专利检索 ap:("GILEAD SCIENCES, INC.") AND inv:"Thomas Butler" 第 1 页

1.

发明申请
PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 1'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS 审中-公开

公开(公告)号：US20180327437A1

公开(公告)日：2018-11-15

申请号：US16011055

申请日：2018-06-18

申请人： GILEAD SCIENCES, INC.

发明人： Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang

IPC分类号： C07H1/00 , C07H19/23

CPC分类号： C07H1/00 , A61K31/7052 , A61K31/7056 , A61K31/706 , C07H19/23

摘要： Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.

2.

再颁专利
1′-substituted carba-nucleoside analogs for antiviral treatment 有权

公开(公告)号：USRE46762E1

公开(公告)日：2018-03-27

申请号：US15288271

申请日：2016-10-07

申请人： Gilead Sciences, Inc.

发明人： Thomas Butler , Aesop Cho , Choung U. Kim , Jay P. Parrish , Oliver L. Saunders , Lijun Zhang

IPC分类号： A01N43/04 , A61K31/70 , C07H5/04 , C07H7/06 , C07H19/23 , C07D487/04

CPC分类号： C07H19/23 , C07D487/04

摘要： Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

3.

发明授权
1′-substituted carba-nucleoside analogs for antiviral treatment 有权
标题翻译： 1'-取代的碳 - 核苷类似物用于抗病毒治疗

公开(公告)号：US08853171B2

公开(公告)日：2014-10-07

申请号：US13649511

申请日：2012-10-11

申请人： Gilead Sciences, Inc.

发明人： Thomas Butler , Aesop Cho , Choung U. Kim , Jay P. Parrish , Oliver L. Saunders , Lijun Zhang

IPC分类号： A01N43/04 , A61K31/70 , C07H5/04 , C07H7/06 , C07H19/23 , C07D487/04

CPC分类号： C07H19/23 , C07D487/04

摘要： Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

摘要翻译： 提供吡咯并[1,2-f] [1,2,4]三嗪基，咪唑并[1,5-f] [1,2,4]三嗪基，咪唑并[1,2-f] [1,2,4 ]三嗪基和[1,2,4]三唑并[4,3-f] [1,2,4]三嗪基核苷，其核苷磷酸酯和前药，其中核苷糖的1'位置被取代。所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。

4.

发明授权
Processes and intermediates for the preparation of 1′-substituted carba-nucleoside analogs 有权

公开(公告)号：US10988498B2

公开(公告)日：2021-04-27

申请号：US16011055

申请日：2018-06-18

申请人： GILEAD SCIENCES, INC.

发明人： Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang

IPC分类号： C07H1/00 , C07H19/23 , A61K31/7056 , A61K31/706 , A61K31/7052

摘要： Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.

5.

发明申请
PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 1`-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS 有权

公开(公告)号：US20210403497A1

公开(公告)日：2021-12-30

申请号：US17209639

申请日：2021-03-23

申请人： Gilead Sciences, Inc.

发明人： Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang

IPC分类号： C07H1/00 , C07H19/23

摘要： Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.