MODIFIED OILS AND MULTIPLE EMULSIONS
    2.
    发明申请
    MODIFIED OILS AND MULTIPLE EMULSIONS 审中-公开
    改性油和多种乳液

    公开(公告)号:US20120093744A1

    公开(公告)日:2012-04-19

    申请号:US13055007

    申请日:2009-07-10

    摘要: According to one aspect, the present invention relates to the use of a perfluoropolyether phosphate (PFPE phosphate), dissolved in water, for the preparation of oil-in-water emuisions (O/W) with high internal phase (HIPE). The internal phase (O) typically comprises at least 74% by volume of the emulsion and includes one or more OiIs1 which acquire, after a treatment with PFPE phosphate, some typical characteristics of high fluorine content compounds, in particular lipophobicity and homophobicity, combined with limited hydrophilicity.

    摘要翻译: 一方面,本发明涉及溶解在水中的全氟聚醚磷酸酯(PFPE磷酸酯)用于制备具有高内相(HIPE)的水包油乳液(O / W)的用途。 内相(O)通常包含至少74体积%的乳液,并且包括一种或多种OiIs1,其在用PFPE磷酸盐处理后获得高含氟化合物的一些典型特征,特别是脂肪酸和同型异构体,与 有限的亲水性。

    Therapeutic, dietary or cosmetic use of compounds with specific anti-apoptotic activity toward caspase-3, and compositions containing these compounds
    9.
    发明授权
    Therapeutic, dietary or cosmetic use of compounds with specific anti-apoptotic activity toward caspase-3, and compositions containing these compounds 有权
    对胱天蛋白酶-3具有特异性抗凋亡活性的化合物的治疗,膳食或化妆品用途以及含有这些化合物的组合物

    公开(公告)号:US08729033B2

    公开(公告)日:2014-05-20

    申请号:US13127446

    申请日:2009-10-30

    IPC分类号: A61K31/047 C07H17/07

    CPC分类号: C07H17/07

    摘要: This invention regards the use of zeaxanthin and/or rutin, as such or further combined with spermidine, as the active principle in a pharmaceutical, dietary, or cosmetic composition, acting to inhibit caspase-3 and therefore to control apoptosis by preventing programmed cell death.The indication for this composition according to the invention is primarily the treatment of scalp disorders characterized by excessive cellular turnover including chemotherapy-induced alopecia, alopecia areata, androgenetic alopecia and telogen effluvium.

    摘要翻译: 本发明涉及玉米黄质和/或芦丁,或与亚精胺进一步联合作为药物,膳食或化妆品组合物中的活性成分,用于抑制胱天蛋白酶-3,因此通过预防程序性细胞死亡来控制凋亡 。 根据本发明的该组合物的适应症主要是治疗特征在于过度细胞周转的头皮疾病,包括化疗诱导的脱发,斑秃,雄激素性脱发和休止期脱落。

    PROCESS FOR THE PREPARATION OF 2,4,6-OCTATRIENE-1-OIC ACID AND 2,4,6-OCTATRIENE-1-OL
    10.
    发明申请
    PROCESS FOR THE PREPARATION OF 2,4,6-OCTATRIENE-1-OIC ACID AND 2,4,6-OCTATRIENE-1-OL 审中-公开
    制备2,4,6-亚甲基-1-酸和2,4,6-十八烯-1-醇的方法

    公开(公告)号:US20120022282A1

    公开(公告)日:2012-01-26

    申请号:US13260260

    申请日:2010-04-16

    摘要: The present invention concerns a process for synthesis of 2,4,6-octatriene-1-oic acid and 2,4,6-octatriene-1-ol, which comprises the following stages: a) reaction between 2,4-trans-hexadienal and triethyl phosphonoacetate to give ethyl 2,4,6-trans-octatrienoate; b) alkaline hydrolysis of ethyl 2,4,6-trans-octatrienoate to give the corresponding alkaline salt; c) acidification of said salt to give 2,4,6-trans-octatrienoic acid, which can be separated or can undergo the following further stages: d) reaction of the 2,4,6-trans-octatrienoic acid with ethyl chloroformiate to give the mixed anhydride formed by 2,4,6-trans-octatrienoic acid and ethyl carbonic acid; e) reduction of said mixed anhydride with sodium borohydride to give 2,4,6-trans-octatrienol; and optionally a purification stage of the end product.

    摘要翻译: 本发明涉及合成2,4,6-辛三烯-1-酸和2,4,6-辛二烯-1-醇的方法,其包括以下步骤:a)2,4-反式 - 己二烯醛和膦酰基乙酸三乙酯,得到2,4,6-反式 - 八碳三烯酸乙酯; b)碱性水解2,4,6-反式 - 八辛酸乙酯,得到相应的碱性盐; c)酸化所述盐以得到2,4,6-反式八碳三烯酸,其可被分离或可经历以下进一步的步骤:d)将2,4,6-反式 - 八碳三烯酸与氯甲酸乙酯反应 得到由2,4,6-反式 - 八碳三烯酸和乙基碳酸形成的混合酸酐; e)用硼氢化钠还原所述混合酸酐得到2,4,6-反式 - 八氢化萘酚; 和任选的最终产物的纯化阶段。