公开(公告)号：US08822430B2

公开(公告)日：2014-09-02

申请号：US13956195

申请日：2013-07-31

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Eda Canales ,  Aesop Cho ,  Jeromy J. Cottell ,  Manoj C. Desai ,  Michael Graupe ,  Hongyan Guo ,  Randall L. Halcomb ,  Darryl Kato ,  Choung U. Kim ,  Thorsten A. Kirschberg ,  Evan S. Krygowski ,  Scott E. Lazerwith ,  John O. Link ,  Hongtao Liu ,  Qi Liu ,  Richard L. Mackman ,  Michael L. Mitchell ,  Jay P. Parrish ,  Hyung-Jung Pyun ,  Joseph H. Saugier ,  Scott D. Schroeder ,  Jianyu Sun ,  James G. Taylor ,  James D. Trenkle ,  Winston C. Tse ,  Randall W. Vivian ,  William J. Watkins ,  Lianhong Xu

IPC: C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  C07D495/04 ,  A61K31/4178 ,  A61K31/7068 ,  A61K31/7052 ,  A61K31/4184 ,  A61P1/16 ,  A61P31/14

CPC classification number: C07D403/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/427 ,  A61K31/435 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/55 ,  A61K45/06 ,  A61P31/12 ,  C07D207/16 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D491/113 ,  C07D495/04 ,  C07F5/025

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20140200188A1

公开(公告)日：2014-07-17

申请号：US14163251

申请日：2014-01-24

Applicant: Gilead Sciences, Inc.

Inventor： Michael O'Neil Hanrahan Clarke ,  Choung U. Kim ,  Willard Lew

IPC: C07H17/02 ,  A61K45/06 ,  A61K31/706

CPC classification number: C07F9/65586 ,  A61K31/137 ,  A61K31/192 ,  A61K31/235 ,  A61K31/351 ,  A61K31/4965 ,  A61K31/7056 ,  A61K31/706 ,  A61K38/21 ,  A61K45/06 ,  C07D487/04 ,  C07H7/06 ,  C07H17/02 ,  A61K2300/00

Abstract: Provided are methods for treating Orthomyxoviridue virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein R2 is halogen. The compounds, compositions, and methods provided are particularly useful for the treatment of Human Influenza virus infections.

Abstract translation: 本发明提供了通过给予式I的核糖苷，核苷磷酸酯及其前体药物治疗正粘病毒病毒感染的方法：其中R2是卤素。 提供的化合物，组合物和方法特别可用于治疗人类流感病毒感染。

公开(公告)号：US08765722B2

公开(公告)日：2014-07-01

申请号：US13927355

申请日：2013-06-26

Applicant: Gilead Sciences, Inc.

Inventor： Aesop Cho ,  Lee S. Chong ,  Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Choung U. Kim ,  Qi Liu ,  William J. Watkins ,  Jennifer R. Zhang

IPC: A61K31/67 ,  A61K31/675 ,  C07F9/6558 ,  C07F9/6553

CPC classification number: C07F9/655345 ,  A61K31/662 ,  A61K31/67 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07F9/65586 ,  C07F9/6561 ,  C07F9/65681

Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

Abstract translation: 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。

公开(公告)号：US20180327437A1

公开(公告)日：2018-11-15

申请号：US16011055

申请日：2018-06-18

Applicant: GILEAD SCIENCES, INC.

Inventor： Thomas Butler ,  Aesop Cho ,  Benjamin R. Graetz ,  Choung U. Kim ,  Samuel E. Metobo ,  Oliver L. Saunders ,  Andrew W. Waltman ,  Jie Xu ,  Lijun Zhang

IPC: C07H1/00 ,  C07H19/23

CPC classification number: C07H1/00 ,  A61K31/7052 ,  A61K31/7056 ,  A61K31/706 ,  C07H19/23

Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.

公开(公告)号：USRE46762E1

公开(公告)日：2018-03-27

申请号：US15288271

申请日：2016-10-07

Applicant: Gilead Sciences, Inc.

Inventor： Thomas Butler ,  Aesop Cho ,  Choung U. Kim ,  Jay P. Parrish ,  Oliver L. Saunders ,  Lijun Zhang

IPC: A01N43/04 ,  A61K31/70 ,  C07H5/04 ,  C07H7/06 ,  C07H19/23 ,  C07D487/04

CPC classification number: C07H19/23 ,  C07D487/04

Abstract: Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

公开(公告)号：US08809266B2

公开(公告)日：2014-08-19

申请号：US13794389

申请日：2013-03-11

Applicant: Gilead Sciences, Inc.

Inventor： Aesop Cho ,  Michael O'Neil Hanrahan Clarke ,  Choung U. Kim ,  John O. Link ,  Hyung-jung Pyun ,  Xiaoning C. Sheng ,  Qiaoyin Wu

IPC: A61K38/00

CPC classification number: C07D417/14 ,  C07D207/16 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/14 ,  C07D487/04 ,  C07K5/0804 ,  C07K5/0808 ,  C07K5/0819 ,  C07K5/0821

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20130274439A1

公开(公告)日：2013-10-17

申请号：US13794389

申请日：2013-03-11

Applicant: Gilead Sciences, Inc.

Inventor： Aesop Cho ,  Michael O'Neil Hanrahan Clarke ,  Choung U. Kim ,  John O. Link ,  Hyung-jung Pyun ,  Xiaoning C. Sheng ,  Qiaoyin Wu

IPC: C07K5/097 ,  C07K5/093

CPC classification number: C07D417/14 ,  C07D207/16 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/14 ,  C07D487/04 ,  C07K5/0804 ,  C07K5/0808 ,  C07K5/0819 ,  C07K5/0821

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US08853171B2

公开(公告)日：2014-10-07

申请号：US13649511

申请日：2012-10-11

Applicant: Gilead Sciences, Inc.

Inventor： Thomas Butler ,  Aesop Cho ,  Choung U. Kim ,  Jay P. Parrish ,  Oliver L. Saunders ,  Lijun Zhang

IPC: A01N43/04 ,  A61K31/70 ,  C07H5/04 ,  C07H7/06 ,  C07H19/23 ,  C07D487/04

CPC classification number: C07H19/23 ,  C07D487/04

Abstract: Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

Abstract translation: 提供吡咯并[1,2-f] [1,2,4]三嗪基，咪唑并[1,5-f] [1,2,4]三嗪基，咪唑并[1,2-f] [1,2,4 ]三嗪基和[1,2,4]三唑并[4,3-f] [1,2,4]三嗪基核苷，其核苷磷酸酯和前药，其中核苷糖的1'位置被取代。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。

公开(公告)号：US08841278B2

公开(公告)日：2014-09-23

申请号：US14045717

申请日：2013-10-03

Applicant: Gilead Sciences, Inc.

Inventor： Elizabeth M. Bacon ,  Eda Canales ,  Aesop Cho ,  Jeromy J. Cottell ,  Manoj C. Desai ,  Michael Graupe ,  Hongyan Guo ,  Randall L. Halcomb ,  Darryl Kato ,  Choung U. Kim ,  Thorsten A. Kirschberg ,  Evan S. Krygowski ,  Scott E. Lazerwith ,  John O. Link ,  Hongtao Liu ,  Qi Liu ,  Richard L. Mackman ,  Michael L. Mitchell ,  Jay P. Parrish ,  Hyung-Jung Pyun ,  Joseph H. Saugier ,  Scott D. Schroeder ,  Jianyu Sun ,  James G. Taylor ,  James D. Trenkle ,  Winston C. Tse ,  Randall W. Vivian ,  William J. Watkins ,  Lianhong Xu

IPC: C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/04 ,  C07D417/14 ,  C07D495/04 ,  A61K31/4178 ,  A61K31/7068 ,  A61K31/7052 ,  A61K31/4184 ,  A61P1/16 ,  A61P31/14

CPC classification number: C07D403/14 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/427 ,  A61K31/435 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5415 ,  A61K31/55 ,  A61K45/06 ,  A61P31/12 ,  C07D207/16 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/04 ,  C07D491/113 ,  C07D495/04 ,  C07F5/025

Abstract: The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：US20130302280A1

公开(公告)日：2013-11-14

申请号：US13927355

申请日：2013-06-26

Applicant: Gilead Sciences, Inc.

Inventor： Aesop Cho ,  Lee S. Chong ,  Michael O'Neil Hanrahan Clarke ,  Edward Doerffler ,  Choung U. Kim ,  Qi Liu ,  William J. Watkins ,  Jennifer R. Zhang

IPC: C07F9/6553 ,  A61K45/06 ,  A61K31/683 ,  A61K31/675 ,  C07F9/6561 ,  C07F9/6568 ,  A61K31/67 ,  C07F9/6558

CPC classification number: C07F9/655345 ,  A61K31/662 ,  A61K31/67 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07F9/65586 ,  C07F9/6561 ,  C07F9/65681

Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

Abstract translation: 提供式I化合物及其药学上可接受的盐和酯。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。