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    LUMINAL ADMINISTRATION OF TAG MOLECULES FOR DIAGNOSTIC APPLICATIONS
    2.
    发明申请
    LUMINAL ADMINISTRATION OF TAG MOLECULES FOR DIAGNOSTIC APPLICATIONS 审中-公开
    用于诊断应用的标签分子的LUMINAL ADMINISTRATION

    公开(公告)号：US20150223675A1

    公开(公告)日：2015-08-13

    申请号：US14425062

    申请日：2013-09-03

    Applicant: GIVEN IMAGING LTD.

    Inventor： Osnat Sella-Tavor ,  Elisha Rabinovitz

    IPC: A61B1/04 ,  A61M31/00 ,  A61K49/00 ,  A61B1/31 ,  A61B1/00 ,  A61B5/00 ,  A61B1/273

    CPC classification number: A61B1/043 ,  A61B1/00009 ,  A61B1/041 ,  A61B1/2736 ,  A61B1/31 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/4238 ,  A61B5/4255 ,  A61B5/7282 ,  A61K49/0034 ,  A61K49/0039 ,  A61K49/0041 ,  A61M31/005

    Abstract: Methods of tagging cancerous tissue for diagnostic applications, mainly for cancer screening purposes, include oral or luminal administrating of a tag molecule into a patient's gastrointestinal lumen either orally or through an enema, and tagging cancerous tissue present within the lumen with the tag molecule. The tag molecule may be a near infrared dye, e.g., IR783 or a derivative thereof, which showed to be of high concentration within cancerous tissue compared to normal tissue. The near infrared IR783 dye is administered, either orally or through an enema, as part of a pharmaceutical composition or formulation either as is or conjugated to a specific polymer. The formulation may comprise an enteric coating in order to keep the formulation intact prior to it reaching the target organ, which is to be tagged by the formulation.

    Abstract translation: 标记用于诊断应用的癌组织的方法，主要用于癌症筛查目的，包括口服或管腔将标签分子口服或通过灌肠剂施用到患者的胃肠腔内，并用标签分子标记存在于内腔内的癌组织。 标签分子可以是与正常组织相比在癌组织中显示出高浓度的近红外染料，例如IR783或其衍生物。 通过口服或通过灌肠剂将近红外IR783染料作为药物组合物或制剂的一部分施用，或者与特定聚合物一样或缀合。 制剂可以包含肠溶衣，以便在制剂到达待配制物标记的靶器官之前保持制剂完整。

    Devices, systems and methods for in-vivo immunoassay
    3.
    发明授权
    Devices, systems and methods for in-vivo immunoassay 有权

    公开(公告)号：US10827953B2

    公开(公告)日：2020-11-10

    申请号：US15578505

    申请日：2016-06-02

    Applicant: GIVEN IMAGING LTD.

    Inventor： Elisha Rabinovitz ,  Osnat Sella-Tavor ,  Amit Pascal

    IPC: A61B5/1455 ,  A61B5/07 ,  A61B5/00 ,  A61B5/145 ,  G01N33/558 ,  A61B5/01 ,  A61B5/05 ,  A61B5/1486

    Abstract: A swallowable in-vivo device comprising a shell formed with at least one inlet extending across a shell wall and configured for allowing ingress of fluid at least into the shell; the shell accommodates therein a lateral flow (LF) arrangement configured for absorbing the fluid; the LF arrangement comprises a test zone configured for coming into contact, in-vivo, with a predetermined N substance present in the fluid or a compound comprising the substance, thereby causing a change in at least one property of the test zone; the shell further accommodates a sensor configured for sensing, in-vivo, the at least one property, at least when changed by interaction with the fluid; the LF arrangement has at least one curved segment, and at least one exposure portion juxtaposed with the inlet, configured for absorbing the fluid passing through the inlet into the shell.

    System and method for automatic navigation of a capsule based on image stream captured in-vivo
    5.
    发明授权
    System and method for automatic navigation of a capsule based on image stream captured in-vivo 有权
    基于在体内捕获的图像流自动导航胶囊的系统和方法

    公开(公告)号：US09545192B2

    公开(公告)日：2017-01-17

    申请号：US14398853

    申请日：2013-05-02

    Applicant: GIVEN IMAGING LTD.

    Inventor： Ori Braun ,  Yaniv Ben Zriham ,  Elisha Rabinovitz ,  Tomer Carmeli ,  Jeremy Pinchas Gerber

    IPC: H04N5/225 ,  A61B1/04 ,  A61B5/00 ,  A61B1/00 ,  A61B5/07 ,  H04N7/18 ,  H04N9/04

    CPC classification number: A61B1/041 ,  A61B1/00016 ,  A61B1/0005 ,  A61B1/00158 ,  A61B5/073 ,  A61B5/6861 ,  G06K2209/057 ,  H04N7/183 ,  H04N9/045 ,  H04N2005/2255

    Abstract: Embodiments of the invention include a method and system for displaying an in vivo imaging procedure. The method includes receiving real-time image data captured by the capsule, and continuously generating an updated summarized color bar, said color bar comprising color strips and time scale marks. The color bar is calculated based on color values of received image data, and is updated continuously as new image data is received. The displayed time period is periodically updated, for example based on predetermined fixed time intervals, based on varying time intervals, or based on an accumulated amount of received image data. Other methods of determining the periodic updates may be used.

    Abstract translation: 本发明的实施例包括用于显示体内成像过程的方法和系统。 所述方法包括接收由胶囊捕获的实时图像数据，并且连续生成更新的汇总色条，所述彩条包括彩条和时标。 彩色条是根据接收到的图像数据的颜色值计算的，并且随着接收到新的图像数据而连续更新。 基于变化的时间间隔，或者基于所接收的图像数据的累积量，例如基于预定的固定时间间隔周期性地更新显示的时间段。 可以使用确定周期性更新的其他方法。

    CRYOTHERAPY SPRAY DEVICE
    7.
    发明申请
    CRYOTHERAPY SPRAY DEVICE 审中-公开
    CRYOTHERAPY喷雾装置

    公开(公告)号：US20160287309A1

    公开(公告)日：2016-10-06

    申请号：US15183601

    申请日：2016-06-15

    Applicant: GIVEN IMAGING LTD.

    Inventor： Ori BRAUN ,  Gavriel J. Iddan ,  Eyal Kochavi ,  Elisha Rabinovitz ,  Zvika Gilad

    IPC: A61B18/02 ,  A61B1/273 ,  A61B1/018

    CPC classification number: A61B18/0218 ,  A61B1/00082 ,  A61B1/00087 ,  A61B1/00091 ,  A61B1/00094 ,  A61B1/015 ,  A61B1/018 ,  A61B1/2736 ,  A61B18/02 ,  A61B2018/0022 ,  A61B2018/00238 ,  A61B2018/00482 ,  A61B2018/00577 ,  A61B2018/00982 ,  A61B2018/0212

    Abstract: A device for cryotherapy treatment of gastrointestinal lesions includes a cooling member that may be attached to a first tube for pressurizing cryogenic fluid through the tube and into the cooling member through nozzles located at the distal end of the first tube. A second tube may be attached to the cooling member for evacuating the cryogenic fluid from within the cooling member, following the fluid's expansion once it exits the first tube. The cryotherapy device may be attached to an endoscope such that the first tube may be passed through the endoscope's working channel, while the second tube may be passed along the endoscope's circumference. The cryotherapy device may further comprise securing means attached to the first tube, for securing the first tube to the endoscope's working channel, thus preventing free rotation of the cryotherapy device within the endoscope, relative to the rotation of the endoscope. In addition, the securing means assist in maintaining a constant and known location of the nozzles relative to the distal end of the endo scope.

    Abstract translation: 用于冷冻治疗胃肠损伤的装置包括冷却构件，该冷却构件可以附接到第一管，用于通过管加压低温流体并通过位于第一管的远端的喷嘴进入冷却构件。 第二管可以附接到冷却构件，用于从冷却构件内部排出低温流体，一旦其离开第一管，流体膨胀。 冷冻治疗装置可以附接到内窥镜，使得第一管可以通过内窥镜的工作通道，而第二管可以沿着内窥镜的圆周通过。 冷冻治疗装置还可以包括附接到第一管的固定装置，用于将第一管固定到内窥镜的工作通道，从而防止冷冻治疗装置相对于内窥镜的旋转在内窥镜内的自由旋转。 此外，固定装置有助于保持喷嘴相对于内窥镜远端的恒定且已知的位置。

    METHOD FOR DETECTING COLORECTAL CANCER
    8.
    发明申请
    METHOD FOR DETECTING COLORECTAL CANCER 审中-公开
    检测彩色癌的方法

    公开(公告)号：US20150148626A1

    公开(公告)日：2015-05-28

    申请号：US14416064

    申请日：2013-07-23

    Applicant: GIVEN IMAGING LTD.

    Inventor： Osnat Sella-Tavor ,  Elisha Rabinovitz

    IPC: A61B5/1459 ,  A61B5/00 ,  A61B5/145

    CPC classification number: A61B5/1459 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/073 ,  A61B5/14507 ,  A61B5/42 ,  A61B5/4848 ,  A61K38/00 ,  C12Q1/6886

    Abstract: In-vivo methods and kits for detecting presence of a combination of biomarkers indicating colorectal cancer are described. One of the methods includes inserting into a patient a combination of binding agents comprising one binding agent having high affinity to CEACAM5 and at least one binding agent having high affinity to at least one of two biomarkers selected from Olfactomedin 4- (OLFM4) and S100P. The method further includes inserting into the patient an in-vivo sensing device, detecting an optical change using the in-vivo sensing device, which occurs when at least one of the combination of binding agents binds to at least one of the corresponding combination of biomarkers, and determining, based on the optical change, presence of colorectal cancer in the patient.

    Abstract translation: 描述了用于检测指示结肠直肠癌的生物标志物的组合的存在的体内方法和试剂盒。 方法之一包括将包含与CEACAM5具有高亲和力的一种结合剂和至少一种与至少一种选自Olfactomedin 4-（OLFM4）和S100P）的生物标志物的亲和力的结合剂结合在一起的患者。 该方法还包括向患者插入体内感测装置，使用体内感测装置检测光学变化，当粘合剂的组合中的至少一种与至少一个生物标志物的组合结合时发生 ，并且基于光学变化确定患者中结肠直肠癌的存在。

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