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    CLOSED EVAPORATION SYSTEM
    1.
    发明申请
    CLOSED EVAPORATION SYSTEM 审中-公开
    封闭蒸发系统

    公开(公告)号：US20160260511A1

    公开(公告)日：2016-09-08

    申请号：US15027633

    申请日：2014-10-17

    Applicant: GE HEALTHCARE LIMITED

    Inventor： Xavier Franci ,  Steve Lignon ,  Audrey Lange

    IPC: G21F9/08 ,  B01J19/00 ,  C07B59/00 ,  C07H19/06 ,  G21G4/08 ,  B01D1/30

    CPC classification number: G21F9/08 ,  B01D1/30 ,  B01J19/0093 ,  B01J2219/00799 ,  B01J2219/00873 ,  B01J2219/00885 ,  B01J2219/009 ,  B01J2219/00959 ,  B01J2219/00963 ,  C07B59/00 ,  C07B59/005 ,  C07B2200/05 ,  C07C227/40 ,  C07C2601/04 ,  C07D233/91 ,  C07H19/06 ,  C07J1/007 ,  G21G1/0005 ,  G21G4/08 ,  C07C229/48 ,  C07C229/36

    Abstract: The present invention provides a system for evaporating a radioactive fluid, a method for the synthesis of a radiolabelled compound including this system, and a cassette for the synthesis of a radiolabelled compound comprising this system. The present invention provides advantages over known methods for evaporation of a radioactive fluid as it reduces drastically the amount of radioactive gaseous chemicals that are released in the hot cell. It is gentler and more secure compared to the known process and provides access to radiosyntheic processes that may not been acceptable for safety reasons related to release of volatile radioactive gases during evaporation. In addition, the process yields are higher because the radioactive volatiles are labelled intermediate species.

    Abstract translation: 本发明提供了一种用于蒸发放射性流体的系统，用于合成包括该系统的放射性标记化合物的方法和用于合成包含该系统的放射性标记化合物的盒。 本发明提供了优于已知的用于放射性液体蒸发的方法的优点，因为其显着降低了在热电池中释放的放射性气体化学品的量。 与已知的方法相比，它更加温和，更安全，并提供了与放射性放射性气体在蒸发过程中释放相关的安全原因可能无法接受的放射性合成过程。 此外，由于放射性挥发物被标记为中间物种，因此工艺产率更高。

    PET tracer purification system
    5.
    发明授权
    PET tracer purification system 有权

    公开(公告)号：US10662125B2

    公开(公告)日：2020-05-26

    申请号：US15526245

    申请日：2015-11-12

    Applicant: GE Healthcare Limited

    Inventor： Xavier Franci ,  Steve Lignon ,  Audrey Marie Lange ,  Nicolas Verbrugge

    IPC: C07B59/00 ,  B01D15/18 ,  B01D15/32 ,  B01D15/36 ,  C07H5/02

    Abstract: The present invention provides a new chemical process, a new cassette configuration, and new software for the automated production of multiple batches of an [18F]-labelled compound on a single cassette. The invention allows one synthesizer in one hot cell to produce sequentially a plurality of batches of [18F]-labelled PET tracer in the same day. In particular, the present invention provides a novel arrangement useful for purifying two consecutive batches of a reaction mixture comprising an 18F-labelled compound.

    Closed evaporation system
    7.
    发明授权
    Closed evaporation system 有权

    公开(公告)号：US11094424B2

    公开(公告)日：2021-08-17

    申请号：US16555484

    申请日：2019-08-29

    Applicant: GE HEALTHCARE LIMITED

    Inventor： Xavier Franci ,  Steve Lignon ,  Audrey Lange

    IPC: A61K51/00 ,  A61M36/14 ,  G21F9/08 ,  G21G4/08 ,  C07H19/06 ,  B01J19/00 ,  C07B59/00 ,  C07C227/40 ,  C07D233/91 ,  C07J1/00 ,  G21G1/00 ,  B01D1/30

    Abstract: The present invention provides a system for evaporating a radioactive fluid, a method for the synthesis of a radiolabelled compound including this system, and a cassette for the synthesis of a radiolabelled compound comprising this system. The present invention provides advantages over known methods for evaporation of a radioactive fluid as it reduces drastically the amount of radioactive gaseous chemicals that are released in the hot cell. It is gentler and more secure compared to the known process and provides access to radiosyntheic processes that may not been acceptable for safety reasons related to release of volatile radioactive gases during evaporation. In addition, the process yields are higher because the radioactive volatiles are labelled intermediate species.

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