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1.
公开(公告)号:US20180327437A1
公开(公告)日:2018-11-15
申请号:US16011055
申请日:2018-06-18
Applicant: GILEAD SCIENCES, INC.
Inventor: Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
CPC classification number: C07H1/00 , A61K31/7052 , A61K31/7056 , A61K31/706 , C07H19/23
Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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公开(公告)号:US20180298011A1
公开(公告)日:2018-10-18
申请号:US15923726
申请日:2018-03-16
Applicant: Gilead Sciences, Inc.
Inventor: Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang
IPC: C07D487/04 , A61K45/06 , C07F9/6561 , C07D519/00 , A61K31/519 , C07D495/04 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , C07D513/04
Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
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公开(公告)号:USRE46762E1
公开(公告)日:2018-03-27
申请号:US15288271
申请日:2016-10-07
Applicant: Gilead Sciences, Inc.
Inventor: Thomas Butler , Aesop Cho , Choung U. Kim , Jay P. Parrish , Oliver L. Saunders , Lijun Zhang
CPC classification number: C07H19/23 , C07D487/04
Abstract: Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
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4.
公开(公告)号:US08809330B2
公开(公告)日:2014-08-19
申请号:US14069685
申请日:2013-11-01
Applicant: Gilead Sciences, Inc.
Inventor: Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang
IPC: A61P31/14
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D495/04 , C07D513/04 , C07D519/00 , C07F9/65616
Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
Abstract translation: 本发明提供了本文所述的式I或式II化合物或其药学上可接受的盐或酯。 其化合物及其组合物可用于治疗肺炎链球菌病毒感染。 提供的化合物,组合物和方法特别可用于治疗人呼吸道合胞病毒感染。
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5.
公开(公告)号:US10988498B2
公开(公告)日:2021-04-27
申请号:US16011055
申请日:2018-06-18
Applicant: GILEAD SCIENCES, INC.
Inventor: Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
IPC: C07H1/00 , C07H19/23 , A61K31/7056 , A61K31/706 , A61K31/7052
Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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公开(公告)号:US20170362244A1
公开(公告)日:2017-12-21
申请号:US15639970
申请日:2017-06-30
Applicant: Gilead Sciences, Inc.
Inventor: Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang
IPC: C07D487/04 , C07D519/00 , C07D513/04 , C07D495/04 , A61K45/06 , A61K31/675 , A61K31/551 , A61K31/55 , A61K31/5377 , C07F9/6561 , A61K31/519
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D495/04 , C07D513/04 , C07D519/00 , C07F9/65616
Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
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7.
公开(公告)号:US20160130275A1
公开(公告)日:2016-05-12
申请号:US14995486
申请日:2016-01-14
Applicant: Gilead Sciences, Inc.
Inventor: Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang
IPC: C07D487/04 , A61K31/5377 , A61K45/06 , A61K31/551 , A61K31/55 , A61K31/519 , C07D519/00
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D495/04 , C07D513/04 , C07D519/00 , C07F9/65616
Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
Abstract translation: 本发明提供了本文所述的式I或式II化合物或其药学上可接受的盐或酯。 其化合物及其组合物可用于治疗肺炎链球菌病毒感染。 提供的化合物,组合物和方法特别可用于治疗人呼吸道合胞病毒感染。
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8.
公开(公告)号:US09238039B2
公开(公告)日:2016-01-19
申请号:US13905410
申请日:2013-05-30
Applicant: Gilead Sciences, Inc.
Inventor: Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang
IPC: C07D487/04 , A61K31/519 , A61K31/55 , A61K31/551 , A61P11/00 , A61K31/675 , A61K45/06 , A61K31/5377 , C07D495/04 , C07D513/04 , C07F9/6561
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D495/04 , C07D513/04 , C07D519/00 , C07F9/65616
Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
Abstract translation: 本发明提供了本文所述的式I或式II化合物或其药学上可接受的盐或酯。 其化合物及其组合物可用于治疗肺炎链球菌病毒感染。 提供的化合物,组合物和方法特别可用于治疗人呼吸道合胞病毒感染。
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公开(公告)号:US20140072554A1
公开(公告)日:2014-03-13
申请号:US14069685
申请日:2013-11-01
Applicant: Gilead Sciences, Inc.
Inventor: Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang
IPC: A61K31/519 , A61K45/06 , C07D487/04
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D495/04 , C07D513/04 , C07D519/00 , C07F9/65616
Abstract: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
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10.
公开(公告)号:US20210403497A1
公开(公告)日:2021-12-30
申请号:US17209639
申请日:2021-03-23
Applicant: Gilead Sciences, Inc.
Inventor: Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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