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    Biomatrix for soft tissue regeneration using mesenchymal stem cells
    2.
    发明授权
    Biomatrix for soft tissue regeneration using mesenchymal stem cells 有权
    使用间充质干细胞进行软组织再生的Biomatrix

    公开(公告)号：US06174333B1

    公开(公告)日：2001-01-16

    申请号：US09222688

    申请日：1998-12-29

    申请人： Sudhakar Kadiyala ,  Arnold I. Caplan ,  David J. Fink ,  Randall G. Young

    发明人： Sudhakar Kadiyala ,  Arnold I. Caplan ,  David J. Fink ,  Randall G. Young

    IPC分类号： A61F202

    CPC分类号： A61B17/1146 ,  A61B17/06066 ,  A61B17/06166 ,  A61B2017/00004

    摘要： An implant for repair of a tissue defect comprises a plurality of physiologically compatible load-bearing sutures for securing under tension tissue adjacent to the defect to be repaired, the sutures for supporting a tissue reparative cell mass in the defect and a tissue reparative cell mass supported thereby. The sutures have a central portion encapsulated in a cell containing matrix which is contracted under a tensile load by the cells thereof and formed into a mat sheet during the contraction. Spring metal wires hold the sutures in tension during the contraction. The matrix is a collagen gel or other material which the cells contract, the cells comprising human mesenchymal stem cells. The mat sheet is then rolled into a spiral roll with the sutures extending from opposite roll ends to form the desired implant. Different embodiments are disclosed.

    摘要翻译： 用于修复组织缺损的植入物包括多个生理上相容的承载缝合线，用于固定在待修复的缺损部位的紧张组织附近，用于支撑缺损中的组织修复细胞块的缝线和支撑的组织修复细胞块 从而。 缝线具有封装在含有细胞的基质中的中心部分，该细胞在细胞的拉伸载荷下收缩并在收缩期间形成垫片。 弹簧金属线在收缩期间将缝合线张紧。 基质是胶原凝胶或细胞收缩的其他物质，细胞包含人间充质干细胞。 然后将垫片卷成螺旋卷，其中缝合线从相对的辊端延伸以形成期望的植入物。 公开了不同的实施例。

    Human mesenchymal stem cells
    6.
    发明授权
    Human mesenchymal stem cells 失效
    人类间充质干细胞

    公开(公告)号：US5486359A

    公开(公告)日：1996-01-23

    申请号：US193262

    申请日：1994-02-08

    申请人： Arnold I. Caplan ,  Stephen E. Haynesworth

    发明人： Arnold I. Caplan ,  Stephen E. Haynesworth

    IPC分类号： A61F2/28 ,  A61F2/30 ,  A61K35/12 ,  A61K35/28 ,  A61L27/38 ,  A61L31/00 ,  C07K16/28 ,  C12N5/00 ,  C12N5/0775 ,  C12N5/08

    CPC分类号： A61L27/3834 ,  A61F2/28 ,  A61K35/28 ,  A61L27/3843 ,  A61L31/005 ,  C07K16/28 ,  C12N5/0068 ,  C12N5/0663 ,  A61F2/30756 ,  A61K2035/124 ,  A61L2430/10 ,  C12N2501/23 ,  C12N2501/39 ,  C12N2533/18

    摘要： Isolated human mesenchymal stem cells which can differentiate into more than one tissue type (e.g. bone, cartilage, muscle or marrow stroma), a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. "mesenchymal stem cells" or "hMSCs"), and characterization of and uses, particularly research reagent, diagnostic and therapeutic uses for such cells. The stem cells can be culture expanded without differentiating. Monoclonal antibodies specific for human mesenchymal stem cells and the monoclonal hybridoma cell lines (ATCC nos. 10743-10745) that synthesize and secrete these monospecific antibodies, and uses of the monoclonal antibodies for diagnostic and/or therapeutic purposes.

    摘要翻译： 可以分化成多于一种组织类型（例如骨，软骨，肌肉或骨髓基质）的分离的人类间充质干细胞，分离，纯化和培养人间充质干细胞（即“间充质干细胞”或“hMSC”）的方法 “），以及这些细胞的特征和用途，特别是研究试剂，诊断和治疗用途。 干细胞可以培养扩大而不分化。 合成和分泌这些单特异性抗体的人类间充质干细胞特异性单克隆抗体和单克隆杂交瘤细胞系（ATCC nos。10743-10745）以及单克隆抗体用于诊断和/或治疗目的的用途。

    Osteoarthritis cartilage regeneration
    7.
    发明授权
    Osteoarthritis cartilage regeneration 失效
    骨关节炎软骨再生

    公开(公告)号：US06835377B2

    公开(公告)日：2004-12-28

    申请号：US09078531

    申请日：1998-05-13

    申请人： Victor M. Goldberg ,  Arnold I. Caplan ,  Francis P. Barry ,  David J. Fink ,  Daniel R. Marshak ,  James S. Burns

    发明人： Victor M. Goldberg ,  Arnold I. Caplan ,  Francis P. Barry ,  David J. Fink ,  Daniel R. Marshak ,  James S. Burns

    IPC分类号： C12N500

    CPC分类号： C12N5/0655 ,  A61K2035/124 ,  A61K2035/126 ,  C12N5/0663 ,  C12N2501/15 ,  C12N2501/23 ,  C12N2501/39 ,  C12N2533/54

    摘要： For repair of cartilage damaged as part of the degenerative effects of osteoarthritis, the inventors have found that the human mesenchymal stem cell approach makes it possible to: (1) regenerate both shallow cartilage chondral defects and full thickness cartilage defects (osteochondral lesions); (2) broaden the suitable clinical population to routinely include middle-aged patients; (3) eliminate the use of autologous tissue grafts (mature cartilage and the periosteal covering) to repair an articular cartilage injury; (4) regenerate other types of injured cartilage such as patellar and spinal disk cartilage; (5) regenerate articular joint cartilage in older patients with osteoarthritis; and (6) form new cartilage and subchondral bone which fully integrate into the adjacent normal tissue.

    摘要翻译： 为了修复作为骨关节炎退行性疾病的一部分而损伤的软骨，本发明人发现人间充质干细胞方法使得可以：（1）再生浅软骨软骨缺损和全软骨缺损（骨软骨病变）; （2）拓宽适宜的临床人群，常规包括中年患者; （3）消除使用自体组织移植物（成熟软骨和骨膜覆盖物）修复关节软骨损伤; （4）再生其他类型的损伤软骨，如髌骨和脊髓软骨; （5）在老年骨关节炎患者中再生关节软骨; 和（6）形成完全融入相邻正常组织的新软骨和软骨下骨。

    ISOLATING AND THERAPEUTIC USE OF PERIVASCULAR MEDICINAL CELLS
    10.
    发明申请
    ISOLATING AND THERAPEUTIC USE OF PERIVASCULAR MEDICINAL CELLS 审中-公开
    隔离药物细胞的分离和治疗应用

    公开(公告)号：US20140314869A1

    公开(公告)日：2014-10-23

    申请号：US14241872

    申请日：2012-08-27

    申请人： Arnold I. Caplan

    发明人： Arnold I. Caplan

    IPC分类号： A61K35/32 ,  B02C19/00

    CPC分类号： A61K35/32 ,  A61K35/12 ,  B02C19/0056 ,  C12N5/0605 ,  C12N5/0668 ,  C12N2509/00

    摘要： Disclosed are perivascular medicinal cells (PVMCs), methods of isolating PVMCs, and a composition comprising PVMCs having medicinal capabilities. Specifically, the disclosure provides a method of isolating PVMCs from an umbilical cord blood vessel or from bone. The disclosure further provides a method of making an enhanced, autologous bone graft, a method of stimulating bone regeneration comprising administering a therapeutically effective amount of bone-derived PVMCs, a method of reconstructing bone tissue, and methods of treating a disease that affects cellular function. PVMCs capable of secreting a site-dependent trophic factor are also described.

    摘要翻译： 公开了血管周围药物细胞（PVMC），分离PVMC的方法和包含具有药用能力的PVMC的组合物。 具体地，本公开提供了从脐带血管或骨分离PVMC的方法。 本公开进一步提供了一种制备增强的自体骨移植物的方法，一种刺激骨再生的方法，包括施用治疗有效量的骨源性PVMC，重建骨组织的方法和治疗影响细胞功能的疾病的方法 。 还描述了能够分泌位点依赖性营养因子的PVMC。