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公开(公告)号：US10125098B2
公开(公告)日：2018-11-13
申请号：US15988956
申请日：2018-05-24
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D207/16 , C07D277/06 , C07D413/14 , C07D413/12 , C07D401/10 , C07D401/12 , C07C235/54 , C07D405/10 , C07D403/14 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10005724B2
公开(公告)日：2018-06-26
申请号：US15321335
申请日：2015-07-07
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07C235/54 , C07D207/16 , C07D405/10 , C07D401/12 , C07D471/08 , C07D403/14 , C07D401/10 , C07D413/12 , C07D413/14 , C07D277/06
CPC classification number: C07D207/16 , C07C235/42 , C07C235/52 , C07C235/54 , C07C2601/02 , C07C2601/04 , C07C2603/74 , C07D205/04 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/02 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D221/22 , C07D231/06 , C07D263/04 , C07D263/26 , C07D265/30 , C07D277/06 , C07D305/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/10 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D451/02 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10351595B2
公开(公告)日：2019-07-16
申请号：US15312614
申请日：2015-05-19
Applicant: RQX PHARMACEUTICALS, INC. , GENENTECH, INC.
Inventor： Tucker Curran Roberts , Peter Andrew Smith , Robert I. Higuchi , Prasuna Paraselli , Philippe Bergeron , Michael F. T. Koehler , Huiyong Hu , Jacob Bradley Schwarz , Cuong Ly , James John Crawford
IPC: A61K38/00 , C07K5/103 , C07K7/06 , C07K7/08 , C07K5/02 , C07K5/087 , C07K5/09 , C07K5/11 , A61K45/06 , A61K31/395 , A61K31/407 , A61K31/4196 , A61K31/43 , A61K31/431 , A61K31/496 , A61K31/545 , A61K31/546 , A61K38/06 , A61K38/07 , A61K38/08 , C07K5/083 , A61K38/12
Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
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公开(公告)号：US12209075B2
公开(公告)日：2025-01-28
申请号：US17056325
申请日：2019-05-21
Applicant: GENENTECH, INC.
Inventor： Steven McKerrall , Ramsay Beveridge , Kwong Wah Lai , Philippe Bergeron
IPC: C07D401/12 , A61K9/00 , A61P17/04 , A61P29/00
Abstract: The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables Y1-Y6, X, Z, Z1, Z2, R2-R3, and R6 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions. The compounds have sodium channel blocking activity that are useful for treating sodium channel-mediated diseases, in particular for treating pain.
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Patent Agency Ranking
公开(公告)号：US10787446B2
公开(公告)日：2020-09-29
申请号：US15939112
申请日：2018-03-28
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Philippe Bergeron , Kristen Burford , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Michael Edward Grimwood , Abid Hasan , Kwong Wah Lai , Zhiguo Liu , Steven McKerrall , Teresa Phuongtram Nguyen , Brian Safina , Daniel Sutherlin , Tao Wang
IPC: C07D405/14 , C07D417/12 , C07D417/14 , A61P17/04 , C07D401/12 , C07D491/107
Abstract: The invention provides a compound of formula: or a salt thereof, wherein the variables RAA, n, ring A, ring B, R1a, R1b, R2, R3, R4, R5, R6, R7, R8, and R9 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10392422B2
公开(公告)日：2019-08-27
申请号：US15312614
申请日：2015-05-19
Applicant: RQX PHARMACEUTICALS, INC. , GENENTECH, INC.
Inventor： Tucker Curran Roberts , Peter Andrew Smith , Robert I. Higuchi , Prasuna Paraselli , Philippe Bergeron , Michael F. T. Koehler , Huiyong Hu , Jacob Bradley Schwarz , Cuong Ly , James John Crawford
IPC: A61K38/00 , C07K5/103 , C07K7/06 , C07K7/08 , C07K5/02 , C07K5/087 , C07K5/09 , C07K5/11 , A61K45/06 , A61K31/395 , A61K31/407 , A61K31/4196 , A61K31/43 , A61K31/431 , A61K31/496 , A61K31/545 , A61K31/546 , A61K38/06 , A61K38/07 , A61K38/08 , C07K5/083 , A61K38/12
Abstract: Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
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公开(公告)号：US11149002B2
公开(公告)日：2021-10-19
申请号：US16702286
申请日：2019-12-03
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Salvatore Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D207/16 , C07D403/12 , C07D413/14 , C07D221/22 , C07D401/12 , C07D413/12 , C07C235/52 , C07D205/04 , C07D277/06 , C07D209/02 , C07D305/08 , C07D401/14 , C07D231/06 , C07D403/04 , C07D403/14 , C07D409/06 , C07D417/12 , C07D451/02 , C07D263/04 , C07D263/26 , C07C235/42 , C07C235/54 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D401/10 , C07D405/10 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10526285B2
公开(公告)日：2020-01-07
申请号：US16150070
申请日：2018-10-02
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Salvatore Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova
IPC: C07D207/16 , C07D403/12 , C07D413/14 , C07D221/22 , C07D401/12 , C07D413/12 , C07C235/52 , C07D205/04 , C07D277/06 , C07D209/02 , C07D305/08 , C07D401/14 , C07D231/06 , C07D403/04 , C07D403/14 , C07D409/06 , C07D417/12 , C07D451/02 , C07D263/04 , C07D263/26 , C07C235/42 , C07C235/54 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D401/10 , C07D405/10 , C07D471/08
Abstract: The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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公开(公告)号：US10457654B2
公开(公告)日：2019-10-29
申请号：US15799771
申请日：2017-10-31
Applicant: GENENTECH, INC. , XENON PHARMACEUTICALS INC.
Inventor： Daniel Sutherlin , Steven McKerrall , Michael Scott Wilson , Kwong Wah Lai , Philippe Bergeron , Birong Zhang , Ramsay Beveridge , Jean-Philippe Leclerc , Alexandre Lemire , Liang Zhao , Claudio Sturino
IPC: C07D285/08 , C07D277/52 , C07D239/69 , C07D213/76 , C07D261/16 , C07D401/12 , C07D403/12 , C07D417/12 , A61K31/427 , A61P19/02 , A61P29/00
Abstract: The invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables X, Y1—Y5, R1, R2, R3, R4, and Het have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.
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