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    "> HIGH-DENSITY LIPOPROTEIN-LIKE PEPTIDE-PHOSPHOLIPID SCAFFOLD (
    1.
    发明申请
    HIGH-DENSITY LIPOPROTEIN-LIKE PEPTIDE-PHOSPHOLIPID SCAFFOLD ("HPPS") NANOPARTICLES 审中-公开
    高密度脂蛋白样肽 - 磷脂酰胆碱（“HPPS”）纳米颗粒

    公开(公告)号：US20110020242A1

    公开(公告)日：2011-01-27

    申请号：US12747815

    申请日：2008-12-12

    申请人： Gang Zheng ,  Zhihong Zhang ,  Ian Corbin ,  Juan Chen

    发明人： Gang Zheng ,  Zhihong Zhang ,  Ian Corbin ,  Juan Chen

    IPC分类号： A61K49/14 ,  C07K17/02 ,  A61K49/00 ,  A61K9/14 ,  A61P35/00

    CPC分类号： A61K49/0082 ,  A61K47/6917 ,  A61K47/6919 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/0056 ,  B82Y5/00 ,  G01N33/54346 ,  G01N33/587 ,  G01N2800/00

    摘要： The present invention provides a non-naturally occurring High-Density Lipoprotein-like peptide-phospholipid scaffold (“HPPS”) nanoparticle. More particularly, the invention provides a non-naturally occurring peptide-lipid nanoscaffold comprising: (a) at least one phospholipid; (b) at least one unsaturated lipid, preferably an unsaturated sterol ester, further preferably an unsaturated cholesterol ester, further preferably cholsteryl oleate; and (c) at least one peptide, the peptide comprising an amino acid sequence capable of forming at least one amphipathic a-helix; wherein the components a), b) and c) associate to form the peptide-phospholipid nanoscaffold. In embodiments of the present invention, a cell surface receptor ligand is incorporated into the HPPS. In one embodiment, the cell surface receptor ligand is covalently bonded to the peptide scaffold of the HPPS nanoparticles. In other embodiments, a cell surface receptor ligand is coupled to a lipid anchor and is displayed on the surface of the HPPS nanoparticles by incorporation of the lipid anchor into the phospholipids monolayer of the HPPS nanoparticle. The present invention also provides pharmaceutical formulations comprising HPPS nanoparticles and methods of making the HPPS nanoparticles.

    摘要翻译： 本发明提供非天然存在的高密度脂蛋白样肽 - 磷脂支架（“HPPS”）纳米颗粒。 更具体地，本发明提供非天然存在的肽 - 脂质纳米支架，其包含：（a）至少一种磷脂; （b）至少一种不饱和脂质，优选不饱和甾醇酯，更优选不饱和胆固醇酯，更优选油酸胆甾醇酯; 和（c）至少一种肽，所述肽包含能够形成至少一种两亲性α-螺旋的氨基酸序列; 其中组分a），b）和c）缔合形成肽 - 磷脂纳米支架。 在本发明的实施方案中，将细胞表面受体配体掺入HPPS中。 在一个实施方案中，细胞表面受体配体共价键合到HPPS纳米颗粒的肽支架上。 在其它实施方案中，将细胞表面受体配体偶联到脂质锚定物上，并通过将脂质锚点掺入HPPS纳米颗粒的磷脂单层中而显示在HPPS纳米颗粒的表面上。 本发明还提供了包含HPPS纳米颗粒的药物制剂和制备HPPS纳米颗粒的方法。

    Antineoplastic agents targeted via glut transporters
    4.
    发明授权
    Antineoplastic agents targeted via glut transporters 有权
    通过谷氨酸转运蛋白靶向的抗肿瘤剂

    公开(公告)号：US07943586B2

    公开(公告)日：2011-05-17

    申请号：US10560075

    申请日：2004-06-09

    申请人： Gang Zheng ,  Jerry D. Glickson ,  Britton Chance

    发明人： Gang Zheng ,  Jerry D. Glickson ,  Britton Chance

    IPC分类号： C07G3/00 ,  C07G11/00 ,  C07H15/00 ,  C07H17/00 ,  C07H5/06 ,  A01N43/04 ,  A61K31/70

    CPC分类号： A61K41/0071 ,  A61K41/0057 ,  A61K47/549 ,  A61K49/0036 ,  A61K49/0052 ,  C07H17/04

    摘要： The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neo-plastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker is attached to a therapeutic or diagnostic agent. The invention also relates to methods of treating tumor disease and methods of making the novel compounds of the present invention. The agents of the present invention are superior to previous agents as they are targeted via GLUT transporters.

    摘要翻译： 本发明涉及通过GLUT运输系统特异性靶向新塑料细胞的新型抗肿瘤剂和癌症诊断剂。 更具体地，本发明涉及2-脱氧葡萄糖的缀合物，其中包含共价键的接头在2位连接于2-脱氧葡萄糖，并且接头连接到治疗剂或诊断剂。 本发明还涉及治疗肿瘤疾病的方法和制备本发明新化合物的方法。 本发明的药剂优于先前的药剂，因为它们通过GLUT转运蛋白靶向。

    Passive Optical Network System and Method for Protecting the Services of the Same
    5.
    发明申请
    Passive Optical Network System and Method for Protecting the Services of the Same 有权
    被动光网络系统及其保护方法

    公开(公告)号：US20070217788A1

    公开(公告)日：2007-09-20

    申请号：US11611382

    申请日：2006-12-15

    申请人： Hai Gao ,  Gang Zheng

    发明人： Hai Gao ,  Gang Zheng

    IPC分类号： H04B10/00

    CPC分类号： H04Q11/0067 ,  H04J3/14 ,  H04J3/1694 ,  H04Q2011/0081

    摘要： The present disclosure provides a passive optical network (PON) system and a method for protecting the service of the system for service recovery and fault locating in case of a failure of the network, wherein the PON system comprises an optical line terminal (OLT), an optical distribution network (ODN) and an optical network terminal (ONT) equipment protection group comprising a plurality of ONT equipment groups, each of which is connected to at least one of other ONT equipment groups within the ONT equipment protection group for the mutual protection relationship. The PON system of the present disclosure does not require equipment and link redundancy for backup, contributes to reduced cost and improved utilization of resources, and provides a means for diagnosing any faults of the links and equipment in the network.

    摘要翻译： 本公开提供了一种无源光网络（PON）系统和一种在网络故障的情况下保护用于服务恢复和故障定位的系统的服务的方法，其中PON系统包括光线路终端（OLT）， 光分配网络（ODN）和包括多个ONT设备组的光网络终端（ONT）设备保护组，每个ONT设备组连接到ONT设备保护组内的其他ONT设备组中的至少一个，用于相互保护 关系。 本公开的PON系统不需要用于备份的设备和链路冗余，有助于降低成本并提高资源的利用率，并且提供用于诊断网络中的链路和设备的任何故障的手段。

    Machine-to-machine platform service processing method and machine-to-machine platform
    6.
    发明授权
    Machine-to-machine platform service processing method and machine-to-machine platform 有权
    机对机平台服务处理方法和机对机平台

    公开(公告)号：US08839022B2

    公开(公告)日：2014-09-16

    申请号：US13574771

    申请日：2011-03-17

    申请人： Yue He ,  Gang Zheng ,  Changjun Zhao ,  Liang Meng

    发明人： Yue He ,  Gang Zheng ,  Changjun Zhao ,  Liang Meng

    IPC分类号： G06F11/00 ,  H04W4/00

    CPC分类号： H04W4/005 ,  H04W4/70

    摘要： A method for processing Machine-to-Machine (M2M) platform services and a M2M platform are disclosed. The method comprises: receiving a service request sent by a terminal; selecting a corresponding application according to capacity required by the service request; and forwarding the service request to the corresponding application, and feeding back a response result of the application to the terminal. The method for processing M2M platform services and the M2M platform in accordance with the present implement a platform for providing a variety applications for users.

    摘要翻译： 公开了一种用于处理机器对机器（M2M）平台服务和M2M平台的方法。 该方法包括：接收终端发送的服务请求; 根据服务请求所需的容量选择相应的应用; 并将所述服务请求转发到相应的应用，并将所述应用的响应结果反馈给所述终端。 M2M平台服务处理方法和M2M平台按照现在实现为用户提供各种应用的平台。

    Passive optical network system and method for protecting the services of the same
    7.
    发明授权
    Passive optical network system and method for protecting the services of the same 有权
    被动光网络系统及其保护方法

    公开(公告)号：US07831145B2

    公开(公告)日：2010-11-09

    申请号：US11611382

    申请日：2006-12-15

    申请人： Hai Gao ,  Gang Zheng

    发明人： Hai Gao ,  Gang Zheng

    IPC分类号： G02F1/00

    CPC分类号： H04Q11/0067 ,  H04J3/14 ,  H04J3/1694 ,  H04Q2011/0081

    摘要： The present disclosure provides a passive optical network (PON) system and a method for protecting the service of the system for service recovery and fault locating in case of a failure of the network, wherein the PON system comprises an optical line terminal (OLT), an optical distribution network (ODN) and an optical network terminal (ONT) equipment protection group comprising a plurality of ONT equipment groups, each of which is connected to at least one of other ONT equipment groups within the ONT equipment protection group for the mutual protection relationship. The PON system of the present disclosure does not require equipment and link redundancy for backup, contributes to reduced cost and improved utilization of resources, and provides a means for diagnosing any faults of the links and equipment in the network.

    摘要翻译： 本公开提供了一种无源光网络（PON）系统和一种在网络故障的情况下保护用于服务恢复和故障定位的系统的服务的方法，其中PON系统包括光线路终端（OLT）， 光分配网络（ODN）和包括多个ONT设备组的光网络终端（ONT）设备保护组，每个ONT设备组连接到ONT设备保护组内的其他ONT设备组中的至少一个，用于相互保护 关系。 本公开的PON系统不需要用于备份的设备和链路冗余，有助于降低成本并提高资源的利用率，并且提供用于诊断网络中的链路和设备的任何故障的手段。

    MACHINE-TO-MACHINE PLATFORM SERVICE PROCESSING METHOD AND MACHINE-TO-MACHINE PLATFORM
    9.
    发明申请
    MACHINE-TO-MACHINE PLATFORM SERVICE PROCESSING METHOD AND MACHINE-TO-MACHINE PLATFORM 有权
    机器到机器平台服务处理方法和机器到机器平台

    公开(公告)号：US20120290872A1

    公开(公告)日：2012-11-15

    申请号：US13574771

    申请日：2011-03-17

    申请人： Yue He ,  Gang Zheng ,  Changjun Zhao ,  Liang Meng

    发明人： Yue He ,  Gang Zheng ,  Changjun Zhao ,  Liang Meng

    IPC分类号： G06F15/16 ,  G06F11/20

    CPC分类号： H04W4/005 ,  H04W4/70

    摘要： A method for processing Machine-to-Machine (M2M) platform services and a M2M platform are disclosed. The method comprises: receiving a service request sent by a terminal; selecting a corresponding application according to capacity required by the service request; and forwarding the service request to the corresponding application, and feeding back a response result of the application to the terminal. The method for processing M2M platform services and the M2M platform in accordance with the present implement a platform for providing a variety applications for users.

    摘要翻译： 公开了一种用于处理机器对机器（M2M）平台服务和M2M平台的方法。 该方法包括：接收终端发送的服务请求; 根据服务请求所需的容量选择相应的应用; 并将所述服务请求转发到相应的应用，并将所述应用的响应结果反馈给所述终端。 M2M平台服务处理方法和M2M平台按照现在实现为用户提供各种应用的平台。

    Antineoplastic Agents Targeted via Glut Transporters
    10.
    发明申请
    Antineoplastic Agents Targeted via Glut Transporters 审中-公开
    通过谷物转运蛋白靶向的抗肿瘤药物

    公开(公告)号：US20080269112A1

    公开(公告)日：2008-10-30

    申请号：US12027014

    申请日：2008-02-06

    申请人： Gang Zheng ,  Jerry D. Glickson ,  Britton Chance

    发明人： Gang Zheng ,  Jerry D. Glickson ,  Britton Chance

    IPC分类号： A61K38/16

    CPC分类号： A61K41/0071 ,  A61K41/0057 ,  A61K47/549 ,  A61K49/0036 ,  A61K49/0052 ,  C07H17/04

    摘要： The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neoplastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker is attached to a therapeutic or diagnostic agent. The inventions also relates to methods of treating tumor disease and methods of making the novel compounds of the present invention. The agents of the present invention are superior to previous agents as they are targeted via GLUT transporters.

    摘要翻译： 本发明涉及通过GLUT运输系统特异性靶向肿瘤细胞的新型抗肿瘤剂和癌症诊断剂。 更具体地，本发明涉及2-脱氧葡萄糖的缀合物，其中包含共价键的接头在2位连接于2-脱氧葡萄糖，并且接头连接到治疗剂或诊断剂。 本发明还涉及治疗肿瘤疾病的方法和制备本发明新化合物的方法。 本发明的药剂优于先前的药剂，因为它们通过GLUT转运蛋白靶向。