公开(公告)号：US20140344552A1

公开(公告)日：2014-11-20

申请号：US13895595

申请日：2013-05-16

申请人： Frank Binns ,  Matthew C. Merten ,  Mayank Bomb ,  Beeman C. Strong ,  Peter Lachner ,  Jason W. Brandt ,  Itamar Kazachinsky ,  Ofer Levy ,  MD A. Rahman

发明人： Frank Binns ,  Matthew C. Merten ,  Mayank Bomb ,  Beeman C. Strong ,  Peter Lachner ,  Jason W. Brandt ,  Itamar Kazachinsky ,  Ofer Levy ,  MD A. Rahman

IPC分类号： G06F9/30

CPC分类号： G06F11/3636 ,  G06F11/3024 ,  G06F11/3055 ,  G06F11/3476 ,  G06F11/348 ,  G06F2201/865

摘要： In accordance with embodiments disclosed herein, there is provided systems and methods for providing status of a processing device with a periodic synchronization point in an instruction tracing system. For example, the method may include generating a boundary packet based on a unique byte pattern in a packet log. The boundary packet provides a starting point for packet decode. The method may also include generating a plurality of state packets based on status information of the processor. The plurality of state packets follows the boundary packet when outputted into the packet log.

摘要翻译： 根据本文公开的实施例，提供了用于在指令跟踪系统中提供具有周期性同步点的处理设备的状态的系统和方法。 例如，该方法可以包括基于分组日志中的唯一字节模式生成边界分组。 边界包提供了分组解码的起始点。 该方法还可以包括基于处理器的状态信息生成多个状态分组。 当输出到分组日志中时，多个状态分组遵循边界分组。

公开(公告)号：US20140189314A1

公开(公告)日：2014-07-03

申请号：US13730834

申请日：2012-12-29

申请人： Tsvika Kurts ,  Ofer Levy ,  Itamar Kazachinsky ,  Gabi Malka ,  Zeev Sperber ,  Jason W. Brandt

发明人： Tsvika Kurts ,  Ofer Levy ,  Itamar Kazachinsky ,  Gabi Malka ,  Zeev Sperber ,  Jason W. Brandt

IPC分类号： G06F9/30

CPC分类号： G06F9/30145 ,  G06F11/00 ,  G06F11/3471 ,  G06F11/36 ,  G06F13/4068 ,  G06F2201/865

摘要： A method of an aspect includes generating real time instruction trace (RTIT) packets for a first logical processor of a processor. The RTIT packets indicate a flow of software executed by the first logical processor. The RTIT packets are stored in an RTIT queue corresponding to the first logical processor. The RTIT packets are transferred from the RTIT queue to memory predominantly with firmware of the processor. Other methods, apparatus, and systems are also disclosed.

摘要翻译： 一方面的方法包括为处理器的第一逻辑处理器生成实时指令跟踪（RTIT）分组。 RTIT分组指示由第一逻辑处理器执行的软件的流程。 RTIT分组被存储在对应于第一逻辑处理器的RTIT队列中。 RTIT数据包主要通过处理器的固件从RTIT队列传送到存储器。 还公开了其它方法，装置和系统。

公开(公告)号：US20140380027A1

公开(公告)日：2014-12-25

申请号：US13922421

申请日：2013-06-20

申请人： Ahmad Yasin ,  Michael W. Chynoweth ,  Ofer Levy ,  Jason W. Brandt ,  Angela Schmid

发明人： Ahmad Yasin ,  Michael W. Chynoweth ,  Ofer Levy ,  Jason W. Brandt ,  Angela Schmid

IPC分类号： G06F9/30

CPC分类号： G06F9/3806 ,  G06F9/30058 ,  G06F9/30098 ,  G06F11/3419 ,  G06F11/348 ,  G06F2201/865 ,  G06F2201/88

摘要： A processing device implementing an elapsed cycle timer in last branch records (LBRs) is disclosed. A processing device of the disclosure includes a last branch record (LBR) counter to iterate with each cycle of the processing device and an LBR structure communicably coupled to the LBR counter. The LBR structure comprises a plurality of LBR entries. Furthermore, an LBR entry of the plurality of LBR entries comprises an address instruction pointer (IP) of a branch instruction executed by the processing device, an address IP of a target of the branch instruction, and an elapsed time field that stores a value of the LBR counter when the LBR entry is created.

摘要翻译： 公开了一种在最后的分支记录（LBR）中实现经过周期定时器的处理装置。 本公开的处理装置包括与处理装置的每个周期重复的最后一个分支记录（LBR）计数器和可通信地耦合到LBR计数器的LBR结构。 LBR结构包括多个LBR条目。 此外，多个LBR条目的LBR条目包括由处理装置执行的分支指令的地址指令指针（IP），分支指令的目标的地址IP以及存储分支指令的值的经过时间字段 当创建LBR条目时，LBR计数器。

公开(公告)号：US20150006717A1

公开(公告)日：2015-01-01

申请号：US14126313

申请日：2013-06-27

申请人： Thilo Schmitt ,  Peter Lachner ,  Beeman Strong ,  Ofer Levy ,  Thomas Toll ,  Matthew Merten ,  Tong Li ,  Ravi Rajwar ,  Konrad Lai

发明人： Thilo Schmitt ,  Peter Lachner ,  Beeman Strong ,  Ofer Levy ,  Thomas Toll ,  Matthew Merten ,  Tong Li ,  Ravi Rajwar ,  Konrad Lai

IPC分类号： H04L12/26

CPC分类号： G06F9/30189 ,  G06F11/3636

摘要： In accordance with embodiments disclosed herein, there is provided systems and methods for tracking the mode of processing devices in an instruction tracing system. The method may include receiving an indication of a change in a current execution mode of the processing device. The method may also include determining that the current execution mode of the received indication is different than a value of an execution mode of a first execution mode (EM) packet previously-generated by the IT module. The method may also include generating, based on the determining that the current execution mode is different, a second EM packet that provides a value of the current execution mode of the processing device to indicate the change in the execution mode for an instruction in a trace generated by the IT module. The method may further include generating transactional memory (TMX) packets having n bit mode pattern in the packet log. The n is at least two and the n bit mode indicates transaction status of the TMX operation.

摘要翻译： 根据本文公开的实施例，提供了用于跟踪指令跟踪系统中的处理设备的模式的系统和方法。 该方法可以包括接收处理设备的当前执行模式中的改变的指示。 该方法还可以包括确定接收到的指示的当前执行模式不同于IT模块先前生成的第一执行模式（EM）分组的执行模式的值。 该方法还可以包括基于确定当前执行模式不同而生成第二EM分组，其提供处理设备的当前执行模式的值以指示用于跟踪中的指令的执行模式的改变 由IT模块生成。 该方法还可以包括在分组日志中生成具有n位模式模式的事务存储器（TMX）分组。 n至少为2，n位模式表示TMX操作的事务状态。

公开(公告)号：US09626274B2

公开(公告)日：2017-04-18

申请号：US14580676

申请日：2014-12-23

申请人： Ahmad Yasin ,  Rajshree A. Chabukswar ,  Ofer Levy ,  Michael W. Chynoweth ,  Charlie J. Hewett

发明人： Ahmad Yasin ,  Rajshree A. Chabukswar ,  Ofer Levy ,  Michael W. Chynoweth ,  Charlie J. Hewett

IPC分类号： G06F11/00 ,  G06F11/34 ,  G06F11/30 ,  G06F9/38

CPC分类号： G06F11/3471 ,  G06F9/30076 ,  G06F9/38 ,  G06F11/3024 ,  G06F11/3037 ,  G06F11/3466 ,  G06F11/348 ,  G06F2201/81 ,  G06F2201/88

摘要： A processor includes a front end, a decoder, a retirement unit, and a performance monitoring unit. The front end includes a decoder with logic to receive a tracking instruction to enable tracking of execution of a region of memory. The instruction is to define an address range of the region. The retirement includes logic to retire the tracking instruction and candidate instructions. The performance monitoring unit includes logic to determine that the candidate instructions are associated with an entrance and an exit to the address range, and to generate an alert based on the candidate instructions association with the entrance and the exit.

公开(公告)号：US20140056811A1

公开(公告)日：2014-02-27

申请号：US13976502

申请日：2011-12-26

申请人： Etai Jacob ,  Amir Toporik ,  Ronen Shemesh ,  Ofer Levy

发明人： Etai Jacob ,  Amir Toporik ,  Ronen Shemesh ,  Ofer Levy

IPC分类号： A61K47/48

CPC分类号： C07K14/78 ,  A61K47/62 ,  C07K14/47 ,  C07K2319/01

摘要： The present invention is related to peptides, which are suitable for use as cell-penetrating peptides (CPPs), variants thereof and/or complexes, fusion molecules and/or conjugates comprising same, use thereof for manufacture of compositions for diagnosing, treating and/or preventing of medical conditions.

摘要翻译： 本发明涉及适合用作细胞穿透肽（CPP），其变体和/或复合物，包含其的融合分子和/或缀合物的肽，其用于制备用于诊断，治疗和/ 或预防医疗状况。

公开(公告)号：US08529943B2

公开(公告)日：2013-09-10

申请号：US13054914

申请日：2009-07-20

申请人： Yossef Kliger ,  Itamar Borukhov ,  Ofer Levy ,  Zohar Tiran ,  Assaf Wool ,  Ehud Schreiber ,  Anat Amir ,  Zurit Levine ,  Amir Toporik

发明人： Yossef Kliger ,  Itamar Borukhov ,  Ofer Levy ,  Zohar Tiran ,  Assaf Wool ,  Ehud Schreiber ,  Anat Amir ,  Zurit Levine ,  Amir Toporik

IPC分类号： C07K14/515 ,  C07K14/00 ,  C07K7/06 ,  C07K7/08 ,  C07K16/46 ,  A61K38/16 ,  A61K38/08 ,  A61K38/10

CPC分类号： C07K14/515 ,  A61K38/14 ,  A61K38/1891 ,  A61K45/06 ,  C07K9/00 ,  C07K9/001

摘要： Provided are angiopoietin-derived peptides or homologs or derivatives thereof, pharmaceutical composition including them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins including them.

摘要翻译： 提供来自血管生成素的肽或其同系物或衍生物，包含它们的药物组合物，其用于治疗和制备药物的用途，治疗各种病症，疾病和疾病的方法，编码它们的核苷酸序列， 针对其表位的抗体和包括它们的融合蛋白。

公开(公告)号：US20120238460A1

公开(公告)日：2012-09-20

申请号：US12739976

申请日：2008-11-10

申请人： Ofer Levy ,  Eva Guinan ,  Eugenie Suter

发明人： Ofer Levy ,  Eva Guinan ,  Eugenie Suter

IPC分类号： C40B30/04

CPC分类号： G01N33/6863 ,  G01N2333/523 ,  G01N2800/245 ,  G01N2800/50

摘要： Disclosed herein are methods for determining the likelihood of a subject to develop Acute graft versus host disease (aGVHD) upon receiving myeloablative allogeneic hematopoietic stem cell transplantation (HSCT). One such method comprises assaying for baseline plasma concentration of RANTES in a sample obtained from the subject, and comparing the baseline plasma concentration of RANTES to a predetermined level. The method may further comprise assaying for day 7 plasma concentration of RANTES in sample obtained from the subject, and comparing the day 7 plasma concentration of RANTES to a predetermined level. Another such method comprises assaying for day 7 plasma concentration of RANTES in a sample obtained from the subject, and comparing the day 7 plasma concentration of RANTES to a predetermined level. Another such method comprises assaying for donor plasma concentration of RANTES in a sample obtained from a donor of the hemtopoietic stem cells, and comparing the donor plasma concentration of RANTES to a predetermined level, wherein a donor plasma concentration of RANTES less than the predetermined level indicates a likelihood of the subject to develop aGVHD upon receiving myeloablative allogeneic HSCT from that donor. Other methods include assaying for day 0, or for day 7, plasma concentration of MCP-1 in a sample obtained from the subject, and comparing the day 0 or day 7, plasma concentration of MCP-1 to a predetermined level.

摘要翻译： 本文公开了用于确定受试者在接受清髓性同种异体造血干细胞移植（HSCT）时发展为急性移植物抗宿主病（aGVHD）的可能性的方法。 一种这样的方法包括测定从受试者获得的样品中RANTES的基线血浆浓度，并将RANTES的基线血浆浓度与预定水平进行比较。 该方法还可以包括测定从受试者获得的样品中RANTES的第7天血浆浓度，并将RANTES的第7天血浆浓度与预定水平进行比较。 另一种这样的方法包括测定从受试者获得的样品中RANTES的第7天血浆浓度，并将RANTES的第7天血浆浓度与预定水平进行比较。 另一种这样的方法包括测定从造血干细胞的供体获得的样品中RANTES的供体血浆浓度，并将RANTES的供体血浆浓度与预定水平进行比较，其中RANTES的供体血浆浓度小于预定水平表明 接受来自该供体的清髓性同种异体HSCT的受试者可能发生GV​​HD。 其他方法包括测定从受试者获得的样品中的第0天或第7天MCP-1的血浆浓度，并将MCP-1的血浆浓度与第0天或第7天的血浆浓度进行比较。

公开(公告)号：US20110311450A1

公开(公告)日：2011-12-22

申请号：US13131879

申请日：2009-12-08

申请人： Zurit Levine ,  Avi Rosenberg ,  Galit Rotman ,  Amit Novik ,  Amir Toporik ,  Yaron Kinar ,  Sergey Nemzer ,  Shira Walach ,  Eve Montia ,  Shirley Sameach-Greenwald ,  Liat Dassa ,  Merav Beiman ,  Anat Cohen-Dayag ,  Ofer Levy

发明人： Zurit Levine ,  Avi Rosenberg ,  Galit Rotman ,  Amit Novik ,  Amir Toporik ,  Yaron Kinar ,  Sergey Nemzer ,  Shira Walach ,  Eve Montia ,  Shirley Sameach-Greenwald ,  Liat Dassa ,  Merav Beiman ,  Anat Cohen-Dayag ,  Ofer Levy

IPC分类号： A61K49/00 ,  C12N9/96 ,  A61P35/00 ,  A61K39/395 ,  C40B30/04 ,  G01N33/574 ,  C07K16/30 ,  C12N5/078

CPC分类号： C07K16/28 ,  A61K38/00 ,  A61K39/39558 ,  A61K2039/505 ,  C07K14/47 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3038 ,  C07K16/3053 ,  C07K16/3061 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/57484 ,  G01N33/577 ,  G01N2333/47

摘要： This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against KRTCAP3, FAM26F, MGC52498, FAM70A or TMEM154 antigens, which are differentially expressed in cancer, and diagnostic and therapeutic usages. This invention further relates to extracellular domains of KRTCAP3, FAM26F, MGC52498, FAM70A and TMEM154 proteins and variants, and therapeutic usages thereof.

摘要翻译： 本发明涉及用于产生免疫和非免疫的治疗剂和疾病诊断的新靶标。 更具体地，本发明提供针对在癌症中差异表达的KRTCAP3，FAM26F，MGC52498，FAM70A或TMEM154抗原以及诊断和治疗用途的治疗性抗体。 本发明还涉及KRTCAP3，FAM26F，MGC52498，FAM70A和TMEM154蛋白质和变体的细胞外结构域及其治疗用途。

公开(公告)号：US20090327663A1

公开(公告)日：2009-12-31

申请号：US12215526

申请日：2008-06-27

申请人： Zeev Sperber ,  Rafi Marom ,  Ofer Levy

发明人： Zeev Sperber ,  Rafi Marom ,  Ofer Levy

IPC分类号： G06F9/30

CPC分类号： G06F1/3203 ,  G06F1/3287 ,  G06F9/3855 ,  G06F9/3857 ,  G06F9/3865 ,  Y02D10/124 ,  Y02D10/171 ,  Y02D50/20

摘要： In one embodiment, the present invention includes a retirement unit to receive and retire executed instructions. The retirement unit may include a first array to receive information at allocation and a second array to receive information after execution. The retirement unit may further include logic to calculate an event associated with an executed instruction if information associated with the executed instruction is stored in an on-demand portion of at least one of arrays. Other embodiments are described and claimed.

摘要翻译： 在一个实施例中，本发明包括用于接收和退出执行的指令的退休单元。 退休单元可以包括用于在分配时接收信息的第一阵列和用于在执行之后接收信息的第二阵列。 如果与所执行的指令相关联的信息被存储在阵列中的至少一个的按需部分中，退休单元还可以包括用于计算与执行的指令相关联的事件的逻辑。 描述和要求保护其他实施例。