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1.发明申请PROCESS FOR THE PREPARATION OF 2,4,6-OCTATRIENE-1-OIC ACID AND 2,4,6-OCTATRIENE-1-OL 审中-公开制备2,4,6-亚甲基-1-酸和2,4,6-十八烯-1-醇的方法公开(公告)号：US20120022282A1
公开(公告)日：2012-01-26
申请号：US13260260
申请日：2010-04-16
IPC分类号： C07C51/09 , C07C69/587 , C07C69/96 , C07C29/147
CPC分类号： C07C51/09 , C07C29/147 , C07C51/02 , C07C67/343 , C07C68/02 , C07C69/587 , C07C33/02 , C07C57/03 , C07C69/96
摘要： The present invention concerns a process for synthesis of 2,4,6-octatriene-1-oic acid and 2,4,6-octatriene-1-ol, which comprises the following stages: a) reaction between 2,4-trans-hexadienal and triethyl phosphonoacetate to give ethyl 2,4,6-trans-octatrienoate; b) alkaline hydrolysis of ethyl 2,4,6-trans-octatrienoate to give the corresponding alkaline salt; c) acidification of said salt to give 2,4,6-trans-octatrienoic acid, which can be separated or can undergo the following further stages: d) reaction of the 2,4,6-trans-octatrienoic acid with ethyl chloroformiate to give the mixed anhydride formed by 2,4,6-trans-octatrienoic acid and ethyl carbonic acid; e) reduction of said mixed anhydride with sodium borohydride to give 2,4,6-trans-octatrienol; and optionally a purification stage of the end product.
摘要翻译： 本发明涉及合成2,4,6-辛三烯-1-酸和2,4,6-辛二烯-1-醇的方法，其包括以下步骤：a）2,4-反式 - 己二烯醛和膦酰基乙酸三乙酯，得到2,4,6-反式 - 八碳三烯酸乙酯; b）碱性水解2,4,6-反式 - 八辛酸乙酯，得到相应的碱性盐; c）酸化所述盐以得到2,4,6-反式八碳三烯酸，其可被分离或可经历以下进一步的步骤：d）将2,4,6-反式 - 八碳三烯酸与氯甲酸乙酯反应 得到由2,4,6-反式 - 八碳三烯酸和乙基碳酸形成的混合酸酐; e）用硼氢化钠还原所述混合酸酐得到2,4,6-反式 - 八氢化萘酚; 和任选的最终产物的纯化阶段。
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2.发明授权Pharmaceutical, dermatological, nutritional or cosmetic composition for combating the immunosuppresive action of aggressive agents on the skin 有权药物，皮肤病学，营养或化妆品组合物，用于抵抗攻击性药物对皮肤的免疫抑制作用公开(公告)号：US09138394B2
公开(公告)日：2015-09-22
申请号：US13260245
申请日：2010-04-30
申请人： Giammaria Giuliani , Anna Benedusi
发明人： Giammaria Giuliani , Anna Benedusi
IPC分类号： A61K31/353 , A61Q17/04 , A61K8/49 , A61P37/00 , A61P29/00 , A23L1/30 , A61K9/00 , A61K9/06 , A61K9/20 , A61K9/48 , A61K31/352 , A61Q19/00
CPC分类号： A61K8/498 , A23L33/105 , A23L33/11 , A23V2002/00 , A61K9/0014 , A61K9/0095 , A61K9/06 , A61K9/2009 , A61K9/2054 , A61K9/4825 , A61K9/4858 , A61K31/352 , A61K31/353 , A61K2300/00 , A61K2800/92 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A23V2250/2116 , A23V2250/21168 , A23V2200/324
摘要： The object of the invention is a mixture of catechin and quercetin in a molar ratio varying between 3:1 and 6:1, respectively, for the treatment of the immunosuppression induced in the skin by aggressive agents such as airborne pollutants, dehydrating agents, ultraviolet radiation, and thermal and osmotic shocks, and a pharmaceutical, dermatological, nutritional or cosmetic composition containing said mixture as an active ingredient.
摘要翻译： 本发明的目的是分别以3:1和6:1之间的摩尔比变化的儿茶素和槲皮素的混合物，用于治疗皮肤中诱导的免疫抑制剂，例如空气传播的污染物，脱水剂，紫外线 辐射和热和渗透冲击，以及含有所述混合物作为活性成分的药物，皮肤病学，营养或化妆品组合物。
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公开(公告)号：US09668984B2
公开(公告)日：2017-06-06
申请号：US13128394
申请日：2009-11-10
申请人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
发明人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
IPC分类号： A61K31/202 , C07C57/03 , C07C33/02 , A61K31/045 , A61K31/11 , A61K31/22 , A61K31/231 , A61K31/232
CPC分类号： A61K31/11 , A61K31/045 , A61K31/22 , A61K31/231 , A61K31/232
摘要： The object of the present invention is the use of compounds designed to inhibit the activity of the enzyme 5α-reductase. This is a novel use of compounds of general formula (I): CH3(—CH═CH)n—R (I) where n=from 2 to 7, and R is chosen from among: CHO, CH2OH, CH2O—CO—R′, CO—O(−), where R′ is chosen from among H, and the alky from C1 to C22, each compound of general formula (I) being used as such or in mixtures with other compounds, as the active principle in a pharmaceutical or cosmetic composition designed to inhibit the action of the enzyme 5α-reductase, and of the pharmaceutical or cosmetic compositions deriving therefrom.
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4.发明授权公开(公告)号：US09237753B2
公开(公告)日：2016-01-19
申请号：US12374246
申请日：2007-07-03
申请人： Giammaria Giuliani , Anna Benedusi , Raffaella Di Cagno , Maria De Angelis , Antonella Luisi , Marco Gobbetti
发明人： Giammaria Giuliani , Anna Benedusi , Raffaella Di Cagno , Maria De Angelis , Antonella Luisi , Marco Gobbetti
IPC分类号： C12N1/20 , A21D8/04 , A21D13/04 , A21D13/06 , C12R1/01 , C12R1/225 , C12R1/24 , C12R1/25 , A21D10/00
CPC分类号： A21D8/04 , A21D8/045 , A21D10/002 , A21D13/04 , A21D13/047 , A21D13/066 , A21D13/40 , A23Y2220/05 , A23Y2220/13 , A23Y2220/17 , A23Y2220/25 , A23Y2220/29 , A23Y2220/35 , A23Y2220/37 , A23Y2220/39 , A23Y2220/63 , A23Y2220/65 , A23Y2220/67 , A23Y2220/81 , C12N1/20 , C12R1/01 , C12R1/225 , C12R1/24 , C12R1/25
摘要： The present invention concerns a mixture of lactic bacteria for yeasting of gluten-free baked products. Particularly, the invention concerns the use of “natural yeast” based on selected lactic bacteria as yeasting agent for the production of gluten-free bread, with improved sensory and nutritional property, designed for celiac patients feeding.
摘要翻译： 本发明涉及用于无麸质焙烤产品的酵母的乳酸菌混合物。 特别地，本发明涉及基于选择的乳酸菌的“天然酵母”作为酵母剂用于生产无麸质面包的用途，其具有改进的感官和营养特性，其设计用于腹腔食物喂养。
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5.发明授权Therapeutic, dietary or cosmetic use of compounds with specific anti-apoptotic activity toward caspase-3, and compositions containing these compounds 有权对胱天蛋白酶-3具有特异性抗凋亡活性的化合物的治疗，膳食或化妆品用途以及含有这些化合物的组合物公开(公告)号：US08729033B2
公开(公告)日：2014-05-20
申请号：US13127446
申请日：2009-10-30
申请人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
发明人： Giammaria Giuliani , Anna Benedusi , Sergio Baroni
IPC分类号： A61K31/047 , C07H17/07
CPC分类号： C07H17/07
摘要： This invention regards the use of zeaxanthin and/or rutin, as such or further combined with spermidine, as the active principle in a pharmaceutical, dietary, or cosmetic composition, acting to inhibit caspase-3 and therefore to control apoptosis by preventing programmed cell death.The indication for this composition according to the invention is primarily the treatment of scalp disorders characterized by excessive cellular turnover including chemotherapy-induced alopecia, alopecia areata, androgenetic alopecia and telogen effluvium.
摘要翻译： 本发明涉及玉米黄质和/或芦丁，或与亚精胺进一步联合作为药物，膳食或化妆品组合物中的活性成分，用于抑制胱天蛋白酶-3，因此通过预防程序性细胞死亡来控制凋亡 。 根据本发明的该组合物的适应症主要是治疗特征在于过度细胞周转的头皮疾病，包括化疗诱导的脱发，斑秃，雄激素性脱发和休止期脱落。
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公开(公告)号：US20120093744A1
公开(公告)日：2012-04-19
申请号：US13055007
申请日：2009-07-10
摘要： According to one aspect, the present invention relates to the use of a perfluoropolyether phosphate (PFPE phosphate), dissolved in water, for the preparation of oil-in-water emuisions (O/W) with high internal phase (HIPE). The internal phase (O) typically comprises at least 74% by volume of the emulsion and includes one or more OiIs1 which acquire, after a treatment with PFPE phosphate, some typical characteristics of high fluorine content compounds, in particular lipophobicity and homophobicity, combined with limited hydrophilicity.
摘要翻译： 一方面，本发明涉及溶解在水中的全氟聚醚磷酸酯（PFPE磷酸酯）用于制备具有高内相（HIPE）的水包油乳液（O / W）的用途。 内相（O）通常包含至少74体积％的乳液，并且包括一种或多种OiIs1，其在用PFPE磷酸盐处理后获得高含氟化合物的一些典型特征，特别是脂肪酸和同型异构体，与 有限的亲水性。
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7.发明申请Composition based on vegetal extracts of ajuga reptans for preventing hair loss, stimulating the growth of hair, regulating the production of sebum 有权基于植物提取物的组合物，用于防止脱发，刺激头发的生长，调节皮脂的产生公开(公告)号：US20110020476A1
公开(公告)日：2011-01-27
申请号：US12803113
申请日：2010-06-18
摘要： The present invention relates to preparations based on vegetal extracts of Ajuga reptans for favouring the growth of hair and stimulating the hair bulb. The preparations of the invention are in suitable formulations for oral administration or local application and are specifically suitable for the prevention and treatment of androgenic alopecia in males and females.
摘要翻译： 本发明涉及基于佐美氏植物提取物的制剂，用于有利于头发的生长和刺激毛囊。 本发明的制剂是用于口服给药或局部应用的合适制剂，并且特别适用于预防和治疗雄性和雌性中的雄激素性脱发。
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8.发明授权Compounds provided with antioxidant activity against free radicals, and pharmaceutical and cosmetic compositions containing them 有权提供抗自由基抗氧化活性的化合物，以及含有它们的药物和化妆品组合物公开(公告)号：US09289405B2
公开(公告)日：2016-03-22
申请号：US13642853
申请日：2011-04-22
申请人： Giammaria Giuliani , Anna Benedusi
发明人： Giammaria Giuliani , Anna Benedusi
CPC分类号： A61K31/19 , A61K8/361 , A61K31/22 , A61K45/06 , A61K2800/522 , A61Q5/00 , A61Q5/02 , A61Q19/00 , A61K2300/00
摘要： The invention relates to the use of compounds of general formula (I): CH3(—CH═CH)3—R (I) wherein R is selected from CO—O—R′ or CO—O(−), R′ being selected from H, alkyl or alkenyl from C1 to C22, or sugars, and their pharmaceutically acceptable salts, preferably such as sodium, potassium, or lysine salts, each compound of general formula (I) being used as such or mixed with one or more of the others, as active ingredients in a pharmaceutical or cosmetic composition provided with antioxidant activity against free radicals.
摘要翻译： 本发明涉及通式（I）的化合物：其中R选自CO-O-R'或CO-O（ - ）的CH3（-CH = CH）3-R（I），R'为 选自H，C 1至C 22的烷基或烯基，或糖，及其药学上可接受的盐，优选例如钠，钾或赖氨酸盐，通式（I）的每种化合物原样使用或与一种或多种 作为赋予抗自由基抗氧化活性的药物或化妆品组合物中的活性成分。
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公开(公告)号：US20140065262A1
公开(公告)日：2014-03-06
申请号：US13598515
申请日：2012-08-29
申请人： Giammaria GIULIANI , Anna Benedusi , Raffaella Di Cagno , Carlo Giuseppe Rizzello , Maria De Angelis , Marco Gobbetti , Angela Cassone
发明人： Giammaria GIULIANI , Anna Benedusi , Raffaella Di Cagno , Carlo Giuseppe Rizzello , Maria De Angelis , Marco Gobbetti , Angela Cassone
CPC分类号： A21D13/40 , A21D6/00 , A21D8/00 , A21D8/042 , A21D8/045 , A21D8/047 , A21D10/002 , A21D13/00 , A21D13/04 , A21D13/062 , A21D13/066 , A23L33/30 , A23Y2220/67 , A23Y2220/81 , C12N1/20
摘要： The present invention is directed to a method for preparing flour dough with reduced content of gluten starting from gluten containing cereals flours. In particular, the invention is directed to the use of lactic acid bacteria and fungal enzymes for the partial degradation of gluten in wheat flour in order to obtain flour dough with residual gluten concentration from 20,000-80,000 ppm. The flour dough obtained by the method of the invention can be used to prepare food products with reduced gluten content.
摘要翻译： 本发明涉及从含有谷物面粉的谷蛋白开始制备面粉面积减少的方法。 特别地，本发明涉及乳酸菌和真菌酶在小麦粉中部分降解麸质的用途，以便获得具有20,000-80,000ppm残余麸质浓度的面粉面团。 通过本发明方法获得的面粉面团可用于制备具有降低的面筋含量的食品。
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10.发明申请COMPOUNDS PROVIDED WITH ANTIOXIDANT ACTIVITY AGAINST FREE RADICALS, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM 有权提供抗自由基抗菌活性的化合物，以及含有它们的药物和化妆品组合物公开(公告)号：US20130046017A1
公开(公告)日：2013-02-21
申请号：US13642853
申请日：2011-04-22
申请人： Giammaria Giuliani , Anna Benedusi
发明人： Giammaria Giuliani , Anna Benedusi
IPC分类号： A61K8/36 , C07C69/533 , A61K8/41 , C07C57/03 , A61P17/18 , A61K8/37 , C07C229/30
CPC分类号： A61K31/19 , A61K8/361 , A61K31/22 , A61K45/06 , A61K2800/522 , A61Q5/00 , A61Q5/02 , A61Q19/00 , A61K2300/00
摘要： The invention relates to the use of compounds of general formula (I): CH3(—CH═CH)3—R (I) wherein R is selected from CO—O—R′ or CO—O(−), R′ being selected from H, alkyl or alkenyl from C1 to C22, or sugars, and their pharmaceutically acceptable salts, preferably such as sodium, potassium, or lysine salts,each compound of general formula (I) being used as such or mixed with one or more of the others,as active ingredients in a pharmaceutical or cosmetic composition provided with antioxidant activity against free radicals.
摘要翻译： 本发明涉及通式（I）的化合物：其中R选自CO-O-R'或CO-O（ - ）的CH3（-CH = CH）3-R（I），R'为 选自H，C 1至C 22的烷基或烯基，或糖，及其药学上可接受的盐，优选例如钠，钾或赖氨酸盐，通式（I）的每种化合物原样使用或与一种或多种 作为赋予抗自由基抗氧化活性的药物或化妆品组合物中的活性成分。
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