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公开(公告)号：US08853171B2
公开(公告)日：2014-10-07
申请号：US13649511
申请日：2012-10-11
Applicant: Gilead Sciences, Inc.
Inventor： Thomas Butler , Aesop Cho , Choung U. Kim , Jay P. Parrish , Oliver L. Saunders , Lijun Zhang
CPC classification number: C07H19/23 , C07D487/04
Abstract: Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
Abstract translation: 提供吡咯并[1,2-f] [1,2,4]三嗪基，咪唑并[1,5-f] [1,2,4]三嗪基，咪唑并[1,2-f] [1,2,4 ]三嗪基和[1,2,4]三唑并[4,3-f] [1,2,4]三嗪基核苷，其核苷磷酸酯和前药，其中核苷糖的1'位置被取代。 所提供的化合物，组合物和方法可用于治疗黄病毒科感染，特别是丙型肝炎感染。
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公开(公告)号：US20230295201A1
公开(公告)日：2023-09-21
申请号：US18171950
申请日：2023-02-21
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Gregory F. Chin , Byoung-kwon Chun , Michael O. Clarke , Bindu Goyal , Hon C. Hui , Petr Jansa , Richard L. Mackman , Michael R. Mish , Dustin S. Siegel , David Sperandio , Hai Yang , Lijun Zhang
IPC: C07F9/6561 , A61K31/706
CPC classification number: C07F9/6561 , A61K31/706
Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.
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3.发明申请公开(公告)号：US20210403497A1
公开(公告)日：2021-12-30
申请号：US17209639
申请日：2021-03-23
Applicant: Gilead Sciences, Inc.
Inventor： Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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公开(公告)号：US20180086784A1
公开(公告)日：2018-03-29
申请号：US15643168
申请日：2017-07-06
Applicant: Gilead Sciences, Inc.
Inventor： Constantine G. Boojamra , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Oleg V. Petrakovsky , Adrian S. Ray , Lijun Zhang
IPC: C07H19/16
Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US09579332B2
公开(公告)日：2017-02-28
申请号：US13653982
申请日：2012-10-17
Applicant: Gilead Sciences, Inc.
Inventor： Constantine G. Boojamra , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Oleg V. Petrakovsky , Adrian S. Ray , Lijun Zhang
IPC: C07F9/02 , A61K31/675 , A61K31/662 , C07F9/6561 , C07H19/00 , A61K45/06 , C07H19/20
CPC classification number: C07H19/16 , A61K31/341 , A61K31/513 , A61K31/662 , A61K31/675 , A61K31/683 , A61K45/06 , C07F9/65616 , C07H19/00 , C07H19/20 , A61K2300/00
Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Abstract translation: 本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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Patent Agency Ranking
公开(公告)号：US08697861B2
公开(公告)日：2014-04-15
申请号：US13626687
申请日：2012-09-25
Applicant: Gilead Sciences, Inc.
Inventor： Constantine G. Boojamra , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Oleg V. Petrakovsky , Adrian S. Ray , Lijun Zhang
CPC classification number: C07H19/16 , A61K31/341 , A61K31/513 , A61K31/662 , A61K31/675 , A61K31/683 , A61K45/06 , C07F9/65616 , C07H19/00 , C07H19/20 , A61K2300/00
Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Abstract translation: 本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。
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公开(公告)号：US20220356196A1
公开(公告)日：2022-11-10
申请号：US17176497
申请日：2021-02-16
Applicant: Gilead Sciences, Inc.
Inventor： Daniel H. Byun , Gregory F. Chin , Byoung-kwon Chun , Michael O. Clarke , Bindu Goyal , Hon C. Hui , Petr Jansa , Richard L. Mackman , Michael R. Mish , Dustin S. Siegel , David Sperandio , Hai Yang , Lijun Zhang
IPC: C07F9/6561
Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.
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8.发明授权公开(公告)号：US10988498B2
公开(公告)日：2021-04-27
申请号：US16011055
申请日：2018-06-18
Applicant: GILEAD SCIENCES, INC.
Inventor： Thomas Butler , Aesop Cho , Benjamin R. Graetz , Choung U. Kim , Samuel E. Metobo , Oliver L. Saunders , Andrew W. Waltman , Jie Xu , Lijun Zhang
IPC: C07H1/00 , C07H19/23 , A61K31/7056 , A61K31/706 , A61K31/7052
Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.
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公开(公告)号：US20170088576A1
公开(公告)日：2017-03-30
申请号：US15254684
申请日：2016-09-01
Applicant: Gilead Sciences, Inc.
Inventor： Constantine G. Boojamra , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Oleg V. Petrakovsky , Adrian S. Ray , Lijun Zhang
IPC: C07H19/16
Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：US20190315785A1
公开(公告)日：2019-10-17
申请号：US16195152
申请日：2018-11-19
Applicant: Gilead Sciences, Inc.
Inventor： Constantine G. Boojamra , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Oleg V. Petrakovsky , Adrian S. Ray , Lijun Zhang
IPC: C07F9/6561
Abstract: The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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