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    HIV PROTEASE INHIBITORS
    6.
    发明申请
    HIV PROTEASE INHIBITORS 审中-公开

    公开(公告)号：US20200345699A1

    公开(公告)日：2020-11-05

    申请号：US16849747

    申请日：2020-04-15

    Applicant: Gilead Sciences, Inc.

    Inventor： Aesop Cho ,  John O. Link ,  Jie Xu

    IPC: A61K31/4196 ,  A61K45/06 ,  C07D403/10 ,  C07D403/14 ,  A61P31/18 ,  A61K31/7076 ,  A61K31/537 ,  A61K31/52 ,  A61K31/675

    Abstract: The present disclosure provides compounds, or a pharmaceutically acceptable salt thereof as described herein, useful for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject. The disclosure also provides pharmaceutical compositions comprising these compounds, processes for preparing them, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject using these compounds. The present disclosure also provides compounds, or a pharmaceutically acceptable salt thereof as described herein, useful for treating the proliferation of a coronavirus, treating coronavirus symptoms or delaying the onset of coronavirus symptoms in a subject. The disclosure also provides pharmaceutical compositions comprising these compounds, processes for preparing them, therapeutic methods for treating the proliferation of a coronavirus, treating coronavirus symptoms or delaying the onset of coronavirus symptoms in a subject using these compounds.

    1′-substituted carba-nucleoside analogs for antiviral treatment
    10.
    发明授权
    1′-substituted carba-nucleoside analogs for antiviral treatment 有权
    1'-取代的碳 - 核苷类似物用于抗病毒治疗

    公开(公告)号：US08853171B2

    公开(公告)日：2014-10-07

    申请号：US13649511

    申请日：2012-10-11

    Applicant: Gilead Sciences, Inc.

    Inventor： Thomas Butler ,  Aesop Cho ,  Choung U. Kim ,  Jay P. Parrish ,  Oliver L. Saunders ,  Lijun Zhang

    IPC: A01N43/04 ,  A61K31/70 ,  C07H5/04 ,  C07H7/06 ,  C07H19/23 ,  C07D487/04

    CPC classification number: C07H19/23 ,  C07D487/04

    Abstract: Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.

    Abstract translation: 提供吡咯并[1,2-f] [1,2,4]三嗪基，咪唑并[1,5-f] [1,2,4]三嗪基，咪唑并[1,2-f] [1,2,4 ]三嗪基和[1,2,4]三唑并[4,3-f] [1,2,4]三嗪基核苷，其核苷磷酸酯和前药，其中核苷糖的1'位置被取代。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。

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