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公开(公告)号：US20240150774A1
公开(公告)日：2024-05-09
申请号：US18344219
申请日：2023-06-29
Applicant: Genomatica, Inc.
Inventor： Derek L. GREENFIELD , Andreas W. Schirmer , Elizabeth J. Clarke , Eli S. Groban , Bernardo M. Da Costa , Zhihao Hu , Kevin Holden , Noah Helman
IPC: C12N15/70 , C12N9/00 , C12N9/02 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/88 , C12N9/90 , C12P7/04 , C12P7/6409 , C12P7/6436
CPC classification number: C12N15/70 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/1288 , C12N9/88 , C12N9/90 , C12N9/93 , C12P7/04 , C12P7/6409 , C12P7/6436 , C12Y101/011 , C12Y103/01009 , C12Y103/0101 , C12Y203/01039 , C12Y203/01041 , C12Y203/01179 , C12Y203/0118 , C12Y207/08007 , C12Y402/01059 , C12Y503/03014 , C12Y604/01002
Abstract: The disclosure relates to recombinant host cells including strain modifications effective to improve titer, yield and/or productivity of fatty acid derivatives. The disclosure further relates to cell cultures including the recombinant host cells for the fermentative production of fatty acid derivatives and compositions thereof.
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公开(公告)号：US11359216B2
公开(公告)日：2022-06-14
申请号：US16889211
申请日：2020-06-01
Applicant: Genomatica, Inc.
Inventor： Andreas W. Schirmer , Noah Helman , Haibo Wang , Zhihao Hu , Vikranth Arlagadda , Alma Itzel Ramos-Solis , Elizabeth Clarke
Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.
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公开(公告)号：US20230167419A1
公开(公告)日：2023-06-01
申请号：US17818038
申请日：2022-08-08
Applicant: Genomatica, Inc.
Inventor： Baolong ZHU , Andreas W. Schirmer , Cindy Chang
IPC: C12N9/02 , C12P7/6409
CPC classification number: C12N9/0077 , C12P7/6409
Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for ex pressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.
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公开(公告)号：US11142756B2
公开(公告)日：2021-10-12
申请号：US16802133
申请日：2020-02-26
Applicant: Genomatica, Inc.
Inventor： Derek L. Greenfield , Donald E. Trimbur , Andreas W. Schirmer , Cindy Chang , Behnaz Behrouzian , Jessica Winger
Abstract: The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.
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公开(公告)号：US11008597B2
公开(公告)日：2021-05-18
申请号：US15301754
申请日：2015-04-10
Applicant: Genomatica, Inc.
Inventor： Stephen B. Del Cardayre , Andreas W. Schirmer , Myong Ko , Haibo Wang
Abstract: The present disclosure relates to processes that combine microbial production of organic intermediates and subsequent synthetic transformation to provide compounds of industrial value, including compounds used in fragrances.
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Patent Agency Ranking
公开(公告)号：US20200370024A1
公开(公告)日：2020-11-26
申请号：US16661667
申请日：2019-10-23
Applicant: Genomatica, Inc.
Inventor： Baolong ZHU , Andreas W. Schirmer , Cindy CHANG
Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.
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公开(公告)号：US11981952B2
公开(公告)日：2024-05-14
申请号：US16915454
申请日：2020-06-29
Applicant: Genomatica, Inc.
Inventor： Andreas W. Schirmer , Haibo Wang , Stephen B. Del Cardayre , Zhihao Hu , Louis G. Hom , Baolong Zhu , Cindy Chang , Emanuela E. Popova
IPC: C12P7/6409 , C12N1/21 , C12N9/02 , C12N9/04 , C12N15/52 , C12N15/62 , C12P7/18 , C12P7/42 , C12P7/6436
CPC classification number: C12P7/6409 , C12N9/0006 , C12N9/0008 , C12N9/0071 , C12N9/0077 , C12N15/52 , C12N15/62 , C12P7/18 , C12P7/42 , C12P7/6436 , C12Y114/14001 , C12Y114/15003 , C07K2319/00 , C12Y101/00 , C12Y102/01042 , Y02E50/10
Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.
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公开(公告)号：US11421206B2
公开(公告)日：2022-08-23
申请号：US16661667
申请日：2019-10-23
Applicant: Genomatica, Inc.
Inventor： Baolong Zhu , Andreas W. Schirmer , Cindy Chang
IPC: C12N9/02 , C12N15/62 , C12P7/6409
Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.
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公开(公告)号：US20210040514A1
公开(公告)日：2021-02-11
申请号：US16736405
申请日：2020-01-07
Applicant: Genomatica, Inc.
Inventor： Andreas W. Schirmer , Mathew A. Rude , Shane A. BRUBAKER
Abstract: Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein. The aldehydes, alkanes, and alkenes can be used in biofuels.
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公开(公告)号：US12221644B2
公开(公告)日：2025-02-11
申请号：US17271439
申请日：2019-08-28
Applicant: Genomatica, Inc.
Inventor： Andreas W. Schirmer , Katherine Ann Murphy , Erin Frances Perry
IPC: C12N9/02 , C12N9/04 , C12N9/10 , C12N9/16 , C12N9/88 , C12P7/6418 , C12P7/6481
Abstract: The disclosure relates to the field of specialty chemicals and methods for their synthesis. In embodiments, the disclosure provides viable bacterial cells which comprise heterologous dual 3-hydroxy-acyl-ACP dehydratase/isomerases, etc. The disclosure further provides monounsaturated fatty acid derivative molecules produced by the viable bacterial cells which are non-native to the bacterial cells. The disclosure further provides methods for the preparation and production of non-native monounsaturated fatty acid derivative molecules such as e.g., an ω3-monounsaturated fatty acid derivative, an ω5-monounsaturated fatty acid derivative, an ω9-monounsaturated fatty acid derivative, an ω11-monounsaturated fatty acid fatty acid derivative, etc.
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