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1.发明申请公开(公告)号：US20180327437A1
公开(公告)日：2018-11-15
申请号：US16011055
申请日：2018-06-18
Applicant: GILEAD SCIENCES, INC.
Inventor： Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
CPC classification number: C07H1/00 , A61K31/7052 , A61K31/7056 , A61K31/706 , C07H19/23
Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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2.发明授权公开(公告)号：US10988498B2
公开(公告)日：2021-04-27
申请号：US16011055
申请日：2018-06-18
Applicant: GILEAD SCIENCES, INC.
Inventor： Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
IPC: C07H1/00 , C07H19/23 , A61K31/7056 , A61K31/706 , A61K31/7052
Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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公开(公告)号：US20180079773A1
公开(公告)日：2018-03-22
申请号：US15697136
申请日：2017-09-06
Applicant: Gilead Sciences, Inc.
Inventor： Richard Hung Chiu Yu , Brandon Heath Brown , Richard P. Polniaszek , Benjamin R. Graetz , Keiko Sujino , Duong Tran , Alan Scott Triman , Kenneth M. Kent , Steven Pfeiffer
IPC: C07H19/20 , C07H19/173 , C07F9/6561 , C07H23/00 , C07F9/40 , C07D473/34 , C07F9/44 , C07H19/16 , C07H19/04 , C07H19/02
CPC classification number: C07H19/20 , A61K31/66 , C07D473/34 , C07F9/4075 , C07F9/4449 , C07F9/65616 , C07H19/02 , C07H19/04 , C07H19/16 , C07H19/173 , C07H23/00
Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
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公开(公告)号：US20160355543A1
公开(公告)日：2016-12-08
申请号：US15170728
申请日：2016-06-01
Applicant: Gilead Sciences, Inc.
Inventor： Benjamin R. Graetz , Richard Polniaszek
IPC: C07H19/20 , A61K45/06 , A61K9/20 , A61K31/7076
CPC classification number: C07H19/20 , A61K9/20 , A61K9/2018 , A61K31/675 , A61K31/7076 , A61K45/06 , A61K2300/00
Abstract: The invention is related to salts of anti-viral compounds, compositions containing such salts, and therapeutic methods that include the administration of such salts, as well as to process and intermediates useful for preparing such salts.
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公开(公告)号：US09296779B2
公开(公告)日：2016-03-29
申请号：US14615357
申请日：2015-02-05
Applicant: Gilead Sciences, Inc.
Inventor： Richard Hung Chiu Yu , Brandon Heath Brown , Richard P. Polniaszek , Benjamin R. Graetz , Keiko Sujino , Duong Duc-Phi Tran , Alan Scott Triman , Kenneth M. Kent , Steven Pfeiffer
IPC: C07H19/00 , C07H19/22 , C07H23/00 , C07H19/02 , C07H19/04 , C07H19/173 , C07D473/34 , C07F9/40 , C07F9/44 , C07F9/6561 , C07H19/20 , C07H19/16
CPC classification number: C07H19/20 , C07D473/34 , C07F9/4075 , C07F9/4449 , C07F9/65616 , C07H19/02 , C07H19/04 , C07H19/16 , C07H19/173 , C07H23/00
Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
Abstract translation: 本发明提供可用于制备具有有效抗HIV特性的化合物的合成方法和合成中间体。
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Patent Agency Ranking
公开(公告)号：US20180079772A1
公开(公告)日：2018-03-22
申请号：US15697075
申请日：2017-09-06
Applicant: Gilead Sciences, Inc.
Inventor： Benjamin R. Graetz , Richard P. Polniaszek
IPC: C07H19/20 , A61K31/7076 , A61K45/06 , A61K9/20
CPC classification number: C07H19/20 , A61K9/20 , A61K9/2018 , A61K31/675 , A61K31/7076 , A61K45/06 , A61K2300/00
Abstract: The invention is related to salts of anti-viral compounds, compositions containing such salts, and therapeutic methods that include the administration of such salts, as well as to process and intermediates useful for preparing such salts.
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公开(公告)号：US09783568B2
公开(公告)日：2017-10-10
申请号：US15170728
申请日：2016-06-01
Applicant: Gilead Sciences, Inc.
Inventor： Benjamin R. Graetz , Richard Polniaszek
IPC: A61K31/7076 , A61K45/06 , C07H19/20 , A61K9/20
CPC classification number: C07H19/20 , A61K9/20 , A61K9/2018 , A61K31/675 , A61K31/7076 , A61K45/06 , A61K2300/00
Abstract: The invention is related to salts of anti-viral compounds, compositions containing such salts, and therapeutic methods that include the administration of such salts, as well as to process and intermediates useful for preparing such salts.
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公开(公告)号：US08951986B2
公开(公告)日：2015-02-10
申请号：US14150677
申请日：2014-01-08
Applicant: Gilead Sciences, Inc.
Inventor： Benjamin R. Graetz , Richard Polniaszek
IPC: A61K31/70 , C07H19/04 , C07H19/20 , C07C59/265 , C07C55/00 , A61K31/7076 , A61K45/06
CPC classification number: C07H19/20 , A61K9/20 , A61K9/2018 , A61K31/675 , A61K31/7076 , A61K45/06 , A61K2300/00
Abstract: The invention is related to salts of anti-viral compounds, compositions containing such salts, and therapeutic methods that include the administration of such salts, as well as to processes and intermediates useful for preparing such salts.
Abstract translation: 本发明涉及抗病毒化合物的盐，含有这些盐的组合物，以及包括施用这些盐的治疗方法，以及可用于制备这些盐的方法和中间体。
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9.发明申请公开(公告)号：US20210403497A1
公开(公告)日：2021-12-30
申请号：US17209639
申请日：2021-03-23
Applicant: Gilead Sciences, Inc.
Inventor： Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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公开(公告)号：US10196419B2
公开(公告)日：2019-02-05
申请号：US15697136
申请日：2017-09-06
Applicant: Gilead Sciences, Inc.
Inventor： Richard Hung Chiu Yu , Brandon Heath Brown , Richard P. Polniaszek , Benjamin R. Graetz , Keiko Sujino , Duong Tran , Alan Scott Triman , Kenneth M. Kent , Steven Pfeiffer
IPC: C07H21/00 , C07H19/20 , C07H19/02 , C07H19/04 , C07H19/173 , C07D473/34 , C07F9/40 , C07F9/44 , C07F9/6561 , C07H19/16 , C07H23/00 , A61K31/66
Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare compounds having useful anti-HIV properties.
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