公开(公告)号：US08481254B2

公开(公告)日：2013-07-09

申请号：US12675511

申请日：2008-09-08

申请人： Fumio Yamauchi ,  Kimihiro Yoshimura ,  Katsuaki Kuge ,  Tetsuya Yano ,  Masahiro Shirakawa ,  Yasuhiro Aoyama ,  Shinsuke Sando

发明人： Fumio Yamauchi ,  Kimihiro Yoshimura ,  Katsuaki Kuge ,  Tetsuya Yano ,  Masahiro Shirakawa ,  Yasuhiro Aoyama ,  Shinsuke Sando

IPC分类号： C12Q1/00

CPC分类号： C12Q1/54 ,  C12Q1/32 ,  C12Q1/34 ,  G01N24/088 ,  G01R33/281 ,  G01R33/4633 ,  G01R33/465 ,  G01R33/483 ,  G01R33/5601 ,  Y02P20/582

摘要： Substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing a enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, and a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, being present specifically to the enzyme recognition, thereby detecting presence of the substrate probe and the enzyme activity. Alternatively, imaging of the enzyme activity is performed by a multi-dimensional nuclear resonance imaging method.

摘要翻译： 能够高精度地检测酶活性的底物探针和使用底物探针的多核磁共振法检测酶活性的方法。 通过使用用于通过多维核磁共振法测定酶活性的底物探针进行多维核磁共振，其特征在于含有被活性酶选择性识别的酶识别位点作为 至少一个结构单元和至少三个具有核自旋和不同共振频率的核磁共振活性核连接的基团，其特异性地存在于酶识别中，从而检测底物探针和酶的存在 活动。 或者，通过多维核共振成像方法进行酶活性的成像。

公开(公告)号：US20100248279A1

公开(公告)日：2010-09-30

申请号：US12675511

申请日：2008-09-08

申请人： Fumio Yamauchi ,  Kimihiro Yoshimura ,  Katsuaki Kuge ,  Tetsuya Yano ,  Masahiro Shirakawa ,  Yasuhiro Aoyama ,  Shinsuke Sando

发明人： Fumio Yamauchi ,  Kimihiro Yoshimura ,  Katsuaki Kuge ,  Tetsuya Yano ,  Masahiro Shirakawa ,  Yasuhiro Aoyama ,  Shinsuke Sando

IPC分类号： C12Q1/54 ,  C12Q1/32 ,  C12Q1/37

CPC分类号： C12Q1/54 ,  C12Q1/32 ,  C12Q1/34 ,  G01N24/088 ,  G01R33/281 ,  G01R33/4633 ,  G01R33/465 ,  G01R33/483 ,  G01R33/5601 ,  Y02P20/582

摘要： Substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing a enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, and a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, being present specifically to the enzyme recognition, thereby detecting presence of the substrate probe and the enzyme activity. Alternatively, imaging of the enzyme activity is performed by a multi-dimensional nuclear resonance imaging method.

摘要翻译： 能够高精度地检测酶活性的底物探针和使用底物探针的多核磁共振法检测酶活性的方法。 通过使用用于通过多维核磁共振法测定酶活性的底物探针进行多维核磁共振，其特征在于含有被活性酶选择性识别的酶识别位点作为 至少一个结构单元和至少三个具有核自旋和不同共振频率的核磁共振活性核连接的基团，其特异性地存在于酶识别中，从而检测底物探针和酶的存在 活动。 或者，通过多维核共振成像方法进行酶活性的成像。

公开(公告)号：US08773126B2

公开(公告)日：2014-07-08

申请号：US12676239

申请日：2008-09-08

申请人： Katsuaki Kuge ,  Kimihiro Yoshimura ,  Fumio Yamauchi ,  Tetsuya Yano ,  Masahiro Shirakawa ,  Yasuhiro Aoyama

发明人： Katsuaki Kuge ,  Kimihiro Yoshimura ,  Fumio Yamauchi ,  Tetsuya Yano ,  Masahiro Shirakawa ,  Yasuhiro Aoyama

IPC分类号： G01V3/00 ,  G01R33/485 ,  G01R33/46 ,  G01R33/483 ,  G01R33/56

CPC分类号： G01R33/485 ,  G01R33/4608 ,  G01R33/4633 ,  G01R33/4833 ,  G01R33/5605 ,  G01R33/5607

摘要： The present invention provides a method for measuring nuclear magnetic resonance that employs a compound in which a plurality of nuclei is labeled with isotopes as a probe agent, highly selectively and highly sensitively obtains a nuclear magnetic resonance signal of the above described probe agent, and can attach a spatial positional information to the above described nuclear magnetic resonance signal, and an apparatus therefore.

摘要翻译： 本发明提供一种测定核磁共振的方法，其使用多个核被同位素标记的化合物作为探针剂，高度选择性且高度灵敏地获得上述探针剂的核磁共振信号，并且可以 将空间位置信息附加到上述核磁共振信号，因此装置。

公开(公告)号：US20100225314A1

公开(公告)日：2010-09-09

申请号：US12676239

申请日：2008-09-08

申请人： Katsuaki Kuge ,  Kimihiro Yoshimura ,  Fumio Yamauchi ,  Tetsuya Yano ,  Masahiro Shirakawa ,  Yasuhiro Aoyama

发明人： Katsuaki Kuge ,  Kimihiro Yoshimura ,  Fumio Yamauchi ,  Tetsuya Yano ,  Masahiro Shirakawa ,  Yasuhiro Aoyama

IPC分类号： G01R33/44

CPC分类号： G01R33/485 ,  G01R33/4608 ,  G01R33/4633 ,  G01R33/4833 ,  G01R33/5605 ,  G01R33/5607

摘要： The present invention provides a method for measuring nuclear magnetic resonance that employs a compound in which a plurality of nuclei is labeled with isotopes as a probe agent, highly selectively and highly sensitively obtains a nuclear magnetic resonance signal of the above described probe agent, and can attach a spatial positional information to the above described nuclear magnetic resonance signal, and an apparatus therefore.

摘要翻译： 本发明提供一种测定核磁共振的方法，其使用多个核被同位素标记的化合物作为探针剂，高度选择性且高度灵敏地获得上述探针剂的核磁共振信号，并且可以 将空间位置信息附加到上述核磁共振信号，因此装置。

公开(公告)号：US20100247444A1

公开(公告)日：2010-09-30

申请号：US12675581

申请日：2008-09-08

申请人： Kimihiro Yoshimura ,  Fumio Yamauchi ,  Katsuaki Kuge ,  Tetsuya Yano ,  Masahiro Shirakawa ,  Yasuhiro Aoyama

发明人： Kimihiro Yoshimura ,  Fumio Yamauchi ,  Katsuaki Kuge ,  Tetsuya Yano ,  Masahiro Shirakawa ,  Yasuhiro Aoyama

IPC分类号： A61K49/10 ,  C07F9/02 ,  A61P43/00

CPC分类号： C07C215/40 ,  A61K49/10 ,  C07B2200/05 ,  C07C219/06 ,  C07F9/091 ,  C07F9/106 ,  G01N24/08 ,  G01R33/4608 ,  G01R33/5601 ,  G01R33/5605

摘要： To produce a labeled compound for a selected biological substance not using a radioisotope atom which has a risk of exposure to radioactivity and limitation on handling time but using a stable isotope atom; and that the labeled compound can be measured with good sensitivity separably from naturally occurring compounds of the selected biological substance which are substituted with the stable isotope atom. Choline as a biological substance is labeled by substituting the nitrogen atom of the quaternary ammonium group and all the carbon atoms of the methyl group attached to the nitrogen atom with respective isotopes 15N and 13C and used as a diagnostic agent.

摘要翻译： 为了生产不使用具有暴露于放射性和限制处理时间但使用稳定同位素原子的放射性同位素原子的选定生物物质的标记化合物; 并且可以以与稳定同位素原子取代的所选择的生物物质的天然存在的化合物分离地具有良好的灵敏度来测量标记的化合物。 胆碱作为生物物质通过用各自的同位素15N和13C替代季铵基团的氮原子和与氮原子连接的甲基的所有碳原子并用作诊断剂进行标记。

公开(公告)号：US08772475B2

公开(公告)日：2014-07-08

申请号：US12743777

申请日：2008-11-28

申请人： Teruyuki Kondo ,  Hiroshi Tsujita ,  Zainul Abedin Siddique ,  Shingo Matsuki ,  Hiroki Miura ,  Hidehito Tochio ,  Tetsuya Matsuda ,  Michiko Narazaki ,  Hidetoshi Tsuzuki ,  Katsuaki Kuge ,  Yoshinori Tomida ,  Kimihiro Yoshimura ,  Tetsuya Yano

发明人： Teruyuki Kondo ,  Hiroshi Tsujita ,  Zainul Abedin Siddique ,  Shingo Matsuki ,  Hiroki Miura ,  Hidehito Tochio ,  Tetsuya Matsuda ,  Michiko Narazaki ,  Hidetoshi Tsuzuki ,  Katsuaki Kuge ,  Yoshinori Tomida ,  Kimihiro Yoshimura ,  Tetsuya Yano

IPC分类号： C07D225/00

CPC分类号： C07F5/003 ,  A61K49/106 ,  C07D255/02 ,  C07D257/02 ,  C07D259/00 ,  C07D405/14

摘要： A core of a cyclic structure represented by (—N—(CH2)n—)k is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound with a specific structure for producing a metal complex that exhibits a T1-reducing effect, and the resulting compound is coordinated to a metal ion that has a T1-reducing effect to obtain a metal complex that exhibits an excellent T1-reducing effect which is useful as an effective component of an MRI contrast agent and an MRI contrast agent using the same.

摘要翻译： 由（-N-（CH 2）n - ）k表示的环状结构的核心与核心中所有氮原子上具有特定支化结构的树枝状大分子侧链结合，生成具有特定结构的化合物， 具有T1还原效果的金属络合物，所得化合物与具有T1还原效果的金属离子配位，得到显示出优异的T1还原效果的金属络合物，其可用作有机组分 MRI造影剂和使用其的MRI造影剂。

公开(公告)号：US20110028713A1

公开(公告)日：2011-02-03

申请号：US12743777

申请日：2008-11-28

申请人： Teruyuki Kondo ,  Hiroshi Tsujita ,  Zainul Abedin Siddique ,  Shingo Matsuki ,  Hiroki Miura ,  Hidehito Tochio ,  Tetsuya Matsuda ,  Michiko Narazaki ,  Hidetoshi Tsuzuki ,  Katsuaki Kuge ,  Yoshinori Tomida ,  Kimihiro Yoshimura ,  Tetsuya Yano

发明人： Teruyuki Kondo ,  Hiroshi Tsujita ,  Zainul Abedin Siddique ,  Shingo Matsuki ,  Hiroki Miura ,  Hidehito Tochio ,  Tetsuya Matsuda ,  Michiko Narazaki ,  Hidetoshi Tsuzuki ,  Katsuaki Kuge ,  Yoshinori Tomida ,  Kimihiro Yoshimura ,  Tetsuya Yano

IPC分类号： C07F5/00 ,  C07D405/14 ,  C07D407/12 ,  C07D255/02

CPC分类号： C07F5/003 ,  A61K49/106 ,  C07D255/02 ,  C07D257/02 ,  C07D259/00 ,  C07D405/14

摘要： A core of a cyclic structure represented by (—N—(CH2)n—)k is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound with a specific structure for producing a metal complex that exhibits a T1-reducing effect, and the resulting compound is coordinated to a metal ion that has a T1-reducing effect to obtain a metal complex that exhibits an excellent T1-reducing effect which is useful as an effective component of an MRI contrast agent and an MRI contrast agent using the same.

摘要翻译： 由（-N-（CH 2）n - ）k表示的环状结构的核心与核心中所有氮原子上具有特定支化结构的树枝状大分子侧链结合，生成具有特定结构的化合物， 具有T1还原效果的金属络合物，所得化合物与具有T1还原效果的金属离子配位，得到显示出优异的T1还原效果的金属络合物，其可用作有机组分 MRI造影剂和使用其的MRI造影剂。

公开(公告)号：US20070252596A1

公开(公告)日：2007-11-01

申请号：US11738269

申请日：2007-04-20

申请人： Katsuaki Kuge

发明人： Katsuaki Kuge

IPC分类号： G01V3/00

CPC分类号： G01R33/46 ,  G01N24/087 ,  G01R33/4808

摘要： The nuclear magnetic resonance spectrum of a sample, which is a target material analyzed, and changes in relaxation times of nuclear magnetic resonance signals are measured while the sample is irradiated with terahertz waves containing frequency components corresponding to peak portions of absorption or reflectance spectrum of the sample. On the basis of the changes in relaxation times, the relationship between peak portions and information about a three-dimensional structure, conformational alteration, molecular relaxation, and the like is observed, the peak portions being in the absorption or reflectance spectrum in the terahertz range of the sample.

摘要翻译： 测量作为目标材料的样品的核磁共振谱和核磁共振信号的弛豫时间的变化，同时用包含与吸收或反射光谱的峰值部分对应的频率成分的太赫兹波照射样品 样品。 基于弛豫时间的变化，可以观察到峰部分之间的关​​系和关于三维结构，构象变化，分子松弛等的信息，峰部分在太赫兹范围内的吸收或反射光谱 的样品。

公开(公告)号：US20050079384A1

公开(公告)日：2005-04-14

申请号：US10951686

申请日：2004-09-29

申请人： Akira Tsuboyama ,  Shinjiro Okada ,  Takao Takiguchi ,  Jun Kamatani ,  Manabu Furugori ,  Katsuaki Kuge

发明人： Akira Tsuboyama ,  Shinjiro Okada ,  Takao Takiguchi ,  Jun Kamatani ,  Manabu Furugori ,  Katsuaki Kuge

IPC分类号： H01L51/50 ,  C09K11/06 ,  H01L51/00 ,  H05B33/14

CPC分类号： C09K11/06 ,  C09K2211/1014 ,  C09K2211/1029 ,  C09K2211/1044 ,  C09K2211/188 ,  H01L51/0059 ,  H01L51/0062 ,  H01L51/0077 ,  H01L51/0091 ,  H01L51/5012 ,  H05B33/14 ,  Y10S428/917

摘要： There is provided an organic light-emitting device obtained by using a specific copper coordination compound as a light-emitting material, which has a basic structure in which two copper ions are crosslinked in a ring form by one of atomic groups containing a halogen atom, a sulfur atom, and an nitrogen atom. The light-emitting device provides high luminescence efficiency and high stability at low cost by using an inexpensive copper coordination compound as a light-emitting material.

摘要翻译： 提供了通过使用特定的铜配位化合物作为发光材料而获得的有机发光装置，其具有两个铜离子以含有卤素原子的原子团中的一个环状交联的碱性结构， 硫原子和氮原子。 通过使用便宜的铜配位化合物作为发光材料，发光装置以低成本提供高发光效率和高稳定性。

公开(公告)号：US20100227308A1

公开(公告)日：2010-09-09

申请号：US12712131

申请日：2010-02-24

申请人： Hiroyuki Hashimoto ,  Katsuaki Kuge ,  Manabu Komatsu ,  Kumi Nakamura ,  Kazuhiro Ban ,  Takeshi Imamura ,  Shin Kobayashi ,  Tadashi Okamoto

发明人： Hiroyuki Hashimoto ,  Katsuaki Kuge ,  Manabu Komatsu ,  Kumi Nakamura ,  Kazuhiro Ban ,  Takeshi Imamura ,  Shin Kobayashi ,  Tadashi Okamoto

IPC分类号： C12Q1/00 ,  B01D59/44 ,  H01J49/40

CPC分类号： G01N33/6848 ,  G01N33/4833

摘要： An information acquisition method for acquiring information on a target object, that includes a step of promoting ionization of the target object using a substance for promoting ionization of the target object to cause the target object to emit, and a step of acquiring information on the mass of the flew target object using time-of-flight secondary ion mass spectrometry.

摘要翻译： 一种用于获取关于目标对象的信息的信息获取方法，其包括使用促进所述目标对象的电离的物质促进所述目标对象的电离以使所述目标对象发射的步骤以及获取所述质量信息的步骤 的飞行目标物体使用飞行时间二次离子质谱法。