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    Bone evaluation method
    1.
    发明授权
    Bone evaluation method 失效
    骨骼评价方法

    公开(公告)号：US4903203A

    公开(公告)日：1990-02-20

    申请号：US929308

    申请日：1986-11-12

    申请人： Gentaro Yamashita ,  Yasuhiro Uotani ,  Yoshio Hirano

    发明人： Gentaro Yamashita ,  Yasuhiro Uotani ,  Yoshio Hirano

    IPC分类号： G01N23/04

    CPC分类号： G01N23/04

    摘要： A method for evaluating cancellous bone from a density pattern of the cancellous bone obtained by irradiating the cancellous bone with a radiation wherein trabeculae of the cancellous bone are analyzed based on a power spectrum obtained by a Fourier transformation of the density pattern is provided.Furthermore, a method for evaluating cancellous bone from the density pattern of the cancellous bone obtained by irradiating the cancellous bone with radiation, wherein the density pattern is determined by irradiating the radiation substantially vertically against the main trabecula of the cancellous bone and the degree of the bone atrophy of the cancellous bone is evaluated by using the area (.SIGMA.GS) of the density pattern and/or the value (.SIGMA.GS/D) obtained by dividing the area (.SIGMA.GS) by the bone width (D) of the cancellous bone.

    摘要翻译： 提供了一种基于通过密度图案的傅里叶变换获得的功率谱，从通过用放射线照射松质骨获得的松质骨的密度模式来评估松质骨的方法，其中松质骨的小梁被分析。 此外，从通过用放射线照射松质骨获得的松质骨的密度图案来评估松质骨的方法，其中所述密度图案通过基本上垂直于所述松质骨的主小梁照射所述辐射而确定， 通过使用密度图案的面积（SIGMA GS）和/或通过将面积（SIGMA GS）除以松质骨的骨宽度（D）而获得的值（SIGMA GS / D）来评估松质骨的骨萎缩 骨。

    Method and apparatus for judging deformation of vertebral body
    2.
    发明授权
    Method and apparatus for judging deformation of vertebral body 失效
    用于判断椎体变形的方法和装置

    公开(公告)号：US5224035A

    公开(公告)日：1993-06-29

    申请号：US873900

    申请日：1992-04-24

    申请人： Gentaro Yamashita ,  Yasuhiro Uotani ,  Choju Aoki

    发明人： Gentaro Yamashita ,  Yasuhiro Uotani ,  Choju Aoki

    IPC分类号： A61B5/107 ,  G06F19/00

    CPC分类号： A61B5/107 ,  A61B5/7264 ,  G06F19/321 ,  G06F19/3487

    摘要： A method for judging deformation of a vertebral body includes the steps of measuring a central length (a), rear brim length (c), and front brim length (d) from a profile X-ray image of a vertebral body to be judged, determining ratios of c/d, a/c and a/d, and classifying deformation of the vertebral body to be judged by using indices, c, d, c/d, a/c and a/d. Furthermore, a method for judging deformation of a vertebral body, which comprises obtaining at least two indices by measuring a central length (a), vertebral body width (b), rear brim length (c), and front brim length (d) from a profile X-ray image of a vertebral body, analyzing these indices by a discriminant function, and classifying a deformation of the vertebral body from results of the analysis.

    摘要翻译： 一种用于判断椎体变形的方法，包括以下步骤：从要判断的椎体的轮廓X射线图像测量中心长度（a），后缘长度（c）和前缘长度（d） 确定c / d，a / c和a / d的比例，并通过使用指标c，d，c / d，a / c和a / d来判断椎体的变形。 此外，一种用于判断椎体变形的方法，包括通过测量中心长度（a），椎体宽度（b），后边缘长度（c）和前缘长度（d）来获得至少两个指数，所述方法来自 椎体的轮廓X射线图像，通过判别函数分析这些指标，并根据分析结果对椎体的变形进行分类。

    Slow-releasing medical preparation to be administered by adhering to a wet mucous surface
    5.
    发明授权
    Slow-releasing medical preparation to be administered by adhering to a wet mucous surface 失效
    慢性释放的药物制剂通过粘附在湿的粘液表面进行施用

    公开(公告)号：US4292299A

    公开(公告)日：1981-09-29

    申请号：US202384

    申请日：1980-07-07

    申请人： Yoshiki Suzuki ,  Hiroshi Ikura ,  Gentaro Yamashita

    发明人： Yoshiki Suzuki ,  Hiroshi Ikura ,  Gentaro Yamashita

    IPC分类号： A61K9/02 ,  A61K9/00 ,  A61K9/22 ,  A61K9/24 ,  A61K9/70 ,  A61L15/03

    CPC分类号： A61K9/209 ,  A61K9/006 ,  A61K9/70

    摘要： PCT No. PCT/JP79/00284 Sec. 371 Date Nov. 6, 1979 Sec. 102(e) Date July 7, 1980 PCT Filed July 7, 1980 PCT Pub. No. WO80/00916 PCT Pub. Date May 15, 1980A medical preparation composed of an adhesive layer comprising polymers which have adhesiveness to a wet mucous surface and swellability upon moistening and a nonadhesive layer which has no adhesiveness to a wet mucous surface and is water soluble or water disintegrable, with at least one of the layers made to contain a medicament. The medical preparation is administered by adhering to a wet mucous surface of the mucous membrane and skin of men or animals, whereby exhibiting a property to release the medicament slowly extending over a long period of time to cure or prevent general or local diseases.

    摘要翻译： PCT No.PCT / JP79 / 00284 Sec。 371日期1979年11月6日 102（e）日期1980年7月7日PCT提交1980年7月7日PCT公布。 出版物WO80 / 0091600 日期1980年5月15日由包含对湿粘性表面具有粘附性和润湿时的溶胀性的聚合物的粘合层组成的药物制剂和与湿粘性表面无粘合性并且具有水溶性或水分解性的非粘附层， 制成含有药物的层中的至少一层。 医疗制剂通过粘附在粘膜和湿性粘膜表面上而施用，其粘膜表面与男性或动物的皮肤呈现特性，从而显示出缓慢延长药物的性能，以缓解长期的时间，以治愈或预防一般或局部疾病。

    Pharmaceutical composition for intrarectal administration, and suppository prepared therefrom
    6.
    发明授权
    Pharmaceutical composition for intrarectal administration, and suppository prepared therefrom 失效
    用于直肠内给药的药物组合物和由其制备的栓剂

    公开(公告)号：US4434159A

    公开(公告)日：1984-02-28

    申请号：US249462

    申请日：1981-03-31

    申请人： Kunio Sekine ,  Yoshiki Suzuki ,  Gentaro Yamashita ,  Hisao Yamaguchi

    发明人： Kunio Sekine ,  Yoshiki Suzuki ,  Gentaro Yamashita ,  Hisao Yamaguchi

    IPC分类号： A61K9/02 ,  A61K47/12 ,  A61K47/18 ,  A61K47/22 ,  A61K37/26 ,  A61K31/70 ,  A61K31/725 ,  A61K37/00

    CPC分类号： A61K47/183 ,  A61K47/12 ,  A61K47/22 ,  A61K9/02 ,  Y10S424/15 ,  Y10S514/808

    摘要： A pharmaceutical composition for intrarectal administration comprising a pharmaceutically effective amount of an active ingredient which when administered alone to the rectum, is substantially unabsorbable into the living body through the mucous membrane of the rectum, said composition further containing an absorption aid acting within the rectum in such a way as to induce absorption of said active ingredient through the rectal mucous membrane, said absorption aid being characterized by (1) being substantially nontoxic to living organisms, (2) containing in the molecule at least two hydrophilic groups selected from the class consisting of carboxyl groups, acidic hydroxyl groups, carboxyl groups in the form of pharmaceutically acceptable salts, acidic hydroxyl groups in the form of pharmaceutically acceptable salts, carboxyl groups in the form of amides and acidic hydroxyl groups in the form of esters, (3) containing in the molecule at least two lipophilic groups selected from the class consisting of groups of the formulae ##STR1## and -CH.sub.2 -, the number of the lipophilic groups being not less than that of the hydrophilic groups, and (4) having a molecular weight of from about 100 to about 300; and a suppository prepared therefrom in unit dosage form.

    摘要翻译： 一种用于直肠内给药的药物组合物，其包含药物有效量的活性成分，其当单独施用于直肠时，通过直肠的粘膜基本上不能吸收到生物体中，所述组合物还含有在直肠内作用的吸收辅助剂 所述吸收助剂的特征在于：（1）对活生物体基本上无毒，（2）在分子中含有至少两个选自以下的亲水基团： 羧基，酸性羟基，可药用盐形式的羧基，药学上可接受的盐形式的酸性羟基，酰胺形式的羧基和酯形式的酸性羟基，（3）含有 在分子中至少有两个选自该类的亲脂基团 由式（I）和-CH 2 - 的基团组成，亲油基团的数目不小于亲水基团的数目，和（4）分子量为约100至约300; 和由单位剂型制备的栓剂。

    Albumin-fixed resin, production thereof, and therapeutical use thereof
    7.
    发明授权
    Albumin-fixed resin, production thereof, and therapeutical use thereof 失效
    白蛋白固定树脂，其制备及其治疗用途

    公开(公告)号：US4323486A

    公开(公告)日：1982-04-06

    申请号：US205997

    申请日：1980-11-12

    申请人： Hideaki Suzuki ,  Gentaro Yamashita

    发明人： Hideaki Suzuki ,  Gentaro Yamashita

    IPC分类号： A61L33/00 ,  A61L33/06 ,  A61M1/36 ,  B01D15/08 ,  B01J20/32 ,  C08G18/58 ,  C08G81/00 ,  C08H1/00 ,  C08L63/00 ,  C07G7/00 ,  C08L89/00 ,  C09J3/24

    CPC分类号： C08G81/00 ,  A61L33/068 ,  A61M1/3687 ,  B01D15/08 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28019 ,  B01J20/3092 ,  B01J20/3212 ,  B01J20/3221 ,  B01J20/3274 ,  C08G18/3228 ,  C08G18/3246 ,  C08G18/325 ,  C08G18/58 ,  C08G18/584 ,  C08G18/7671 ,  C08L63/00 ,  B01J2220/58

    摘要： The present invention provides an albumin-fixed resin comprising a crosslinked water-insoluble resin and albumin chemically bound thereto, said water-insoluble resin being a crosslinked epoxy resin containing about 1 to about 30 milliequivalents of amino groups and about 1 to about 50 milliequivalents of hydroxyl groups per gram thereof, said albumin being ionically bound to the amino groups of the epoxy resin and to the hydroxyl groups by hydrogen bonding, and the amount of said albumin fixed being at least about 25% by weight based on the epoxy resin, and also provides a process for producing the albumin-fixed resin, which comprises(1) (a) subjecting a polyepoxy compound containing at least two epoxy groups in the molecule and a polyamine compound containing at least two primary and/or secondary amino groups in the molecule to addition reaction in an inert medium to produce a fully crosslinked resin, or (b) subjecting said compounds to addition reaction to produce an insufficiently crosslinked pre-polymer, and then reacting the pre-polymer with at least one compound selected from the group consisting of organic polyisocyanates, organic polyisothiocyanates and organic polycarboxylic acid halides to crosslink it fully, and(2) contacting the resulting crosslinked epoxy resin containing about 1 to about 30 milliequivalents of amino groups and about 1 to about 50 milliequivalents of hydroxyl groups per gram thereof intimately with an aqueous solution containing albumin optionally after partially neutralizing the amino groups of the epoxy resin.The albumin-fixed resin is useful for removing albumin-binding noxious substances such as bilirubin contained in the blood of a warm-blooded animal.

    摘要翻译： 本发明提供一种白蛋白固定树脂，其包含交联的水不溶性树脂和化学键合的白蛋白，所述水不溶性树脂是交联的环氧树脂，其含有约1至约30毫当量的氨基和约1至约50毫当量的 羟基，其中所述白蛋白通过氢键键合到环氧树脂的氨基和羟基上，并且所述白蛋白的量相对于环氧树脂为至少约25重量％，和 还提供了生产白蛋白固定树脂的方法，其包括（1）（a）在分子中使含有至少两个环氧基的多环氧化合物和包含至少两个伯和/或仲氨基的多胺化合物在 在惰性介质中进行加成反应以产生完全交联的树脂，或（b）使所述化合物进行加成反应以产生不充分的 交联预聚物，然后使预聚物与选自有机多异氰酸酯，有机多异氰酸酯和有机多羧酸卤化物中的至少一种化合物反应以使其完全交联，和（2）使所得到的交联环氧树脂 1至约30毫当量的氨基和约1至约50毫克的羟基/克，与含有白蛋白的水溶液密切相关，任选地在部分中和环氧树脂的氨基之后。 白蛋白固定树脂可用于除去白血病结合的有毒物质如温血动物血液中所含的胆红素。

    Powdery pharmaceutical composition and powdery preparation for application to the nasal mucosa, and method for administration thereof
    8.
    发明授权
    Powdery pharmaceutical composition and powdery preparation for application to the nasal mucosa, and method for administration thereof 失效
    用于鼻粘膜的粉末状药物组合物和粉末制剂及其施用方法

    公开(公告)号：US4294829A

    公开(公告)日：1981-10-13

    申请号：US173906

    申请日：1980-07-30

    申请人： Yoshiki Suzuki ,  Hiroshi Ikura ,  Gentaro Yamashita ,  Tsuneji Nagai

    发明人： Yoshiki Suzuki ,  Hiroshi Ikura ,  Gentaro Yamashita ,  Tsuneji Nagai

    IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K47/38 ,  A61K31/58 ,  A01N43/36 ,  A61K31/56

    CPC分类号： A61K9/0043 ,  Y10S514/951

    摘要： A powdery pharmaceutical composition and a powdery preparation in unit dosage form for application to the mucosa of the nasal cavity, at least about 90% of which consists of particles having an effective particle diameter of about 20 to about 250 microns, said composition comprising a lower alkyl ether of cellulose having a viscosity, determined at about 37.degree. C. for a 2% aqueous solution thereof, of at least about 5 centipoises and a pharmaceutically effective amount of a drug; and a method for treating or preventing a human nasal disease, which comprises administering a powdery preparation in unit dosage form to the nasal cavity of a human being requiring treatment or prevention of a nasal disease through his nostrils.

    摘要翻译： 一种粉末状药物组合物和单位剂量形式的粉末制剂，其用于鼻腔粘膜，其至少约90％由具有约20至约250微米的有效粒径的颗粒组成，所述组合物包含较低的 在约37℃下测定其2％水溶液的粘度为至少约5厘泊和药物有效量的药物的纤维素的烷基醚; 以及用于治疗或预防人鼻疾病的方法，其包括将单位剂型的粉末制剂施用于需要通过鼻孔治疗或预防鼻部疾病的人的鼻腔。