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1.发明授权Desazapurine-nucleotide derivatives, processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof for nucleic acid sequencing and as antiviral agents 失效脱氮嘌呤核苷酸衍生物，其制备方法，含有它们的药物组合物及其用于核酸测序的用途和作为抗病毒剂公开(公告)号：US06211158B1
公开(公告)日：2001-04-03
申请号：US07908513
申请日：1992-06-26
申请人： Frank Seela , Heinz-Peter Muth , Klaus Kaiser , Werner Bourgeois , Klaus Mühlegger , Herbert Von der Eltz , Hans-Georg Batz
发明人： Frank Seela , Heinz-Peter Muth , Klaus Kaiser , Werner Bourgeois , Klaus Mühlegger , Herbert Von der Eltz , Hans-Georg Batz
IPC分类号： A01N4304
CPC分类号： C07D471/04 , C07D487/04 , C07H19/14 , C07H19/16 , C07H19/20
摘要： The present invention provides desazapurine-nucleoside derivatives of the general formula: wherein X is a nitrogen atom or a methine radical, W is a nitrogen atom or a C—R4 radical, R1, R2, R3 and R4, which can be the same or different, are hydrogen or halogen atoms, hydroxyl or mercapto groups, lower alkyl, lower alkylthio, lower alkoxy, aralkyl, aralkoxy or aryloxy radicals or amino groups optionally substituted once or twice, R5 is a hydrogen atom or a hydroxyl group, R6 and R7 are each hydrogen atoms or one of them is a halogen atom or a cyano or azido group or an amino group optionally substituted once or twice, whereby one of R6 and R7 can also be a hydroxyl group when X is a methine radical and, in addition, R5 and R7 can together also represent a further valency bond between C-2′ and C-3′ and Y is a hydrogen atom or a mono-, di- or tri-phosphate group.
摘要翻译： 本发明提供了以下通式的脱氮嘌呤 - 核苷衍生物：其中X是氮原子或次甲基，W是氮原子或C-R 4基团，R 1，R 2，R 3和R 4可以相同或 不同的是氢或卤素原子，羟基或巯基，低级烷基，低级烷硫基，低级烷氧基，芳烷基，芳烷氧基或芳氧基或任选取代一次或两次的氨基，R5是氢原子或羟基，R6和R7 各自为氢原子或其中一个为卤素原子或氰基或叠氮基或任选取代一次或两次的氨基，其中当X为次甲基时，R6和R7中的一个也可为羟基，另外 ，R 5和R 7一起也代表C-2'和C-3'之间的进一步的价键，Y是氢原子或一，二或三磷酸基。
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2.发明授权2-deoxy-isoguanosines isosteric analogues and isoguanosine derivatives as well as their synthesis 失效2-脱氧 - 异鸟嘌呤等位基因类似物和异鸟苷衍生物及其合成公开(公告)号：US06498241B1
公开(公告)日：2002-12-24
申请号：US09712454
申请日：2000-11-13
IPC分类号： C07H2104
摘要： 2′-Deoxyisoguanosine, isosteric analogues and isoguanosine derivatives of formulae I-V, processes for their production via compounds of the general formulae a or b and reaction with aroyl isocyanates or from compounds of the general formulae VI-IX by photochemical irradiation. A further production process is the conversion of deoxyguanosines or guanosines by means of persilylation, reaction with ammonia and deamination in the 2 position. The compounds are suitable as pharmaceutical agents with antiviral efficacy.
摘要翻译： 2-脱氧异鸟苷，式I-V的异构体类似物和异鸟嘌呤衍生物，其通过通式a或b的化合物生产并通过光化学辐射与芳酰基异氰酸酯或通式VI-IX的化合物反应。 进一步的生产过程是通过去硅藻土或鸟氨酸的转化，通过与二氨基反应和脱氨作用。 该化合物适合作为具有抗病毒功效的药剂。
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3.发明授权公开(公告)号：US06320035B1
公开(公告)日：2001-11-20
申请号：US09695210
申请日：2000-10-25
IPC分类号： C12Q168
摘要： The invention concerns pyrrolo-[3,2-d]pyrimidine, pyrazolo-[4,3-d]pyrimidine and pyrimidine-furanosides i.e. so-called C-nucleosides of the general formulae I-V or appropriate derivatives as well as processes for their production.
摘要翻译： 本发明涉及吡咯并[3,2-d]嘧啶，吡唑并[4,3-d]嘧啶和嘧啶 - 呋喃糖苷，即所谓的通式I-V的C-核苷和合适的衍生物，以及它们 生产。
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公开(公告)号：US06403786B1
公开(公告)日：2002-06-11
申请号：US09254644
申请日：1999-07-02
IPC分类号： C07H1910
CPC分类号： C07D405/04 , C07D413/04 , C07F9/65586 , C07H7/06 , C07H19/04 , C07H19/048 , C07H19/06 , C07J51/00
摘要： The invention concerns compounds of the general formula (I) in which i:he residues R1 to R7 have the meanings given in the application as well as methods for their preparation. The compounds are in particular suitable as substrates for RNA or DNA polymerases and can thus be incorporated into RNA or DNA oligonucleotides and are especially suitable for labelling and detecting nucleic acids or for DNA sequencing.
摘要翻译： 本发明涉及通式（I）的化合物，其中I：残基R1至R7具有本申请中给出的含义及其制备方法。 该化合物特别适合作为RNA或DNA聚合酶的底物，因此可以并入RNA或DNA寡核苷酸，特别适用于标记和检测核酸或进行DNA测序。
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公开(公告)号：US06875859B2
公开(公告)日：2005-04-05
申请号：US10096786
申请日：2002-03-11
IPC分类号： C12N15/09 , A61K31/7072 , C07D405/04 , C07D413/04 , C07F9/6558 , C07H7/06 , C07H19/04 , C07H19/048 , C07H19/06 , C07H21/00 , C07J51/00 , C12Q1/68 , C07H19/10 , A61K31/70 , C07H19/01
CPC分类号： C07D405/04 , C07D413/04 , C07F9/65586 , C07H7/06 , C07H19/04 , C07H19/048 , C07H19/06 , C07J51/00
摘要： The invention concerns compounds of the general formula (I) in which the residues R1 to R7 have the meanings given in the application as well as methods for their preparation. The compounds are in particular suitable as substrates for RNA or DNA polymerases and can thus be incorporated into RNA or DNA oligonucleotides and are especially suitable for labelling and detecting nucleic acids or for DNA sequencing
摘要翻译： 本发明涉及通式（I）的化合物，其中残基R 1至R 7具有本申请中给出的含义及其制备方法。 这些化合物特别适合作为RNA或DNA聚合酶的底物，因此可以并入RNA或DNA寡核苷酸，特别适用于标记和检测核酸或DNA测序
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