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公开(公告)号：US20240101529A1
公开(公告)日：2024-03-28
申请号：US18319846
申请日：2023-05-18
Applicant: Gilead Sciences, Inc.
Inventor： Aesop Cho , Katherine De La Fuente , Thomas P. Stratton , Peiyuan Wang , William J. Watkins , Jie Xu , Kin S. Yang
IPC: C07D401/10 , C07D403/10 , C07D417/10 , C07D413/10 , C07D405/14 , C07D209/08 , C07D405/06 , A61P31/22
CPC classification number: C07D401/10 , C07D403/10 , C07D417/10 , C07D413/10 , C07D405/14 , C07D209/08 , C07D405/06 , A61P31/22
Abstract: The present disclosure relates to indolinyl compounds. The present disclosure further relates to compounds that inhibit viral helicase-primase. The present disclosure further relates to the use of the compounds for the preparation a medicament for the treatment of diseases and/or condition through inhibiting viral helicase-primase. The present disclosure also relates to use of those compounds in the treatment of viral infections. The present disclosure further relates to intermediates for its preparation and to pharmaceutical compositions containing those compounds.
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公开(公告)号：US20230212155A1
公开(公告)日：2023-07-06
申请号：US18060934
申请日：2022-12-01
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Aesop Cho , Zhimin Du , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Prasenjit Kumar Mukherjee , Devan Naduthambi , Eric Q. Parkhill , Barton W. Phillips , Scott Preston Simonovich , Neil H. Squires , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC: C07D403/14 , A61P31/20 , A61P35/02 , A61K31/496 , C07D519/00 , C07D241/20 , C07D487/10 , C07D405/14 , C07D487/08 , A61K31/497 , C07D491/107 , C07D241/18 , A61P35/00
CPC classification number: C07D403/14 , A61P31/20 , A61P35/02 , A61K31/496 , C07D519/00 , C07D241/20 , C07D487/10 , C07D405/14 , C07D487/08 , A61K31/497 , C07D491/107 , C07D241/18 , A61P35/00 , C07K16/2818
Abstract: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US20230116253A1
公开(公告)日：2023-04-13
申请号：US17844871
申请日：2022-06-21
Applicant: Gilead Sciences, Inc.
Inventor： Julian A. Codelli , Michael Graupe , Juan A. Guerrero , Jesse M. Jacobsen , Tetsuya Kobayashi , Jonathan William Medley , Yasamin Moazami , Leena B. Patel , Jie Xu , Suet C. Yeung
IPC: C07D471/14
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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4.发明授权公开(公告)号：US10988498B2
公开(公告)日：2021-04-27
申请号：US16011055
申请日：2018-06-18
Applicant: GILEAD SCIENCES, INC.
Inventor： Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
IPC: C07H1/00 , C07H19/23 , A61K31/7056 , A61K31/706 , A61K31/7052
Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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公开(公告)号：US20190210978A1
公开(公告)日：2019-07-11
申请号：US16158446
申请日：2018-10-12
Applicant: Gilead Sciences, Inc.
Inventor： Zhenhong R. Cai , Aesop Cho , Ana Zurisadai Gonzalez Buenrostro , Xiaochun Han , Salman Y. Jabri , Ryan McFadden , Yingmei Qi , Johannes Voigt , Hong Yang , Jie Xu , Lianhong Xu
IPC: C07D247/00 , A61P31/18
Abstract: The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herin. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
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Patent Agency Ranking
公开(公告)号：US20240182476A1
公开(公告)日：2024-06-06
申请号：US18450646
申请日：2023-08-16
Applicant: GILEAD SCIENCES, INC. , CARNA BIOSCIENCES, INC.
Inventor： Masaaki Sawa , Mai Arai , Ryoko Nakai , Hirokazu Matsumoto , Catherine Pugh , Eric Hu , Juan Guerrero , Jesse Jacobsen , Jonathan William Medley , Jie Xu , Latesh Lad , Leena Patel , Michael Graupe , Qingming Zhu , Stephen Holmbo , Tetsuya Kobayashi , Will Watkins , Yasamin Moazami , Suet C. Yeung , Julian A. Codelli , Heath A. Weaver
IPC: C07D487/04 , A61K31/395 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/553 , A61K31/695 , A61K31/704 , A61K31/7068 , A61K35/15 , A61K35/17 , A61K39/395 , A61K45/06 , C07D519/00 , C07F7/18
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/553 , A61K31/5545 , A61K31/695 , A61K31/704 , A61K31/7068 , A61K35/15 , A61K35/17 , A61K39/3955 , A61K45/06 , C07D519/00 , C07F7/1804
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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7.发明申请公开(公告)号：US20210403497A1
公开(公告)日：2021-12-30
申请号：US17209639
申请日：2021-03-23
Applicant: Gilead Sciences, Inc.
Inventor： Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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公开(公告)号：US20210024494A1
公开(公告)日：2021-01-28
申请号：US16923750
申请日：2020-07-08
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Aesop Cho , Michael Graupe , Lateshkumar Thakorlal Lad , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Devan Naduthambi , Barton W. Phillips , Scott Preston Simonovich , Peiyuan Wang , William J. Watkins , Jie Xu , Kin Shing Yang , Christopher Allen Ziebenhaus
IPC: C07D401/14 , A61K31/444 , A61K31/497 , A61K31/704 , A61K31/7068 , A61K39/395 , C07D471/08
Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US20200157094A1
公开(公告)日：2020-05-21
申请号：US16660219
申请日：2019-10-22
Applicant: Gilead Sciences, Inc.
Inventor： Zhimin Du , Michael Graupe , Paulo A. Machicao Tello , Jonathan William Medley , Samuel E. Metobo , Eric Q. Parkhill , Barton W. Phillips , Scott P. Simonovich , Peiyuan Wang , Jie Xu , Christopher A. Ziebenhaus
IPC: C07D471/04 , C07D513/04 , C07D401/12 , C07D413/10 , C07D217/04 , C07D401/14 , C07D471/08 , C07D487/04 , C07D495/04
Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
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公开(公告)号：US20240400568A1
公开(公告)日：2024-12-05
申请号：US18645837
申请日：2024-04-25
Applicant: GILEAD SCIENCES, INC. , CARNA BIOSCIENCES, INC.
Inventor： Masaaki Sawa , Mai Arai , Ryoko Nakai , Hirokazu Matsumoto , Catherine Pugh , Eric Hu , Juan Guerrero , Jesse Jacobsen , Jonathan William Medley , Jie Xu , Latesh Lad , Leena Patel , Michael Graupe , Qingming Zhu , Stephen Holmbo , Tetsuya Kobayashi , Will Watkins , Yasamin Moazami , Suet C. Yeung , Julian A. Codelli , Heath A. Weaver
IPC: C07D487/04 , A61K31/395 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/553 , A61K31/695 , A61K31/704 , A61K31/7068 , A61K35/15 , A61K35/17 , A61K39/395 , A61K45/06 , C07D519/00 , C07F7/18
Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
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