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    Biomatrix for soft tissue regeneration using mesenchymal stem cells
    2.
    发明授权
    Biomatrix for soft tissue regeneration using mesenchymal stem cells 有权
    使用间充质干细胞进行软组织再生的Biomatrix

    公开(公告)号：US06174333B1

    公开(公告)日：2001-01-16

    申请号：US09222688

    申请日：1998-12-29

    申请人： Sudhakar Kadiyala ,  Arnold I. Caplan ,  David J. Fink ,  Randall G. Young

    发明人： Sudhakar Kadiyala ,  Arnold I. Caplan ,  David J. Fink ,  Randall G. Young

    IPC分类号： A61F202

    CPC分类号： A61B17/1146 ,  A61B17/06066 ,  A61B17/06166 ,  A61B2017/00004

    摘要： An implant for repair of a tissue defect comprises a plurality of physiologically compatible load-bearing sutures for securing under tension tissue adjacent to the defect to be repaired, the sutures for supporting a tissue reparative cell mass in the defect and a tissue reparative cell mass supported thereby. The sutures have a central portion encapsulated in a cell containing matrix which is contracted under a tensile load by the cells thereof and formed into a mat sheet during the contraction. Spring metal wires hold the sutures in tension during the contraction. The matrix is a collagen gel or other material which the cells contract, the cells comprising human mesenchymal stem cells. The mat sheet is then rolled into a spiral roll with the sutures extending from opposite roll ends to form the desired implant. Different embodiments are disclosed.

    摘要翻译： 用于修复组织缺损的植入物包括多个生理上相容的承载缝合线，用于固定在待修复的缺损部位的紧张组织附近，用于支撑缺损中的组织修复细胞块的缝线和支撑的组织修复细胞块 从而。 缝线具有封装在含有细胞的基质中的中心部分，该细胞在细胞的拉伸载荷下收缩并在收缩期间形成垫片。 弹簧金属线在收缩期间将缝合线张紧。 基质是胶原凝胶或细胞收缩的其他物质，细胞包含人间充质干细胞。 然后将垫片卷成螺旋卷，其中缝合线从相对的辊端延伸以形成期望的植入物。 公开了不同的实施例。

    Cell-containing bone graft material
    7.
    发明授权
    Cell-containing bone graft material 有权
    含细胞的骨移植材料

    公开(公告)号：US08313742B2

    公开(公告)日：2012-11-20

    申请号：US10109946

    申请日：2002-03-29

    申请人： Sudhakar Kadiyala ,  Scott P. Bruder

    发明人： Sudhakar Kadiyala ,  Scott P. Bruder

    IPC分类号： A61F2/28 ,  C12N5/00

    CPC分类号： A61L27/425 ,  A61F2/08 ,  A61F2/28 ,  A61F2/30756 ,  A61F2002/2835 ,  A61F2002/2842 ,  A61L27/3608 ,  A61L27/3645 ,  A61L27/3683 ,  A61L27/3804 ,  A61L27/3843

    摘要： This invention relates to a musculoskeletogenic MSG graft composite made from whole bone marrow aspirate BMA having native levels of musculoskeletal progenitor cells MSPCs, comprising: a) a suspension of fractionated BMA comprising: i) MSPCs present at a level greater than their native level in whole BMA, and ii) red blood cells RBCs present at a level less than their native level in whole BMA, and b) a porous sterile matrix having an average pore size of at least 20 μm.

    摘要翻译： 本发明涉及由具有天然水平的肌骨骼祖细胞MSPC的全骨髓吸出物BMA制备的肌肉发生性MSG接枝复合物，其包含：a）分级BMA的悬浮液，其包含：i）整体上存在于其天然水平以上的水平的MSPC BMA，和ii）在整个BMA中存在的水平低于其天然水平的红细胞RBC，以及b）具有至少20μm的平均孔径的多孔无菌基质。

    Biodegradable foams for cell transplantation
    10.
    发明授权
    Biodegradable foams for cell transplantation 失效
    可生物降解的泡沫用于细胞移植

    公开(公告)号：US5686091A

    公开(公告)日：1997-11-11

    申请号：US219017

    申请日：1994-03-28

    申请人： Kam W. Leong ,  Hungnan Lo ,  Sudhakar Kadiyala

    发明人： Kam W. Leong ,  Hungnan Lo ,  Sudhakar Kadiyala

    IPC分类号： A61F2/02 ,  A61F2/00

    CPC分类号： A61F2/022 ,  Y10T428/249955 ,  Y10T428/249958 ,  Y10T428/249978

    摘要： A structurally rigid biodegradable foam scaffold useful for cell transplantation is provided. The foam can be loaded with nutrients and/or drugs that elute from the foam during transplant to promote growth of the cells. The foam, which features a continuous network of pores, is fabricated using a novel method involving phase separation and consequent expansion upon sublimation of a liquid solvent, preferably naphthalene.

    摘要翻译： 提供了可用于细胞移植的结构刚性可生物降解泡沫支架。 泡沫可以装载在移植期间从泡沫中洗脱的营养物和/或药物以促进细胞的生长。 具有连续的孔孔网的泡沫体使用涉及液相溶剂（优选萘）升华的相分离和随后膨胀的新方法制造。