Lanfranco Callegaro , Aurelio Romeo
IPC分类号： C08B37/08 , A61K31/715 , A61K31/728 , A61P19/08 , A61P43/00
CPC分类号： C08B37/0072
摘要： The present invention is drawn to hyaluronic acid fractions having molecular weights in the range of from about 20,000 to about 60,000 daltons, wherein these hyaluronic acid fractions possess osteoinductive activity. The present invention further includes pharmaceutical compositions comprising such hyaluronic acid fractions to be used in the treatment of various types of bone disorders, as well as methods of treating such disorders using the pharmaceutical compositions.
摘要翻译： PCT No.PCT / EP93 / 00932 Sec。 371日期1995年1月17日 102（e）日期1995年1月17日PCT 1993年4月16日PCT公布。 出版物WO93 / 20827 日期：1993年10月28日本发明涉及分子量在约20,000至约60,000道尔顿范围内的透明质酸部分，其中这些透明质酸部分具有骨诱导活性。 本发明还包括药物组合物，其包含用于治疗各种类型的骨骼疾病的这种透明质酸组分，以及使用该药物组合物治疗此类病症的方法。
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9.发明授权Biodegradable and bioabsorbable guide channels for use in nerve treatment and regeneration 失效用于神经治疗和再生的可生物降解和生物可吸收的引导通道
公开(公告)号：US5735863A
公开(公告)日：1998-04-07
申请号：US104025
申请日：1994-05-24
IPC分类号： A61L31/00 , A61B17/11 , A61F2/00 , A61F2/02 , A61F2/04 , A61L31/04 , A61L31/12 , A61L31/14 , A61L31/16 , A61B17/00
CPC分类号： A61L31/148 , A61L31/042 , A61L31/129 , A61B17/1128 , A61F2/0077 , A61F2/04 , A61F2210/0004 , A61L2430/32
摘要： The present invention is drawn to medical devices comprised of biodegradable guide channels for use in repair and regeneration of nerve tissue. The guide channels are comprised of threads embedded in a matrix and coextruded with active factors wherein both the matrix and the threads are comprised of biocompatible and bioabsorbable esters of hyaluronic acid.
摘要翻译： PCT No.PCT / EP92 / 00285 Sec。 371日期：1994年5月24日 102（e）日期1994年5月24日PCT提交1992年2月10日PCT公布。 出版物WO92 / 13579 日本1992年8月20日本发明涉及由可用于修复和再生神经组织的生物可降解导向通道构成的医疗器械。 引导通道由嵌入基质中的螺纹组成并与活性因子共挤出，其中基质和螺纹均由透明质酸的生物相容性和生物可吸收的酯组成。
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公开(公告)号：US5622707A
公开(公告)日：1997-04-22
申请号：US992697
申请日：1992-12-18
IPC分类号： A61L15/22 , A61F2/10 , A61L15/07 , A61L27/48 , A61L31/00 , A61L31/04 , A61L31/12 , A61L31/14 , D01F9/00 , D01F9/04 , D03D15/00 , D04H1/42 , D04H13/00 , D06M15/03 , A61K9/70 , A61K31/00
CPC分类号： A61L31/148 , A61F2/105 , A61L27/48 , A61L31/041 , A61L31/042 , A61L31/129 , Y10T428/24124 , Y10T442/172
摘要： Biomaterials are disclosed comprised of biodegradable, biocompatible, and bioabsorbable composite membranes for use in surgery for the guided regeneration of tissues. The composite membranes are comprised of threads embedded in a matrix, wherein both the matrix and the threads can be comprised of esters of hyaluronic acid, used singly or in combination, or esters of hyaluronic acid in combination with esters of alginic acid or other polymers.
摘要翻译： 公开的生物材料包括用于组织引导再生的手术中的可生物降解的，生物相容的和生物可吸收的复合膜。 复合膜由嵌入基质中的线组成，其中基质和丝线都可以由透明质酸单独或组合使用的酯，或透明质酸的酯与藻酸或其它聚合物的酯组合而成。
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