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10 条记录 (耗时 0.031 秒)

    Method for simultaneous detection of HIV antigens and HIV antibodies
    1.
    发明授权
    Method for simultaneous detection of HIV antigens and HIV antibodies 有权
    同时检测HIV抗原和HIV抗体的方法

    公开(公告)号：US06593079B1

    公开(公告)日：2003-07-15

    申请号：US09381009

    申请日：2000-01-12

    申请人： Frederic Donie ,  Elke Faatz ,  Barbara Upmeier ,  Eva Hoess ,  Marie-Ange Buyse ,  Eric Saman

    发明人： Frederic Donie ,  Elke Faatz ,  Barbara Upmeier ,  Eva Hoess ,  Marie-Ange Buyse ,  Eric Saman

    IPC分类号： C12Q106

    CPC分类号： G01N33/56988 ,  C07K16/1054

    摘要： The invention concerns a process for diagnosis of an HIV infection by means of an immunoassay using the specific detection of the p24 antigen of HIV1, HIV1-Sub0 and/or the p26 antigen of HIV2, at least one antibody against the env region of HIV1, HIV1-Sub0 and/or of HIV2 and at least one antibody against the pol and/or gag region of HIV1, HIV1-Sub0 and/or HIV2, reagent kits and test strips suitable for diagnostic procedure as well as monoclonal antibodies against p24 and their use.

    摘要翻译： 本发明涉及通过免疫测定来诊断HIV感染的方法，其使用HIV2的HIV1，HIV1-Sub0和/或p26抗原的p24抗原的特异性检测，至少一种针对HIV1的env区域的抗体， HIV1-Sub0和/或HIV2的抗体和抗HIV1，HIV1-Sub0和/或HIV2的pol和/或gag区域的至少一种抗体，适用于诊断程序的试剂盒和测试条以及针对p24的单克隆抗体及其 使用。

    17-KDA Brucella abortus antigen, recombinant polypeptides, nucleic acids coding for the same and use thereof in diagnostic and prophylactic methods and kits
    3.
    发明授权
    17-KDA Brucella abortus antigen, recombinant polypeptides, nucleic acids coding for the same and use thereof in diagnostic and prophylactic methods and kits 失效
    17-KDA布鲁氏菌流产抗原，重组多肽，编码相同的核酸和在诊断和预防方法和试剂盒中的应用

    公开(公告)号：US06296855B1

    公开(公告)日：2001-10-02

    申请号：US08849634

    申请日：1997-12-01

    申请人： Fabienne Hemmen ,  Eric Saman

    发明人： Fabienne Hemmen ,  Eric Saman

    IPC分类号： A61K3902

    CPC分类号： C12Q1/689 ,  A61K39/00 ,  C07K14/23 ,  C07K2319/02 ,  Y10S424/825

    摘要： The present invention relates to an isolated 17-kDa Brucclla antigen characterized by an amino acid sequence having at least 60% homology, preferably at least 70% homology, more preferably having at least 80% homology to the amino acid sequence as shown in SEQ ID No. 1 or 2, with said antigen being specifically recognized by sera from Brucella field infected individuals, more particulary an antigen characterized by the amino acid sequence as shown in SEQ ID No. 1 or 2. The invention also relates to recombinantly produced 17 kDa Brucella antigen, nucleic acids coding for the same and the use thereof in diagnostic and prophylactic methods and kits.

    摘要翻译： 本发明涉及分离的17-kDa布鲁氏菌抗原，其特征在于与SEQ ID NO：1所示的氨基酸序列具有至少60％的同源性，优选至少70％的同源性，更优选与SEQ ID NO： 所述抗原由来自布鲁氏菌感染的个体的血清特异性地识别，更特别的是以SEQ ID No.1或2所示的氨基酸序列为特征的抗原。本发明还涉及重组产生的17kDa 布鲁氏杆菌抗原，编码相同的核酸及其在诊断和预防方法和试剂盒中的用途。

    HIV-3 retrovirus and its use
    10.
    发明授权
    HIV-3 retrovirus and its use 失效
    HIV-3逆转录病毒及其用途

    公开(公告)号：US5567603A

    公开(公告)日：1996-10-22

    申请号：US228519

    申请日：1994-04-15

    申请人： Robert De Leys ,  Bart Vanderborght ,  Eric Saman ,  Hugo Van Heuverswyn

    发明人： Robert De Leys ,  Bart Vanderborght ,  Eric Saman ,  Hugo Van Heuverswyn

    IPC分类号： G01N33/569 ,  A61K39/00 ,  C07K14/00 ,  C07K14/155 ,  C07K14/16 ,  C07K16/00 ,  C07K16/10 ,  C12N7/00 ,  C12N7/01 ,  C12N15/02 ,  C12N15/09 ,  C12N15/48 ,  C12N15/49 ,  C12P21/00 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12Q1/70 ,  C12R1/92 ,  G01N33/53 ,  G01N33/577 ,  C07H21/04

    CPC分类号： C07K14/005 ,  C07K16/1045 ,  C07K16/1054 ,  C12N7/00 ,  G01N33/56988 ,  A61K2039/505 ,  A61K39/00 ,  C12N2740/16021 ,  C12N2740/16122 ,  C12N2740/16222 ,  G01N2333/16 ,  Y10S435/974 ,  Y10S435/975 ,  Y10S530/809

    摘要： Described is a new retrovirus designated HIV-3, samples of which have been deposited in the European Collection of Animal Cell Cultures (ECACC) under V88060301. The morphological and immunological properties exhibited by the HIV-3 retrovirus class include:a diameter of approximately 120 nm; a tropism for T4 lymphocytes; cultivation in T4 receptor-bearing immortalized cell lines; cytotoxicity for the lymphocytes that it infects; a magnesium dependent reverse transcriptase activity;the genomic RNA of HIV-3 hybridizes neither with the sequences of HIV-1 nor with the sequences of HIV-2 under stringent hybridization conditions;lysates of the virus contain a p25 protein which is immunologically distinct from the p19 protein of HTLV-I and the p24 proteins of HIV-1 and HIV-2 as determined by Western blot analysis, respectively;lysates of the virus contain a gp120 protein which is immunologically distinct from the gp110 protein of HTLV-I, the gp120 of HIV-1 and the gp120 of HIV-2 as determined by Western blot analysis;the lysate of the virus contains in addition a gp41 glycoprotein with a molecular weight of 40,000-45,000; andlysates of the virus contain a p12 protein which is immunologically distinct from the p12 proteins of HIV-1 and HIV-2 as determined by Western blot analysis.Also described are nucleic acid sequences derived from HIV-3 RNA which can be used as hybridization probes to detect the presence of HIV-3 virus.

    摘要翻译： 描述了一种新的逆转录病毒，称为HIV-3，其样品已经存放在欧洲动物细胞培养物库（ECACC）V88060301中。 HIV-3逆转录病毒类的形态学和免疫学特性包括：直径约120nm; T4淋巴细胞趋向性; 在含有T4受体的永生化细胞系中培养; 感染淋巴细胞的细胞毒性; 镁依赖逆转录酶活性; 在严格杂交条件下，HIV-3的基因组RNA既不与HIV-1的序列也不与HIV-2的序列杂交; 该病毒的裂解物含有与HTLV-1的p19蛋白和HIV-1和HIV-2的p24蛋白免疫区别的p25蛋白，分别通过蛋白质印迹分析确定; 病毒的裂解物含有与HIV-1的gp110和HIV-2的gp120的HIV-2的gp110蛋白免疫区别的gp120蛋白，通过Western印迹分析测定; 病毒的裂解物另外含有分子量为40,000-45,000的gp41糖蛋白; 并且病毒的裂解物含有通过蛋白质印迹分析测定的与HIV-1和HIV-2的p12蛋白免疫学上不同的p12蛋白。 还描述了衍生自HIV-3RNA的核酸序列，其可用作检测HIV-3病毒存在的杂交探针。