公开(公告)号：US07497865B2

公开(公告)日：2009-03-03

申请号：US10855604

申请日：2004-05-26

申请人： Geoffrey H. Willis ,  Thomas A. Kramer ,  Paul A. Spence ,  George T. Christakis ,  Timothy J. McCoy ,  John W. Davis ,  Bradley D. Blackwood ,  Peter Callas ,  Michael Francis Wei ,  Jonathan L. Podmore ,  Andrew Knight ,  Thomas J. Ward ,  Warren P. Williamson, IV

发明人： Geoffrey H. Willis ,  Thomas A. Kramer ,  Paul A. Spence ,  George T. Christakis ,  Timothy J. McCoy ,  John W. Davis ,  Bradley D. Blackwood ,  Peter Callas ,  Michael Francis Wei ,  Jonathan L. Podmore ,  Andrew Knight ,  Thomas J. Ward ,  Warren P. Williamson, IV

IPC分类号： A61B17/08 ,  A61B17/10 ,  A61B17/04

CPC分类号： A61B17/1152 ,  A61B17/11 ,  A61B17/115 ,  A61B2017/1107 ,  A61B2017/1132 ,  A61B2017/1135 ,  A61B2017/1139

摘要： A ring for use in anastomosis. Preferably, the ring is integrally formed from metal, and includes a ring portion and tines and docking members that extend from the ring portion. The ring portion and tines are malleable, and preferably also the docking members are malleable. The ring portion and tines are malleable in the sense that once deformed from a first shape into a second shape, they will not relax back into the first shape from the second. To install the ring in a vessel with the ring portion extending around an incision or other orifice, the tines pierce the tissue around the orifice and are curled against an anvil. The action of curling the tines inverts the tissue near the orifice edges to expose the inside surface of the vessel or organ. Other aspects of the invention are a method and apparatus for installing an anastomosis ring in an incision or other orifice in a vessel or other organ, a method and apparatus for precisely aligning two anastomosis rings (each installed in an incision or other orifice of a different organ) and fastening the aligned rings together. The clips can be crimped onto the aligned rings, or they can be spring clips which are sprung onto the aligned rings to clamp the rings together by spring force. Also within the scope of the invention are crimping and spring clips for use in listening together two aligned anastomosis rings. In other embodiments, the invention is a method for performing an anastomosis by installing an anastomosis ring in an orifice in an organ, installing another anastomosis ring in an orifice in another organ, precisely aligning the two installed anastomosis rings, and fastening the aligned rings together.

摘要翻译： 用于吻合的戒指。 优选地，环由金属一体地形成，并且包括从环部延伸的环部分和尖齿和对接构件。 环形部分和尖齿是可延展的，并且优选的是对接部件是可延展的。 环形部分和尖齿在从第一形状变形成第二形状的意义上是可延展的，它们将不会从第二形状放松回第一形状。 为了将环安装在具有围绕切口或其他孔口延伸的环部分的容器中，齿刺穿孔周围的组织并且卷绕在砧座上。 卷曲尖齿的作用使孔边缘附近的组织反转以暴露血管或器官的内表面。 本发明的其它方面是用于将吻合环安装在容器或其他器官中的切口或其它孔中的方法和装置，用于精确地对准两个吻合环（每个安装在切口或不同的其他孔中的其他孔中的方法和装置） 器官）并将对准的环固定在一起。 夹子可以压接在对准的环上，或者它们可以是弹簧夹，弹簧夹被弹簧上对准的环，以通过弹簧力将环夹在一起。 也在本发明的范围内的是压接和弹簧夹，用于一起收听两个对准的吻合环。 在其他实施例中，本发明是一种通过在器官中的孔中安装吻合环来进行吻合的方法，在另一个器官的孔中安装另一个吻合环，精确对准两个安装的吻合环，并将对准的环固定在一起 。

公开(公告)号：US06811555B1

公开(公告)日：2004-11-02

申请号：US09654605

申请日：2000-09-01

申请人： Geoffrey H. Willis ,  Thomas A. Kramer ,  Paul A. Spence ,  George T. Christakis ,  Timothy J. McCoy ,  John W. Davis ,  Bradley D. Blackwood ,  Peter Callas ,  Michael Francis Wei ,  Jonathan L. Podmore ,  Andrew Knight ,  Thomas J. Ward ,  Warren P. Williamson, IV

发明人： Geoffrey H. Willis ,  Thomas A. Kramer ,  Paul A. Spence ,  George T. Christakis ,  Timothy J. McCoy ,  John W. Davis ,  Bradley D. Blackwood ,  Peter Callas ,  Michael Francis Wei ,  Jonathan L. Podmore ,  Andrew Knight ,  Thomas J. Ward ,  Warren P. Williamson, IV

IPC分类号： A61B1708

CPC分类号： A61B17/1152 ,  A61B17/11 ,  A61B17/115 ,  A61B2017/1107 ,  A61B2017/1132 ,  A61B2017/1135 ,  A61B2017/1139

摘要： A ring for use in anastomosis. Preferably, the ring is integrally formed from metal, and includes a ring portion and tines and docking members that extend from the ring portion. The ring portion and tines are malleable, and preferably also the docking members are malleable. The ring portion and tines are malleable in the sense that once deformed from a first shape into a second shape, they will not relax back into the first shape from the second. To install the ring in a vessel with the ring portion extending around an incision or other orifice, the tines pierce the tissue around the orifice and are curled against an anvil. The action of curling the tines inverts the tissue near the orifice edges to expose the inside surface of the vessel or organ. Other aspects of the invention are a method and apparatus for installing an anastomosis ring in an incision or other orifice in a vessel or other organ, a method and apparatus for precisely aligning two anastomosis rings (each installed in an incision or other orifice of a different organ) and fastening the aligned rings together. The clips can be crimped onto the aligned rings, or they can be spring clips which are sprung onto the aligned rings to clamp the rings together by spring force. Also within the scope of the invention are crimping and spring clips for use in fastening together two aligned anastomosis rings. In other embodiments, the invention is a method for performing an anastomosis by installing an anastomosis ring in an orifice in an organ, installing another anastomosis ring in an orifice in another organ, precisely aligning the two installed anastomosis rings, and fastening the aligned rings together.

摘要翻译： 用于吻合的戒指。 优选地，环由金属一体地形成，并且包括从环部延伸的环部分和尖齿和对接构件。 环形部分和尖齿是可延展的，并且优选的是对接部件是可延展的。 环形部分和尖齿在从第一形状变形成第二形状的意义上是可延展的，它们将不会从第二形状放松回第一形状。 为了将环安装在具有围绕切口或其他孔口延伸的环部分的容器中，齿刺穿孔周围的组织并且卷绕在砧座上。 卷曲尖齿的作用使孔边缘附近的组织反转以暴露血管或器官的内表面。 本发明的其它方面是用于将吻合环安装在容器或其他器官中的切口或其它孔中的方法和装置，用于精确地对准两个吻合环（每个安装在切口或不同的其他孔中的其他孔中的方法和装置） 器官）并将对准的环固定在一起。 夹子可以压接在对准的环上，或者它们可以是弹簧夹，弹簧夹被弹簧上对准的环，以通过弹簧力将环夹在一起。 也在本发明的范围内的是压接和弹簧夹，用于将两个对准的吻合环紧固在一起。 在其他实施例中，本发明是一种通过在器官中的孔中安装吻合环来进行吻合的方法，在另一个器官的孔中安装另一个吻合环，精确对准两个安装的吻合环，并将对准的环固定在一起 。

公开(公告)号：US06884251B2

公开(公告)日：2005-04-26

申请号：US10384250

申请日：2003-03-06

申请人： Paul A. Spence ,  Warren P. Williamson, IV ,  George Christakis ,  Mark Ortiz ,  Craig B. Berky ,  Douglas P. Allen ,  Matthew J. Huddleston ,  Delbert Ted Leimbach ,  Cecil R. Robinson ,  E. Dale VanHoose ,  Thomas J. Ward ,  Marty J. Warnecke

发明人： Paul A. Spence ,  Warren P. Williamson, IV ,  George Christakis ,  Mark Ortiz ,  Craig B. Berky ,  Douglas P. Allen ,  Matthew J. Huddleston ,  Delbert Ted Leimbach ,  Cecil R. Robinson ,  E. Dale VanHoose ,  Thomas J. Ward ,  Marty J. Warnecke

IPC分类号： A61B17/11 ,  A61B17/115 ,  A61B17/08

CPC分类号： A61B17/11 ,  A61B17/1152 ,  A61B2017/1135 ,  A61B2017/1139

摘要： An anastomosis is performed using a flexible mounting structure mounted on the outside of at least one vessel. Fasteners extend through the vessel and are bent towards the incision to attach the flexible mounting structure to the vessel in a manner that controls the edge of the vessel adjacent to the incision. The mounting structures are oriented on each vessel so fasteners on one mounting structure interdigitate with fasteners on the other mounting structure at the location of contact between the vessels when the two vessels are brought together. This creates two complementary sinusoidal-shaped vessel edges with peaks of one edge being accommodated in the valleys of the other edge. The peak-to-valley orientation forms a sinusoidal-shaped joint which is leak free. The fasteners are spaced so proper pressure is applied to the tissue to promote healing without leaking. Furthermore, the fasteners are sized and shaped to properly engage the tissue and bend in a desired manner. Methods and tools for carrying out the anastomosis according to the invention are also disclosed. Methods for forming the fastener and the tines having the proper characteristics are disclosed. An absorbable ring-shaped stent is also disclosed.

摘要翻译： 使用安装在至少一个容器的外部的柔性安装结构进行吻合。 紧固件延伸穿过容器并朝向切口弯曲，以将控制与切口相邻的容器边缘的方式将柔性安装结构附接到容器。 安装结构被定向在每个容器上，因此当两个容器被接合在一起时，在一个安装结构上的紧固件与另一个安装结构上的紧固件在容器之间的接触位置处相互交错。 这产生两个互补的正弦形容器边缘，其中一个边缘的峰值被容纳在另一个边缘的谷部中。 峰 - 谷取向形成无泄漏的正弦形接头。 紧固件间隔开，以便适当的压力施加到组织以促进愈合而不泄漏。 此外，紧固件的尺寸和形状适于适当地接合组织并以期望的方式弯曲。 还公开了用于进行根据本发明的吻合的方法和工具。 公开了用于形成紧固件和具有适当特性的尖齿的方法。 还公开了可吸收的环形支架。

公开(公告)号：US5972004A

公开(公告)日：1999-10-26

申请号：US026671

申请日：1998-02-20

申请人： Warren P. Williamson, IV ,  Paul A. Spence ,  George A. Keller ,  Cecil R. Robinson ,  Thomas J. Ward

发明人： Warren P. Williamson, IV ,  Paul A. Spence ,  George A. Keller ,  Cecil R. Robinson ,  Thomas J. Ward

IPC分类号： A61B17/00 ,  A61B17/04 ,  A61B17/064 ,  A61B17/068 ,  A61B17/072 ,  A61B17/115 ,  A61B17/34 ,  A61B19/00 ,  A61F2/24

CPC分类号： A61B17/0469 ,  A61B17/0644 ,  A61B17/0684 ,  A61B17/072 ,  A61F2/2409 ,  A61F2/2427 ,  A61B17/0401 ,  A61B17/0467 ,  A61B17/0487 ,  A61B17/064 ,  A61B17/115 ,  A61B2017/00243 ,  A61B2017/0406 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/047 ,  A61B2017/0641 ,  A61B2017/3486 ,  A61B2090/061 ,  A61B2090/395

摘要： Wire fasteners having legs with lengths that can be one hundred times the width of the fastener are used to secure items, such as prosthesis valves to a patient during minimally invasive surgery. The fasteners are manipulated into position and then are immobilized by means of the legs thereof for tensioning, cutting and forming in situ. The fasteners are manipulated, tensioned and formed from the leg end of the fasteners. Tools for initially placing the fasteners and for immobilizing, tensioning, cutting and bending the fastener legs are disclosed. Once the fasteners are initially placed, the prosthesis is placed on the long legs of the placed fasteners and is guided into position on the legs. Once the prosthesis is in position, the legs of the fasteners are immobilized, tensioned, cut and bent into staple-like shapes to secure the prosthesis to the patient. A method for carrying out the procedure using the long fastener is also disclosed. Using the teaching of the present disclosure, a surgeon can customize a fastener to the particular surgery or even to the particular portion of surgery being performed during the surgery.

摘要翻译： 具有长度为紧固件宽度的一百倍的腿的电线紧固件用于在微创手术期间将物品（例如假体瓣膜）固定到患者。 紧固件被操纵到位，然后通过其腿部固定，用于原位张紧，切割和成形。 紧固件由紧固件的腿端被操纵，张紧和形成。 公开了用于初始放置紧固件并固定，张紧，切割和弯曲紧固件腿的工具。 一旦紧固件被初始放置，假体被放置在所放置的紧固件的长腿上并且被引导到腿上的位置。 一旦假体就位，紧固件的腿被固定，张紧，切割并弯曲成钉状形状以将假体固定到患者身上。 还公开了一种使用该长紧固件执行该过程的方法。 使用本公开的教导，外科医生可以定制针对特定手术的紧固件，或甚至可以在手术期间执行手术的特定部分。

公开(公告)号：US6162233A

公开(公告)日：2000-12-19

申请号：US369196

申请日：1999-08-06

申请人： Warren P. Williamson, IV ,  Paul A. Spence ,  George A. Keller ,  Cecil R. Robinson ,  Thomas J. Ward

发明人： Warren P. Williamson, IV ,  Paul A. Spence ,  George A. Keller ,  Cecil R. Robinson ,  Thomas J. Ward

IPC分类号： A61B17/00 ,  A61B17/04 ,  A61B17/064 ,  A61B17/068 ,  A61B17/072 ,  A61B17/115 ,  A61B17/34 ,  A61B19/00 ,  A61F2/24 ,  A61B17/10

CPC分类号： A61B17/0644 ,  A61B17/0401 ,  A61B17/0467 ,  A61B17/0469 ,  A61B17/0487 ,  A61B17/064 ,  A61B17/0684 ,  A61B17/072 ,  A61B17/115 ,  A61B2017/00243 ,  A61B2017/0406 ,  A61B2017/0454 ,  A61B2017/0464 ,  A61B2017/047 ,  A61B2017/0472 ,  A61B2017/07214 ,  A61B2017/07242 ,  A61B2017/3486 ,  A61B2090/061 ,  A61B2090/395 ,  A61F2/2409 ,  A61F2/2427

摘要： Wire fasteners having legs with lengths that can be one hundred times the width of the fastener are used to secure items, such as prosthesis valves to a patient during minimally invasive surgery. The fasteners are manipulated into position and then are immobilized by the legs thereof for tensioning, cutting and forming in situ. The fasteners are manipulated, tensioned and formed from the leg end of the fasteners. Tools for initially placing the fasteners and for immobilizing, tensioning, cutting and bending the fastener legs are disclosed. Once the fasteners are initially placed, the prosthesis is placed on the long legs of the placed fasteners and is guided into position on the legs. Once the prosthesis is in position, the legs of the fasteners are immobilized, tensioned, cut and bent into staple-like shapes to secure the prosthesis to the patient. A method for carrying out the procedure using the long fastener is also disclosed. Using the teaching of the present disclosure, a surgeon can customize a fastener to the particular surgery or even to the particular portion of surgery being performed during the surgery.

摘要翻译： 具有长度为紧固件宽度的一百倍的腿的电线紧固件用于在微创手术期间将物品（例如假体瓣膜）固定到患者。 紧固件被操纵到位，然后被其腿固定，用于张紧，切割和成形。 紧固件由紧固件的腿端被操纵，张紧和形成。 公开了用于初始放置紧固件并固定，张紧，切割和弯曲紧固件腿的工具。 一旦紧固件被初始放置，假体被放置在所放置的紧固件的长腿上并被引导到腿上的位置。 一旦假体就位，紧固件的腿被固定，张紧，切割并弯曲成钉状形状以将假体固定到患者身上。 还公开了一种使用该长紧固件执行该过程的方法。 使用本公开的教导，外科医生可以定制针对特定手术的紧固件，或甚至可以在手术期间执行手术的特定部分。

公开(公告)号：US07722642B2

公开(公告)日：2010-05-25

申请号：US10786657

申请日：2004-02-25

申请人： Warren P. Williamson, IV ,  Paul A. Spence ,  George A. Keller ,  Cecil R. Robinson ,  Thomas J. Ward

发明人： Warren P. Williamson, IV ,  Paul A. Spence ,  George A. Keller ,  Cecil R. Robinson ,  Thomas J. Ward

IPC分类号： A61B17/08 ,  A61B17/10

CPC分类号： A61F2/2427 ,  A61B17/0401 ,  A61B17/0467 ,  A61B17/0469 ,  A61B17/0487 ,  A61B17/064 ,  A61B17/0644 ,  A61B17/0684 ,  A61B17/072 ,  A61B17/115 ,  A61B2017/00243 ,  A61B2017/0406 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/047 ,  A61B2017/0641 ,  A61B2017/0725 ,  A61B2017/07271 ,  A61B2017/3486 ,  A61B2090/061 ,  A61B2090/395 ,  A61F2/2409

摘要： Wire fasteners having legs with lengths that can be one hundred times the width of the fastener are used to secure items, such as prosthesis valves to a patient during minimally invasive surgery. The fasteners are manipulated into position and then are immobilized by means of the legs thereof for tensioning, cutting and forming in situ. The fasteners are manipulated, tensioned and formed from the leg end of the fasteners. Tools for initially placing the fasteners and for immobilizing, tensioning, cutting and bending the fastener legs are disclosed. Once the fasteners are initially placed, the prosthesis is placed on the long legs of the placed fasteners and is guided into position on the legs. Once the prosthesis is in position, the legs of the fasteners are immobilized, tensioned, cut and bent into staple-like shapes to secure the prosthesis to the patient. A method for carrying out the procedure using the long fastener is also disclosed. Using the teaching of the present disclosure, a surgeon can customize a fastener to the particular surgery or even to the particular portion of surgery being performed during the surgery.

摘要翻译： 具有长度为紧固件宽度的一百倍的腿的电线紧固件用于在微创手术期间将物品（例如假体瓣膜）固定到患者。 紧固件被操纵到位，然后通过其腿部固定，用于原位张紧，切割和成形。 紧固件由紧固件的腿端被操纵，张紧和形成。 公开了用于初始放置紧固件并固定，张紧，切割和弯曲紧固件腿的工具。 一旦紧固件被初始放置，假体被放置在所放置的紧固件的长腿上并且被引导到腿上的位置。 一旦假体就位，紧固件的腿被固定，张紧，切割并弯曲成钉状形状以将假体固定到患者身上。 还公开了一种使用该长紧固件执行该过程的方法。 使用本公开的教导，外科医生可以定制针对特定手术的紧固件，或甚至可以在手术期间执行手术的特定部分。

公开(公告)号：US06565581B1

公开(公告)日：2003-05-20

申请号：US09641284

申请日：2000-08-17

申请人： Paul A. Spence ,  Warren P. Williamson IV ,  George Christakis ,  Mark Ortiz ,  Craig B. Berky ,  Douglas P. Allen ,  Matthew J. Huddleston ,  Delbert Ted Leimbach ,  Cecil R. Robinson ,  E. Dale VanHoose ,  Thomas J. Ward ,  Marty J. Warnecke

发明人： Paul A. Spence ,  Warren P. Williamson IV ,  George Christakis ,  Mark Ortiz ,  Craig B. Berky ,  Douglas P. Allen ,  Matthew J. Huddleston ,  Delbert Ted Leimbach ,  Cecil R. Robinson ,  E. Dale VanHoose ,  Thomas J. Ward ,  Marty J. Warnecke

IPC分类号： A61B1708

CPC分类号： A61B17/11 ,  A61B17/1152 ,  A61B2017/1135 ,  A61B2017/1139

摘要： An anastomosis is performed using a flexible mounting structure mounted on the outside of at least one vessel. Fasteners extend through the vessel and are bent towards the incision to attach the flexible mounting structure to the vessel in a manner that controls the edge of the vessel adjacent to the incision. The mounting structures are oriented on each vessel so fasteners on one mounting structure interdigitate with fasteners on the other mounting structure at the location of contact between the vessels when the two vessels are brought together. This creates two complementary sinusoidal-shaped vessel edges with peaks of one edge being accommodated in the valleys of the other edge. The peak-to-valley orientation forms a sinusoidal-shaped joint which is leak free. The fasteners are spaced so proper pressure is applied to the tissue to promote healing without leaking. Furthermore, the fasteners are sized and shaped to properly engage the tissue and bend in a desired manner. Methods and tools for carrying out the anastomosis according to the invention are also disclosed. Methods for forming the fastener and the tines having the proper characteristics are disclosed. An absorbable ring-shaped stent is also disclosed.

摘要翻译： 使用安装在至少一个容器的外侧上的柔性安装结构进行吻合。 紧固件延伸穿过容器并朝向切口弯曲，以将控制与切口相邻的容器边缘的方式将柔性安装结构附接到容器。 安装结构被定向在每个容器上，因此当两个容器被接合在一起时，在一个安装结构上的紧固件与另一个安装结构上的紧固件在容器之间的接触位置处相互交错。 这产生两个互补的正弦形容器边缘，其中一个边缘的峰值被容纳在另一个边缘的谷部中。 峰 - 谷取向形成无泄漏的正弦形接头。 紧固件间隔开，以便适当的压力施加到组织以促进愈合而不泄漏。 此外，紧固件的尺寸和形状适于适当地接合组织并以期望的方式弯曲。 还公开了用于进行根据本发明的吻合的方法和工具。 公开了用于形成紧固件和具有适当特性的尖齿的方法。 还公开了可吸收的环形支架。

公开(公告)号：US6042607A

公开(公告)日：2000-03-28

申请号：US802948

申请日：1997-02-21

申请人： Warren Williamson, IV ,  Paul A. Spence ,  George T. Christakis ,  Thomas J. Ward ,  Dominic P. DiNovo ,  George A. Keller ,  Cecil R. Robinson ,  E. Dale VanHoose

发明人： Warren Williamson, IV ,  Paul A. Spence ,  George T. Christakis ,  Thomas J. Ward ,  Dominic P. DiNovo ,  George A. Keller ,  Cecil R. Robinson ,  E. Dale VanHoose

IPC分类号： A61B17/00 ,  A61B17/04 ,  A61B17/064 ,  A61B17/068 ,  A61B17/072 ,  A61B17/115 ,  A61B17/34 ,  A61B19/00 ,  A61F2/24

CPC分类号： A61B17/072 ,  A61B17/0469 ,  A61B17/0644 ,  A61B17/0684 ,  A61F2/2409 ,  A61F2/2427 ,  A61F2/2496 ,  A61B17/0401 ,  A61B17/0467 ,  A61B17/0487 ,  A61B17/064 ,  A61B17/115 ,  A61B2017/00243 ,  A61B2017/0406 ,  A61B2017/047 ,  A61B2017/3486 ,  A61B2090/061 ,  A61B2090/395

摘要： A heart valve can be replaced using minimally invasive methods which include a sutureless sewing cuff that and a fastener delivery tool that holds the cuff against the patient's tissue while delivering fasteners, two at a time to attach the cuff to the tissue from the inside out. The tool stores a plurality of fasteners. Drawstrings are operated from outside the patient's body and cinch the sewing cuff to the valve body. The cuff is releasably mounted on the tool and the tool holds the cuff against tissue and drives the fastener through the cuff and the tissue before folding over the legs of the fastener whereby secure securement between the cuff and the tissue is assured. At least two rows of staggered fasteners are formed whereby fasteners are located continuously throughout the entire circumference of the cuff. A minimally invasive surgical method is disclosed, and a method and tool are disclosed for repairing abdominal aortic aneurysms in a minimally invasive manner.

摘要翻译： 可以使用微创方法来替换心脏瓣膜，所述方法包括无缝线缝合口袋，以及紧固件递送工具，其在递送紧固件的同时将袖带保持在患者组织上，同时两次将袖带从内向外连接到组织。 该工具存储多个紧固件。 束带从患者身体外部进行操作，并将缝合袖带固定在阀体上。 袖带可释放地安装在工具上，并且工具将袖带保持抵靠组织，并且在折叠紧固件的腿部之前通过袖口和组织驱动紧固件，从而确保袖带和组织之间的牢固固定。 形成至少两排交错的紧固件，由此紧固件连续地位于袖带的整个圆周上。 公开了一种微创手术方法，并且公开了一种以微创方式修复腹主动脉瘤的方法和工具。

公开(公告)号：US08609431B2

公开(公告)日：2013-12-17

申请号：US12836102

申请日：2010-07-14

申请人： Warren P. Williamson, IV ,  Craig B. Berky ,  Stephen P. Whitlatch ,  Thomas J. Ward

发明人： Warren P. Williamson, IV ,  Craig B. Berky ,  Stephen P. Whitlatch ,  Thomas J. Ward

IPC分类号： G01N1/28

CPC分类号： G01N1/36 ,  B01L3/508 ,  B01L9/52 ,  B01L2300/043 ,  G01N2001/315 ,  G01N2001/366 ,  Y10T436/25

摘要： The disclosure relates to a cassette, frame and mold for holding a tissue sample during an embedding and mircotoming process, and related methods. The cassette is sectionable in a microtome and includes a body with a bottom wall and a plurality of side walls. First and second side walls are generally V-shaped to present an apex of the “V” to the microtome blade. A lid of the cassette is stiffer than the bottom wall of the cassette to assist with positioning the tissue sample. The side walls of the cassette are perforated so as to significantly reduce the amount of cassette material that must be cut by the microtome blade. In one embodiment, to additionally reduce blade wear the ribs on one side wall are offset lengthwise relative to the ribs on an opposite side wall. An upper flange of the cassette includes depressions configured to register with detents in the frame.

摘要翻译： 本公开涉及一种用于在嵌入和微型切割过程期间保持组织样本的盒，框架和模具及相关方法。 盒子可在切片机中切片，并且包括具有底壁和多个侧壁的主体。 第一侧壁和第二侧壁通常为V形以呈现与切片机叶片“V”的顶点。 盒的盖比盒的底壁更硬，以帮助定位组织样品。 盒的侧壁是穿孔的，以便显着减少必须由切片机刀片切割的盒材料的量。 在一个实施例中，为了额外地减少刀片磨损，一个侧壁上的肋相对于相对侧壁上的肋纵向偏移。 盒的上凸缘包括配置成与框架中的棘爪对准的凹陷。

公开(公告)号：US07722810B2

公开(公告)日：2010-05-25

申请号：US11010773

申请日：2004-12-13

申请人： Douglas P. Allen ,  Dominic P. DiNovo ,  Matthew J. Huddleston ,  Kenneth E. Hughes ,  George A. Keller ,  Keith A. Kuisick ,  Rebeccah P. Quam ,  Cecil R. Robinson ,  Jonathan E. Turner ,  Ernest D. VanHoose ,  Thomas J. Ward ,  Warren P. Williamson, IV

发明人： Douglas P. Allen ,  Dominic P. DiNovo ,  Matthew J. Huddleston ,  Kenneth E. Hughes ,  George A. Keller ,  Keith A. Kuisick ,  Rebeccah P. Quam ,  Cecil R. Robinson ,  Jonathan E. Turner ,  Ernest D. VanHoose ,  Thomas J. Ward ,  Warren P. Williamson, IV

IPC分类号： G01N21/00

CPC分类号： G01N1/36 ,  G01N35/00732 ,  G01N2001/366 ,  Y10T436/2525 ,  Y10T436/2575

摘要： An automated machine for handling and embedding tissue samples contained on microtome sectionable supports. The machine includes an input member configured to hold a plurality of the microtome sectionable supports prior to a tissue embedding operation. An output member is configured to hold a plurality of the microtome sectionable supports after the tissue embedding operation. A cooling unit is configured to hold at least one of the microtome sectionable supports during the tissue embedding operation. A motorized carrier assembly is mounted for movement and configured to hold at least one of the microtome sectionable supports. The carrier assembly moves the support from the input member to the cooling unit and, finally, to the output member. A dispensing device dispenses an embedding material onto the microtome sectionable support and at least one tissue sample carried by the microtome sectionable support during the embedding operation.

摘要翻译： 一种用于处理和嵌入包含在切片机可切片支架上的组织样本的自动化机器。 该机器包括一个输入构件，构造成在组织嵌入操作之前保持多个切片机可切割支架。 输出构件被配置为在组织嵌入操作之后保持多个切片机可切割支撑件。 冷却单元构造成在组织嵌入操作期间保持切片机可分段支撑件中的至少一个。 安装电动载体组件用于移动并且构造成保持切片机可分段支撑件中的至少一个。 托架组件将支撑件从输入构件移动到冷却单元，最后移动到输出构件。 分配装置在嵌入操作期间将嵌入材料分配到切片机可切片支撑件和由切片机可切割支撑件携带的至少一个组织样本。