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公开(公告)号：US20120123244A1
公开(公告)日：2012-05-17
申请号：US13337183
申请日：2011-12-26
Applicant: Dan Hashimshony , Gil Cohen , Iddo Geltner
Inventor： Dan Hashimshony , Gil Cohen , Iddo Geltner
CPC classification number: A61B6/032 , A61B5/0059 , A61B5/015 , A61B5/0536 , A61B5/055 , A61B5/103 , A61B5/4312 , A61B5/6834 , A61B5/6843 , A61B5/6844 , A61B5/6885 , A61B5/6886 , A61B6/4417 , A61B6/5247 , A61B8/13
Abstract: The present invention relates to a device for tissue-characterization, designed for effective sensor-to-tissue contact. The device includes an element, having a rigid surface of a linear cross-section, on which at least one sensor is arranged, and a mechanism for applying a force to a soft tissue, the line of force being at an acute angle with the rigid surface, for stretching or stretching and pushing the soft tissue against the rigid surface, thus achieving effective contact between the tissue and the at least one sensor. In consequence, the accuracy of the sensing is improved. In accordance with another embodiment, a plurality of sensors is employed, arranged along a curved element, for providing three-dimensional information regarding the tissue, for example, by small-scale computerized tomography.
Abstract translation: 本发明涉及一种用于组织表征的设备，用于有效的传感器与组织接触。 该装置包括具有线性横截面的刚性表面的元件，至少一个传感器布置在该元件上，以及用于向软组织施加力的机构，该力与刚性线成锐角 表面，用于拉伸或拉伸并将软组织推靠在刚性表面上，从而实现组织与至少一个传感器之间的有效接触。 因此，传感的精度得到改善。 根据另一个实施例，采用多个传感器，沿弯曲元件布置，用于提供关于组织的三维信息，例如通过小规模计算机断层摄影。
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2.发明授权Probes, systems, and methods for examining tissue according to the dielectric properties thereof 有权用于根据其介电性质检查组织的探针，系统和方法公开(公告)号：US08019411B2
公开(公告)日：2011-09-13
申请号：US11705143
申请日：2007-02-12
Applicant: Dan Hashimshony , Gil Cohen , Iddo Geltner
Inventor： Dan Hashimshony , Gil Cohen , Iddo Geltner
IPC: A61B5/05
Abstract: The present invention relates to probes, systems, and methods for tissue characterization by its dielectric properties, wherein a physical feature of the probe is designed to define and delimit a tissue volume, at a tissue edge, where characterization takes place. Thus, the probe for tissue-edge characterization comprises: a first inner conductor, which comprises: proximal and distal ends, with respect to a tissue edge, along an x-axis; a first sharp edge, inherently associated with the proximal end; at least one feature, issuing from the first inner conductor, substantially at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a generally predefined tissue volume, at the tissue edge, the tissue volume being generally defined by physical parameters associated with the at least one feature; and a dielectric material, which encloses the conductor, in the y-z planes.
Abstract translation: 本发明涉及用于通过其介电特性进行组织表征的探针，系统和方法，其中探针的物理特征被设计成在组织边缘处限定和限定组织体积，其中进行表征。 因此，用于组织边缘表征的探针包括：第一内部导体，其包括：沿x轴的相对于组织边缘的近端和远端; 固有地与近端相关联的第一锋利边缘; 至少一个特征，从第一内部导体发出，基本上在近端处，用于形成至少一个额外的锋利边缘，用于在组织边缘处的通常预定的组织体积内增强组织中的局部电气条纹区域， 组织体积通常由与至少一个特征相关联的物理参数限定; 以及在y-z平面中包围导体的电介质材料。
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公开(公告)号：US07899515B2
公开(公告)日：2011-03-01
申请号：US11887571
申请日：2006-03-29
Applicant: Dan Hashimshony , Gil Cohen , Iddo Geltner
Inventor： Dan Hashimshony , Gil Cohen , Iddo Geltner
IPC: A61B5/05
CPC classification number: A61B5/05 , G01R27/2664
Abstract: A sensor for tissue characterization is provided, comprising: a resonator, configured to be placed proximally to an edge of a tissue for characterization, without penetrating the tissue, the resonator comprising a conductive structure associated with a diameter-equivalent dimension D, in a plane substantially parallel with the edge, and with a feature size d; and at least one conductive lead, for providing communication with an external system, wherein the resonator is configured to resonate at a frequency which corresponds to a free-air wavelength range of between about lambda and about 40 lambda, wherein lambda is at least about ten times the diameter-equivalent D, and wherein upon receiving a signal in the range of between about lambda and about 40 lambda, the sensor is configured to induce electric and magnetic fields, in a near zone, in the tissue, the near zone having a diameter of about D, so that the tissue in the near zone effectively functions as part of the resonator, influencing its resonating values, and so the tissue in the near zone is thereby characterized by its electromagnetic properties, by the resonating response of the resonator.
Abstract translation: 提供了一种用于组织表征的传感器，包括：谐振器，被配置为被放置在组织的边缘的近侧，用于表征，而不穿透组织，所述谐振器包括与直径等效尺寸D相关联的导电结构 基本上与边缘平行，具有特征尺寸d; 以及用于提供与外部系统的通信的至少一个导电引线，其中所述谐振器被配置为以对应于约λ至约40λ之间的自由空气波长范围的频率谐振，其中λ为至少约十 倍，直径等效D，并且其中当接收到在约λλ和约40λ之间的范围内的信号时，所述传感器被配置为在所述组织中的近区域中诱导电场和磁场，所述近区具有 大约D的直径，使得近区域中的组织有效地用作谐振器的一部分，影响其谐振值，因此通过谐振器的谐振响应，近区域中的组织的特征在于其电磁特性。
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公开(公告)号：US20090062637A1
公开(公告)日：2009-03-05
申请号：US11887571
申请日：2006-03-29
Applicant: Dan Hashimshony , Gil Cohen , Iddo Geltner
Inventor： Dan Hashimshony , Gil Cohen , Iddo Geltner
IPC: A61B5/05
CPC classification number: A61B5/05 , G01R27/2664
Abstract: A sensor for tissue characterization is provided, comprising: a resonator, configured to be placed proximally to an edge of a tissue for characterization, without penetrating the tissue, the resonator comprising a conductive structure associated with a diameter-equivalent dimension D, in a plane substantially parallel with the edge, and with a feature size d; and at least one conductive lead, for providing communication with an external system, wherein the resonator is configured to resonate at a frequency which corresponds to a free-air wavelength range of between about lambda and about 40 lambda, wherein lambda is at least about ten times the diameter-equivalent D, and wherein upon receiving a signal in the range of between about lambda and about 40 lambda, the sensor is configured to induce electric and magnetic fields, in a near zone, in the tissue, the near zone having a diameter of about D, so that the tissue in the near zone effectively functions as part of the resonator, influencing its resonating values, and so the tissue in the near zone is thereby characterized by its electromagnetic properties, by the resonating response of the resonator.
Abstract translation: 提供了一种用于组织表征的传感器，包括：谐振器，被配置为被放置在组织的边缘的近侧，用于表征，而不穿透组织，所述谐振器包括与直径等效尺寸D相关联的导电结构 基本上与边缘平行，具有特征尺寸d; 以及用于提供与外部系统的通信的至少一个导电引线，其中所述谐振器被配置为以对应于约λ至约40λ之间的自由空气波长范围的频率谐振，其中λ为至少约十 倍，直径等效D，并且其中当接收到在约λλ和约40λ之间的范围内的信号时，所述传感器被配置为在所述组织中的近区域中诱导电场和磁场，所述近区具有 大约D的直径，使得近区域中的组织有效地用作谐振器的一部分，影响其谐振值，因此通过谐振器的谐振响应，近区域中的组织的特征在于其电磁特性。
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公开(公告)号：US07720532B2
公开(公告)日：2010-05-18
申请号：US10558831
申请日：2005-03-23
Applicant: Dan Hashimshony , Gil Cohen , Iddo Geltner
Inventor： Dan Hashimshony , Gil Cohen , Iddo Geltner
CPC classification number: A61B5/415 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/0091 , A61B5/01 , A61B5/015 , A61B5/0507 , A61B5/053 , A61B5/055 , A61B5/06 , A61B5/4312 , A61B8/0858 , A61B8/12 , A61B8/4245 , A61B8/4472 , A61B18/082 , A61B34/20 , A61B2017/00026 , A61B2034/107 , A61B2034/2051 , A61B2034/2055 , A61B2090/061 , A61B2090/367 , A61B2090/378
Abstract: An integrated tool is provided, having a tissue-type sensor, for determining the tissue type at a near zone volume of a tissue surface, and a distance-measuring sensor, for determining the distance to an interface with another tissue type, for (i) confirming an existence of a clean margin of healthy tissue around a malignant tumor, which is being removed, and (ii) determining the depth of the clean margin. The integrated tool may further include a position tracking device and an incision instrument. The soft tissue may be held within a fixed frame, while the tumor is being removed. Additionally a method for malignant tumor removal is provided, comprising, fixing the soft tissue within a frame, performing imaging with the hand-held, integrated tool, from a plurality of locations and orientations around the soft tissue, reconstructing a three-dimensional image of the soft tissue and the tumor within, defining a desired clean margin on the reconstructed image, calculating a recommended incision path, displaying the recommended path on the reconstructed image, and cutting the tissue while determining its type, at the near zone volume of the incision surface. The method may further include continuously imaging with the cutting, continuously correcting the reconstructed image and the recommended incision path, and continuously determining the tissue type, at the near zone volume of the incision surface.
Abstract translation: 提供了一种集成工具，具有用于确定组织表面的近区域体积处的组织类型的组织型传感器和用于确定与另一组织类型的界面的距离的距离测量传感器，用于（i ）确认正在被去除的恶性肿瘤周围存在健康组织的清洁边缘，以及（ii）确定清洁边缘的深度。 集成工具还可以包括位置跟踪装置和切口装置。 当肿瘤被移除时，软组织可以保持在固定框架内。 另外，提供了一种用于恶性肿瘤去除的方法，包括：将软组织固定在框架内，利用手持式集成工具从软组织周围的多个位置和取向进行成像，重建三维图像 软组织和肿瘤内，在重建图像上限定所需的清洁边缘，计算推荐切口路径，在重建图像上显示推荐路径，以及在确定其类型的同时切割组织，在切口的近区体积处 表面。 该方法可以进一步包括连续成像切割，连续校正重建图像和推荐切口路径，以及在切口表面的近区域体积处连续地确定组织类型。
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Patent Agency Ranking
公开(公告)号：US20080249434A1
公开(公告)日：2008-10-09
申请号：US10582135
申请日：2006-03-02
Applicant: Dan Hashimshony , Orit Yarden , Gal Aharonowitz , Gil Cohen , Iddo Geltner
Inventor： Dan Hashimshony , Orit Yarden , Gal Aharonowitz , Gil Cohen , Iddo Geltner
CPC classification number: A61B10/0096 , A01N1/02 , A01N1/0273 , A61B90/39 , A61B2017/320064 , A61B2090/0807 , A61B2090/0811 , A61B2090/3908 , B01L3/508 , G01N1/312
Abstract: A device and method and provided for tissue handling, while maintaining the in-vivo tissue orientation. The device includes a structure, configured for receiving and holding a tissue specimen, wherein the tissue specimen includes tissue positional references; and device positional references, associated with the structure, for fixing the orientation of the tissue specimen, when held by the device, so as to reflect the tissue specimen positional references.
Abstract translation: 一种装置和方法，并提供用于组织处理，同时保持体内组织取向。 所述装置包括构造成用于接收和保持组织样本的结构，其中所述组织样本包括组织位置参考; 以及与所述结构相关联的用于固定所述组织样本的取向的装置位置参考，当被所述装置保持时，以便反映所述组织样本位置参考。
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公开(公告)号：US20080039742A1
公开(公告)日：2008-02-14
申请号：US11745334
申请日：2007-05-07
Applicant: Dan Hashimshony , Gil Cohen , Iddo Geltner
Inventor： Dan Hashimshony , Gil Cohen , Iddo Geltner
IPC: A61B5/103
CPC classification number: A61B5/415 , A61B5/0071 , A61B5/0073 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/0091 , A61B5/01 , A61B5/015 , A61B5/0507 , A61B5/053 , A61B5/055 , A61B5/06 , A61B5/068 , A61B5/4312 , A61B8/0858 , A61B8/12 , A61B8/4245 , A61B8/4472 , A61B34/20 , A61B34/30 , A61B2017/00026 , A61B2017/00057 , A61B2017/00061 , A61B2017/00106 , A61B2034/107 , A61B2034/2051 , A61B2090/061 , A61B2090/367 , Y10S607/901
Abstract: An integrated tool is provided, having a tissue-type sensor, for determining the tissue type at a near zone volume of a tissue surface, and a distance-measuring sensor, for determining the distance to an interface with another tissue type, for (i) confirming an existence of a clean margin of healthy tissue around a malignant tumor, which is being removed, and (ii) determining the depth of the clean margin. The integrated tool may further include a position tracking device and an incision instrument. The soft tissue may be held within a fixed frame, while the tumor is being removed. Additionally a method for malignant tumor removal is provided, comprising, fixing the soft tissue within a frame, performing imaging with the hand-held, integrated tool, from a plurality of locations and orientations around the soft tissue, reconstructing a three-dimensional image of the soft tissue and the tumor within, defining a desired clean margin on the reconstructed image, calculating a recommended incision path, displaying the recommended path on the reconstructed image, and cutting the tissue while determining its type, at the near zone volume of the incision surface. The method may further include continuously imaging with the cutting, continuously correcting the reconstructed image and the recommended incision path, and continuously determining the tissue type, at the near zone volume of the incision surface.
Abstract translation: 提供了一种集成工具，具有用于确定组织表面的近区域体积处的组织类型的组织型传感器和用于确定与另一组织类型的界面的距离的距离测量传感器，用于（i ）确认正在被去除的恶性肿瘤周围存在健康组织的清洁边缘，以及（ii）确定清洁边缘的深度。 集成工具还可以包括位置跟踪装置和切口装置。 当肿瘤被移除时，软组织可以保持在固定框架内。 另外，提供了一种用于恶性肿瘤去除的方法，包括：将软组织固定在框架内，利用手持式集成工具从软组织周围的多个位置和取向进行成像，重建三维图像 软组织和肿瘤内，在重建图像上限定所需的清洁边缘，计算推荐切口路径，在重建图像上显示推荐路径，以及在确定其类型的同时切割组织，在切口的近区体积处 表面。 该方法可以进一步包括连续成像切割，连续校正重建图像和推荐切口路径，以及在切口表面的近区域体积处连续地确定组织类型。
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8.发明申请公开(公告)号：US20070032747A1
公开(公告)日：2007-02-08
申请号：US11350102
申请日：2006-02-09
Applicant: Dan Hashimshony , Gil Cohen , Iddo Geltner
Inventor： Dan Hashimshony , Gil Cohen , Iddo Geltner
CPC classification number: A61B6/032 , A61B5/0059 , A61B5/015 , A61B5/0536 , A61B5/055 , A61B5/103 , A61B5/4312 , A61B5/6834 , A61B5/6843 , A61B5/6844 , A61B5/6885 , A61B5/6886 , A61B6/4417 , A61B6/5247 , A61B8/13
Abstract: The present invention relates to a device for tissue-characterization, designed for effective sensor-to-tissue contact. The device includes an element, having a rigid surface of a linear cross-section, on which at least one sensor is arranged, and a mechanism for applying a force to a soft tissue, the line of force being at an acute angle with the rigid surface, for stretching or stretching and pushing the soft tissue against the rigid surface, thus achieving effective contact between the tissue and the at least one sensor. In consequence, the accuracy of the sensing is improved. In accordance with another embodiment, a plurality of sensors is employed, arranged along a curved element, for providing three-dimensional information regarding the tissue, for example, by small-scale computerized tomography.
Abstract translation: 本发明涉及一种用于组织表征的设备，用于有效的传感器与组织接触。 该装置包括具有线性横截面的刚性表面的元件，至少一个传感器布置在该元件上，以及用于向软组织施加力的机构，该力与刚性线成锐角 表面，用于拉伸或拉伸并将软组织推靠在刚性表面上，从而实现组织与至少一个传感器之间的有效接触。 因此，传感的精度得到改善。 根据另一个实施例，采用多个传感器，沿弯曲元件布置，用于提供关于组织的三维信息，例如通过小规模计算机断层摄影。
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9.发明授权Method and apparatus for examining a substance, particularly tissue, to characterize its type 有权用于检查物质，特别是组织以表征其类型的方法和装置公开(公告)号：US07082325B2
公开(公告)日：2006-07-25
申请号：US10891750
申请日：2004-07-15
Applicant: Dan Hashimshony , Gil Cohen
Inventor： Dan Hashimshony , Gil Cohen
IPC: A61B5/055
CPC classification number: G01R33/60 , A61B5/053 , A61B5/055 , A61B10/0266 , A61B90/39 , G01R33/3808
Abstract: A method and apparatus for examining a substance volume to characterize its type, particularly useful for examining tissue to characterize it as cancerous or non-cancerous. The method comprises: applying a polarizing magnetic field through the examined substance; applying RF pulses locally to the examined substance volume such as to invoke electrical impedance (EI) responses signals corresponding to the electrical impedance of the substance, and magnetic resonance (MR) responses signals corresponding to the MR properties of the substance; detecting the EI and MR response signals; and utilizing the detected response signals for characterizing the examined substance volume type.
Abstract translation: 用于检查物质体积以表征其类型的方法和装置，特别用于检查组织以将其表征为癌性或非癌性。 该方法包括：通过被检物质施加极化磁场; 将RF脉冲局部施加到所检查的物质体积，以便调用对应于物质的电阻抗的电阻抗（EI）响应信号，以及对应于物质的MR性质的磁共振（MR）响应信号; 检测EI和MR响应信号; 以及利用检测到的响应信号来表征所检查的物质体积类型。
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10.发明授权公开(公告)号：US09526460B2
公开(公告)日：2016-12-27
申请号：US13337183
申请日：2011-12-26
Applicant: Dan Hashimshony , Gil Cohen , Iddo Geltner
Inventor： Dan Hashimshony , Gil Cohen , Iddo Geltner
CPC classification number: A61B6/032 , A61B5/0059 , A61B5/015 , A61B5/0536 , A61B5/055 , A61B5/103 , A61B5/4312 , A61B5/6834 , A61B5/6843 , A61B5/6844 , A61B5/6885 , A61B5/6886 , A61B6/4417 , A61B6/5247 , A61B8/13
Abstract: The present invention relates to a device for tissue-characterization, designed for effective sensor-to-tissue contact. The device includes an element, having a rigid surface of a linear cross-section, on which at least one sensor is arranged, and a mechanism for applying a force to a soft tissue, the line of force being at an acute angle with the rigid surface, for stretching or stretching and pushing the soft tissue against the rigid surface, thus achieving effective contact between the tissue and the at least one sensor. In consequence, the accuracy of the sensing is improved. In accordance with another embodiment, a plurality of sensors is employed, arranged along a curved element, for providing three-dimensional information regarding the tissue, for example, by small-scale computerized tomography.
Abstract translation: 本发明涉及一种用于组织表征的设备，用于有效的传感器与组织接触。 该装置包括具有线性横截面的刚性表面的元件，其上布置有至少一个传感器，以及用于向软组织施加力的机构，该力与刚性线成锐角 表面，用于拉伸或拉伸并将软组织推靠在刚性表面上，从而实现组织与至少一个传感器之间的有效接触。 因此，传感的精度得到改善。 根据另一个实施例，采用多个传感器，沿弯曲元件布置，用于提供关于组织的三维信息，例如通过小规模计算机断层摄影。
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