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公开(公告)号：US07736292B2
公开(公告)日：2010-06-15
申请号：US11554731
申请日：2006-10-31
CPC分类号： A61N5/1007 , A61N5/1014 , A61N5/1027 , A61N2005/1005 , A61N2005/1011 , A61N2005/1012 , A61N2005/1023 , A61N2005/1094
摘要： Apparatus, systems and methods for delivering brachytherapy to a target tissue region of a human or other mammalian body. In some embodiments, a flexible brachytherapy device is implanted that includes a therapy delivery portion having one or more radioactive sources securely retained thereto, and a tail portion extending from the therapy delivery portion. Once implanted, the tail portion may extend outside the body, where it may be folded and secured flat against the skin. The device may be removed at therapy completion. Other embodiments of the invention are directed to systems and methods for delivering brachytherapy devices to the body.
摘要翻译： 用于将近距离放射治疗递送到人或其他哺乳动物身体的靶组织区域的装置，系统和方法。 在一些实施例中，植入柔性近距离放射治疗装置，其包括具有一个或多个可靠地保持在其上的放射源的治疗递送部分和从治疗递送部分延伸的尾部。 一旦植入，尾部可以延伸到身体的外部，在那里它可以被折叠并且平坦地固定在皮肤上。 在治疗完成时可以移除该装置。 本发明的其它实施例涉及用于将近距离放射治疗装置输送到身体的系统和方法。
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公开(公告)号：US20100249487A1
公开(公告)日：2010-09-30
申请号：US12815374
申请日：2010-06-14
IPC分类号： A61M36/04
CPC分类号： A61N5/1007 , A61N5/1014 , A61N5/1027 , A61N2005/1005 , A61N2005/1011 , A61N2005/1012 , A61N2005/1023 , A61N2005/1094
摘要： Apparatus, systems and methods for delivering brachytherapy to a target tissue region of a human or other mammalian body. In some embodiments, a flexible brachytherapy device is implanted that includes a therapy delivery portion having one or more radioactive sources securely retained thereto, and a tail portion extending from the therapy delivery portion. Once implanted, the tail portion may extend outside the body, where it may be folded and secured flat against the skin. The device may be removed at therapy completion. Other embodiments of the invention are directed to systems and methods for delivering brachytherapy devices to the body.
摘要翻译： 用于将近距离放射治疗递送到人或其他哺乳动物身体的靶组织区域的装置，系统和方法。 在一些实施例中，植入柔性近距离放射治疗装置，其包括具有一个或多个可靠地保持在其上的放射源的治疗递送部分和从治疗递送部分延伸的尾部。 一旦植入，尾部可以延伸到身体的外部，在那里它可以被折叠并且平坦地固定在皮肤上。 在治疗完成时可以移除该装置。 本发明的其它实施例涉及用于将近距离放射治疗装置输送到身体的系统和方法。
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公开(公告)号：US20090156882A1
公开(公告)日：2009-06-18
申请号：US12277286
申请日：2008-11-24
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.
摘要翻译： 用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。 细长构件可在折叠和膨胀构型之间移动。 在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。 细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。
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公开(公告)号：US08517907B2
公开(公告)日：2013-08-27
申请号：US12277286
申请日：2008-11-24
IPC分类号： A61M36/12
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.
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公开(公告)号：US20080221384A1
公开(公告)日：2008-09-11
申请号：US11757231
申请日：2007-06-01
申请人： Eduardo Chi Sing , George D. Hermann , Doug S. Sutton , Tommy G. Nguyen , Mark A. Ritchart , Steven L. Gex
发明人： Eduardo Chi Sing , George D. Hermann , Doug S. Sutton , Tommy G. Nguyen , Mark A. Ritchart , Steven L. Gex
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.
摘要翻译： 用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。 细长构件可在折叠和膨胀构型之间移动。 在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。 细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。
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公开(公告)号：US08771161B2
公开(公告)日：2014-07-08
申请号：US12642626
申请日：2009-12-18
申请人： Doug S. Sutton , George D. Hermann
发明人： Doug S. Sutton , George D. Hermann
CPC分类号： A61N5/1014 , A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways. The apparatus may include features to prevent overexpansion of the elongate members and/or to facilitate rapid collapse of the elongate members.
摘要翻译： 用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。 细长构件可在折叠和膨胀构型之间移动。 在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。 细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。 该装置可以包括防止细长构件的过度膨胀和/或促进细长构件的快速塌缩的特征。
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公开(公告)号：US20100237163A1
公开(公告)日：2010-09-23
申请号：US12409366
申请日：2009-03-23
申请人： James E. Chomas , Doug S. Sutton
发明人： James E. Chomas , Doug S. Sutton
CPC分类号： B01F5/0682 , B01F5/0688 , B01F11/0065 , B01F15/0205 , B01F15/0225 , B01F2215/0034
摘要： Disclosed is a device and method for generating a microbubble infused solution, the device comprising a cartridge including a first and second compartment separated by a small channel, wherein the cartridge is formed from a pliable and gas-impermeable material, and having a bubble solution inside the cartridge. Applying pressure to a substantial portion of an outer side of a selected compartment forces at least a portion of the bubble solution inside the selected compartment through the small channel to an unselected compartment and form microbubbles inside the cartridge.
摘要翻译： 公开了一种用于产生微泡输注溶液的装置和方法，该装置包括一个盒，该盒包括由小通道隔开的第一和第二隔室，其中该盒由柔韧且气体不可渗透的材料形成，并且内部具有气泡溶液 墨盒。 对选定隔室的外侧的大部分施加压力，迫使所选隔室内的气泡溶液的至少一部分通过小通道施加到未选择的隔室，并在筒内形成微泡。
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公开(公告)号：US20080200864A1
公开(公告)日：2008-08-21
申请号：US11771960
申请日：2007-06-29
IPC分类号： A61M37/00
CPC分类号： A61N7/00 , A61B2017/00747 , A61B2017/22008 , A61N1/327 , A61N2007/0008
摘要： A device comprising a housing defining a mixing chamber; means for mixing solution contained in the mixing chamber to generate microbubbles in the solution; a needle array removably attached to the housing and in fluid connection with the mixing chamber, the needle array including at least one needle; and means for adjusting a needle insertion depth of the at least one needle.
摘要翻译： 一种装置，包括限定混合室的壳体; 用于混合包含在混合室中的溶液以在溶液中产生微泡的装置; 针阵列，其可移除地附接到所述壳体并与所述混合室流体连接，所述针阵列包括至少一个针; 以及用于调节所述至少一个针的针插入深度的装置。
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公开(公告)号：US20080195036A1
公开(公告)日：2008-08-14
申请号：US11771966
申请日：2007-06-29
IPC分类号： A61M37/00
CPC分类号： A61N7/00 , A61B2017/00747 , A61B2017/22008 , A61B2017/308 , A61M37/0092 , A61M2005/1585 , A61N1/327 , A61N2007/0008
摘要： A device, comprising a housing defining a mixing chamber; means for mixing solution contained in the mixing chamber to generate microbubbles in the solution; a needle array removably attached to the housing and in fluid connection with the mixing chamber, the needle array including at least one needle; and tissue apposition means for pulling the needle array into apposition with tissue.
摘要翻译： 一种装置，包括限定混合室的壳体; 用于混合包含在混合室中的溶液以在溶液中产生微泡的装置; 针阵列，其可移除地附接到所述壳体并与所述混合室流体连接，所述针阵列包括至少一个针; 以及组织安置装置，用于将针阵列拉伸成与组织相配合。
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公开(公告)号：US08167280B2
公开(公告)日：2012-05-01
申请号：US12409366
申请日：2009-03-23
申请人： James E. Chomas , Doug S. Sutton
发明人： James E. Chomas , Doug S. Sutton
IPC分类号： B01F3/04
CPC分类号： B01F5/0682 , B01F5/0688 , B01F11/0065 , B01F15/0205 , B01F15/0225 , B01F2215/0034
摘要： Disclosed is a device and method for generating a microbubble infused solution, the device having a cartridge including a first and second compartment separated by a small channel, wherein the cartridge is formed from a pliable and gas-impermeable material, and having a bubble solution inside the cartridge. Applying pressure to a substantial portion of an outer side of a selected compartment forces at least a portion of the bubble solution inside the selected compartment through the small channel to an unselected compartment and form microbubbles inside the cartridge.
摘要翻译： 公开了一种用于产生微泡输注溶液的装置和方法，该装置具有一个盒，该盒包括由小通道隔开的第一和第二隔室，其中该盒由柔性和不透气材料形成，并且在其内具有气泡溶液 墨盒。 对选定隔室的外侧的大部分施加压力，迫使所选隔室内的气泡溶液的至少一部分通过小通道施加到未选择的隔室，并在筒内形成微泡。
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